• Journal of the Korean Geotechnical Society
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• v.28 no.10
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• pp.69-77
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• 2012

Clogging of drainage pipes by scale is an important problem in civil engineering works. Although scale deposits can be removed by acid treatment or water jetting, these treatments are costly and have many disadvantages. In this study, scale samples from tunnel drainage pipes were analyzed using SEM-EDS and XRD. The main ingredient in scale was $CaCO_3$ of the calcite crystal form. Drainage experiments and recirculation type experiments were conducted to control and remove scale deposits, which were determined through visual and weight measuring analysis. As a result, Quantum Stick has the effect of limiting formation of scale.

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.2
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• pp.451-456
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• 2003

We investigated the effects of Sabaek-san (SBS) water extract on the growth of human lung carcinoma A549 cells. Upon treatment with SBS extract, a concentration-dependent inhibition of cell viability was observed and cells developed many of the hallmark features of apoptosis. including condensation of chromatin. Flow cytometry analysis confirmed that SBS treatment increased populations of apoptotic-sub G1 phase. In addition. proteolytic cleavages of poly(ADP-ribose) polymerase and β-catenin protein were observed after treatment of SBS extract. These apoptotic effects of SBS in A549 cells were associated with marked inhibition of Bcl-2 and Bel-xL mRNA in a dose-dependent manner. however the levels of Bax expression were not affected, SBS treatment also induced a proteolytic activation of caspase-3. which is believed to play a central role In the apoptotic signaling pathway. The previous and present results indicated that SBS-induced inhibition of lung cancer cell proliferation is associated with the blockage of G1/S progression and the induction of apoptosis.

• International Journal of Highway Engineering
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• v.19 no.6
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• pp.105-115
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• 2017

PURPOSES : The occurrence of unexpected disasters, including fire events, increases as the road network becomes complicated and traffic volume increases. When a fire event occurs on and under bridges, the damage extensively influences direct damage to structures, vehicles, and human life and secondary socioeconomic issues owing to traffic blockage. This study investigated potential fire-hazard risks on bridges of the Korean national route road. METHODS : The investigation was conducted using field investigation and analysis with satellite pictures and road views from commercial websites and the Bridge Management System (BMS). From the filed investigation, various potential fire resources were identified. The satellite pictures and road views were helpful in measuring and recognizing conditions underneath bridges, stowage areas, etc. RESULTS : There are various potential fire resources underneath bridges such as piled agricultural products, parked petroleum tanks, construction equipment, and attached high-voltage cables. A total of 94.6% of bridges have underneath clearances of less than 15 m. A bridge underneath volume that can stow a potential fire hazard resource was $7,332m^3$ on average, and most bridges have about $4,000m^3$ of space. Based on the BMS data, the amounts of PSC and steel girders were 29% and 25%, respectively. CONCLUSIONS : It was found that the amount of stowed potential fire hazard resources was proportional to the underneath space of bridges. Most bridges have less than 15 m of vertical clearance that can be considered as a critical value for a bridge fire. The fire risk investigation results should be helpful for developing bridge fire-protection tools.

• Journal of Radiation Protection and Research
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• v.39 no.4
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• pp.176-181
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• 2014

The object of this paper is to evaluate the fission product inventories and radiological doses in a non-LOCA event, based on the U.S. NRC's regulatory methodologies recommended by the TID-14844 and the RG 1.195. For choosing a non-LOCA event, one fuel assembly was assumed to be melted by a channel blockage accident. The Hanul nuclear power reactor unit 6 and the CE $16{\times}16$ fuel assembly were selected as the computational models. The burnup cross section library for depletion calculations was produced using the TRITON module in the SCALE6.1 computer code system. Based on the recently licensed values for fuel enrichment and burnup, the source term calculation was performed using the ORIGEN-ARP module. The fission product inventories released into the environment were obtained with the assumptions of the TID-14844 and the RG 1.195. With two kinds of source terms, the radiological doses of public in normal environment reflecting realistic circumstances were evaluated by applying the average condition of meteorology, inhalation rate, and shielding factor. The statistical analysis was first carried out using consecutive three year-meteorological data measured at the Hanul site. The annual-averaged atmospheric dispersion factors were evaluated at the shortest representative distance of 1,000 m, where the residents are actually able to live from the reactor core, according to the methodology recommended by the RG 1.111. The Korean characteristic-inhalation rate and shielding factor of a building were considered for a series of dose calculations.

• Journal of Cancer Prevention
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• v.23 no.4
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• pp.170-175
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• 2018

Background: Human hepatocellular carcinoma (HCC) is a common liver tumor and the main cause of cancer-related death. Tyrosine kinase inhibitors, such as imatinib and GNF5 which were developed to treat chronic myelogenous leukemia, regulate the progression of various cancers. The aim of this study was to confirm the anti-tumor activity of tyrosine kinase inhibitors through regulation of S-phase kinase-associated protein 2 (Skp2), an important oncogenic factor in various cancer cells, in human hepatocarcinoma SK-HEP1 cells. Methods: Cell viability and colony formation assays were conducted to evaluate the effects of imatinib, GNF5 and GNF2 on the growth of SK-HEP1 cells. Using immunoblot analysis, we assessed change of the activation of caspases, PARP, Akt, mitogen-activated protein kinases, and Skp2/p27/p21 pathway by imatinib and GNF5 in SK-HEP1 cells. Using sh-Skp2 HCC cells, the role of Skp2 in the effects of imatinib and GNF5 was evaluated. Results: Imatinib and GNF5 significantly inhibited the growth of SK-HEP1 cells. Treatment of imatinib and GNF5 decreased Skp2 expression and Akt phosphorylation, and increased the expression of p27, p21, and active-caspases in SK-HEP1 cells. In sh-Skp2 HCC cells, cell growth and the expression of Skp2 were inhibited by more than in the mock group treated with imatinib and GNF5. Conclusions: These results suggest that the anti-growth activity of tyrosine kinase inhibitors may be associated with the regulation of p27/p21 and caspases through Skp2 blockage in HCC cells.

• Korean Journal of Construction Engineering and Management
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• v.10 no.5
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• pp.123-134
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• 2009

Since 1970s, urethane waterproofing method is broadly used in rooftops, underground spaces, and sports stadium for its outstanding ultraviolet blockage, watertightness, and elasticity. However, development of slippage-resistance and endurance, improvement of function considering convenience and visually pleasing of users, urethane waterproofing method is necessary, since rooftops and underground spaces have slippage and external force risks. Therefore, many improved waterproofing methods are being developed and, recently, embo-thane waterproofing method, which applies embo-spray coating system, has been developed. This paper explains exposure, nonexposure, and floor-material of embo-thane waterproofing method, and then perform experimental study for comparison with urethane waterproofing method about tensile strength, coefficient of expansion, performance of bond, anti-abrasion, and slippage-resistance. In addition, the performance index was presented for the superiority of embo-thane waterproofing method compared to urethane by setting up evaluation criteria considering not only physical performance but also design side of embo-thane waterproofing method, and Value Analysis applying AHP. Also for an assessment considering uncertain result, Monte Carlo Simulation Method was used to operate reliability analysis through statistic approach method.

• Science of Emotion and Sensibility
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• v.14 no.3
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• pp.459-466
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• 2011

Sleep diseases such as snoring and sleep apnea are physically, mentally harmful and results serious health problems. Snoring, known as breathing noise, is caused by coupled oscillation of the airway when the air passes through the trachea, and sleep apnea is caused by upper airway blockage. In order to solve these problems, many attempts have been made to detect the snoring during sleep and alleviate it. In this study, a new sensing system and analysis algorithm were developed in order to detect snoring sounds correctly under various sleep environments. Two polyvinylidene fluoride (PVDF) vibration sensors were used inside the pillow. The first PVDF sensor detects vibration transmitted through skull caused by snoring. And the second PVDF sensor detects both snoring sounds and ambient noises. The signals of two sensors were acquired through the designed analog circuits, and analyzed for snoring detection. Ten volunteers were participated for the experiment under five different conditions. Data from two PVDF sensors were processed by the established analysis algorithm, and snoring sounds were compared to noises. The results indicated that the energy of snoring is 70% bigger than that of ambient noise, which proves effectiveness of sensing system and analysis algorithm. Further study would be continued for more wide clinical studies with various environment noises. Based on this study, development of anti-snore pillow and sleep monitoring system for comfort sleep could be developed.

• The Korean Journal of Pain
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• v.30 no.1
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• pp.3-17
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• 2017

Background: Postherpetic neuralgia (PHN) is a common and painful complication of acute herpes zoster. In some cases, it is refractory to medical treatment. Preventing its occurrence is an important issue. We hypothesized that applying nerve blocks during the acute phase of herpes zoster could reduce PHN incidence by attenuating central sensitization and minimizing nerve damage and the anti-inflammatory effects of local anesthetics and steroids. Methods: This systematic review and meta-analysis evaluates the efficacy of using nerve blocks to prevent PHN. We searched the MEDLINE, EMBASE, Cochrane Library, ClinicalTrials.gov and KoreaMed databases without language restrictions on April, 30 2014. We included all randomized controlled trials performed within 3 weeks after the onset of herpes zoster in order to compare nerve blocks vs active placebo and standard therapy. Results: Nine trials were included in this systematic review and meta-analysis. Nerve blocks reduced the duration of herpes zoster-related pain and PHN incidence of at 3, 6, and 12 months after final intervention. Stellate ganglion block and single epidural injection did not achieve positive outcomes, but administering paravertebral blockage and continuous/repeated epidural blocks reduced PHN incidence at 3 months. None of the included trials reported clinically meaningful serious adverse events. Conclusions: Applying nerve blocks during the acute phase of the herpes zoster shortens the duration of zoster-related pain, and somatic blocks (including paravertebral and repeated/continuous epidural blocks) are recommended to prevent PHN. In future studies, consensus-based PHN definitions, clinical cutoff points that define successful treatment outcomes and standardized outcome-assessment tools will be needed.

• Journal of Korea Water Resources Association
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• v.38 no.12 s.161
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• pp.1039-1049
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• 2005

The objective of this study is to produce optimal radar-derived rainfall for hydrologic utilization. The ground clutter and beam blockage effects from Mt. Kwanak station (E.L 608m) are removed from radar reflectivities by POD analysis. The reflectivities are used to produce radar rainfall data in the form of rain rates (mm/h) by the application of the Marshall-Palmer reflectivity versus rainfall relationship. However, these radar-derived rainfall are underestimated in temporal and spatial scale compared with observed one, so it is necessary to hire a correction scheme based on the gauge-to-radar (G/R) statistical adjustment technique. The selected watershed for studying the real-time correction of radar-rainfall estimation is the Soyang dam site, which is located approximately 100km east of Kwanak radar station. The results indicate that adjusted radar rainfall with the gauge measurement have reasonal G/R ratio ranged on 0.95-1.32 and less uncertainty with that mean standard deviation of G/R ratio are decreased by $9-28\%$. Mean areal precipitation from adjusted radar rainfall are well agreed to the observed one on the Soyang River watershed. It is concluded that the real-time bias adjustment scheme is useful to estimate accurate basin-based radar rainfall for hydrologic application.

• Journal of Korean Tunnelling and Underground Space Association
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• v.17 no.3
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• pp.319-332
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• 2015

The pressure wave formed by the piston effects of the train proceeds within the tunnel when a train enters the tunnel with a high speed. Depending on the condition of tunnel exit, the compression waves reflect at a open end, change to the expansion waves, transfer to tunnel entrance back. Due to interference in the pressure waves and running train, passengers experience severe pressure fluctuations. And these pressure waves result in energy loss, noise, vibration, as well as in the passengers' ears. In this study, we performed comparison between numerical analysis and field experiments about the characteristics of the pressure waves transport in tunnel that appears when the train enter a tunnel and the variation of pressure penetrating into the train staterooms according to blockage ratio of train. In addition, a comparative study was carried out with the ThermoTun program to examine the applicability of the compressible 1-D model(based on the Method of Characteristics). Furthermore examination for the adequacy of the governing equations analysis based on compressible 1-D numerical model by Baron was examined.