Proceedings of the KOSOMBE Conference (대한의용생체공학회:학술대회논문집)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Antimicrobial activity of rifampicin released from the rifampicin-containing-polyurethane immobilized on the surface with the polyallyamine membrane using photochemical reaction

광화학반응으로 polyallyamine막이 표면에 고정화된 리팜피신-함유 폴리우레탄으로부터 유리되는 리팜피신의 항균 활성에 관한 연구

  • Jeon, S.M. (Institute of Biomedical Engineering, College of Medicine, Seoul National University) ;
  • Lee, K.B. (Biomedical Research Center, Korea Institute of Science and Technology) ;
  • Kim, H.J. (Institute of Biomedical Engineering, College of Medicine, Seoul National University) ;
  • Kim, M.N. (Department of Biology, Sangmyung University) ;
  • Min, B.G. (Institute of Biomedical Engineering, College of Medicine, Seoul National University)
  • 전성민 (서울대학교 의과대학 의공학연구소) ;
  • 이규백 (한국과학기술연구원 의과학연구센타) ;
  • 김현정 (서울대학교 의과대학 의공학연구소) ;
  • 김말남 (상명대학교 생물학과) ;
  • 민병구 (서울대학교 의과대학 의공학연구소)
  • Published : 1997.05.23
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Abstract

A new method for the prevention of foreign body-associated infections by controlled release of antibiotic was developed. The polyurethane (PU) matrix containing rifampicin was immobilized with hydrophilic photoreactive polyallylamine (PPA) containing azidophenyl groups. The rifampicin release characteristics and the long-lasting antimicrobial activities of the new material was compared with rifampicin-containing PU matrix without PPA membrane. The release rate of antibiotic from rifampicin-containing PU with PPA membrane significantly decreased as the thickness of PPA membrane was increased. The PPA-immobilized rifampicin-containing PU discs immersed in the PBS for 47 days had an efficient antimicrobial activity against both S. aureus and S. epidermidis.

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