• 한국가금학회지
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• 제48권3호
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• pp.123-131
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• 2021

본 연구는 한국 토종닭의 암수 분리 사육과 혼합 사육이 개체의 생산능력에 미치는 영향을 비교 분석하여 토종닭의 생산성 향상을 위한 바람직한 사육 체계를 제시하고자 한 것이다. 시험은 토종 실용계인 GSP한협토종닭^® 1,140수를 대상으로 암컷 사육 구, 수컷 사육 구 및 암수 혼합 사육 구로 구분하고, 1일령부터 12주령까지 생존율, 체중, 사료 섭취량 및 사료요구율을 조사하였다. 분석 결과, 전체 시험 구의 평균 생존율은 97.9%로서 사육 형태 간 차이는 없었다. 체중은 모든 주령에서 사육 형태 간 유의한 차이를 보이며(P<0.01), 4주령 이후부터 수컷 분리 사육 구, 혼합 사육 구, 암컷 분리 사육 구의 순으로 높은 체중을 나타내었다. 사육형태별 집단의 체중 균일도는 10주령 체중의 경우 암컷 분리 사육 구가 78%의 높은 균일도를 보이고, 혼합 사육 구는 44%로 매우 낮게 나타났다. 사육 형태에 따른 수컷 간 체중비교에서 분리 사육 개체가 혼합 사육 개체보다 대부분의 주령에서 높게 나타났으나, 암컷 간에는 거의 차이가 없는 것으로 나타났다. 사육 형태별 사료 섭취량은 수컷 사육 구, 암수 혼합 사육 구, 암컷 사육 구의 순으로 높게 나타났고, 사료요구율은 이와 반대 양상을 보였다. 결론적으로 암수 분리 사육과 혼합 사육 간 암컷과 수컷 공히 개체 간 생산능력의 차이는 없으나, 생산성 측면에서 집단 균일도로 인하여 암수 분리 사육이 혼합 사육에 비해 훨씬 유리한 사육 형태라 사료된다.

• Clinical and Experimental Pediatrics
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• 제49권9호
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• pp.966-971
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• 2006

목 적 : 성인의 심혈관질환은 태아발달 동안이나 이른 어린이 시기부터 시작된다는 태아프로그래밍 개념과 출생시 작게 태어난 경우에 성인기에 혈압이 상승된다는 연구들을 고려하여 볼 때, 출생시기부터의 혈압 변화에 대한 연구가 필요함을 느꼈다. 본 연구에서는 신생아의 여러 자궁내 발육 지표와 신생아의 혈압 관련성에 대해 살펴보고자 하였다. 방 법 : 이화여자대학교 목동병원에 내원한 임산부 중 연구참여에 동의한 산모를 대상으로 코호트를 구축하고 이들의 127명의 출생아에 대한 의무기록에 근거하여 자료를 추적, 수집하였고, 생후 24시간 이내에 신생아의 혈압을 측정하였다. 결 과 : 신생아 수축기 혈압과 태내 성장지표는 유의한 양의 상관관계를 보였다; 출생체중(r=0.4), 머리둘레(r=0.4), 출생신장(r=0.3). 그러나 체중대비 머리둘레 비는 신생아 혈압과 유의한 음의 상관관계를 보였다(r=-0.4). 아기의 성과 엄마의 혈압수준, 재태연령을 보정한 상태에서도 신생아 수축기 혈압은 태내 성장지표와 연관성을 보였다. 수축기 혈압은 출생체중이 가장 높은 군에서(90 백분위수 이상) 낮은 군과 비교하여(10 백분위수 미만) 7 mmHg 높았다, 한편 출생체중 대비 머리둘레의 비가 가장 높은 군(90 백분위수 이상)에서 낮은 군(10 백분위수 미만)에 비해 17 mmHg 낮게 나타났다. 결 론 : 우리 연구 결과 자궁내 성장 지연이 신생아의 혈압을 높이는데 영향을 미치는 것을 관찰할 수 없었다. 혈압 프로그래밍은 출생 이후에 성장기간에 시작되는 것으로 생각된다. 자궁내 성장지연으로 인해 혈압이 상승하는 주요 시작 지점이 언제인지 알아보기 위해서 출생 이후부터 따라잡기 성장과 함께 아동기시기 혈압 변화에 대한 지속적인 연구가 필요하다.

• 한국가금학회지
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• 제48권4호
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• pp.193-206
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• 2021

이 연구는 국립축산과학원 가금연구소에서 보유하고 있는 토종닭 순계 12계통의 육성기 성장능력을 파악하기 위해 생시(0주령)부터 16주령까지 2주 간격으로 체중, 증체량을 측정하고, 성장곡선을 추정하여 제시하였다. 각 주령별 체중에 대한 성별 효과와 계통 효과는 전 기간에서 각각 유의적인 차이를 보였으며 전 기간 체중은 수컷이 암컷보다 유의적으로 무겁게 나타났다. 계통별 체중 차이는 코니쉬 품종과 그 외 품종으로 구분되어 나타났고, 코니쉬 품종이 생시 체중을 제외하고 다른 품종에 비해 약 2배 정도 체중이 무거운 경향을 보였다. 증체량의 경우 생시부터 6주령까지 증체량이 빠르게 증가하는 경향과 이후 피크에 도달하고 12주령부터 14주령까지 기간에 증체량이 감소하는 경향은 모든 성별과 계통에서 공통적으로 나타났다. 그러나 성별과 계통에 따라 증체량의 피크 도달 시점과 횟수의 차이를 보였다. 주령별 체중 간 상관분석 결과, 토종닭 시장 출하 주령인 10주령과 8주령 체중에서 가장 높은 표현형 상관계수를 나타났다. 증체량과 증체량 간의 상관분석 결과는 0-2주령 증체량과 2~4주령 증체량 간 표현형 상관계수를 제외하고 -0.16에서 0.29로 낮은 표현형 상관을 보였다. 성장곡선 모형의 결정계수와 수정된 결정계수는 99.1~99.9로 계통과 성별에 상관없이 모두 높은 적합도를 나타냈다. 그러나 각 모형별 적합도는 성별과 계통에 따라 차이가 나타났다. 암컷의 성장 곡선은 D계통을 제외한 모든 계통에서 Von Betalanffy 모형이 가장 높은 적합도를 보였다. 반면에 수컷의 성장 곡선은 C계통을 제외한 모든 계통에서 Gompertz 모형이 가장 높은 적합도를 보였다. Logistic 모형은 모든 성별과 계통에서 모든 모형 중 가장 낮은 모형 적합도를 보였다. 성숙체중(α)의 경우 모든 성별과 계통에서 Von Bertalanffy, Gompertz, Logistic 모형 순으로 높게 나타났으며, 성장비(β)와 성숙률(γ)은 Logistic, Gompertz, Von Bertalanffy 모형 순으로 높게 나타났다. 성장곡선 모수인 α, β, γ는 암컷보다 수컷에서 높게 나타나는 경향을 보였다. 이 연구에서 수행한 가금연구소 보유 토종닭 순계 12계통의 육성기 성장 특성은 향후 토종닭 종계, 실용계를 생산하기 위한 교배조합 시험 설계와 순계의 개량방향, 그리고 사료 제한급이를 위한 기초자료로 활용될 것이다.

• Environmental Analysis Health and Toxicology
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• 제31권
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• pp.1.1-1.13
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• 2016

Objectives To investigate the accuracy and scientific validity of the current very low risk factor for hereditary diseases in humans following exposures to ionizing radiation adopted by the United Nations Scientific Committee on the Effects of Atomic Radiation and the International Commission on Radiological Protection. The value is based on experiments on mice due to reportedly absent effects in the Japanese atomic bomb (A-bomb) survivors. Methods To review the published evidence for heritable effects after ionising radiation exposures particularly, but not restricted to, populations exposed to contamination from the Chernobyl accident and from atmospheric nuclear test fallout. To make a compilation of findings about early deaths, congenital malformations, Down's syndrome, cancer and other genetic effects observed in humans after the exposure of the parents. To also examine more closely the evidence from the Japanese A-bomb epidemiology and discuss its scientific validity. Results Nearly all types of hereditary defects were found at doses as low as one to 10 mSv. We discuss the clash between the current risk model and these observations on the basis of biological mechanism and assumptions about linear relationships between dose and effect in neonatal and foetal epidemiology. The evidence supports a dose response relationship which is non-linear and is either biphasic or supralinear (hogs-back) and largely either saturates or falls above 10 mSv. Conclusions We conclude that the current risk model for heritable effects of radiation is unsafe. The dose response relationship is non-linear with the greatest effects at the lowest doses. Using Chernobyl data we derive an excess relative risk for all malformations of 1.0 per 10 mSv cumulative dose. The safety of the Japanese A-bomb epidemiology is argued to be both scientifically and philosophically questionable owing to errors in the choice of control groups, omission of internal exposure effects and assumptions about linear dose response.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제23권5호
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• pp.447-456
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• 2020

Purpose: Food insecurity, which is the inability to obtain food or inadequate food consumption in terms of quality and quantity, has physical and psychological consequences on children's health. This study aimed to investigate the relationship between children's growth disorders and food insecurity in Qazvin city, Iran. Methods: A case-control study was conducted on 177 cases and 355 controls of children aged 3 to 6 years, who were referred to health centers in Qazvin city. The case group consisted of children with growth disorders. Data were obtained with the 18-item US Department of Agriculture questionnaire, a household socioeconomic questionnaire, a and growth monitoring card. The data were analyzed with using IBM SPSS Version 22.0, by independent sample t-test, chi-square test, and logistic regression. Results: A significant relationship was found between children's growth disorders and household food insecurity with (p<0.05, odds ratio [OR]=17.0, confidence interval [CI]=5.9, 48.8) and without hunger (p<0.05, OR=2.69, CI=1.4, 4.9). There were also significant relationships between children's growth disorders and socioeconomic status (p<0.05, OR=3.4, CI=1.4, 8.5), the duration of breastfeeding (p<0.05, OR=0.94, CI=0.9, 0.98), and children's ages (p<0.05, OR=0.94, CI=0.92, 0.96). Sex and birth order, and the age of the parents was not found to be significantly related with growth disorders. Conclusion: Lower socioeconomic status and household food insecurity were the important predictors of children's growth disorders. Policymakers should focus more on promoting steady employment and income among family members. Nutritional education for mothers is also recommended, in order to better meet the nutritional needs of the children.

• Clinical and Experimental Pediatrics
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• 제61권9호
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• pp.279-284
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• 2018

Purpose: This study aimed to determine the frequency of abnormalities in the newborn oral cavity and to evaluate the association with prenatal and perinatal factors. Methods: This cross-sectional study evaluated 2,216 newborns. Oral findings were assessed in the first 24 hours of life using visual examination. Sex, weight, length, gestational age, and medical disorders at birth were recorded. Maternal demographic and medical information was also obtained. Results: The most common oral findings were Bohn's nodules, Epstein's pearls, and dental lamina cysts. Other intraoral findings included odontogenic cysts, ankyloglossia, and natal teeth, among others. In logistic regression analyses, folic acid consumption during pregnancy was significantly associated with Bohn's nodules (odds ratio [OR], 1.79; 95% confidence interval [CI], 1.23-2.55; P=0.002), Epstein's pearls (OR, 1.63; 95% CI, 1.14-2.33; P=0.007), and dental lamina cysts (OR, 1.45; 95% CI, 1.02-2.05; P=0.038). Moreover, preterm births were negatively associated with prevalence of Bohn's nodules (OR, 0.63; 95% CI, 0.50-0.80; $P{\leq}0.0001$). Comparison between newborns with and without oral inclusion cysts showed that maternal folic acid and iron intake were significantly different (P<0.05). Conclusion: Maternal folic acid and iron intake were associated with the prevalence of oral inclusion cysts.

• Safety and Health at Work
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• 제10권2호
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• pp.141-150
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• 2019

Background: Evidence on associations between occupational diesel exhaust and gasoline exposure and colorectal cancer is limited. We aimed to assess the effect of workplace exposure to diesel exhaust and gasoline on the risk of colorectal cancer. Methods: This case-control study included 181,709 colon cancer and 109,227 rectal cancer cases diagnosed between 1961 and 2005 in Finland, Iceland, Norway, and Sweden. Cases and controls were identified from the Nordic Occupational Cancer Study cohort and matched for country, birth year, and sex. Diesel exhaust and gasoline exposure values were assigned by country-specific job-exposure matrices. Odds ratios and 95% confidence intervals were calculated by using conditional logistic regression models. The results were adjusted for physical strain at work and occupational exposure to benzene, formaldehyde, ionizing radiation, chlorinated hydrocarbons, chromium, and wood dust. Results: Diesel exhaust exposure was associated with a small increase in the risk of rectal cancer (odds ratio - 1.05, 95% confidence interval 1.02-1.08). Gasoline exposure was not associated with colorectal cancer risk. Conclusion: This study showed a small risk increase for rectal cancer after workplace diesel exhaust exposure. However, this finding could be due to chance, given the limitations of the study.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• 제26권1호
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• pp.59-86
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• 2023

Purpose: Information regarding functional gastrointestinal disorders (FGIDs) in infants is currently lacking in Indonesia. This study aimed to describe the prevalence and risk factors of FGIDs in infants aged 6 weeks to 4 months in Indonesia. Methods: This cross-sectional study of 433 infants was conducted between September 2018 and February 2020. Information on FGIDs was collected using the Infant Gastrointestinal Symptom Questionnaire and the Feeding Practice and Gut Comfort Questionnaire. Adapted Rome IV criteria were used to define the FGIDs. Results: The prevalence of regurgitation was 26.3%; 16.8% of the infants presented cryingrelated symptoms and 5.5% exhibited constipation. The statistical analyses revealed that constipation was associated with sex (odds ratio [OR], 2.74; 95% confidence interval [CI], 1.07-7.71; p=0.043), employment of the father (OR, 0.3; 95% CI, 0.12-0.77; p=0.01), and education of the mother (OR, 1.92; 95% CI, 1.07-3.51; p=0.031). Length at birth (OR, 0.74; 95% CI, 0.55-0.99; p=0.042) was associated with constipation. Length at visit (OR, 0.83; 95% CI, 0.76-0.91; p<0.001) was associated with regurgitation, and the weight at visit (OR, 0.58; 95% CI, 0.35-0.96; p=0.038) was associated with crying and/or colic. A history of parental FGIDs was associated with crying-related symptoms (OR, 2.12; 95% CI, 1.23-3.68; p=0.007). Conclusion: Regurgitation, crying, and constipation are common FGIDs in infants. Some parental and infant characteristics may be predictors for FGIDs. Further investigations are needed to evaluate the clinical relevance of our findings. Understanding the determinants of FGIDs will benefit healthcare professionals and parents to improve infant's quality of life and better manage these condition.

• 대한한의학회지
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• 제21권3호
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• pp.166-173
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• 2000

Objectives : These experiments were undertaken to evaluate the effect of the administration on Korean herbal medicines, Kyoaekungkue-tang, Bojungykki-tang, Kungso-san, Antae-eum, and Antaegumchul-tang, on the reproductive functions in pregnant mice. Methods : Prepared herbal medicines(Kyoaekungkue-tang, Bojungykki-tang, Kungso-san, Antae-eum, Antaegumchul-tang) were administered to three different pregnant staged mice. We designed 3 experiments as follows; prepared herbal medicine administered from ovulation to embryo implantation (Experiment I), or administered after implantation to fetal organogenesis (Experiment II) and lastly administered from end of organogenesis to parturition (Experiment III). At day 14 of pregnancy, the whole uteri of half of the treated mice were retrieved from the Experiment I and in the Experiment II the implantation and mean weight of the fetuses were examined. The mean numbers of offspring, sex ratio and mean birth weight were examined in the other half of the mice. Results : The results from these studies were summarized as followed; 1. From the experiment I (administered from ovulation to embryo implantation), the no. of implantation between control and herbal medicine treated groups were shown similar results. Litter size after parturition was significantly decreased in the herbal medicine treated groups, except for Antaegumchul-tang. However, the mean weight of offspring after parturition showed a tendency to increase in the three herbal medicine treated groups. 2. From the experiment II (administered after implantation to fetal organogenesis), the implantation rates from the herbal medicine treated groups increased more significantly than that of the control Also, litter size and birth weight in the herbal medicine groups, except Antaeeum, increased more significantly than that of the control group. 3. From the experiment III group (administered after organogenesis to parturition), the mean number of offspring in Kyoaekungkue-tang and Antaegumchul-tang treated groups were significantly increased than that of control However, the litter size of the Kungso-san treated mice was significantly decreased compared with that of the control group. Compared with the control and other herbal treated groups, the mean weight of fetuses after parturition in the Kyoaekungkue-tang and Antaegumchul-tang treated groups increased significantly. Conclusions : From these results, it can be concluded that Antaegumchul-tang showed more beneficial effects on the reproductive functions, implantation, maintenance of pregnancy, litter size and mean weight than other herbs.

• Advances in pediatric surgery
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• 제7권2호
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• pp.95-104
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• 2001

Biliary atresia (BA) is very difficult to distinguish from neonatal hepatitis (NH) and its prognosis depends on the age at the time of Kasai operation. Therefore early differentiation between these two conditions is very important. Although various clinical and laboratory tests have been reported to differentiate between them, they are still of limited value. From 1980 to 1999, forty-five infants were referred to our pediatric surgical unit for operation for suspected BA. Eight patients underwent Kasai operation immediately because of late diagnosis. These were excluded from the study. The clinical history, physical findings. radiologic and laboratory examinations of 37 cases were analyzed retrospectively. The average age of BA (n=20) was $55.1{\pm}16.7$ days, and that of NH (n=17) was $55.8{\pm}15.6$ days. The sex ratio of BA was 13:7, and that of NH was 14:3. All the patients had obstructive jaundice and acholic stool except 4 BA and 6 NH patients. Acholic stool with yellow component was more frequent in NH. Onset of jaundice was within 2 weeks after birth in 85 % of BA, and in 65% of NH. The onset of acholic stool was within 2 weeks after birth in 60 % of BA, and in 23.5 % of NH. The duration of jaundice and acholic stool of BA were $50.9{\pm}16.6$ days and $41.3{\pm}18.4$ days and those of NH were $40.1{\pm}23.1$ days and $26.6{\pm}25.4$ days respectively. The ultrasonogram and hepatobiliary scan were useful, but not a definitively reliable method for the differentiation of these two diseases. There was no difference in laboratory data. Seventeen cases had NH among 45 referred cases for Kasai operation with the clinical impression of BA, and 4 cases of 17 NH cases needed to be explored to rule out BA. In conclusion. false positive rate of clinical impression of BA was 37.8 %. and negative exploration rate was 8.9 %, Therefore. careful clinical observation for 1-2 weeks by an experienced pediatric surgeon was very important to avoid unnecessary operation to rule out NH up to the age of 8 - 10 weeks. so long as the stool had yellow component.