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Simultaneous feeding of calcium butyrate and tannin extract decreased the incidence of diarrhea and proinflammatory markers in weaned piglets

  • Maito, Camila Demarco;Melo, Antonio Diego Brandao;de Oliveira, Angela Cristina da Fonseca;Genova, Jansller Luiz;Filho, Jair Rodini Engracia;de Macedo, Renata Ernlund Freitas;Monteiro, Kelly Mazutti;Weber, Saulo Henrique;Koppenol, Astrid;Costa, Leandro Batista
    • Animal Bioscience
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    • v.35 no.1
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    • pp.87-95
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    • 2022
  • Objective: This study was conducted to investigate the effect of associating calcium butyrate with tannin extract, compared to an antimicrobial on the growth performance, incidence of diarrhea, intestinal histology, immune-expression of cyclooxygenase-2 (COX-2) and tumor necrosis factor α (TNF-α) in piglets. Methods: Seventy-two piglets (36 barrows and 36 gilts) weaned at 28±2 d and initial body weight of 7.17±1.07 kg were allocated to 3 treatments in a randomized complete block design with 8 replicates per treatment and 3 animals per experimental unit. Treatments were composed of NC, negative control: basal diet without additives; PC, positive control: basal diet + 40 mg/kg of colistin sulfate; or BT, basal diet + calcium butyrate + tannin extract. The butyrate and tannin inclusion levels were 0.15% in the pre-starter phase and 0.075% in the starter phase. Incidence of diarrhea was monitored daily, and on d 14 and 35 of experiment, 1 animal from each experimental unit was slaughtered to collect intestinal samples. Results: No significant differences were observed for growth performance. The butyrate-and tannin-based additive resulted in reduced (p<0.05) incidence of diarrhea in piglets during d 1 to 14 and d 1 to 35 in comparison with the other treatments. Piglets that consumed the diet containing the calcium-butyrate and tannin showed a lower (p<0.05) crypt depth in the duodenum than those receiving the NC treatment at 14 d of experimentation. The BT treatment provided a lower (p<0.05) immune-expression of COX-2 at 14 d and TNF-α at 35 d in the duodenum. Conclusion: Association between calcium butyrate and tannin extract resulted in a significant decrease in the incidence of diarrhea and inflammatory process in the duodenum of piglets. Therefore, calcium-butyrate combined with tannin could be a part of an alternative program to reduce the use of antimicrobials in the diet of weaned piglets.

Anesthetic efficacy of supplemental buccal infiltration versus intraligamentary injection in mandibular first and second molars with irreversible pulpitis: a prospective randomized clinical trial

  • Zargar, Nazanin;Shojaeian, Shiva;Vatankhah, Mohammadreza;Heidaryan, Shirin;Ashraf, Hengameh;Baghban, Alireza Akbarzadeh;Dianat, Omid
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.22 no.5
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    • pp.339-348
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    • 2022
  • Background: To compare the anesthetic efficacy of supplemental buccal infiltration (BI) (1.7 ml) versus intraligamentary (IL) injection containing 0.4 ml of 4% articaine with 1:100.000 epinephrine after an inferior alveolar nerve block (IANB) with 1.7 ml 2% lidocaine in the first and second mandibular molars diagnosed with irreversible pulpitis (IP). Methods: One hundred subjects diagnosed with IP of either the mandibular first (n = 50) or second molars (n = 50) and failed profound anesthesia following an IANB were selected. They randomly received either the IL or BI techniques of anesthesia. Pain scores on a 170 mm Heft-Parker visual analog scale were recorded initially, before, and during supplemental injections. Furthermore, pulse rate was measured before and after each supplemental injection. During the access cavity preparation and initial filing, no or mild pain was assumed to indicate anesthetic success. The chi-square test, Mann-Whitney U test, and independent samples t-test were used for the analyses. Results: The overall success rates were 80% in the IL group and 74% in the BI group, with no significant difference (P = 0.63). In the first molars, there was no significant difference between the two techniques (P = 0.088). In the second molars, IL injection resulted in a significantly higher success rate (P = 0.017) than BI. IL injection was statistically more successful (P = 0.034) in the second molars (92%) than in the first molars (68%). However, BI was significantly more successful (P = 0.047) in the first molars (88%) than in the second molars (64%). The mean pulse rate increase was significantly higher in the IL group than in the BI group (P < 0.001). Conclusions: Both the IL and BI techniques were advantageous when used as supplemental injections. However, more favorable outcomes were observed when the second molars received IL injection and the first molars received BI.

Anesthetic efficacy of primary and supplemental buccal/lingual infiltration in patients with irreversible pulpitis in human mandibular molars: a systematic review and meta-analysis

  • Gupta, Alpa;Sahai, Aarushi;Aggarwal, Vivek;Mehta, Namrata;Abraham, Dax;Jala, Sucheta;Singh, Arundeep
    • Journal of Dental Anesthesia and Pain Medicine
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    • v.21 no.4
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    • pp.283-309
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    • 2021
  • Achieving profound anesthesia in mandibular molars with irreversible pulpitis is a tedious task. This review aimed at evaluating the success of buccal/lingual infiltrations administered with a primary inferior alveolar nerve block (IANB) injection or as a supplemental injection after the failure of the primary injection in symptomatic and asymptomatic patients with irreversible pulpitis in human mandibular molars. The review question was "What will be the success of primary and supplemental infiltration injection in the endodontic treatment of patients with irreversible pulpitis in human mandibular molars?" We searched electronic databases, including Pubmed, Scopus, and Ebsco host and we did a comprehensive manual search. The review protocol was framed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) checklist. We included clinical studies that evaluated and compared the anesthetic outcomes of primary IANB with primary and/or supplementary infiltration injections. Standard evaluation of the included studies was performed and suitable data and inferences were assessed. Twenty-six studies were included, of which 13 were selected for the meta-analysis. In the forest plot representation of the studies evaluating infiltrations, the combined risk ratio (RR) was 1.88 (95% CI: 1.49, 2.37), in favor of the secondary infiltrations with a statistical heterogeneity of 77%. The forest plot analysis for studies comparing primary IANB + infiltration versus primary IANB alone showed a low heterogeneity (0%). The included studies had similar RRs and the combined RR was 1.84 (95% CI: 1.44, 2.34). These findings suggest that supplemental infiltrations given along with a primary IANB provide a better success rate. L'Abbe plots were generated to measure the statistical heterogeneity among the studies. Trial sequential analysis suggested that the number of patients included in the analysis was adequate. Based on the qualitative and quantitative analyses, we concluded that the infiltration technique, either as a primary injection or as a supplementary injection, given after the failure of primary IANB, increases the overall anesthetic efficacy.

Experimental study on vertically upward steam-water two-phase flow patterns in narrow rectangular channel

  • Zhou, Jiancheng;Ye, Tianzhou;Zhang, Dalin;Song, Gongle;Sun, Rulei;Deng, Jian;Tian, Wenxi;Su, G.H.;Qiu, Suizheng
    • Nuclear Engineering and Technology
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    • v.53 no.1
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    • pp.61-68
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    • 2021
  • Experiments of vertically upward steam-water two-phase flow have been carried out in single-side heated narrow rectangular channel with a gap of 3 mm. Flow patterns were identified and classified through visualization directly. Slug flow was only observed at 0.2 MPa but replaced by block-bubble flow at 1.0 MPa. Flow pattern maps at the pressure of 0.2 MPa and 1.0 MPa were plotted and the difference was analyzed. The experimental data has been compared with other flow pattern maps and transition criteria. The results show reasonable agreement with Hosler's, while a wide discrepancy is observed when compared with air-water two-phase experimental data. Current criteria developed based on air-water experiments poorly predict bubble-slug flow transition due to the different formation and growth of bubbles. This work is significant for researches on heat transfer, bubble dynamics and flow instability.

Effect of Post Solidification Cooling Condition on the Mechanical Behavior of the 0.36Mn Containing Ductile Iron (0.36Mn이 함유된 구상흑연주철의 냉각조건에 따른 기계적 거동 고찰)

  • Kim, Suck-Dong;Kim, Sung-Gyoo
    • Journal of Korea Foundry Society
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    • v.41 no.4
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    • pp.349-356
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    • 2021
  • Effects of cooling condition after solidification on the microstructure and the mechanical properties of 0.36Mn containing ductile cast iron have been studied based on the minimized addition of Cu and Sn for vehicle component applications with better quality and cost competitiveness. Cu and Sn were selected for additional elements judging from the well-known fact of strong tendency of pearlite promotion followed by the tensile property improvement. After pouring of the Mg treated cast iron melt with various chemical compositions into the block specimens, two ways of post solidification cooling conditions were applied for comparison; both cooling in the mold and cooling in the air after dismantle at 800℃. The pearlite fraction of the mold-cooled specimens was analyzed as 27-44%, with the tensile strength and elongation of 513-568N/mm2 and 10.4-14.3%, respectively. Whilest, the air cooled specimens showed the pearlite fraction of 77~85%, with the tensile strength and elongation of 728~758N/mm2 and 3.2~6.0%, respectively. It is worthwhile to note that the remarkable improvement of both tensile strength and elongation of the ductile iron was achieved by the present air cooling condition with the minimized combined addition of Cu and Sn to the 0.36Mn containing ductile iron.

Effects of Additional Levels of Phyllostachys bambusoides on Ruminal Fermentation Characteristics and Methane Emission in in vitro (왕대의 첨가수준이 반추위 in vitro 발효성상과 메탄 발생량에 미치는 영향)

  • Jo, Seong-Uk;Lee, Shin-Ja;Lee, Ye-Jun;Kim, Hyun-Sang;Eom, Jun-Sik;Choi, You-Young;Bae, Eun-Ji;Lee, Sung-Sill
    • Korean Journal of Organic Agriculture
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    • v.29 no.2
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    • pp.241-256
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    • 2021
  • The current study was to evaluate the antioxidant activity of Phyllostachys bambusoides (PHB) as a feed additives and investigate whether its antioxidant activity could be helpful for increasing rumen fermentation characteristics and methane reduction. The antioxidant activity results showed that total polyphenols and flavonoids contents were 43.54 ± 8.68 mg CE/g and 17.13 ± 0.45 mg QE/g, respectively, and the IC50 values for 1,1-diphenyl-2-prcrylhydrazyl (DPPH) and 2,2'-azino-bis (3- ethylbenzthiazoline-6- sulphonic acid) (ABTS) radical scavenging activity were 163.13 ± 19.25 ㎍/mL and 97.07 ± 4.46 ㎍/mL, respectively. Two heads of cannulated Hanwoo (450 ± 30 kg), consuming timothy hay and a commercial concentrate (60:40, w/w) twice daily (at 09:00 and 17:30) at 2% of body weight, with free access to water and a mineral block, were used as rumen fluid donors. An in vitro incubation experiment was performed after 6, 12, 24, 48, and 72 hr with PHB added at concentration of 2, 4, and 6% of timothy hay basis. Total gas emission decreased as the amount of PHB addition increased at 6 and 24 hr of incubation. However, PHB addition did not affect total volatile fatty acid production, and methane and carbon dioxide emission also decreased as the amount of addition increased at 48 hr of incubation. Therefore, PHB was expected to be used as methane reducing additives in the ruminants.

The Effect of Social Anxiety on Fake News Acceptance Attitude : Focused on the Use Degree of SNS (사회불안감이 가짜뉴스 수용태도에 미치는 영향 : SNS 이용정도를 중심으로)

  • Oh, Ji-Hee
    • Journal of Korea Entertainment Industry Association
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    • v.15 no.6
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    • pp.179-191
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    • 2021
  • Social anxiety continues due to the emergence and spread of covid-19 infections. In this situation, false information related to the covid-19 infection is distributed through SNS in the form of fake news, which is a stumbling block to overcoming the national crisis. This study tried to present a theoretical basis for the establishment of policies for the regulation and eradication of fake news circulated through SNS by examining the effect of social anxiety on the fake news acceptance attitude by focusing on the use degree of SNS. For this study, a survey of 380 university students in the Seoul metropolitan area was conducted, and 336 data collected among them were analyzed as SPSS 25.0 and AMOS 23.0. According to the analysis results, social anxiety has a positive effect on the fake news acceptance attitude and the use degree of SNS, also the use degree of SNS has a positive effect on the fake news acceptance attitude. In addition, social anxiety has been confirmed to have a positive effect on fake news acceptance attitude through the use degree of SNS. These results empirically confirm the relationship between social anxiety, fake news acceptance attitude, and the use degree of SNS.

Ground Vibration Reduction Technology Using High Damping Polymer Concrete (고 감쇠 폴리머 콘크리트를 활용한 지반진동 저감기술에 대한 연구)

  • Kim, Jeong-Jin;Seok, Won-Gyun;We, Joon-Woo;Ahn, So-Hee
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.25 no.6
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    • pp.154-160
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    • 2021
  • Recently, there have been increasing construction works carried out in urban centers, which are inducing frequent artificial vibration in the vicinity of existing structures due to such construction works. moreover, in case of industrial estates, vibration is induced due to operation of machines in the surrounding areas, thereby causing problems. meanwhile, in case of ordinary concrete that compose structure has low level of damping capability for vibration. accordingly, there are difficulties in blocking a wide range of vibrations delivered to the structures from outside including not only vibrations generated in the structures themselves but also ground vibration. recently, numerous studies are being carried out actively on high-damping system that markedly enhanced the damping performances of structures by utilizing polymer concrete in order to block the vibrations delivered to the structures through ground. therefore, this study compared the performances of polymer concrete with those of ordinary concrete, polyurethane pad and foamed rubber pad in order to review its performances in reducing ground vibration. for this purpose, review of FRF and vibration acceleration as dynamic characteristics was made. after comparative verification on the dynamic characteristics is made when polymer concrete and other aforementioned materials are applied to underground structures, the possibility of application of polymer concrete to structures is reviewed.

Analysis of Satisfaction of Pre-service and In-service Elementary Teachers with Artificial Intelligence Education using App Inventor

  • Junghee, Jo
    • Journal of the Korea Society of Computer and Information
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    • v.28 no.3
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    • pp.189-196
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    • 2023
  • This paper analyzes the level of satisfaction of two groups of teachers who were educated about artificial intelligence using App Inventor. The participants were 13 pre-service and 9 in-service elementary school teachers and the data was collected using a questionnaire. As a result of the study, in-service teachers were all more satisfied than pre-service teachers in terms of interest, difficulty, and participation in the education. In addition, the questions investigating whether education helped motivate learning of artificial intelligence and whether there is a willingness to apply it to elementary classes in the future were also more positive for in-service teachers than for pre-service teachers. In general, pre-service teachers had somewhat more negative views than in-service teachers, but they were more positive than in-service teachers in terms of whether the education helped improve their understanding of artificial intelligence and whether they were willing to participate in additional education. Analysis of the Mann-Whitney test to see if there was a significant difference in satisfaction between the two groups showed no significance. This may be because most of the students in the two groups already had block-type or text-type programming experience, so they were able to participate in the education without any special resistance or difficulty with App Inventor, resulting in high levels of satisfaction from both groups. The results of this study can provide basic data for the future development and operation of programs for artificial intelligence education for both pre-service and in-service elementary school teachers.

Design of a Depth Encoding Detector using Light Guides with Different Reflector Patterns for Each Layer (각 층별 반사체 패턴이 서로 다른 광가이드를 사용한 반응 깊이 측정 검출기 설계)

  • Seung-Jae, Lee
    • Journal of the Korean Society of Radiology
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    • v.17 no.1
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    • pp.31-36
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    • 2023
  • Among imaging and treatment devices for small animals, positron emission tomography(PET) causes a change in spatial resolution within a field of view. This is a phenomenon caused by using a small gantry and a thin and long scintillation pixel, and detectors that measure the interaction depth are being developed and researched to solve this problem. In this study, a detector that measures the interaction depth was designed using several scintillator blocks and light guides with different reflector patterns. The scintillator block composed of 4 × 4 arrays of 3 mm × 3 mm × 5 mm scintillation pixels formed four layers, and a light guide was inserted in each layer to configure the entire detector. In order to check whether the interaction depth was measured, a gamma ray interaction was generated at the center of all scintillation pixels to acquire data and then reconstructed into a flood image. The reflector patterns of the light guides inserted between the layers were all different, so the positions of the scintillation pixels for each layer were formed in different locations. It is considered that even spatial resolution can be achieved over all regions of the field of view if all positions of the scintillation pixels thus formed are separated and used for image reconstruction.