• 한국재료학회:학술대회논문집
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• 한국재료학회 2010년도 춘계학술발표대회
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• pp.40.2-40.2
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• 2010

In this study, oxidized alginate/gelatin/biphase calcium phosphate (BCP)- based hydrogel composites were fabricated. Alginate sodium was oxidized by periodate. The oxidized product was confirmed by using $^1H$ and $^{13}C$ NMR spectra. The number average molecular weight ($M_n$), the average molecular weight ($M_w$) of the oxidized alginate were determined by Gel Permeation Chromatography (GPC). The hydrogel was formed from the oxidized alginate and gelatin solution via Schift-base reaction. The hydrogel showed a highly porosity by a Scanning Electron Microscope (SEM) and Mercury Intrusion Porosimetry (MIP). Crosslinked density of the gel matrix were assessd by trinitrobenzene sulfonic acid (TNBS) assay that shows a high effect on swelling ratio. Increment of the crosslinked desity resulted in enhancing compressive strength of the hydrogel composite. The cytotoxity of hydrogel was assessed with osteoblast MG-63. The hydrogel composites show a high compatibility. The obtained results showed a potential application for bone regeneration in future.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1997년도 추계학술대회
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• pp.343-346
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• 1997

A new type of stent was invented using a Nitinol wire. The hoop strength of the new stent was found to be 2 times larger than that of the Cragg or Memotherm stents. However, the longitudinal flexibility of the new stent was inferior to both the Cragg and Memotherm stents. This new stent seems to be useful or the treatment of stenosis with straight configuration, but need to be improved or use in tortuous stenotic region. The stent was applied to the patients with esophargeal stenosis and showed a good result.

• 대한의용생체공학회:의공학회지
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• 제35권2호
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• pp.14-18
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• 2014

This study is about e-Book program based on human-computer interaction(HCI) system for physically handicapped person. By acquiring background knowledge of HCI, we know that if we use vision-based interface we can replace current computer input devices by extracting any characteristic point and tracing it. We decided betweeneyes as a characteristic point by analyzing facial input image using webcam. But because of three-dimensional structure of glasses, the person who is wearing glasses wasn't suitable for tracing between-eyes. So we changed characteristic point to the bridge of the nose after detecting between-eyes. By using this technique, we could trace rotation of head in real-time regardless of glasses. To test this program's usefulness, we conducted an experiment to analyze the test result on actual application. Consequently, we got 96.5% rate of success for controlling e-Book under proper condition by analyzing the test result of 20 subjects.

• 대한의용생체공학회:학술대회논문집
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• 대한의용생체공학회 1996년도 추계학술대회
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• pp.189-191
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• 1996

Computerized spirometer was developed in a form of proto type system. The system consisted of pneumotachometer, flow measurement unit, fan ventilator unit, and software program. Patient's respiratory flow signal was first converted to corresponding pressure drop signal by a screen type pneumotachometer, sensed by a differential pressure transducer, amplified and low pass filtered, and digitized at a rate of 100 Hz, then fed into a PC thru RS-232C serial port. Customized application software controls data acquisition followed by computation of test parameters. The fan ventilator unit dries and eliminates microorganism in the pneumotachometer after each test. The system performs conventional spirometic tests and manages the test results in a database for retrograde research. The proto type system was fully developed and the commercialized system is currently being built up.

• 대한의생명과학회지
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• 제29권4호
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• pp.344-354
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• 2023

This study emphasizes the importance of early diagnosis and response to COVID-19, leading to the development of a rapid diagnostic kit using quantum dots. The research focuses on finely tuning bioconjugation with quantum dots to enhance the accuracy and sensitivity of COVID-19 diagnosis. We have developed a COVID-19 rapid diagnostic kit that exhibits a sensitivity more than 50 times higher than existing COVID-19 diagnostic kits. Quantum dots enable the accurate detection of COVID-19 viral antigens even at low concentrations, providing a rapid response in the early stages of infection. The COVID-19 quantum dot diagnostic kit offers quick analysis time, utilizing the quantum properties of particles to swiftly measure COVID-19 infection for immediate response and isolation measures. Additionally, this diagnostic kit allows for multiple analyses with ease, as multiple quantum dots can detect various antigens and antibodies simultaneously in a single experiment. This efficiency enhances testing, reduces sample requirements, and lowers experimental costs. The application of this diagnostic technology is anticipated in the future for early diagnosis and monitoring of other infectious diseases.

• Journal of Electrical Engineering and Technology
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• 제10권1호
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• pp.364-371
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• 2015

In this study, we developed a feasible structure of a textile-based inductive sensor using a machine embroidery method, and applied it to a non-contact type vital sign sensing device based on the principle of magnetic-induced conductivity. The mechanical heart activity signals acquired through the inductive sensor embroidered with conductive textile on fabric were compared with the Lead II ECG signals and with respiration signals, which were simultaneously measured in every case with five subjects. The analysis result showed that the locations of the R-peak in the ECG signal were highly associated with sharp peaks in the signals obtained through the textile-based inductive sensor (r=0.9681). Based on the results, we determined the feasibility of the developed textile-based inductive sensor as a measurement device for the heart rate and respiration characteristics.

• 셀메드
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• 제3권3호
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• pp.22.1-22.10
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• 2013

Traditional Chinese medicine (TCM) in single herb or formula prescription has been used for thousands of years. Many of them possess antioxidant activity and the activity may contribute the therapeutic effect. This paper would review the relationship of traditional herbal medicine and antioxidant with particular reference to ginseng. This medicinal herb has been used worldwide with extensive tonic effect. The comet assay, a technique for DNA protecting and damaging investigation would be introduced and the application of comet assay on TCM would be discussed.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2005년도 BIOINFO 2005
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• pp.366-370
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• 2005

Tissue microarry is one of the high throughput technologies in the post-genomic era. Using tissue microarray, the researchers are able to investigate large amount of gene expressions at the level of DNA, RNA, and protein The important aspect of tissue microarry is its ability to assess a lot of biomarkers which have been used in clinical practice. To manipulate the categorical data of tissue microarray, we applied Bayesian network classifier algorithm. We identified that Bayesian network classifier algorithm could analyze tissue microarray data and integrating prior knowledge about gastric cancer could achieve better performance result. The results showed that relevant integration of prior knowledge promote the prediction accuracy of survival status of the immunohistochemical tissue microarray data of 18 tumor suppressor genes. In conclusion, the application of Bayesian network classifier seemed appropriate for the analysis of the tissue microarray data with clinical information.

• 대한의생명과학회지
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• 제8권2호
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• pp.83-88
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• 2002

To investigate the skin toxicity of xylene, xylene (25 mg/$\textrm{cm}^2$) has been sequentially applied to the rat skin for four days. On the light microscopic examination, epithelium was left out with infiltration of inflammatory cells in border with dermis, and formation of new epithelial layer was shown under the inflammatory zone. Application of xylene to the rat skin showed the marked rise of cutaneous xanthine oxidase activity whereas, He activities of oxygen free radical scavenging enzymes, superoxide dismutase and glutathione S-transferase, were significantly declined. Furthermore, the content of cutaneous glutathione was more and less decreased in rat skin applied with xylene. In conclusion, these results suggest that a part of oxygen free radical may be responsible for morphological changes in skin by applying xylene to the rat skin.

• International Journal of Control, Automation, and Systems
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• 제6권4호
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• pp.613-619
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• 2008

A method to produce a desired current pattern in a multiple-source EIT system using voltage sources is presented. Application of current patterns to a body is known to be superior to the application of voltage patterns in terms of high spatial frequency noise suppression, resulting in high accuracy in conductivity and permittivity images. Since current sources are difficult and expensive to build, the use of voltage sources to apply the current pattern is desirable. An iterative algorithm presented in this paper generates the necessary voltage pattern that will produce the desired current pattern. The convergence of the algorithm is shown under the condition that the estimation error of the linear mapping matrix from voltage to current is small. Simulation results are presented to illustrate the convergence of the output current.