Clinical Nutrition Research

The Korean Society of Clinical Nutrition (한국임상영양학회)
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Low-Molecular Collagen Peptide Supplementation and Body Fat Mass in Adults Aged ≥ 50 Years: A Randomized, Double-Blind, Placebo-Controlled Trial

  • Jeongbin Park (Department of Medical Nutrition, Graduate School of East-West Medical Nutrition, Kyung Hee University) ;
  • Minji Kim (Department of Medical Nutrition, Graduate School of East-West Medical Nutrition, Kyung Hee University) ;
  • Hyeri Shin (Department of Gerontology, AgeTech-Service Convergence Major, Kyung Hee University) ;
  • Hyejin Ahn (Department of Gerontology, AgeTech-Service Convergence Major, Kyung Hee University) ;
  • Yoo Kyoung Park (Department of Medical Nutrition, Graduate School of East-West Medical Nutrition, Kyung Hee University)
  • Received : 2023.09.15
  • Accepted : 2023.10.25
  • Published : 2023.10.30
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Abstract

A randomized, double-blind, placebo-controlled trial was conducted to confirm whether collagen peptide supplementation for 12 week has a beneficial effect on body fat control in older adults at a daily physical activity level. Participants were assigned to either the collagen group (15 g/day of collagen peptide) or the placebo group (placebo drink). Body composition was measured by bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DEXA). In total, 74 participants (collagen group, n = 37; placebo group, n = 37) were included in the final analysis. The collagen group showed a significant reduction in total body fat mass compared with the placebo group, as evidenced by both BIA (p = 0.021) and DEXA (p = 0.041) measurements. Body fat mass and percent body fat of the whole body and trunk reduced at 12 weeks compared with baseline only in the collagen group (whole body: body fat mass, p = 0.002; percent body fat, p = 0.002; trunk: body fat mass, p = 0.001; percent body fat, p = 0.000). Total fat mass change (%) (collagen group, -0.49 ± 3.39; placebo group, 2.23 ± 4.20) showed a significant difference between the two groups (p = 0.041). Physical activity, dietary intake, and biochemical parameters showed no significant difference between the groups. The results confirmed that collagen peptide supplementation had a beneficial effect on body fat reduction in older adults aged ≥ 50 years with daily physical activity level. Thus, collagen peptide supplementation has a positive effect on age-related changes.

Keywords

Acknowledgement

The authors would like to thank the BK21 program "AgeTech-Service Convergence Major" through the National Research Foundation by the Ministry of Education of Korea [5120200313836].

References

  1. Parra-Peralbo E, Talamillo A, Barrio R. Origin and development of the adipose tissue, a key organ in physiology and disease. Front Cell Dev Biol 2021;9:786129. 
  2. Giglio BM, Schincaglia RM, da Silva AS, Fazani ICS, Monteiro PA, Mota JF, Cunha JP, Pichard C, Pimentel GD. Whey protein supplementation compared to collagen increases blood Nesfatin concentrations and decreases android fat in overweight women: a randomized double-blind study. Nutrients 2019;11:2051. 
  3. Oh SJ, Cho YG, Kim DH, Hwang YH. Effect of Lactobacillus sakei OK67 in reducing body and visceral fat in lifestyle-modified overweight individuals: a 12-week, randomized, double-blind, placebo-controlled clinical trial. Nutrients 2023;15:3074. 
  4. Lorenzini A, Monti D, Santoro A. Editorial: adipose tissue: which role in aging and longevity? Front Endocrinol (Lausanne) 2020;11:583. 
  5. Mazzeo RS, Tanaka H. Exercise prescription for the elderly: current recommendations. Sports Med 2001;31:809-18. 
  6. Frestedt JL, Zenk JL, Kuskowski MA, Ward LS, Bastian ED. A whey-protein supplement increases fat loss and spares lean muscle in obese subjects: a randomized human clinical study. Nutr Metab (Lond) 2008;5:8. 
  7. Zdzieblik D, Oesser S, Baumstark MW, Gollhofer A, Konig D. Collagen peptide supplementation in combination with resistance training improves body composition and increases muscle strength in elderly sarcopenic men: a randomised controlled trial. Br J Nutr 2015;114:1237-45. 
  8. Short KR, Nair KS. The effect of age on protein metabolism. Curr Opin Clin Nutr Metab Care 2000;3:39-44. 
  9. Maggio CA, Pi-Sunyer FX. Obesity and type 2 diabetes. Endocrinol Metab Clin North Am 2003;32:805-22. 
  10. Ito N, Seki S, Ueda F. Effects of composite supplement containing collagen peptide and ornithine on skin conditions and plasma IGF-1 levels-A randomized, double-blind, placebo-controlled trial. Mar Drugs 2018;16:482. 
  11. Nemati M, Oveisi MR, Abdollahi H, Sabzevari O. Differentiation of bovine and porcine gelatins using principal component analysis. J Pharm Biomed Anal 2004;34:485-92. 
  12. Oesser S, Adam M, Babel W, Seifert J. Oral administration of (14)C labeled gelatin hydrolysate leads to an accumulation of radioactivity in cartilage of mice (C57/BL). J Nutr 1999;129:1891-5. 
  13. Reilly DM, Lozano J. Skin collagen through the lifestages: importance for skin health and beauty. Plast Aesthet Res 2021;8:2. 
  14. Schunck M, Zague V, Oesser S, Proksch E. Dietary supplementation with specific collagen peptides has a body mass index-dependent beneficial effect on cellulite morphology. J Med Food 2015;18:1340-8. 
  15. Zdzieblik D, Brame J, Oesser S, Gollhofer A, Konig D. The influence of specific bioactive collagen peptides on knee joint discomfort in young physically active adults: a randomized controlled trial. Nutrients 2021;13:523.
  16. Jendricke P, Centner C, Zdzieblik D, Gollhofer A, Konig D. Specific collagen peptides in combination with resistance training improve body composition and regional muscle strength in premenopausal women: a randomized controlled trial. Nutrients 2019;11:892. 
  17. Marques DL, Neiva HP, Marinho DA, Marques MC. Manipulating the resistance training volume in middle-aged and older adults: a systematic review with meta-analysis of the effects on muscle strength and size, muscle quality, and functional capacity. Sports Med 2023;53:503-18. 
  18. Daskalaki MG, Axarlis K, Tsoureki A, Michailidou S, Efraimoglou C, Lapi I, Kolliniati O, Dermitzaki E, Venihaki M, Kousoulaki K, Argiriou A, Tsatsanis C. Fish-derived protein hydrolysates increase insulin sensitivity and alter intestinal microbiome in high-fat-induced obese mice. Mar Drugs 2023;21:343. 
  19. Astre G, Deleruyelle S, Dortignac A, Bonnet C, Valet P, Dray C. Diet-induced obesity and associated disorders are prevented by natural bioactive type 1 fish collagen peptides (Naticol®) treatment. J Physiol Biochem 2018;74:647-54. 
  20. Tak YJ, Kim YJ, Lee JG, Yi YH, Cho YH, Kang GH, Lee SY. Effect of oral ingestion of low-molecular collagen peptides derived from skate (Raja Kenojei) skin on body fat in overweight adults: a randomized, double-blind, placebo-controlled trial. Mar Drugs 2019;17:157. 
  21. Choi R, Park MJ, Oh Y, Kim SH, Lee SG, Lee EH. Validation of multiple equations for estimating low-density lipoprotein cholesterol levels in Korean adults. Lipids Health Dis 2021;20:111. 
  22. St-Onge MP, Gallagher D. Body composition changes with aging: the cause or the result of alterations in metabolic rate and macronutrient oxidation? Nutrition 2010;26:152-5. 
  23. Wycherley TP, Noakes M, Clifton PM, Cleanthous X, Keogh JB, Brinkworth GD. A high-protein diet with resistance exercise training improves weight loss and body composition in overweight and obese patients with type 2 diabetes. Diabetes Care 2010;33:969-76. 
  24. Dodds MWJ, Haddou MB, Day JEL. The effect of gum chewing on xerostomia and salivary flow rate in elderly and medically compromised subjects: a systematic review and meta-analysis. BMC Oral Health 2023;23:406. 
  25. de Souto Barreto P, Cesari M, Morley JE, Roberts S, Landi F, Cederholm T, Rolland Y, Vellas B, Fielding R. Appetite loss and anorexia of aging in clinical care: an ICFSR task force report. J Frailty Aging 2022;11:129-34. 
  26. Morley JE. Decreased food intake with aging. J Gerontol A Biol Sci Med Sci 2001;56 Spec No 2:81-8. 
  27. Campbell WW, Crim MC, Dallal GE, Young VR, Evans WJ. Increased protein requirements in elderly people: new data and retrospective reassessments. Am J Clin Nutr 1994;60:501-9. 
  28. Churchward-Venne TA, Breen L, Phillips SM. Alterations in human muscle protein metabolism with aging: protein and exercise as countermeasures to offset sarcopenia. Biofactors 2014;40:199-205. 
  29. Wyss M, Kaddurah-Daouk R. Creatine and creatinine metabolism. Physiol Rev 2000;80:1107-213. 
  30. Brosnan JT, da Silva RP, Brosnan ME. The metabolic burden of creatine synthesis. Amino Acids 2011;40:1325-31. 
  31. Smith AD. The worldwide challenge of the dementias: a role for B vitamins and homocysteine? Food Nutr Bull 2008;29:S143-72. 
  32. Leon-Lopez A, Morales-Penaloza A, Martinez-Juarez VM, Vargas-Torres A, Zeugolis DI, Aguirre-Alvarez G. Hydrolyzed collagen-sources and applications. Molecules 2019;24:24. 
  33. Yamamoto S, Deguchi K, Onuma M, Numata N, Sakai Y. Absorption and urinary excretion of peptides after collagen tripeptide ingestion in humans. Biol Pharm Bull 2016;39:428-34.