• 제목/요약/키워드: Biomedical polyurethane

검색결과 87건 처리시간 0.023초

광화학반응으로 polyallyamine막이 표면에 고정화된 리팜피신-함유 폴리우레탄으로부터 유리되는 리팜피신의 항균 활성에 관한 연구 (Antimicrobial activity of rifampicin released from the rifampicin-containing-polyurethane immobilized on the surface with the polyallyamine membrane using photochemical reaction)

  • 전성민;이규백;김현정;김말남;민병구
    • 대한의용생체공학회:학술대회논문집
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    • 대한의용생체공학회 1997년도 춘계학술대회
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    • pp.31-34
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    • 1997

  • A new method for the prevention of foreign body-associated infections by controlled release of antibiotic was developed. The polyurethane (PU) matrix containing rifampicin was immobilized with hydrophilic photoreactive polyallylamine (PPA) containing azidophenyl groups. The rifampicin release characteristics and the long-lasting antimicrobial activities of the new material was compared with rifampicin-containing PU matrix without PPA membrane. The release rate of antibiotic from rifampicin-containing PU with PPA membrane significantly decreased as the thickness of PPA membrane was increased. The PPA-immobilized rifampicin-containing PU discs immersed in the PBS for 47 days had an efficient antimicrobial activity against both S. aureus and S. epidermidis.

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Fabrication and Characterization of Porous TCP coated Al2O3 Scaffold by Polymeric Sponge Method

  • Sarkar, Swapan Kumar;Kim, Young-Hee;Kim, Min-Sung;Min, Young-Ki;Yang, Hun-Mo;Song, Ho-Yeon;Lee, Byong-Taek
    • 한국세라믹학회지
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    • 제45권10호
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    • pp.579-583
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    • 2008

  • A porous $Al_2O_3$, scaffold coated with tricalcium phosphate(TCP) was fabricated by replica method using polyurethane(PU) foam as a fugitive material. Successive coatings of $Al_2O_3$ and hydroxyapatite(HAp) were applied via dip coating onto polyurethane foam, which has a slender and well interconnected network. A porous structure was obtained after sequentially burning out the foam and then sintering at $1500^{\circ}C$. The HAp phase was changed to TCP phase at high temperature. The scaffold showed excellent interconnected porosity with pore sizes ranging from $300{\sim}700{\mu}m$ in diameter. The inherent well interconnected structural feature of PU foam remained intact in the fabricated porous scaffold, where the PU foam material was entirely replaced by $Al_2O_3$ and TCP through a consecutive layering process. Thickness of the $Al_2O_3$ base and the TCP coating was about $7{\sim}10{\mu}m$ each. The TCP coating was homogeneously dispersed on the surface of the $Al_2O_3$ scaffold.

  • https://doi.org/10.4191/KCERS.2008.45.1.579 인용 PDF KSCI

패치형 웨어러블 심전도 측정 시스템을 위한 접착성 폴리우레탄 기반의 용량성 전극 (Adhesive Polyurethane-based Capacitive Electrode for Patch-type Wearable Electrocardiogram Measurement System)

  • 이정수;이원규;임용규;박광석
    • 대한의용생체공학회:의공학회지
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    • 제35권6호
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    • pp.203-210
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    • 2014

  • Wearable medical device has been a resurgence of interest thanks to the development of technology and propagation of smart phone in recent years. Various types of wearable devices have been introduced and available in market. Capacitive coupled electrode which measures electrocardiogram over cloth is able to be applied wearable device. In previous approaches of capacitive electrode, they need proper pressure for stable contact of the electrode to body surface. However, wearable device that gives pressure on body surface is not suitable for long-term monitoring. In this study, we proposed adhesive polyurethane-based capacitive electrode for patch-type wearable electrocardiogram (ECG) monitoring device. Self-adhesive polyurethane make the electrode and whole system be adhered to the surface of skin without any pressure. The patch-type system is consisted of analog filter, analog-to-digital converter and wireless transmission module and designed to be attached on the body as a patch. To validate the feasibility of the developed system, we measured ECG signal in stable and active state and extracted heart rate. Therefore, we observed skin response after long-term attachment for biocompatibility of the adhesive polyurethane and adhesive strength of it. The result shows the possibility of applying the developed system for ECG monitoring in real-life.

  • https://doi.org/10.9718/JBER.2014.35.6.203 인용 PDF KSCI

폴리우레탄 표면의 광화학적 공유결합을 이용한 새로운 LK 고정화 방법에 관한 연구 (A novel method with photochemical reaction for LK immobilization on the polyurethane surface)

  • 김현정;;심재희;유규하;김종원;;민병구
    • 대한의용생체공학회:학술대회논문집
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    • 대한의용생체공학회 1996년도 춘계학술대회
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    • pp.91-96
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    • 1996

  • 광반응을 이용하여 fibrinolytic 활성을 보이는 LK (lumbrokinase)를 생체재료인 PU (polyurethane) 표면에 고정화하는 방법에 관하여 연구하였다. 먼저 PU표면에 amino 작용기를 도입하기 위하여 side chain 작용기로 phenylazide 와 amino작용기를 갖는 AzPhPAL을 이용하였으며 광반응은 266nm 이상의 UV light을 약 1분간 조사시키는 방법을 이용하였다. LK를 amino작용기가 유도된 PU 표면에 공유결합시키기 위하여 amide결합 형성시 사용되는 수용성 carbodiimide인 EDC를 이용하였다. ESCA측정시, AzPhPAL으로 공유결합시킨 경우 반응하지 않은 PU표면에 비하여 N/C가 0.1717로, LK 고정시 S/C가 0.0043로 증가된것을 알 수 있었다. 이것으로부터 AzPhPAL과 LK가 PU표면에 공유결합된 것을 확인할 수 있었으며 static contact angle 측정으로 표면개질된 PU표면이 소수성에서 친수성으로 변화된 것을 확인 할 수 있었다. 또한 공유결합된 LK의 활성을 확인하기 위하여 fibrin plate test를 실시하였는데 그 결과 고정화된 후에도 LK의 활성이 존재함을 알 수 있었다.

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