• 센서학회지
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• 제21권4호
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• pp.287-292
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• 2012

A fiber-optic radiation sensor was fabricated using a sensing probe, a plastic optical fiber, a photomultiplier tube, and a multichannel analyzer for gamma-ray spectroscopy. As an inorganic scintillator of the sensing probe, a LYSO crystal was used. In this study, we obtained the relationship between the photon counts of the fiber-optic radiation sensor and the activity of the radioactive isotope. In addition, the gamma-ray energy spectra were also measured using a fiber-optic radiation sensor to discriminate species of gamma-ray emitters.

• 센서학회지
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• 제16권5호
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• pp.331-336
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• 2007

In this study, we have fabricated an infrared optical fiber based sensor which can monitor the respiration of a patient. The design of a chalcogenide optical fiber based sensor is suitable for insertion into a high electro-magnetic field environment because the sensor consists of low cost and compact mid-infrared components such as an infrared light source, a chalcogenide optical fiber and a thermopile sensor. A fiber-optic respiration sensor is capable of detecting carbon dioxide ($CO_{2}$) in exhalation of a patient using the infrared absorption characteristics of carbon gases. The modulated infrared radiation due to the presence of carbon dioxide is guided to the thermopile sensor via a chalcogenide receiving fiber. It is expected that a mid-infrared fiber-optic respiration sensor which can be developed based on the results of this study would be highly suitable for respiration measurements of a patient during the procedure of an MRI.

• 센서학회지
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• 제18권6호
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• pp.467-474
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• 2009

In this study, we describe the feasibility of developing a fiber-optic temperature sensor using a thermochromic material such as 2,4,5-triphenylimidazole or also called Lophine. A sensor-tip is fabricated by mixing of a Lophine powder, which has a non-toxic and hydrophobic characteristics, and an epoxy resin. The temperature change in the sensor-tip gives rise to a change in the optical absorbance of the Lophine, and the transmittance of a light through the Lophine is also changed. We have measured the intensities of modulated lights due to the change of optical absorbance of the Lophine by using of a photo-multiplier tube(PMT). The relationships between the temperatures and the output voltages of PMT are determined to measure the temperature of water. The measurable temperature range of the fiber-optic sensor is from 5 to $30^{\circ}C$.

• 센서학회지
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• 제16권1호
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• pp.33-38
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• 2007

In this study, one-dimensional fiber-optic radiation sensor with an organic scintillator tip is fabricated to measure high energy X-ray beam profile of CLINAC. According to the energy and field size of X-ray, scintillating light signal from one-dimensional fiber-optic sensor is measured using a photodiode-amplifier system. This sensor has many advantages such as high resolution, real-time measurement and ease calibration over conventional ion chamber and film.

• 대한의용생체공학회:의공학회지
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• 제27권6호
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• pp.337-342
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• 2006

We have developed a noncontact temperature sensor using a silver halide optical fiber. The infrared collimator and focus head are connected both ends of a silver halide optical fiber with SMA connectors and used to collimate radiations of a heat source and to focus them to infrared sensors such as a pyroelectric sensor and a thermopile sensor, respectively. The relation ships between the temperatures of a heat source and the output signals of the infrared sensors are determined to measure the surface temperature of a heat source. The measurable temperature range is from 25 to $60^{\circ}C$. It is expected that a noncontact temperature sensor using a silver halide optical fiber can be developed for medical usages such as temperature monitoring during hyperthermia, cryosurgery, laser surgery and diagnostic procedure based on the results of this study.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2008년도 제39회 하계학술대회
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• pp.1987-1988
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• 2008

In this study, we try to implement an image segmentation algorithm to extract only the tooth regions from the tooth color image so that we can assess the color features to estimate the status of denticulus progression.

• 한국수정란이식학회:학술대회논문집
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• 한국수정란이식학회 2004년도 제4회 발생공학 국제심포지움 및 학술대회
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• pp.85-86
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• 2004

• 대한생식의학회:학술대회논문집
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• 대한불임학회 2006년도 제51차 추계학술대회
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• pp.150-150
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• 2006

• 대한생식의학회:학술대회논문집
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• 대한불임학회 2006년도 The 5th Biannual Meeting of Pacific Rim Society for Fertility and Sterility
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• pp.168.2-168.2
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• 2006

• Biomolecules & Therapeutics
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• 제30권3호
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• pp.274-283
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• 2022

KRAS activating mutations, which are present in more than 90% of pancreatic cancers, drive tumor dependency on the RAS/mitogen-activated protein kinase (MAPK) and phosphoinositide 3-kinase (PI3K)/AKT signaling pathways. Therefore, combined targeting of RAS/MAPK and PI3K/AKT signaling pathways may be required for optimal therapeutic effect in pancreatic cancer. However, the therapeutic efficacy of combined MAPK and PI3K/AKT signaling target inhibitors is unsatisfactory in pancreatic cancer treatment, because it is often accompanied by MAPK pathway reactivation by PI3K/AKT inhibitor. Therefore, we developed an inRas37 antibody, which directly targets the intra-cellularly activated GTP-bound form of oncogenic RAS mutation and investigated its synergistic effect in the presence of the PI3K inhibitor BEZ-235 in pancreatic cancer. In this study, inRas37 remarkably increased the drug response of BEZ-235 to pancreatic cancer cells by inhibiting MAPK reactivation. Moreover, the co-treatment synergistically inhibited cell proliferation, migration, and invasion and exhibited synergistic anticancer activity by inhibiting the MAPK and PI3K pathways. The combined administration of inRas37and BEZ-235 significantly inhibited tumor growth in mouse models. Our results demonstrated that inRas37 synergistically increased the antitumor activity of BEZ-235 by inhibiting MAPK reactivation, suggesting that inRas37 and BEZ-235 co-treatment could be a potential treatment approach for pancreatic cancer patients with KRAS mutations.