• Clinical and Experimental Pediatrics
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• 제48권5호
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• pp.476-480
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• 2005

Immunosuppressive therapy in pediatric renal transplant recipients is changing consequence of the increasing number of available immunosuppressive agents. The optimal use of immunosuppressive agents requires a thorough understanding of the pharmacokinetic characteristics, but the information on the pharmacokinetic characteristics of these drugs in pediatric transplant recipients is still limited. In general, patients younger than 5 years old show higher clearance rates, therefore the need for higher dosages in younger patients seems evident. By the therapeutic drug monitoring, trough($C_{min}$) and peak level($C_{max}$) are measured and the area under the blood concentration-time curve(AUC), which is taken as being representative of total systemic exposure can be calculated. Cyclosporine A (CSA) has poor bioavailability, which contributes to high inter- and intra-patient pharmacokinetic variability. CSA concentration measured 2 hours after administration($C_2$) has better correlation with the AUC than $C_{min}$ and is an alternative technique that predicts the AUC. Tacrolimus(Tac) has a great deal of inter-individual variability like CSA but intra-individual variability in systemic exposure is considered to be low. Both CSA and Tac are metabolized by a cytochrome P-450 enzyme isoform(CYP3A4). We should consider changing the dosages when CSA or Tac is used in combination with the medicines that inhibit or induce the CYP3A4. In case of steroid-free immunosuppressive therapy, the blood concentration of Tac should be frequently checked and dosage adjustment may be needed.

• 한국운동역학회지
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• 제20권3호
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• pp.303-310
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• 2010

The purpose of this study was (a)to compare electromyographic (EMG) activities and physiological variables on the development of fatigue induced by ergometer test, (b)to determine investigate the differences in the stage of fatigue between the electromyographic characteristics and physiological variables. Nine male university students who have no musculoskeletal disorder were recruited as the subjects. The electromyographic characteristics(peak IEMG, average IEMG, median frequency, mean edge frequency) and physiological variables(HR, RPE, blood lactate) were determined for each stage(15, 30, 45, 60 minutes, all out). For each dependent variable, one-way analysis of variance(ANOVA) with repeated measures and correlation analysis were performed to test if significant difference existed(p<.05). The results showed that peak IEMG, average IEMG from low extremity and physiological variables were significantly increased during the all-out stage. EMG parameters in VL, VM show significantly correlation with physiological variables during whole stages. This indicated that IEMG values may be proper parameters to determine muscle fatigue rather than physiological variables.

• Asian-Australasian Journal of Animal Sciences
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• 제23권12호
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• pp.1594-1600
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• 2010

A study was conducted to determine the dietary effects of a clay mineral (sodium bentonite, NaB) on manure gas emission, health, production, and meat characteristics of Hanwoo steers. Two diets fed to steers included a control diet (concentrate mix and rice straw) and a treatment diet (control diet+1.0% clay mineral/concentrate mix). Dietary NaB addition considerably reduced concentrations of gases ($H_2S$, $SO_2$ and $NH_3$) in the manure of Hanwoo steers. Growing steers fed NaB had similar blood profiles with the exception of lower (p<0.05) concentrations of blood alkaline phosphatase and lactate dehydrogenase. Dietary NaB addition tended to increase (p = 0.10) live weight by 30 kg at slaughtering and did not affect carcass yield and quality traits. Dietary NaB addition increased concentrations of P (p<0.01), Mg (p<0.01), Na (p<0.01), Zn (p<0.005), K (p = 0.08), Fe (p = 0.08) and Cu (p = 0.07) in the longissimus muscle compared to the control but did not affect (p>0.05) fatty acid composition. The study demonstrated that the dietary addition of a clay mineral could be effective in improving mineral bioavailability to Hanwoo steers, which could be one of the reasons for their improved performance.

• 대한의생명과학회지
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• 제8권4호
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• pp.275-282
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• 2002

This study was carried out to investigate the effect of fibrinogen genotype and other characteristics on the plasma fibrinogen levels. Many studies have conformed that high plasma fibrinogen levels are associated with the increased risk of ischaemic heart disease, stroke and arterial disease. And fibrinogen levels are related with age, obesity, cholesterol and alcohol consumption, genotypes. For this study the blood samples were collected from 93 healthy Koreans (66 males and 27 females). The blood samples were individually analyzed by smoking status, cholesterol levels, genotype, age, and gender. The plasma fibrinogen was assayed by clotting method (modified Clauss assay) and cholesterol was assayed by cholesterol oxidase method. Subjects were classified by current smokers, ex-smokers (<6 month), or nonsmokers. The $\beta$-fibrinogen genotype was detected by PCR of relevant region and digestion with HaeIII, with the H$_1$H$_1$ allele allowing cleavage by this restriction enzyme and H$_2$H$_2$ allele being refractory. In conclusion, the study shows that the factor of the increasement in the fibrinogen level was closely related with the cholesterol level, smoking status and genotype (H$_1$H$_2$); but there was no significant difference by gender, Especially, among the people over 50 years of age, fibrinogen level was higher with the increasement of cholesterol level (<200 mg/dl), current smoker, and genotype H$_1$H$_2$.

• Journal of Pharmaceutical Investigation
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• 제31권1호
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• pp.43-47
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• 2001

Sterically stabilized liposomes (SSL) have been introduced for longer circulation in blood than conventional liposomes (CL). However, there are a couple of problems in SSL preparation due to the instability of phospholipid and the degradation of drug in aqueous conditions. To solve these problems, it is necessary to go through lyophilization process. Therefore, in this study, effects of lyophilization on SSL were evaluated for physical characteristics changes upon rehydration of lyophilized SSL such as the particle size, efficiency of drug entrapment, turbidity and drug release. SSL containing streptozocin, a water-soluble anticancer drug as a model compound, were prepared with DSPC and DSPE-PEG 2000. The size was controlled to 100 nm by extrusion with polycarbonate membrane, and sucrose was used as a cryoprotectant for lyophilization at the 1:3 (lipid:sucrose) ratio. Upon rehydration of lyophilized SSL, the average size was in the range of $50{\sim}200\;nm$ which is adequate for longer circulation in blood, and the encapsulation efficiency was kept as its initial state. Rehydrated SSL were not adsorbed to rat plasma protein and revealed a similar drug release profile to that of fresh SSL before lyophilization. Therefore, lyophilization could be introduced efficiently to overcome aqueous instability problems of SSL.

• 약학회지
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• 제48권5호
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• pp.278-284
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• 2004

In order to determine the bioavailability of c1onazepam, an anxiolytic drug, a simple, rapid and sensitive HPLC analysis was developed in healthy Korean volunteers. The analysis system was validated in specificity, accuracy, precision and linearity. The analysis condition we established was 2.58 min and 5 ng/$m\ell$ in retention time and limit of quantitation of c1onazepam, respectively, using reverse-phase C18 column connected to UV detector. Quantitation was performed at 235 nm wave length with p-hydroxybenzoic acid ethyl ester as internal standard. The method involved a simple extraction. In order to study blood level profiles as a function of time, eight volunteers were enrolled and orally took 6 mg clonazepam once. The blood samples were collected from 0 to 120 h after the drug administration. Mean AUC and Cmax value were 1028.17$\pm$568.165 (ng/$m\ell$$.$hr) and 41.25$\pm$10.82 (ng/$m\ell$), respectively. And mean Tmax and T$_{1}$2/ value were 1.08$\pm$0.42 (hr) and 30.78$\pm$3.26 (hr). From the results we determine the pharmacokinetic characteristics of clonazepam in Korean people using a newly developed and useful HPLC method.

• 한국보건간호학회지
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• 제23권2호
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• pp.306-317
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• 2009

Objectives: The purpose of this study was to assess the characteristics of body weight perception and physiological index in young adult women. Methods: Subjects were 283 Korea women. Data was from the 2005 Korean National Health and Survey. Three groups-low normal and overweight-were based on Body mass index(BMI). General characteristics, health status perception, weight control behavior and physiological index such as BMI, total cholesterol, high-density cholesterol (HDL), low-density cholesterol (LDL), triglyceride, systolic and diastolic blood pressure, and waist circumference were compared. Data were analyzed by t-test, $x^2$-test and ANOVA using SPSS program. Results: Of the normal weight group, 28.7% of subjects perceived themselves as overweight. Of the low weight group, 30.3% regarded their weight as normal weight. Of the overweight subjects, weight control was attempted by exercise (50.1%) and food reduction (77.1%). Significant group-related differences were evident in HDL, LDL, triglyceride, systolic blood pressure and waist circumference among three groups. Conclusions: Perception and attitude regarding body weight can be inaccurate. A weight control program should consider the relation of physiological index and weight based on BMI.

• 한국초지조사료학회지
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• 제33권4호
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• pp.281-289
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• 2013

본 연구는 다양한 수준의 셀레늄 강화 청보리 사일리지와 무기셀레늄을 급여 시 비육기 거세한우의 생산성, 혈액 성상, 도체특성 및 조직 내 셀레늄 축적에 미치는 영향을 조사하였다. 시험은 거세비육우 20두를 공시하였고, 처리구는 셀레늄 수준에 따라 0.1 ppm Se(대조구), 0.3 ppm Se (T1), 0.9 ppm Se (T2) 및 무기셀레늄 0.9 ppm Se (T3) 급여구로 4처리를 나누어 처리구 구당 5두씩 완전임의 배치하여 90일간 사양시험을 실시하였다. 각 시험사료는 셀레늄 강화 및 셀레늄 무처리 관행 청보리 사일리지를 조합하여 건물기준 30% 함유하도록 배합하였다. 실험사료 내에 셀레늄 강화수준은 사료섭취량과 증체에 영향을 미치지 않았고, 혈중 총 지질과 중성지방농도는 대조구보다 T2구가 유의하게 낮았다(p<0.05). 혈중 면역글로불린은 셀레늄함유량이 많을수록 높게 나타나 T2와 T3구가 대조구보다 유의하게 높았다(p<0.05). 혈중 셀레늄농도는 유기태 셀레늄을 0.9 ppm 급여한 T2구가 가장 높았다(p<0.05). 도체율, 배최장근, 등지방두께, 근내지방도, 육색 및 지방색은 셀레늄급여로 인한 효과가 나타나지 않았다. 또한, 사료 내 셀레늄 수준 및 형태는 육질 및 육량등급 간에 관련성이 형성되지 않았다. 신장, 간장 및 후지 내 셀레늄 함량은 사료 내 셀레늄 강화수준이 증가함에 따라 유의하게 직선적으로 증가하였고(p<0.05), 무기셀레늄급여는 대조구와 유의한 차이가 나타나지 않아, 조직 내 셀레늄함량 증가에 도움이 되지 않았다(p>0.05). 이상의 결과에서 셀레늄 강화 청보리 사일리지 내 존재하는 셀레늄은 조직 내 셀레늄함량을 증가시키기에 유효한 셀레늄급원인 것으로 나타났고, 셀레늄 강화 청보리 최고수준(0.9 ppm Se)으로 급여하여 생산된 한우 후지육 100 g에 함유되어 있는 셀레늄은 성인기준 1일 최소 셀레늄 권장량($40{\mu}g$)의 약 69%를 충족시키는 것으로 조사되었다.

• Journal of Preventive Medicine and Public Health
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• 제36권3호
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• pp.289-297
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• 2003

Objectives : The main objectives of this study are to identify the factors associated with hypertension control and to determine the influencing factors associated with antihypertensive therapy. Methods : The study was conducted on 107 subjects who participated in the 1999 and 2002 Gwacheon Study and who had had uncontrolled hypertension (systolic$\geq$140 or diastolic$\geq$ 90mmHg) in 1999, We compared the characteristics of the controlled and uncontrolled hypertensive group and investigated the characteristics of those taking antihypertensive medication. Univariate associations between hypertension control and its characteristics and the association between antihypertension treatment and its characteristics were tested with $x^2$-test. We also peformed logistic regression analysis. Results : The participants who had their blood pressure checked within 6 months before their first measurement and those who had taken the antihypertensive medication showed significantly better hypertension control during the follow-up. The multivariate analysis showed that baseline antihypertensive therapy was the most important determinant factor of hypertension control during the follow-up. Socioeconomic level and life style did not affect hypertension control when controlled by the treatment variable in this study. The factors associated with antihypertensive therapy at follow-up were previous antihypertensive therapy, old age, and high educational level. Conclusions : Those who received antihypertensive therapy and those who had their blood pressure re-checked within 6 months both showed well controlled hypertension. The subjects with high educational level complied well with the antihypertensive regimen, but those in their forties did not.

• 감성과학
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• 제16권4호
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• pp.481-492
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• 2013

이 연구는 성인 남녀 462명을 대상으로 사전 설문검사를 통해 성별, 손잡이, 혈액형, 연령 등의 개인별 특성 집단과 다중지능 유형별 점수를 분류하였다. 그런 다음 뇌파측정시스템을 이용하여 전전두엽 부위인 Fp1과 Fp2 부위에 측정 전극을 부착하고 무자극 상태와 순수한 Pink noise 청각자극 상태에서의 집중력의 변화와 다중지능과의 관계를 알아보고자 하였다. 공분산분석 결과, 무자극에 비해 Pink noise 자극 시 대상자 전체의 평균 집중력이 유의하게 높게 나타났다. 개인별 특성에서는 남녀 성별을 제외한 왼손잡이, A형, 30대 집단에서 집중력이 유의하게 높게 나타났다. 그리고 무자극에 비해 Pink noise 상태의 집중력은 공간적 지능과의 관계가 더욱 강화되었고, 음악적 지능과는 음적 상관관계를 형성하였다. 이러한 결과는 집중력 향상을 위한 Pink noise 활용 시 개인별 특성을 반영해야할 필요성이 있음을 시사하였다.