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Preparation and Characterization of PEG-PLA(PLGA) Micelles for Solubilization of Rosiglitazone  

Kim, Yon-Hwan (Department of Polymer Science and Engineering, Chungnam National University)
Im, Jeong-Hyuk (Department of Polymer Science and Engineering, Chungnam National University)
Min, Hyun-Su (Department of Polymer Science and Engineering, Chungnam National University)
Kim, Jun-Ki (Department of Chemical and Biological Engineering, Chungju National University)
Lee, Yong-Kyu (Department of Chemical and Biological Engineering, Chungju National University)
Park, Go-Eun (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Uijeongbu St. Mary's Hospital)
Cho, Kwang-Jae (Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Uijeongbu St. Mary's Hospital)
Huh, Kang-Moo (Department of Polymer Science and Engineering, Chungnam National University)
Publication Information
Polymer(Korea) / v.34, no.3, 2010 , pp. 274-281 More about this Journal
Abstract
In this study, PEG-PLA(or PLGA) amphiphilic di-block copolymers were synthesized by ring opening polymerization of D,L-lactide(or glycolide) and applied to polymeric micelle system for solubilization of a rosiglitazone as diabetes drug. The drug could be efficiently loaded into the polymer micelle by solid dispersion technique, and the drug-loaded micelles were characterized and evaluated as a drug delivery carrier by fluorescence spectrometer, DSC, and DLS measurements. The colloidal stability of drug loaded micelles in aqueous media could be enhanced by addition of 2-hydroxy-N-picolylnitinamide as a hydrotropic agent. The polymer micelles also showed biocompatible and nontoxic properties in vitro cell viability using MTT assay, and the drug loaded micelles were observed to be more effective than free drug for decreasing glucose in blood of rats.
Keywords
PEG-PLA(PLGA) diblock copolymer; polymer micelle; rosiglitazone; hydrotropic agent;
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