• Polymer(Korea)
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• v.34 no.3
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• pp.274-281
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• 2010

In this study, PEG-PLA(or PLGA) amphiphilic di-block copolymers were synthesized by ring opening polymerization of D,L-lactide(or glycolide) and applied to polymeric micelle system for solubilization of a rosiglitazone as diabetes drug. The drug could be efficiently loaded into the polymer micelle by solid dispersion technique, and the drug-loaded micelles were characterized and evaluated as a drug delivery carrier by fluorescence spectrometer, DSC, and DLS measurements. The colloidal stability of drug loaded micelles in aqueous media could be enhanced by addition of 2-hydroxy-N-picolylnitinamide as a hydrotropic agent. The polymer micelles also showed biocompatible and nontoxic properties in vitro cell viability using MTT assay, and the drug loaded micelles were observed to be more effective than free drug for decreasing glucose in blood of rats.

• Journal of KIISE:Computing Practices and Letters
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• v.9 no.3
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• pp.266-277
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• 2003

Every conceptual temporal rat relationship can be described using one of seven relations (before, meets, overlaps, during, starts, finishes, and equals ). The conceptual representation provides an efficient means for our multimedia authoring system to automatically fill in the necessary timing details. We developed a multimedia Presentation authoring system that supports a mechanism for conceptually representing the temporal relations of different media. Among the many editors that make up our system, the temporal relation editor provides users with an intuitive mechanism for representing the conceptual flow of a presentation by simple and direct graphical manipulations. Our system is based on the SMIL(Synchronized Multimedia Integration Language). The conceptual temporal relation editor and other editors of our system exchange their information in real-time and automatically generate SMIL codes through the SMIL Object Manager. Our system uses TRN(Temporal Relation Network) as its internal multimedia presentation representation. The TRN corresponds exactly to the structure seen in the graphical representation of the presentation. A parallel relationship found in a TRN can be collapsed into a single synchronization block. This facilitates the determination of the playing time of each component and can be the basic unit for reusability of already prepared blocks of presentation code.

• Journal of Veterinary Clinics
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• v.33 no.4
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• pp.234-236
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• 2016

A 14 kg, 9-year-old, spayed female, Cocker Spaniel was presented to the Veterinary Medical Teaching Hospital of Seoul National University with a history of head tilt and circling. Otitis externa and media were diagnosed by computerized tomography, and total ear canal ablation was performed. In preanesthetic evaluation, systemic hypertension and second-degree atrioventricular block were observed, but there was no regurgitation through the heart valves. Systemic hypertension was managed with amlodipine (0.1 mg/kg, PO, BID) for the anesthesia. The dog was premedicated with cefazolin (22 mg/kg, IV) and midazolam (0.2 mg/kg, IV). Anesthesia was induced with alfaxalone (2 mg/kg, IV) and maintained with isoflurane and 100% oxygen following intubation. During surgery, vital signs (heart rate, respiratory rate, blood pressure, end tidal carbon dioxide partial pressure and body temperature) were maintained within normal ranges, but bradycardia was observed and corrected with glycopyrrolate (5 ug/kg IV, twice). During subcuticular suture, electrohemostasis was applied at the incision line, which was close to the trigeminal nerve. In no time at all, heart rate dramatically decreased from 110 to 60 beats per minute. No additional treatment was done because mean blood pressure was maintained above 70 mmHg. The heart rate recovered according to the decrease of end tidal isoflurane concentration and there were no complications associated with the anesthesia and surgery. Sudden bradycardia after electrical stimulation around the trigeminal nerve was considered as trigeminocardiac reflex (TCR). It is recommended to be careful of bradycardia from TCR when electrocautery is used in the craniofacial area during surgery.

• The korean journal of orthodontics
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• v.39 no.2
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• pp.105-111
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• 2009

Objective: To estimate the effects of bracket material type on enamel decalcification during orthodontic treatment, this study analyzed the adhesion level of mutans streptococci (MS) to orthodontic bracket materials in vivo. Methods: Three different types of orthodontic bracket materials were used: stainless steel, monocrystalline sapphire, and polycrystalline alumina. A balanced complete block design was used to exclude the effect of positional variation of bracket materials in the oral cavity. Three types of plastic individual trays were made and one subject placed the tray in the mouth for 12 hours. Then, the attached bacteria were isolated and incubated on a mitis salivarius media containing bacitracin for 48 hours. Finally, the number of colony forming units of MS was counted. The experiments were independently performed 5 times with each of the 3 trays, resulting in a total of 15 times. Mixed model ANOVA was used to compare the adhesion amount of MS. Results: There was no difference in colony forming units among the bracket materials irrespective of jaw and tooth position. Conclusions: This study suggested that the result of quantitative analysis of MS adhesion to various orthodontic bracket materials in vivo may differ from that of the condition in vitro.

• Journal of Broadcast Engineering
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• v.25 no.3
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• pp.325-337
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• 2020

Versatile Video Coding (VVC) is a new video coding standard that is being developed by the Joint Video Experts Team of ISO/IEC/ITU-T and it has adopted various technologies including screen content coding tools. Screen contents have a feature that blocks are likely to have diagonal edges like character regions. If triangular partitioning coding is allowed for screen contents having such the feature, coding efficiency would increase. This paper proposes a intra prediction method using triangular partitioning prediction for screen content coding. Similar to the Triangular Prediction Mode of VVC that supports the triangular partitioning prediction, the proposed method derives two prediction blocks using Horizontal and Vertical modes and then it blends the predicted blocks applying masks with triangle shape to generate a final prediction block. The experimental results of the proposed method showed an average of 1.86%, 1.49%, and 1.55% coding efficiency in YUV, respectively, for VVC screen content test sequences.

• Molecules and Cells
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• v.38 no.7
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• pp.663-668
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• 2015

hBMSCs are multipotent cells that are useful for tissue regeneration to treat degenerative diseases and others for their differentiation ability into chondrocytes, osteoblasts, adipocytes, hepatocytes and neuronal cells. In this study, biodegradable elastic hydrogels consisting of hydrophilic poly(ethylene glycol) (PEG) and hydrophobic poly(${\varepsilon}$-caprolactone) (PCL) scaffolds were evaluated for tissue engineering because of its biocompatibility and the ability to control the release of bioactive peptides. The primary cultured cells from human bone marrow are confirmed as hBMSC by immunohistochemical analysis. Mesenchymal stem cell markers (collagen type I, fibronectin, CD54, $integrin1{\beta}$, and Hu protein) were shown to be positive, while hematopoietic stem cell markers (CD14 and CD45) were shown to be negative. Three different hydrogel scaffolds with different block compositions (PEG:PCL=6:14 and 14:6 by weight) were fabricated using the salt leaching method. The hBMSCs were expanded, seeded on the scaffolds, and cultured up to 8 days under static conditions in Iscove's Modified Dulbecco's Media (IMDM). The growth of MSCs cultured on the hydrogel with PEG/PCL= 6/14 was faster than that of the others. In addition, the morphology of MSCs seemed to be normal and no cytotoxicity was found. The coating of the vascular endothelial growth factor (VEGF) containing scaffold with Matrigel slowed down the release of VEGF in vitro and promoted the angiogenesis when transplanted into BALB/c nude mice. These results suggest that hBMSCs can be supported by a biode gradable hydrogel scaffold for effective cell growth, and enhance the angiogenesis by Matrigel coating.

• Development and Reproduction
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• v.21 no.1
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• pp.47-54
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• 2017

Unlike mouse results, cloning efficiency of nuclear transfer from porcine induced pluripotent stem cells (piPSCs) is very low. The present study was performed to investigate the effect of cell cycle inhibitors on the cell cycle synchronization of piPSCs. piPSCs were generated using combination of six human transcriptional factors under stem cell culture condition. To examine the efficiency of cell cycle synchronization, piPSCs were cultured on a matrigel coated plate with stem cell media and they were treated with staurosporine (STA, 20 nM), daidzein (DAI, $100{\mu}M$), roscovitine (ROSC, $10{\mu}M$), or olomoucine (OLO, $200{\mu}M$) for 12 h. Flow Cytometry (FACs) data showed that piPSCs in control were in G1 ($37.5{\pm}0.2%$), S ($34.0{\pm}0.6%$) and G2/M ($28.5{\pm}0.4%$). The proportion of cells at G1 in DAI group was significantly higher than that in control, while STA, ROSC and OLO treatments could not block the cell cycle of piPSCs. Both of viability and apoptosis were affected by STA and ROSC treatment, but there were no significantly differences between control and DAI groups. Real-Time qPCR and FACs results revealed that DAI treatment did not affect the expression of pluripotent gene, Oct4. In case of OLO, it did not affect both of viability and apoptosis, but Oct4 expression was significantly decreased. Our results suggest that DAI could be used for synchronizing piPSCs at G1 stage and has any deleterious effect on survival and pluripotency sustaining of piPSCs.

• 대한공업교육학회지
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• v.34 no.1
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• pp.171-195
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• 2009

The purpose of this study is 1) to survey to identify how high school students think about career guidance and job and 2) to pursue effective career guidance. According to the survey result, first, most students have thought about their career. They chose friends as a counselor for their future. Among respondents, 39.84% of them said they did not consult with teachers. They said academic record is a stumbling block in choosing career. Second, many students responded career guidance should start at 'Junior High school'. 76.56% of respondents said they were lack of career guidance resources. With respect to career, an important subject was shown as the following order: social study, English, Korean, Science and Math. Third, students recognized the face that aptitude and ability should be the utmost important factors in choosing career. They chose mass media as a main source to gain information relative to career, which accounted for 52.34% and 20.31% for teachers. In the case of students who have rather 'poor'home background, teachers were the main sources for career information, whose proportion was relatively high. Forth, parents were the most influential people who helped students choose which high school to go(40.69%). In terms of scope of higher education, 65.63% said they wanted to graduate university. Students who has good academic records and good home environment wanted to pursue Master's or Doctor's degrees. 70.31% of respondents said they attended a high school just because they wanted to have a desired job.

• Journal of Broadcast Engineering
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• v.15 no.3
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• pp.407-413
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• 2010

In DCA (Dynamic Channel Allocation) scheme of uplink cellular system appling a frequency reuse factor of one, when a new call requests a channel, the new call will be blocked if its SINR (Carrier to Noise and Interference Ratio) is less than the required SINR or there is no available channel. The additional channel allocation for the blocked new call can be performed with channel borrowing in the adjacent cells. The channel borrowing causes the CCI (Co-Channel Interference), thus the SINR of the existing calls is deteriorated and the channel reallocation for the existing calls is required. As a result, the channel borrowing leads to a complex calculation so that it is a NP-hard problem. Therefore, to overcome the problem, we propose a novel Group Search-based DCA scheme which decreases the number of the blocked new calls and then reduces the number of the channel reallocation by the channel borrowing for the blocked new calls. The proposed scheme searches the all channels in a group of the adjacent cells and home cell at the same time in order to minimizes the number of the blocked new calls. The simulation results show that proposed Group Search-based DCA scheme provides better new call blocking probability and system throughput than the existing Single Search-based DCA scheme which searches only the channels in home cell.

• Journal of Broadcast Engineering
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• v.15 no.3
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• pp.380-390
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• 2010

The most recent standard video codec, H.264/AVC achieves significant coding efficiency by using a rate-distortion optimization(RDO). The RDO is a measurement for selecting the best mode which minimizes the Lagrangian cost among several modes. As a result, the computational complexity is increased drastically in encoder. In this paper, a method for fast intra prediction mode decision is proposed to reduce the RDO complexity. To speed up Intra$4{\times}4$ and Chroma Intra encoding, the proposed method decides the case that MPM (Most Probable Mode) is the best prediction mode. In this case, the RDO process is skipped, and only MPM is used for encoding the block in Intra$4{\times}4$. And the proposed method is also applied to the chroma Intra prediction mode in a similar way to the Intra$4{\times}4$. The experimental results show that the proposed method achieves an average encoding time saving of about 63% with negligible loss of PSNR (Peak Signal-to-Noise Ratio).