• Title/Summary/Keyword: Biological sensor

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Design and Control of a New Micro End-effector for Biological Cell Manipulation

  • Shim, Jae-Hong;Cho, Sung-Yong;Cho, Young-Im;Kim, Deok-Ho;Kim, Byung-Kyu
    • 제어로봇시스템학회:학술대회논문집
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    • 2003.10a
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    • pp.2445-2450
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    • 2003
  • Recently, biological technology industry shows great development. Instruments and systems related biological technology have been developed actively. In this paper, we developed a new micro end-effector for biological cell manipulation. The existing micro end-effector for biological cell manipulation has not any force sensing mechanism. Usually, excessive contact force occurring when the end-effector and a cell collide might make a damage on the cell. However, unfortunately, user can not notice the condition in case of using the existing end-effector. In order to overcome we proposed the improved micro end-effector having a force sensing mechanism. This paper presents the design concepts of the new micro end-effector. We carried out calibration of the force sensor and tested the performance of the proposed micro end-effector. Through a series of experiments the new micro end-effector shows the possibility of application for precision biological cell manipulation such as DNA operation

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Characterization of Protein Factor Regulating the Superoxide-Sensor SoxR in Escherichia coli

  • Koo, Mi-Sun;Rah, So-Yeon;Lee, Kang-Lok;Roe, Jung-Hye
    • Proceedings of the Korean Biophysical Society Conference
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    • 2001.06a
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    • pp.64-64
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    • 2001
  • Escherichia coli has developed soxRS regulon to defend against toxicity of superoxide radical. SoxR, superoxide sensor, is oxidized by superoxide-generating agents or nitric oxide and oxidized SoxR activates the transcription of soxS gene. In order to find out the trans-acting factors regulating SoxR activity in vivo, soxS::lacZ single copy operon fusion construct was prepared and random Tn10 insertional mutatons were performed.(omitted)

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Machine Learning in FET-based Chemical and Biological Sensors: A Mini Review

  • Ahn, Jae-Hyuk
    • Journal of Sensor Science and Technology
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    • v.30 no.1
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    • pp.1-9
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    • 2021
  • This mini review summarizes some of the recent advances in machine-learning (ML)-driven chemical and biological sensors. Specific focus is on field-effect-transistor (FET)-based sensors with a description of their structures and detection mechanisms. Key ML techniques are briefly reviewed for an audience not familiar with the basic principles. We mainly discuss two aspects: (1) data analysis based on ML and (2) ML applied to sensor design. In conclusion, the challenges and opportunities for the advancement of ML-based sensors are briefly considered.

Bending Motion Control of Electroactive Polymer Actuator-Sensor Hybrid Structure for Finger Exoskeleton (손가락 외골격용 전기활성 고분자 구동체-센서 하이브리드 구조체의 굽힘 동작 제어)

  • Han, Dong Gyun;Song, Dae Seok;Jho, Jae Young;Kim, Dong Min
    • Journal of the Korean Society for Precision Engineering
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    • v.32 no.10
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    • pp.865-871
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    • 2015
  • This study was conducted in order to develop a finger exoskeleton system using ionic polymer metal composites (IPMCs) as the actuator and sensor in a hybrid structure. To use the IPMC as an actuator producing large force, a first order transfer function was obtained using results from a block force for DC excitation that applied to two IPMCs of 20mm-width, 50mm-length, and 2.4mm thickness together. After which the validation of 200gf control with anti-windup PI controller was confirmed. A 5mm-width, 50mm-length, 0.6mm-thickness of IPMC was also modeled as a sensor for tip displacement. As a result, the IPMC sensor could been utilized as a trigger role for the actuator. Finally, an IPMC sensor and actuator were installed on the joint of a single DOF exoskeleton in the hybrid structure, and test for the control of 40gf of block force and predefined sequence of motion was performed.

Colorimetric Detection of Chelating Agents Using Polydiacetylene Vesicles (폴리다이아세틸렌 베시클을 이용한 킬레이트제의 색전이 검출)

  • Park, Moo-Kyung;Kim, Kyung-Woo;Ahn, Dong-June;Oh, Min-Kyu
    • Korean Chemical Engineering Research
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    • v.49 no.3
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    • pp.348-351
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    • 2011
  • In this research, we developed a sensor system which can easily detect several chelating agents using polydiacetylene(PDA) vesicles. In comparison to other sensors, PDA based sensor has several advantages. First, detection method is much simpler and faster because it does not require any labeling step in the experiment procedure. Second, significant color-transition from blue to red based upon external stimulus allows us the detection by naked eyes. Finally, it is also possible to perform quantitative analysis of the concentration of the chelating agent by measuring the colorimetric response. In this paper, five types of chelating agents were used, including EDTA, EGTA, NTA, DCTA and DTPA. Among them, EDTA and DCTA triggered especially strong color-transition. In conclusion, this study has led to a successful development of a color transition-based PDA sensor system for easy and rapid detection of chelating agents.

The Wearable Sensor System to Monitor the Head & Neck Posture in Daily Life (웨어러블 센서를 이용한 일상생활중 머리-목 자세 측정 시스템)

  • Lee, Jaehyun;Chee, Youngjoon;Bae, Jieun;Kim, Haseon;Kim, Younghoon
    • Journal of Biomedical Engineering Research
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    • v.37 no.3
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    • pp.112-118
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    • 2016
  • The neck pain is fairly common occurance. Forward head posture and text neck are poor postures which may be related with neck pain but the evidence is not enough. We developed the wearable sensor which can assess the head & neck posture in daily life. Microprocessor, Bluetooth low energy, and 3-axis accelerometer, rechargeable battery and vibratior for reminding are used to implement the wearable sensor. Real-time algorithm to parameterize the posture for one epoch is implemented which classifies the posture in the epoch into three classed; dynamic, static_good posture, and static_poor posture. Also the algorithm makes reminding to its wearer to give them the prolonged poor posture is detected. The mean error of measurement was 1.2 degree. The correlation coefficient between neck angle and craniovertebral angle was 0.9 or higher in all cases. With the pilot study on text neck syndrome was also quatified. Average of neck angle were 74.3 degree during the listening in the classroom and 57.8 degree during the smartphoning. Using the wearable sensor suggested, the poor postures of forward head posture and neck neck can be detected in real-time which can remind the wearer according to his/her setting.

On-line Measurement of Buffer Capacity of a Fermentation medium and Estimation of Organic Aicd Production (발효배지의 완충용량의 온라인 측정 및 유기산 생산 추정)

  • Hur, Won;Jung, Yoon-Keun
    • KSBB Journal
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    • v.13 no.4
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    • pp.461-467
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    • 1998
  • A fermentation system was supplemented with a device for the measurement of the durations of alkali pump feeding for automatic pH control and an A/D convertor for precise monitoring of pH value by computer. A software program was developed to measure buffer capacities from the pH signal and the pH control signal during fermentation. By measuring the buffer capacity on-line, levels of acetic acid were estimated by a software sensor using pH signal in a fermentation process of E.coli growing in a minimal medium. The measured values of acetic acid showed correlation to those of estimated by the software sensor. Lacitic acid production was also successfully estimated by the values of buffer capacities measured on-line.

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Biological data transmission performance of virtual cattle feedlot sensor network (가상센서네트워크를 이용한 사육장 생체데이터 전송성능에 관한 연구)

  • Kang, Hyun-Joong;Ju, Hui-Dong;Lee, Meong-Hun;Yoe, Hyun
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.12 no.6
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    • pp.1134-1141
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    • 2008
  • As sensor network technologies developed, the sphere field of application is escalated unfortunately, the applicable size is smaller than the actual quantity of cattle in feedlot. In this paper, we simulated and evaluated biological data transmission performance of virtual cattle feedlot. Deducted conclusions show us a more efficient cattle control scenario is required and effective routing protocol design and modification are needed.

A Coumarin-based Fluorescent Sensor for Selective Detection of Copper (II)

  • Wang, Jian-Hong;Guo, Xin-Ling;Hou, Xu-Feng;Zhao, Hui-Jun;Luo, Zhao-Yang;Zhao, Jin
    • Bulletin of the Korean Chemical Society
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    • v.35 no.8
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    • pp.2400-2402
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    • 2014
  • Cu (II) detection is of great importance owing to its significant function in various biological processes. In this report, we developed a novel coumarin-based chemosensor bearing the salicylaldimine unit (2) for $Cu^{2+}$ selective detection. The results from fluorescence spectra demonstrated that the sensor could selectively recognize $Cu^{2+}$ over other metal cations and the detection limit is as low as $0.2{\mu}M$. Moreover, the confocal fluorescence imaging in HepG2 cells illustrated its potential for biological applications.