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Whitening Effect of the Extracts from Juglans mandshurica (가래나무 추출물의 미백효과)

  • Lee, Gye-Won;Lee, Ju-Yeon;Cho, Young-Ho
    • KSBB Journal
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    • v.25 no.1
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    • pp.18-24
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    • 2010
  • Juglans mandshurica belongs to the family Juglandaceae is known to contain a wide range of pharmacological activities including anti-cancer, anti-inflammation, astringent, and anti-human immunodeficiency virus-type 1 (HIV-1). Melanogenesis refers to the biosynthesis of melanin pigment in melanocytes. In this study, to investigate the whitening activity of the extracts from Juglans mandshurica, we measured effects on a tyrosinase activity, a melanogenesis, and a tyrosinase synthesis in the B16/BL6 melanoma cells and an antioxidant activity. The extracts significantly scavenged a 1,1-diphenyl-2-picrylhydrazyl (DPPH) and a superoxide anion radicals in a dose-dependent manner with a $SC_{50}$ value of $20\;{\mu}g/mL$ and $25\;{\mu}g/mL$, respectively. Also, the tyrosinase activity and melanogenesis were significantly inhibited by the extracts. Furthermore, the synthesis of tyrosinase protein was significantly decreased by the extracts in enzyme-linked immunosorbent assay. Double blind study on the clinical efficacy of a cream containing 2% of the extracts showed that the extracts have a significant skin whitening effect. Therefore, this study demonstrates that the extracts from Juglans mandshurica may be useful as a potential agent for skin whitening.

The Actual State and Evaluation of Artificial Lighting on Coffee Houses Using Study Place around University (학습공간으로 이용되는 대학주변 커피전문점의 조명 실태 및 평가)

  • Choe, Sol-ji;Choi, Yoon-Jung
    • KIEAE Journal
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    • v.11 no.6
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    • pp.53-62
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    • 2011
  • This study aimed at suggesting improvement of lighting environment of the coffee house using study place. To this end, a series of field investigation was conducted in four possible target coffee houses around university. The field measurement included measurement of general illuminance and tabletop illuminance, observing illumination condition, and status of artificial lighting. Also, on-site questionnaire survey was administrated to 80 users of field measurement targets about using characteristics of coffee house and user's subjective response on light environment. The results are summarized as follows: (1) According to questionnaire survey, most of users checked 'learning (study and reading)' in 'purpose of coffee house using', and 'slightly dark' was checked most in each subjective response (brightness on general space and on tabletop at daytime/night); (2) as results of measurements on general illuminance and on tabletop illuminance during daytime, only one coffee house was suitable for standard; (3) as results of measurements on illuminance during night, all target coffee houses were not met the standard; (4) as results of uniformity ratios, almost uniformities of general illuminance were not met the standard except one case. The common problems of lighting environment of coffee house were analyzed as lack of daylight illumination e.g. having low amount of sunshine from skylight, un-uniformity of insolation by floor plan and absence of window blind, and un-uniformity of artificial luminous intensity e.g. lack of the number or brightness of artificial lighting, using the indirect lighting, using only local lighting, and non-uniform arrangement of artificial lighting.

A Study on Frequency Hopping Signal Detection Using a Polyphase DFT Filterbank (다상 DFT 필터뱅크를 이용한 도약신호 검출에 관한 연구)

  • Kwon, Jeong-A;Lee, Cho-Ho;Jeong, Eui-Rim
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.17 no.4
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    • pp.789-796
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    • 2013
  • It is known that the detection of hopping signals without any information about hopping duration and hopping frequency is rather difficult. This paper considers the blind detection of hopping signal's information such as hopping duration and hopping frequency from the sampled wideband signals. In order to find hopping information from the wideband signals, multiple narrow-band filters are required in general, which leads to huge implementation complexity. Instead, this paper employs the polyphase DFT(discrete Fourier transform) filterbank to reduce the implementation complexity. This paper propose hopping signal detection algorithm from the polyphase DFT filterbank output. Specifically, based on the binary image processing, the proposed algorithm is developed to decrease the memory size and H/W complexity. The performance of the proposed algorithm is evaluated through the computer simulation and FPGA (field programmable gate array) implementation.

An Efficient Transceiver Technique for Wideband VHF Baseband Modem (광대역 VHF 기저대역 모뎀의 효율적인 송·수신 기법)

  • Lee, Hwang-Hee;Kim, Jae-Hwan;Yang, Won-Young;Cho, Yong-Soo
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.38B no.4
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    • pp.305-313
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    • 2013
  • As an FMT (Filtered Multi-Tone) transmission method of Wideband VHF communication system specified by the ETS (European Telecommunications Standards) EN 300 392-2, this paper introduces three existing realization methods, i.e., the direct filtering method using different band SRRC (Square-Root Raised Cosine) filters for each subcarrier, the PPN-DFT method using the IDFT-PPN (Poly-Phase Network) and PPN-DFT at the transmitter and receiver, respectively, and the Extended DFT method. Then, it proposes the extended IDFT-SDFT (Sliding Discrete Fourier Transform) that computes the DFT values only for interested subcarriers every sample time, and shows that it has an advantage of blind symbol timing (using no training symbol) individually for each user signal (independently of other users' signals) in the multi-user environment where the subcarriers are assigned in contiguous or interleaved blocks to each user and each user signal possibly experiences different channels.

Kernel Classification Using Data Distribution and Soft Decision MCT-Adaboost (데이터 분포와 연판정을 이용한 MCT-Adaboost 커널 분류기)

  • Kim, Kisang;Choi, Hyung-Il
    • KIPS Transactions on Software and Data Engineering
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    • v.6 no.3
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    • pp.149-154
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    • 2017
  • The MCT-Adaboost algorithm chooses an optimal set of features in each rounds. On each round, it chooses the best feature by calculate minimizing error rate using feature index and MCT kernel distribution. The involved process of weak classification executed by a hard decision. This decision occurs some problems when it chooses ambiguous kernel feature. In this paper, we propose the modified MCT-Adaboost classification using soft decision. The typical MCT-Adaboost assigns a same initial weights to each datum. This is because, they assume that all information of database is blind. We assign different initial weights with our propose new algorithm using some statistical properties of involved features. In experimental results, we confirm that our method shows better performance than the traditional one.

A Study on the Information Needs and Behavior of Visually Handicapped (시각장애인의 정보요구 및 이용행태에 관한 연구 - 대구광역시립수성도서관 이용자를 중심으로 -)

  • Oh, Seon-Kyung
    • Journal of Information Management
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    • v.41 no.1
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    • pp.97-126
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    • 2010
  • Many visually handicapped people face difficulties with using libraries. Public libraries are thus required to meet the need of visually handicapped people. Public libraries should guarantee the visually handicapped the right to use appropriate services. If so, the visually handicapped can improve their life quality by decreasing information gap and increasing information comprehension or accessibility. This study is designed to analyze how visually handicapped people can use public libraries. Based on the analysis, this study can provide actual suggestions to improve opportunities for the visually handicapped to use libraries. Data are collected from visually handicapped people who are the members of Suseong Public Library, Daegu, Korea. In specific, this study can analyze various characteristics(i.e., information needs, selection and use behavior of information sources, difficulties and gaps to access information, use behavior and service satisfaction of public library) regarding their library use by telephone interviews.

Effects of Electroacupuncture on the Hemiplegic Upper Extremity after Stroke (중풍 환자의 상지마비에 대한 전침치료의 효과)

  • 류순현;이경섭;김태경;최요섭;윤상필;장종철;문상관;고창남;조기호
    • The Journal of Korean Medicine
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    • v.23 no.2
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    • pp.180-189
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    • 2002
  • Background and Purpose : The hemiplegic upper extremity is affected in many stroke patients, and recovery is often poor. The purpose of this study was to assess the efficacy of electroacupuncture (EA) in enhancing the upper extremity motor and functional recovery of ischemic stroke patients. Subjects and Methods : Forty ischemic stroke patients (the upper extremity Fugl-Meyer motor scale (FM) score lower than 46, lesion location within middle cerebral artery territory) within 2 weeks of stroke onset were randomly allocated to either an EA group that received EA treatment or a control group that received only routine ward care. The EA was applied at Quchi-Shousanli (LI11-LI10), Waiguan-Hegu (TE5-LI4) points on the hemiparetic side six times per week for 4 weeks. The frequency of stimulation was 25-50Hz and the intensity was set at a level sufficient to induce muscle contraction. EA treatment was given for 30 minutes and all patients of both groups received standard rehabilitation program. Outcomes were assessed, in a blind manner, before treatment began and at 4 weeks after treatment, with the FM, the Motor Power score (MP) for shoulder/elbow, and the subsection of the Modified Barthel Index (MBI) for drinking/feeding/dressing upper body/grooming. Results : These 2 groups had comparable clinical characteristics, lesion location, lesion size, and pretreatment impairment scores. By the end of treatment, the EA group showed significantly more improvement than the control group in the subsection of the FM for shoulder/elbow/coordination (6.4 vs. 3.7; P=0.047) and the MP for shoulder/elbow (5.3 vs. 3.3; P=0.008). The subsection scores of the MBI for drinking/feeding/dressing upper body/grooming were not significantly different between two groups. No adverse effects due to treatment were found Conclusion : These results suggest that EA enhances the upper extremity motor recovery of acute stroke patients. However, this study failed to demonstrate any significant functional benefit related with upper extremity. Future study should be carried out in a larger sample size and use the functional outcome measure that is more specific and sensitive to the upper extremity.

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A Randomized Controlled Trial to Verify Effects of Kuesu Point on Low Back Pain and Accompanied Sciatica

  • Lee, Jeong-Won;Kim, Dong-Il
    • The Journal of Korean Medicine
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    • v.28 no.4
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    • pp.86-94
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    • 2007
  • Objective : Kuesu point is a newly discovered point, it is located in 3-cun from the centre of sacrum laterally, paralleled to the 4th foramen on the sacrum. This controlled trial was to evaluate the superior effect of Kuesu point on back pain which radiated to lower extremities. Methods : Randomized Controlled Trial (RCT) and Single Blind in patient was designed. Patients (n=31) were randomized to two groups, Kuesu-point acupuncture group (Group A, n=16) and non Kuesu point acupuncture group (Group B, n=15). Group A was acupunctured on B25 (大腸兪), B26 (關元兪) and B60 (崑崙) with Kuesu point. Group B was acupunctured on the same points without Kuesu point. The clinical subjects were female patients. Beside acupuncture, the other therapies were excluded. Clinical period was three weeks total. Each group was treated 4-5 times per week for 3 weeks. The outcome measurements were The Estimation Index of Backache (quality of life), Pain Rating Scale (pain intensity) and other physical examinations (ROM, SLR, etc.). Results : 31 patients (Group A: n=16, Group B: n=15) were Randomized, 6 of them dropped out. Eventually 25 patients (Group A: n=15, Group B: n=10) were included in the analysis. Group A acupunctured on Kuesu point scored more significant Estimation Index of Backache and lower PRS (Pain Rating Scale) than Group B acupunctured without Kuesu point (p=0.003/2). It turned out that the group acupunctured on Kuesu point show meaningful high improvement index. And other examination's results showed that the treatment effects of Group A are twice as better as Group B. Conclusion : These results suggest that Kuesu point acupuncture was more effective on lower back pain and improved the life quality of patients, being compared with non Kuesu point acupuncture.

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The Efficacy and Safety of Beef Tallow Extract Including Cis-9-cetylmyristoleate in Patients with Osteoarthritis - As an Adjuvant Pharmacological Treatment -

  • Lee, Sang-Hoon;Kim, June-Hyuk;Cho, Whan-Seong;Seo, Sung-Wook;Kim, Sung-Kyu;Oh, Joo-Han
    • Preventive Nutrition and Food Science
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    • v.10 no.3
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    • pp.285-289
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    • 2005
  • In this double-blind, placebo-controlled trial, we assessed the efficacy and safety of beef tallow extract (BTE) including Cis-9-cetylmyristoleate in patients with arthritis. Between May and December 2003, we selected 80 patients (n=80) who showed/manifested arthritic symptoms and whose radiological findings were suggestive of arthritis, and randomly assigned them to placebo-controlled (n=40) and treatment group (n=40). The placebo (corn starch 350 mg) and BTE (208 mg) were orally administered to placebo-controlled and treatment group three times a day, respectively. We assessed the efficacy and safety based on the visual analogue scale (V AS) and modified knee society knee scores (MKSKS) at baseline and endpoint, respectively. To assess the safety, we monitored the adverse effects noted in liver, kidney, cardiovascular and gastrointestinal system for 3 weeks. Then, we performed not only a questionnaire study but also laboratory tests (e.g., liver function test, kidney function test, urinalysis, electrocardiography [EKG], complete blood cell counts [CBC] and chest X-ray). For statistical analysis, Student (-test and paired (-test were done using SPSS■ Version 11.0. Statistical significance was set at p < 0.05. The scores between V AS and MKSKS showed statistical significance (p < 0.05) with an improvement of $69.2\%$ (27/39) and $3.8\%$ (21/39) of treatment-group patients, respectively. Abnormal laboratory findings were noted in neither placebo-controlled nor treatment group. In conclusion, our results indicate that the administration of BTE was a safe and effective treatment regimen for patients with arthritis. In addition, the efficacy of BTE was more remarkable in alleviating the symptoms rather than improving the function.

New Social Risks and Social Welfare for Gender in Blind Spot (새로운 사회적 위험과 사각지대의 여성복지)

  • Seo, Dong-Hee
    • The Journal of the Korea Contents Association
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    • v.9 no.3
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    • pp.320-328
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    • 2009
  • New social risks is likely to emerge from instability of family structure, flexible of labor market, movement of globalization which is related with the post-industrial society and so on. Especially, a lot of women are exposure to not only old social risks but also new social risks. A breakdown of traditional family structure, flexible of labor market which is be followed by globalization, women's poverty and limited approaches at social security services are the representation risk which is confront to women. In this study, therefore, the social risk is recognized by breakdown of traditional family structure risk which comes from the social change, aging of population, the decrease of labor population and New Right ideology. The purpose of the study is to arrange the new welfare state at gender equality level by anglicizing about women's new social risks.