• Proceedings of the Korean Society of Computer Information Conference
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• 2009.01a
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• pp.249-254
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• 2009

유비쿼터스 핵심 기술 중 하나인 RFID 기술은 의료산업분야 전반에 걸쳐 활용이 증가하고 있으나, RFID 기술은 태그의 내용을 리더기를 통해 무선주파수로 식별하는 기술임으로 태그의 크기와 위치에 따라 태그의 인식률에 대한 차이가 크기 때문에 태그의 인식률의 성능이 입증되지 않아 도입의 큰 어려움을 겪고 있다. 본 연구에서는 사물의 다중인식이 가능한 RFID 시스템을 의약품 창고 관리에 적용하기 위하여 병원 내에서 사용하는 기밀용기에 대한 태그 부착위치와 크기에 대한 인식률 연구를 수행하였다. 실제 병원 약제실의 책장을 모델링하여 Test Bed로 구축하였으며, 구축된 Test-Bed를 통해 병원에서 사용하는 의료용 기밀용기에 태그를 부착하여 최적의 위치를 찾고, 리더기의 최적의 위치에 대한 연구를 수행하였으며, 인식률 향상을 위한 최적의 조건을 제공하고자 한다.

• Molecules and Cells
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• v.20 no.2
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• pp.219-227
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• 2005

Purkinje cell degeneration (pcd) mice are characterized by death of virtually all cerebellar Purkinje cells by postnatal day 30. In this study, we used DNA microarray analysis to investigate differences in gene expression between the brains of wild type and pcd mice on postnatal day 20, before the appearance of clear-cut phenotypic abnormalities. We identified 300 differentially expressed genes, most of which were involved in metabolic and physiological processes. Among the differentially expressed genes were several calcium binding proteins including calbindin-28k, paravalbumin, matrix gamma-carboxyglutamate protein and synaptotagamins 1 and 13, suggesting the involvement of abnormal $Ca^{2+}$ signaling in the pcd phenotype.

• Archives of Pharmacal Research
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• v.19 no.1
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• pp.30-35
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• 1996

Poly(l-lactic acid)(PLLA) microspheres loaded with ampicillin sodium (AMP-Na_, .betha.-lactam antibiotic, were prepared by a w/o/w multiple emulsion-solvent evaporation method. The amounts of each component in three phases (inner water phase, organic phase, and outer water phase) wre carefully examined in the preparation of PLLA microspheres. The stirring rate, another preparation parameter, was also investigated for study on the effect of mechanical stress on the drug loading and morphology of PLLA microspheres. Most of the preparation parameters had a great influence on the drug loading, surface morphology and size distribution of PLLA microspheres. PLLA microspheres with 15.89 w/w% drug loading were subjected to the in vitro release experimet. The release of ampicillin sodium was constant at a rate of 1.68 $mug/ml/day$ per 1 mg of microspheres for 18 days initial burst effect.

• Archives of Pharmacal Research
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• v.19 no.2
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• pp.106-111
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• 1996

Alginate microspheres were prepared by the emulsification process as a drug delivery system of ampicillin sodium (AMP-Na). The preparation parameters such as the concentration of calcium chloride, the stirring time and the amount of AMP-NA were investigated. The alginate microspheres containing hydroxypropylmethylcellulose (HPMC) were found to be generally spherical, discrete and had smoother surfaces when compared to without HPMC. However, there was no significant difference in the release profile of AMP-NA from alginate microspheres prepared with or without HPMC. The concentration of calcium chloride solution and the stirring time in the preparation of alginate microspheres influenced the aggregation of alginate microspheres. The amount of AMP-NA in alginate microspheres influenced the surface morphology and the practical drug content in microspheres.

• BMB Reports
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• v.54 no.8
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• pp.431-436
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• 2021

In recent years, restoring anti-tumor immunity has garnered a growing interest in cancer treatment. As potential therapeutics, immune checkpoint inhibitors have demonstrated benefits in many clinical studies. Although various methods have been applied to suppress immune checkpoints to boost anti-tumor immunity, including the use of immune checkpoint inhibitors, there are still unmet clinical needs to improve the response rate of cancer treatment. Here, we show that acetate can suppress the expression of poliovirus receptor (PVR/CD155), a ligand for immune checkpoint, in colon cancer cells. We demonstrated that acetate treatment could enhance effector responses of CD8⁺ T cells by decreasing the expression of PVR/CD155 in cancer cells. We also found that acetate could reduce the expression of PVR/CD155 by deactivating the PI3K/AKT pathway. These results demonstrate that acetate-mediated expression of PVR/CD155 in cancer cells might potentiate the anti-tumor immunity in the microenvironment of cancer. Our findings indicate that maintaining particular acetate concentrations could be a complementary strategy in current cancer treatment.

• Journal of Electrical Engineering and Technology
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• v.10 no.5
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• pp.2155-2161
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• 2015

This study suggests an optical method to measure cardinal of gait (step width, step length, and stride length) with position sensitive detector (PSD). The effect of reflector’s shape (flat and cylinder) on the PSD output voltage was examined for the application of the suggested system to real situations with a curved shape reflector (e.g. shoes). Various mathematical models were evaluated to find the optimal equation for the distance measurement. Considering the effect of shape on detected signal, the inverse polynomial model was developed. The suggested method is simple to operate, low in cost, small in size, and can evaluate gait parameters in real time. This method is expected to be useful in the field of rehabilitation and sport science

• 한국약용작물학회:학술대회논문집
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• 2011.09a
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• pp.336-337
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• 2011

• 한국약용작물학회:학술대회논문집
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• 2011.09a
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• pp.338-339
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• 2011

• 한국약용작물학회:학술대회논문집
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• 2011.09a
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• pp.314-315
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• 2011

• 한국약용작물학회:학술대회논문집
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• 2010.10a
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• pp.533-534
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• 2010