Browse > Article
http://dx.doi.org/10.3746/jfn.2005.10.3.285

The Efficacy and Safety of Beef Tallow Extract Including Cis-9-cetylmyristoleate in Patients with Osteoarthritis - As an Adjuvant Pharmacological Treatment -  

Lee, Sang-Hoon (Department of Orthopedic Surgery, Seoul National University College of Medicine)
Kim, June-Hyuk (Department of Orthopedic Surgery, Seoul National University College of Medicine)
Cho, Whan-Seong (Department of Orthopedic Surgery, Seoul National University College of Medicine)
Seo, Sung-Wook (Department of Orthopedic Surgery, Seoul National University College of Medicine)
Kim, Sung-Kyu (ChungAng University College of Pharmacy)
Oh, Joo-Han (Department of Orthopedic Surgery, Seoul National University College of Medicine, Department of Orthopedic Surgery, Seoul National University Bundnng Hospital)
Publication Information
Preventive Nutrition and Food Science / v.10, no.3, 2005 , pp. 285-289 More about this Journal
Abstract
In this double-blind, placebo-controlled trial, we assessed the efficacy and safety of beef tallow extract (BTE) including Cis-9-cetylmyristoleate in patients with arthritis. Between May and December 2003, we selected 80 patients (n=80) who showed/manifested arthritic symptoms and whose radiological findings were suggestive of arthritis, and randomly assigned them to placebo-controlled (n=40) and treatment group (n=40). The placebo (corn starch 350 mg) and BTE (208 mg) were orally administered to placebo-controlled and treatment group three times a day, respectively. We assessed the efficacy and safety based on the visual analogue scale (V AS) and modified knee society knee scores (MKSKS) at baseline and endpoint, respectively. To assess the safety, we monitored the adverse effects noted in liver, kidney, cardiovascular and gastrointestinal system for 3 weeks. Then, we performed not only a questionnaire study but also laboratory tests (e.g., liver function test, kidney function test, urinalysis, electrocardiography [EKG], complete blood cell counts [CBC] and chest X-ray). For statistical analysis, Student (-test and paired (-test were done using SPSS■ Version 11.0. Statistical significance was set at p < 0.05. The scores between V AS and MKSKS showed statistical significance (p < 0.05) with an improvement of $69.2\%$ (27/39) and $3.8\%$ (21/39) of treatment-group patients, respectively. Abnormal laboratory findings were noted in neither placebo-controlled nor treatment group. In conclusion, our results indicate that the administration of BTE was a safe and effective treatment regimen for patients with arthritis. In addition, the efficacy of BTE was more remarkable in alleviating the symptoms rather than improving the function.
Keywords
beef tallow extract; Cis-9-cetylmyristoleate; osteoarthritis;
Citations & Related Records
연도 인용수 순위
  • Reference
1 Rubin BR. 2001. Osteoarthritis. J Am Osteopath Assoc 101 (Suppl 4 part 2): 2-5
2 Clive DM, Stoff JS. 1984. Renal syndroms associated with nonsteroidal anti-inflammatory drugs. N Engl J Med 310: 563-572   DOI   ScienceOn
3 Sol AH, Weinstein WM, Kurata J, McCarthy D. 1991. Nonsteroidal anti-inflammatory drugs and peptic ulcer disease. Ann Intern Med 114: 307-319   DOI   ScienceOn
4 Wilcox CM, Shalek KA, Cotsonis G. 1994. Striking prevalence of over-the-counter nonsteroidal anti-inflammatory drug use in patients with upper gastrointestinal hemorrhage. Arch intern Med 154: 42-45   DOI   ScienceOn
5 Guthann S, Rodriguez G, Raiford D. 1997. Indivisual nonsteroidal anti-inflammatory drugs and other risk factors for upper gastrointestinal bleeding and perforation. Epidemiology 8: 18-24   DOI   ScienceOn
6 Diehl HW, May EL. 1994. Cetyl myristoleate isolated from swiss albino mice: an apparent protective agent against adjuvant arthritis in rats. J Pharm Sci 83: 296-299   DOI   ScienceOn
7 Hunter KW Jr, Gault RA, Stehouwer JS, Tam-Chang SW. 2003. Synthesis of cetyl myristoleate and evaluation of its therapeutic efficacy in a murine model of collagen-induced arthritis. Pharmacol Res 47: 43-47   DOI   ScienceOn
8 Martinez-Dominguez E, de la Puerta R, Ruiz-Gutierrez V. 2001. Protective effects upon experimental inflammation models of a polyphenol-supplemented virgin olive oil diet. Inflamm Res 50: 102-106   DOI
9 Kremer JM. 2000. n-3 fatty acid supplements in rheumatoid arthritis. Am J Clin Nutr 71: 349S-351S
10 Steinhilber D. 1999. 5-Lipoxygenase: a target for anti-inflammatory drugs revisited. Curr Med Chem 6: 71-85
11 Perneger TV, Wheiton PK, Klag MJ. 1994. Risk of kidney failure associated with the use of acetaminophen, aspirin, and nonsteroidal anti-inflammatory drugs. N Engl J Med 331: 1675-1679   DOI   ScienceOn
12 Ariza-Ariza R, Mestanza-Peralta M, Cardiel MH. 1998. Omega-3 fatty acids in rheumatoid arthritis: an overview. Semin Arthritis Rheum 27: 366-370   DOI   ScienceOn
13 Bonnet C, Bertin P, Cook-Moreau J, Chable-Rabinovitch H, Treves R, Rigaud M. 1995. Lipoxygenase products and expression of 5-lipoxygenase and 5-lipoxygenase-activating protein in human cultured synovial cells. Prostaglandins 50: 127-135   DOI   ScienceOn
14 Iguchi K, Okumura N, Usui S, Sajiki H, Hirota K, Kiran K. 2001. Myristoleate acid, a cytotoxic component in the extract from serenoa sepens, induces apoptosis and necrosis in human LNCaP cells. Prostate 47: 59-65   DOI   ScienceOn
15 Treadwell MJ, Franck LS, Vichinsky E. 2002. Using quality improvement strategies to enhance pediatric pain assessment. Int J Qual Health Care 14: 39-47   DOI   ScienceOn
16 Ranawat AS, Ranawat CS, Elkus M, Rasquinha VJ, Rossi R, Babhulkar S. 2005. Total knee arthroplasty for severe valgus deformity. J Bone Joint Surg Am 87 (Suppl 1): 271-284   DOI
17 Goldring MB. 2000. Osteoarthritis and cartilage: the role of cytokines. Curr Rheumatol Rep 2: 459-465   DOI   ScienceOn