• Title/Summary/Keyword: Biomedical research

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Characteristic analysis of a thermochromic material based fiber-optic temperature sensor for measuring temperature of subsurface water (열변성 물질을 이용한 지하수 온도 측정용 광섬유 온도센서의 특성분석)

  • Seo, Jeong-Ki;Yoo, Wook-Jae;Cho, Dong-Hyun;Jang, Kyoung-Won;Heo, Ji-Yeon;Lee, Bong-Soo;Koh, Yong-Kwon
    • Journal of Sensor Science and Technology
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    • v.18 no.6
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    • pp.467-474
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    • 2009
  • In this study, we describe the feasibility of developing a fiber-optic temperature sensor using a thermochromic material such as 2,4,5-triphenylimidazole or also called Lophine. A sensor-tip is fabricated by mixing of a Lophine powder, which has a non-toxic and hydrophobic characteristics, and an epoxy resin. The temperature change in the sensor-tip gives rise to a change in the optical absorbance of the Lophine, and the transmittance of a light through the Lophine is also changed. We have measured the intensities of modulated lights due to the change of optical absorbance of the Lophine by using of a photo-multiplier tube(PMT). The relationships between the temperatures and the output voltages of PMT are determined to measure the temperature of water. The measurable temperature range of the fiber-optic sensor is from 5 to $30^{\circ}C$.

Analysis of Skin Conductance Level for Cognitional and Emotional Responses associated with Unexpected Situation during Driving (운전 중 돌발 상황과 관련된 인지 처리 및 감정 반응의 피부전도수준 해석)

  • Lee, Su-Jeong;Yang, Jae-Woong;Kim, Ji-Hye;Choi, Mi-Hyun;Mun, Kyung-Ryoul;Kim, Han-Soo;Choi, Jin-Seung;Ji, Doo-Hwan;Min, Byung-Chan;Tack, Gye-Rae;Chung, Soon-Cheol
    • Journal of the Ergonomics Society of Korea
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    • v.29 no.6
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    • pp.869-874
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    • 2010
  • The purpose of this study was to analyze the skin conductance level (SCL) induced by unexpected situation which reflected the emotional and cognitional responses during driving. The participants included 57 college graduates; 28 males aged $24.5{\pm}1.3$ with $2.3{\pm}1.5$ years of driving experiences and 29 females aged $23.6{\pm}2.6$ with $2.2{\pm}1.7$ years of driving experience. Reaction time of brake, averaged SCL, maximum SCL, and rising time to maximum amplitude were measured. They were analysed according to condition (crash, non-crash) and gender (male, female). The reaction time of brake was more faster and averaged SCL was greater during non-crash condition than during crash condition. There were no significant differences between male and female drivers in the reaction time of brake and averaged SCL whether or not it crash. There were no significant differences between crash and non-crash conditions in the maximum SCL and rising time to maximum amplitude, but there were significant differences between male and female in them. These results support the hypothesis that averaged SCL is more related to cognitional response and maximum SCL and rising time to maximum amplitude are more related to emotional responses.

The Comparison of Driving Pattern by Gender Using Driving Simulator and Motion Data (시뮬레이터 및 동작데이터를 이용한 남녀 운전 수행 패턴의 비교)

  • Mun, Kyung-Ryoul;Choi, Jin-Seung;Kang, Dong-Won;Lee, Su-Jeong;Yang, Jae-Woong;Choi, Mi-Hyun;Ji, Doo-Hwan;Min, Byung-Chan;Chung, Soon-Cheol;Tack, Gye-Rae
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.33 no.2
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    • pp.56-62
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    • 2010
  • The purpose of this study was to compare the difference of driving pattern between male and female drivers for a straight driving and unexpected situation using driving simulator and motion data. The participants included total 60 university students; 30 males aged 24.3$\pm$1.4 years and 30 females aged 23.2$\pm$1.9 years with 1~3 years of driving experience. The driving task required participants to keep the constant distance (20m, 25m or 30m) with preceding vehicle running at 55~65km/hr speed using driving simulator which was programed unexpected situation for two minutes. Simulator and motion data were acquired. The acquired data was divided in straight driving block for 40 second and unexpected situation block for 2 second. The coefficient of variation (CV) of lane keeping and jerk-cost (JC) function were analyzed for straight driving and unexpected situation blocks. The results show that CV was smaller in males than females for both straight and unexpected situation blocks (p < .05). JC was smaller in females than males for both straight and unexpected situation blocks. As the distance of vehicles become longer, JC was smaller for both male and female (p < .05).

Fiber-optic Temperature Sensor Using a Silicone Oil and an OTDR (OTDR을 이용한 실리콘 오일 기반의 광섬유 온도 센서)

  • Jang, Jae Seok;Yoo, Wook Jae;Shin, Sang Hun;Lee, Dong Eun;Kim, Mingeon;Kim, Hye Jin;Song, Young Beom;Jang, Kyoung Won;Cho, Seunghyun;Lee, Bongsoo
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.64 no.11
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    • pp.1592-1597
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    • 2015
  • In this study, we developed a fiber-optic temperature sensor (FOTS) based on a silicone oil and an optical time domain reflectometer (OTDR) to apply the measurement of a coolant leakage in the nuclear power plant. The sensing probe of the FOTS consists of a silicone oil, a stainless steel cap, a FC terminator, and a single mode optical fiber. Fresnel reflection arising at the interface between the silicone oil and the single mode optical fiber in the sensing probe is changed by varying the refractive index of the silicone oil according to the temperature. Therefore, we measured the optical power of the light signals reflected from the sensing probe. The measurable temperature range of the FOTS using a Cu-coated silica fiber is from $70^{\circ}C$ to $340^{\circ}C$ and the maximum operation temperature of the FOTS is sufficient for usage at the secondary system in the nuclear power plant.

Development of Noncontact Temperature Sensor Using Silver Halide Optical Fiber for Medical Usages (Silver Halide 광섬유를 이용한 의료용 비접촉식 온도 센서 개발)

  • Yoo, Wook-Jae;Cho, Dong-Hyun;Jang, Kyoung-Won;Chung, Soon-Cheol;Tack, Gye-Rae;Lee, Bong-Soo
    • Journal of Biomedical Engineering Research
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    • v.27 no.6
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    • pp.337-342
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    • 2006
  • We have developed a noncontact temperature sensor using a silver halide optical fiber. The infrared collimator and focus head are connected both ends of a silver halide optical fiber with SMA connectors and used to collimate radiations of a heat source and to focus them to infrared sensors such as a pyroelectric sensor and a thermopile sensor, respectively. The relation ships between the temperatures of a heat source and the output signals of the infrared sensors are determined to measure the surface temperature of a heat source. The measurable temperature range is from 25 to $60^{\circ}C$. It is expected that a noncontact temperature sensor using a silver halide optical fiber can be developed for medical usages such as temperature monitoring during hyperthermia, cryosurgery, laser surgery and diagnostic procedure based on the results of this study.

Measurement of relative dose irradiated from a Co-60 source using a scintillating fiber-optic dosimeter (광섬유 방사선량계를 이용한 Co-60 방사선원으로부터 조사되는 상대선량측정)

  • Jang, Kyoung-Won;Cho, Dong-Hyun;Yoo, Wook-Jae;Seo, Jeong-Ki;Heo, Ji-Yeon;Lee, Bong-Soo;Shin, Sang-Hun;Park, Byung-Gi;Kim, Sin
    • Journal of Sensor Science and Technology
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    • v.19 no.1
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    • pp.52-57
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    • 2010
  • In this study, we have fabricated a scintillating fiber-optic dosimeter for a radiotherapy dosimetry. And ${\gamma}$-rays generated by a Co-60 are measured using a scintillating fiber-optic dosimeter and percent depth dose curves are obtained according to the different depths of solid water phantoms. Also, Cerenkov radiations generated by primary or secondary electrons are measured at different depths of water phantom using a background optical fiber.

Measurements of relative depth dose rates for a brachytherapy Ir-192 sourceusing an organic scintillator fiber-optic radiation sensor (유기 섬광체-광섬유 방사선 센서를 이용한 근접 방사선원 Ir-192의 상대 깊이 선량율 측정)

  • Shin, Sang-Hun;Jang, Kyoung-Won;Cho, Dong-Hyun;Yoo, Wook-Jae;Seo, Jeong-Ki;Lee, Bong-Soo;Moon, Joo-Hyun;Kim, Sin;Park, Byung-Gi
    • Journal of Sensor Science and Technology
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    • v.17 no.6
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    • pp.462-469
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    • 2008
  • In this study, we have fabricated a fiber-optic radiation sensor using an organic scintillator and plastic optical fiber for brachytherapy dosimetry. Also, we have measured relative depth dose rates of Ir-192 source using a fiber-optic sensor and compared them with the results obtained using a conventional EBT film. Cerenkov lights which can be a noise in measuring scintillating light with a fiber-optic sensor are measured and eliminated by using of a background optical fiber. It is expected that a fiber-optic radiation sensor can be used in brachytherapy dosimetry due to its advantages such as a low cost, simple usage and a small volume.

Effect of Modified Fiber Tip on Joint Angle Measurement (광섬유 종단각도 효과를 이용한 관절각 측정)

  • Jung, Gu-In;Kim, Ji-Sun;Lee, Tae-Hee;Choi, Ju-Hyeon;O, Han-Byeol;Kim, A-Hee;Jun, Jae-Hoon
    • The Transactions of The Korean Institute of Electrical Engineers
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    • v.63 no.7
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    • pp.929-933
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    • 2014
  • The measurement of joint angle is important to evaluate the patient's disability. The modified fiber tip and light propagation of the developed fiber sensor were investigated to increase the range of angle detection. Different shapes of fiber tips were manufactured with a polishing machine to deliver light signal in various patterns. Output signals were analyzed to obtain joint angle change with inverse polynomial models. The measured joint angles were displayed with LabVIEW program and the reliability was tested by comparing with a commercial angle sensor. This method can be used in rehabilitation field to determine patient's progress.

Effect of Probiotics Lactobacillus and Bifidobacterium on Gut-Derived Lipopolysaccharides and Inflammatory Cytokines: An In Vitro Study Using a Human Colonic Microbiota Model

  • Rodes, Laetitia;Khan, Afshan;Paul, Arghya;Coussa-Charley, Michael;Marinescu, Daniel;Tomaro-Duchesneau, Catherine;Shao, Wei;Kahouli, Imen;Prakash, Satya
    • Journal of Microbiology and Biotechnology
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    • v.23 no.4
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    • pp.518-526
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    • 2013
  • Gut-derived lipopolysaccharides (LPS) are critical to the development and progression of chronic low-grade inflammation and metabolic diseases. In this study, the effects of probiotics Lactobacillus and Bifidobacterium on gut-derived lipopolysaccharide and inflammatory cytokine concentrations were evaluated using a human colonic microbiota model. Lactobacillus reuteri, L. rhamnosus, L. plantarum, Bifidobacterium animalis, B. bifidum, B. longum, and B. longum subsp. infantis were identified from the literature for their anti-inflammatory potential. Each bacterial culture was administered daily to a human colonic microbiota model during 14 days. Colonic lipopolysaccharides, and Gram-positive and negative bacteria were quantified. RAW 264.7 macrophage cells were stimulated with supernatant from the human colonic microbiota model. Concentrations of TNF-${\alpha}$, IL-$1{\beta}$, and IL-4 cytokines were measured. Lipopolysaccharide concentrations were significantly reduced with the administration of B. bifidum ($-46.45{\pm}5.65%$), L. rhamnosus ($-30.40{\pm}5.08%$), B. longum ($-42.50{\pm}1.28%$), and B. longum subsp. infantis ($-68.85{\pm}5.32%$) (p < 0.05). Cell counts of Gram-negative and positive bacteria were distinctly affected by the probiotic administered. There was a probiotic strain-specific effect on immunomodulatory responses of RAW 264.7 macrophage cells. B. longum subsp. infantis demonstrated higher capacities to reduce TNF-${\alpha}$ concentrations ($-69.41{\pm}2.78%$; p < 0.05) and to increase IL-4 concentrations ($+16.50{\pm}0.59%$; p < 0.05). Colonic lipopolysaccharides were significantly correlated with TNF-${\alpha}$ and IL-$1{\beta}$ concentrations (p < 0.05). These findings suggest that specific probiotic bacteria, such as B. longum subsp. infantis, might decrease colonic lipopolysaccharide concentrations, which might reduce the proinflammatory tone. This study has noteworthy applications in the field of biotherapeutics for the prevention and/or treatment of inflammatory and metabolic diseases.