• 동의생리병리학회지
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• 제27권6호
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• pp.782-788
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• 2013

Chrysanthemum zawadskii Herbich var. latilobum Kitamura (Compositae), colloquially known "Gujulcho" in Korea, has been used in traditional medicine for the treatment of various diseases, including cough, common cold, bladder-related disorders, gastroenteric disorders, hypertension, and inflammatory diseases, such as pneumonia, bronchitis, pharyngitis, and rheumatoid arthritis (RA) However, the effect of Chrysanthemum zawadskii var. latilobum on breast cancer invasion is unknown. In this study, we investigated the inhibitory effect of Chrysanthemum zawadskii var. latilobum extract (CZE) on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced matrix metalloproteinase-9 (MMP-9) expression and cell invasion, as well as the molecular mechanisms involved in MCF-7 cells. CZE were not cytotoxic up to 100 ${\mu}g/ml$ concentration in the MCF-7 cell line. CZE decreased MMP-9 expression. TPA substantially increased NF-${\kappa}B$ DNA binding activity. Pre-treatment with CZE inhibited TPA-stimulated NF-${\kappa}B$ binding activity and NF-${\kappa}B$ related protein expression. To identify invasion ability of MCF-7 cells decreased by CZE, we used martrigel invasion assay. As a result, it is significantly decreased cell invasion. These results indicate that CZE-mediated inhibition of TPA-induced MMP-9 expression and cell invasion involves the suppression of the NF-${\kappa}B$ pathway in MCF-7 cells. Chrysanthemum zawadskii var. latilobum may have potential value in restricting breast cancer metastasis.

• 대한간호학회지
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• 제36권7호
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• pp.1193-1203
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• 2006

Purpose: The purpose of this study was to describe the current status of utilization and costs of home health nursing care by the levels of medical institutes in Korea. Method: A secondary analysis of existing data was used from the national electronic data information(EDI) of 148 home health agencies for 6 months from May to Oct 2005 in total. Result: The 148 agencies had multiple services in cerebral infaction, essential hypertension, sequoia of cerebrovascular disease, type 2 diabetes mellitus, etc.. The highest 10 rankings of 76 categories of home health nursing services were composed of 96.4% of the total services, such as simple treatment, inflammatory treatment, urethra & bladder irrigation, inserting indwelling catheter etc., in that order. The highest 20 rankings of 226 categories of home examination services were composed of 77.0% of the total home examination services. In addition, the average cost of home health care per visit was 46,088 Won (${\fallingdotseq}$ 48 $, 1 $=960 Won). The costs ranged from 74,523 Won (${\fallingdotseq}$78 $, loss of chronic kidney function, N18) to 32,270 Won (${\fallingdotseq}$34 $, other cerebrovascular diseases, 167). Conclusion: Results suggest that client characteristics of hospital based HHNC are not different from community based HHNC or visiting nursing services for elderly. The national results will contribute to baseline data used to establish a policy for the home health nursing care system and education.

• Journal of Korean Neurosurgical Society
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• 제50권6호
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• pp.523-527
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• 2011

A 67-year-old woman presented for evaluation of severe coccygeal pain. The computed tomography scans and magnetic resonance imaging showed an asymmetric midline sacral tumor invading the right lower portion of S2. To preserve both S2 nerve roots and to obtain negative surgical margins, a modified mid-sacrectomy with an aid of a computed navigation system was performed. The sacral tumor was excised en bloc with negative tumor margins. Both S2 nerve roots were preserved and additional reconstruction was not necessary because of minimal resection of the sacroiliac joint. We report a case of a sacral chordoma which was excised en bloc with adequate surgical margins by a computer-assisted modified mid-sacrectomy. The computed navigation system may be a useful tool for tumor targeting and safe osteotomies in sacral tumor surgery via the posterior only approach.

• The Korean Journal of Pain
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• 제23권1호
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• pp.65-69
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• 2010

Chronic perineal pain is an often encountered problem, which produces a great degree of functional impairment and frustration to the patient and a challenge to the treating physician. The reason for this problem is that the region contains diverse anatomic structures with mixed somatic, visceral and autonomic innervations affecting bladder and bowel control and sexual function. A blockade of nociceptive and sympathetic supply to the perineal region, supplied through the ganglion impar has been shown to benefit patients with chronic perineal pain. Several options to this block have been described that chemical neurolysis, radiofrequency ablation etc. Although the analgesic effect of Botulinum toxin type A (BoNT-A) has long been considered secondary to its action for muscle relaxation, BoNT-A also affects the release of the neurotransmitters that are involved in pain perception. We describe a patient who was successfully given ganglion impar block with BoNT-A.

• 한국과학교육학회지
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• 제14권3호
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• pp.285-292
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• 1994

The purpose of this study is to investigate the misconception about circulatory / excretional system and to determine the effectiveness of two teaching strategies. The subject was 214 middle school students. The control group was instructed with the traditional teaching method.On the other hand, the experimental group was taught with the concept mapping teaching method. Then the effectiveness of the two teaching strategies were compared in terms with the changes of their conceptions about circulatory/excertional system. The major findings of this study are as follows. 1. The major misconception types were identified. 1) The function of blood is only transportation. 2) The artery is equal to arterial blood. 3) The colon and the anus are also excretional organs. 4) Urine is formed from the bladder. 5) Urine and feces are also excrement. 2. Different conceptional change was observed between control group and experimental group at 0.05 significance level. The concept mapping strategy was more effective than traditional teaching method. 3. No significent difference was found between male and female students in the effectiveness of concept mapping strategy.

• 한방안이비인후피부과학회지
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• 제10권1호
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• pp.139-158
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• 1997

A Literature study on the external treatment of nose diseases, the results are as follows; 1. Nose was called "Cheun-bin(天牝)", was outer orifice of the lung, was the gate of vital energe(氣), The main function of nose is divided three pacts. One is the respiration, another is the sense of smell, the other is the sounding consonance. 2. Nose is concerned with The Lung(肺), The Spleen(脾), The Heart(心), The Stomach(胃), The Large intestine(大腸), The Bladder(膀胱) in the organs, is concerned with Lung Meridean, Large intestine Meridean, Stomach Meridean, Heart Meridean, Spleen Meridean, Governor Vessel Meridean etc. 3. The method on the external treatment of nose diseases is classified with obstructive method, pouring method, blowing method, attaching method, plaster method, rubbing method, cleansing method, poulticing method. In frequency of practical use, Obstructive method is used 276 cases, Blowing method is used 123 cases, Attaching method is used 103 cases, Plaster method is used 76 cases. 4. In frequency of the medicinal works on the external treatment of nose diseases, Herba Asari(細辛) is used 134 cases, Pedicellus Melo(瓜 ) is used 85 cases, Radix Aconiti Praeparata(附子) is used 52 cases, Herba Agastachis(麝香) is used 51 cases, Semen Armeniacae Amarurn(杏仁) is used 44 cases etc. In frequency of a prescription on the external treatment of nose diseases, Tongcho-san(通草散) is used 9 cases, $Sesin-go{\cdot}Sinyi-go{\cdot}Changpo-san$ are used 8 cases, $Kwache-san{\cdot}Wungwhang-san$ are used 7 cases etc.

• Journal of applied mathematics & informatics
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• 제39권5_6호
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• pp.785-804
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• 2021

The proposal of new families has been worked out by many authors over recent years. Many ways to generate new families have been developed as the methods of addition, linear combination, composition and, one of the newer, the T-X family of distributions. Using this latter method, Korkmaz et al. (2018) proposed a new class called Weibull Marshall-Olkin-G (WMO-G) family. In the present work, we propose a new distribution, based on the WMO-G family, using the Lomax distribution as baseline, called Weibull Marshall-Olkin Lomax (WMOL) distribution. The hazard rate function of this distribution can be increasing, decreasing, bathtub-shaped, decreasing-increasing-decreasing and unimodal. Some properties of the proposed model are developed. Besides that, we consider method of maximum likelihood for estimating the unknown parameters of the WMOL distribution. We provide a simulation study in order to verify the asymptotic properties of the maximum likelihood estimates. The applicability of the new distribution to modeling real life data is proved by two real data sets.

• Childhood Kidney Diseases
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• 제25권1호
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• pp.40-43
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• 2021

Enuresis is intermittent urinary incontinence during sleep at night in children aged 5 years or older. The main pathophysiology of enuresis involves nocturnal polyuria, abnormal sleep arousal, and low functional bladder capacity. In rare cases, enuresis is an early symptom of endocrine disorders such as diabetes or thyroid disorders. Herein, we report a case of a 12-year-old girl with enuresis as a rare initial presentation of Graves' disease. She complained of nocturnal enuresis from a month before visiting our clinic. She also complained of urinary frequency, headache, and weight loss. On physical examination, she had tachycardia, intention tremors, and a diffuse goiter on her anterior neck with bruit on auscultation. Her thyroid function test results revealed hyperthyroidism, and Graves' disease was diagnosed as the thyroid stimulating hormone receptor autoantibody was positive. After treatment for Graves' disease with methimazole, symptoms of enuresis resolved within 2 weeks as she became clinically and biochemically euthyroid. In children with secondary enuresis, Graves' disease should be considered as a differential diagnosis, and signs of hyperthyroidism should be checked for carefully.

• 대한물리치료과학회지
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• 제3권2호
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• pp.1011-1019
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• 1996

The incidence of spinal cord injury increase due to traffic accident, industrial accident and leisure sports. Spinal cord injury damages motor and sensory function below the injury level, also affects autonomic functions associated with voiding and defecation. Sexual dysfunction and psychosocial, vocational maladaptations are also some of the unwanted consequences of injury. The purpose of this study is look for means to prevent and to manage complications in spinal cord injury through investigation and analysis. The subjects of this study in spinal cord injured patients were admitted to the department of physical therapy, Kwangju christian Hospital, Nam Kwang Hospital, Chun Nam university Hospital and Cho Sun university Hospital, from April, 1, 1995 to March, 31, 1996. The results are as follows: 1. The subjects comprised 96 cases of spinal cord injury, ranging from 17 to 85(mean-40.8 yrs) and included 72 males and 24 females. Among these patients, 58 were cervical injury, 20 were thoracic injury and 18 were lumbar injury. 2. As for a major causative of spinal cord injury were traffic accident(59.4%), fall down (27.1 %), and motocycle(4.2%).. 3. The bladder control were taken by indwelling cathetar(41.7%), Crede maneuver(37.5%) and self voiding(16.7%). The bowel control were taken by all aid(61.5%), assitance(32.3%) and self defecation(6.2%). 4. Possible of sexual function were 35 cases (47.9%). 5. The device of transfer used wheel chair(69.8%) and bed(16.7%). 6. The patients with higher cord lesion got more serious pain than lower cord lesion. Also the patients with higher cord lesion got a serious spasticity. 7. The incidence of decubitus ulcer among 96 patients were in case 46(47.9%). The largest group of the pressure sore sites were sacral portion(82.0%), less than 1 month of onset occured a large numbers(50%). Incidence of pressure sore by spasticity occured many patients in case of mild or moderate. Incidence of pressure sore by pain occured many patients in case of severe pain.

• 동국한의학연구소논문집
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• 제7권2호
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• pp.1-8
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• 1999

한의학은 유기체의 관점에서 생체기능의 통일성을 중요시하고 있다. 생체기능의 유기적 통일성은 기운(氣運)과 이치로 인식되며, 경락(經絡)은 기혈(氣血)의 매개를 통하여 장부(臟腑) 조직 기관의 사이를 밀접하게 연계하여 유기체에 대한 생리(生理) 병리(病理)의 보다 완전한 인식과 변증논치(辨證論治)의 이론적 근거를 제공하고 있다. 이러한 학문적 배경에 근거하여 신장(腎臟)생리의 유기성과 그 병후(病候)를 경기(經氣)의 교통(交通)을 중심으로 고찰하였다. 족소음신경(足少陰腎經)의 경기교통(經氣交通)은 신장(腎臟)과 간(肝) 폐(肺) 심(心) 방광(膀胱) 및 후롱 설본(舌本) 흉부(胸部) 족심(足心) 고내후염(股內後廉) 요(腰)의 형체조직(形體組織)과 밀접한 관계를 구축하여 협조(協助) 통일(統一)의 생리를 발휘하고, 병리적으로 신장(腎臟)의 병변(病變) 병후(病候)에 대한 유기적 인식을 가능케 한다. 따라서 신장(腎臟)과 그 경락(經絡)의 동시적 인식은 한의학의 이론과 임상의 실재에 부합되는 변증논치(辨證論治)의 관건이 된다고 사료(思料)된다.