• 터널과지하공간
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• 제18권3호
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• pp.202-213
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• 2008

이 논문은 3차원 탄성파 토모그래피의 3차원 초동주시 및 역산 알고리즘의 개발과 수치모형 실험을 통하여 3차원 토모그래피 기법의 현장 적용성을 고찰한 연구이다. 3차원 탄성파 주시토모그래피 기법의 현장 적용성을 담보하기 위해서는 한정된 송수신 커버리지에 기인하는 암영대가 발생하지 않아야 하고 또한 경제적인 관점에서 자료처리에 소요되는 시간이 합리적이어야 한다. 이 연구에서는 한정된 송수신 커버리지 문제를 극복하기 위하여 파선 폭의 확장기법의 하나인 프레넬 볼륨에 근거한 3차원 주시 토모그래피 알고리즘을 개발하였다. 또한 3차원 토모그래피 수행에 요구되는 정밀도와 경제성을 확보하기 위해 Fast Marching Method(FMM)을 이용한 초동주시 알고리즘을 선택하였으며 수치모형 실험을 통하여 합리적인 모델변수를 결정하였다. 3차원 고립형 이상체 및 경사진 층서구조 수치모형에 대한 3차원 탄성파속도 입방체를 도출함으로써 개발된 알고리즘의 타당성 및 현장 적용성을 고찰하였다. 재구성된 탄성파 임방체는 원 수치모형과 대비한 결과 상호 부합하는 결과를 확인함으로써 3차원 토모그래피 알고리즘의 타당성 및 현장 적용성을 검증하였다.

• Journal of Periodontal and Implant Science
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• 제44권6호
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• pp.280-287
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• 2014

Purpose: The purpose of this randomized single-blind controlled trial was to elucidate the clinical and antimicrobial effects of daily phototherapy (PT) as an adjunct to scaling and root planing (SRP) in patients with chronic periodontitis. Methods: The study was conducted from December 2013 to May 2014 at Ewha Womans University Mokdong Hospital, Seoul, Korea. Forty-one patients with mild to moderate chronic periodontitis were randomly divided into two therapeutic groups in a 1:1 ratio: SRP+PT and SRP (control) groups. All participants underwent full-mouth SRP. PT was performed thrice a day for a month by using electric toothbrushes with embedded light-emitting diodes. Plaque index, gingival index, probing pocket depth (PPD), clinical attachment level (CAL), and bleeding on probing were assessed before (baseline) and four weeks after (follow-up) the treatment. Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Prevotella intermedia, Fusobacterium nucleatum, Parvimonas micra, Campylobacter rectus, Eikenella corrodens, Streptococcus mutans, and Streptococcus sobrinus levels were detected by a real-time polymerase chain reaction at the same points in time. Results: The clinical parameters improved in both the groups. At the follow-up assessment, PPD was significantly decreased in the SRP+PT group (P=0.00). Further, PPD and CAL showed significantly greater changes in the SRP+PT group than in the SRP group (PPD, P=0.03; CAL, P=0.04). P. gingivalis and T. forsythia levels decreased in this group, but no significant intergroup differences were noted. Conclusions: Adjunctive PT seems to have clinical benefits, but evidence of its antimicrobial effects is not sufficient. Long-term studies are necessary to develop the most effective PT protocol and compare the effectiveness of PT with and without exogenous photosensitizers.

• 대한치과마취과학회지
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• 제6권1호
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• pp.1-5
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• 2006

Background: The aim of this study was to evaluate the preventive effect of propofol on postoperative nausea and vomiting (PONV) following general anesthesia to the patients having oral and maxillofacial surgery. Methods: In a prospective, randomized. case-controlled study. 200 patients were divided into two groups (n = 100 in each). In propofol (P) group, patients received 0.5 mg/kg of propofol intravenously at the end of anesthesia. In control (C) group, no antiemetics was given. Emetic symptoms like nausea, retching and vomiting were assessed by a blind nurse at 1 hour and at 24 hours after anesthesia respectively. Also level of sedation was checked by a blind anesthesiologist at 1 hour after anesthesia. Results: There were no significant differences in frequencies of nausea, retching and vomiting between C group and P group at 1 hour after anesthesia. However, nausea, retching and vomiting were all decreased in P group compared with C group at 24 hours after anesthesia (P < 0.05). Also there was no significant difference in level of sedation at 1 hour after anesthesia between C group and P group (P > 0.05). Conclusions: From the results, prophylactic use of subhypnotic dose of propofol could be effective for preventing PONV without change in level of sedation to the patients undergoing general anesthesia for oral and maxillofaical surgery.

• 동의생리병리학회지
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• 제33권4호
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• pp.239-248
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• 2019

There are no published data on Gyeongokgo (GOK) safety or efficacy despite being commonly use. The Gyeongokgo (GOK) is commonly used in traditional Korean medicine to promote a health qi and blood, but their objective data was not sufficient in clinical field. To investigate the safety and efficacy of GOK with hematologic and serologic testing and the change of the quality of life in healthy individuals. Randomized, subject-assessor-blind, placebo-controlled, single-center pilot study Participants and Interventions 29 healthy volunteer subjects were randomly placed into the GOK group (n = 20) or placebo control group (n = 9) and instructed to take one treatment packet (GOK or placebo) twice daily for 4 weeks. Subjects were assessed using the Fatigue Severity Scale (FSS) and Short Form 36 Health Survey (SF-36) and underwent hematologic and serologic tests and body composition analysis. The FSS total score (p = 0.093) and SF-36 general health index (p = 0.002) were improved following treatment in the GOK group. Post-treatment thyroid-stimulating hormone levels were increased in the GOK group compared with pre-treatment levels (p = 0.0042). C-reactive protein levels decreased (p = 0.0256) in the GOK group compared with that the placebo group. In time-series tests, GOK did not affect post-prandial serum triglycerides, glucose, insulin, or C-peptide levels. Notably, elevations in serum fasting triglycerides at 2- (p = 0.0333) and 4-hours (p = 0.0414) post-prandial were lower than those in the placebo group. GOK reduced fatigue levels and did not significantly affect laboratory test results performed to measure safety, serum glucose, and lipid profiles. Post-meal triglyceride levels were effectively reduced with treatment.

• Journal of Ginseng Research
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• 제46권4호
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• pp.543-549
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• 2022

Background: In physical activity or labor, the human body is in a state of high intensity stress, and all parts or physiological functions of the body respond positively to maintain or balance the need for movement. The human body has many physiological changes in the process of movement, and fatigue is the external manifestation of various complex changes inside the human body. Fatigue is also a physiological mechanism of self-protection after the body reaches a certain level of activity, which can prevent the occurrence of life-threatening excessive functional failure. The generation of fatigue is a very complex process, and its mechanism has not been concluded yet. Therefore, it is an important work to search and screen the effective components of natural plants that have anti-fatigue effect and to explore their mechanism. Methods: This was a 8-week, randomized, double-blind, placebo-controlled clinical trial. A total of 110 subjects who passed physical examination were included according to the scheme design, and randomly divided into a test group which was given KRG and a placebo control group. The calculation is carried out according to the standard of sub-high-intensity exercise test. Results: There was no adverse effect on safety index of subjects after taking red ginseng capsule. After KRG treatment, subjective strength grade is significant lower than placebo treatment. Blood lactic acid content is significantly get lower after trial in KRG group, and significant lower than placebo group. Creatine phosphokinase(CK) content is significantly get lower after trial in KRG group, and significant lower than placebo group. Conclusion: According to the criterion in the test scheme, the result shows that KRG is helpful on relieving physical fatigue.

• Medical Lasers
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• 제9권2호
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• pp.150-158
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• 2020

Background and Objectives Low-level laser therapy (LLLT) is used widely to promote hair growth in androgenetic alopecia (AGA). This study examined the clinical efficacy and safety of a home-use LLLT device with a newly designed array of light sources and software optimized for individual types of AGA. Materials and Methods The study was a randomized, double-blind, sham device-controlled trial. Forty-eight subjects (39 men and nine women) were assigned randomly in a 2:1 ratio to use either the test device (LG Pra'L HGN1, LG electronics, Korea) or sham device. The subjects used the LLLT device three times a week for 16 weeks. Phototrichogram was used to measure the hair density and hair thickness at 0, 8, and 16-weeks. Adverse events were closely monitored. Results After 16 weeks of using the device, the test group showed a significant increase in hair density and hair thickness compared to the control. In the test group, the hair density increased 6.96 counts/cm² at eight weeks and 13.67 counts/cm² at 16 weeks from the baseline. The hair thickness increased 7.21 ㎛ at eight weeks and 11.80 ㎛ at 16 weeks compared to the baseline. Conclusion The home-use LLLT device with a novel array of light sources and an individualized program according to the types of hair loss appears to be an effective and safe treatment modality for both male and female AGA patients.

• Clinical Nutrition Research
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• 제12권4호
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• pp.245-256
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• 2023

A randomized, double-blind, placebo-controlled trial was conducted to confirm whether collagen peptide supplementation for 12 week has a beneficial effect on body fat control in older adults at a daily physical activity level. Participants were assigned to either the collagen group (15 g/day of collagen peptide) or the placebo group (placebo drink). Body composition was measured by bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DEXA). In total, 74 participants (collagen group, n = 37; placebo group, n = 37) were included in the final analysis. The collagen group showed a significant reduction in total body fat mass compared with the placebo group, as evidenced by both BIA (p = 0.021) and DEXA (p = 0.041) measurements. Body fat mass and percent body fat of the whole body and trunk reduced at 12 weeks compared with baseline only in the collagen group (whole body: body fat mass, p = 0.002; percent body fat, p = 0.002; trunk: body fat mass, p = 0.001; percent body fat, p = 0.000). Total fat mass change (%) (collagen group, -0.49 ± 3.39; placebo group, 2.23 ± 4.20) showed a significant difference between the two groups (p = 0.041). Physical activity, dietary intake, and biochemical parameters showed no significant difference between the groups. The results confirmed that collagen peptide supplementation had a beneficial effect on body fat reduction in older adults aged ≥ 50 years with daily physical activity level. Thus, collagen peptide supplementation has a positive effect on age-related changes.

• Journal of Acupuncture Research
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• 제20권2호
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• pp.145-160
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• 2003

Objective : This study was designed to find out whether placebo auricular acupuncture is able to be constituted as an appropriate control group for needle insertion to Korean. Methods : We performed a randomized controlled, single-blind study(n=48) comparing subjective evaluations of needles insertion and avoidance of needles insertion. Both ears were needled concurrently, one real acupuncture(needle insertion) and the other placebo acupuncture(avoidance of needle insertion with blunt tip). Subjects then completed a questionnaire rating the intensity of five sensations in each ear, and also attempted to identity which ear received placebo and which ear received real acupuncture. Results : As for the effects of real and placebo acupuncture on each item(Warmth, Fullness, Pain, Activity, Radiating), real acupuncture was significantly warmer, fuller, more painful than placebo acupuncture. In particular, the real acupuncture only in experienced acupuncture recipients was significantly warmer, fuller, more painful than placebo acupuncture. About the ability to differentiate real and placebo acupuncture, 54.2 percent correctly identified which ear received real acupuncture and which ear received placebo acupuncture. However, the ability to differentiate real and placebo acupuncture for naive and experienced acupuncture recipients was not significantly different. Conclusions : Most of the subjects(Korean) identified which ear received placebo and which ear received real acupuncture. We found that this placebo auricular acupuncture is not able to be applied to Korean, in particular for experienced acupuncture recipients. Further study is needed for new placebo auricular acupuncture or racial difference between American.

• 융합신호처리학회논문지
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• 제19권1호
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• pp.7-13
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• 2018

현재의 연구에서는 소음을 제거하기 위해 블라인드 소스 분리(BSS)접근 방식에 의해 최적화된 두뇌-컴퓨터 인터페이스(BCI)를 제안했다. 모터 이미지(MI)신호와 정상 상태 시각적 제거 전위(SSVEP)신호는 신호 대 잡음비(SNR)의 증가로 인해 쉽게 검출되었다. 또한, MI와 SSVEP사이의 조합은 일반적으로 현재 BCI에서 생성되는 명령 수를 증가시킬 수 있다. 현재 시스템은 계산 시간을 줄이고 BCI를 실제 용도에 가깝게 하기 위해 단일 채널 EEG신호를 사용했다. 또한, 복잡한 신경 네트워크(CNN)가 다중 클래스 분류 모델로 사용되었다. 우리는 비 MS/BCI와 BBS/BCI사이의 정확성 측면에서 성능을 평가했다. 결과적으로 BBS+BCI의 정확도는 비 BBS+BCI의 정확도보다 $16.15{\pm}25.12%$더 높은 수준에 도달했다. 사용하지 않을 때보다 BBS를 사용함으로써 전반적으로 제안된 BCI시스템은 비교적 정확한 다차원 제어 애플리케이션에 적용될 가능성을 입증했다.

• 토지주택연구
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• 제12권1호
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• pp.129-137
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• 2021

외부 차양장치는 대표적인 여름철 일사조절 장치이다. 특히 냉방부하가 높은 업무용 건물에 적합한 기술로 인식되어왔다. 그러나 본 연구에서는 차양장치의 냉방부하 저감뿐만 아니라 난방부하 저감 효과를 검증하기 위한 실험을 수행하였다. 이를 위해 겨울철 야간 천공복사냉각에 따른 영향을 중심으로 일반 창호, 롤 블라인드, 외부 차양장치를 대상으로 실험을 수행하였으며, 그 결과는 다음과 같다. 외부 차양장치가 적용된 경우 유리 내·외표면 온도차는 평균 11.8℃로 차양장치가 없는 경우의 14.6℃ 보다 평균 2.8℃ 낮은 온도차를 나타냈으며, 이는 천공복사에 의한 열교환으로 차양 표면온도가 외기온도보다 낮은 시간때에 발생한다. 한편, 롤 블라인드는 내부 중공층의 평균온도보다 0.8℃ 낮은 온도를 나타냈으며 이 또한 투과체를 통과한 천공복사가 롤 블라인드 표면과 열교환이 이뤄졌기 때문이다. 유리 외부 표면온도만을 고려하면 약 3℃ 이상의 온도 상승이 예상된다. 그리고 차양장치가 없는 경우 일반적인 온도구배를 나타내고 있었다. 한편 남동향과 남서향에 외부 차양장치가 설치되었을 때 남서향의 외측 유리 표면온도가 더 낮게 나타나는 특징이 있다. 이 결과는 천공복사에 의한 냉방 저감 효과를 정량화할 수는 없지만 적어도 타당성은 확인할 수 있었다. 향후 연구에서는 천공복사 냉각과 에너지 소비 사이의 상관관계를 조사하고 외부 차양장치의 난방에너지 절감 효과에 대한 독립 챔버 실험을 진행할 계획이다.