• Proceedings of the Korea Contents Association Conference
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• 2015.05a
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• pp.337-338
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• 2015

알츠하이머병은 뇌에 비이상적으로 베타아밀로이드 단백질의 축적으로 인해 신경세포가 손상되는 질병으로 아직까지 명확한 질병의 메커니즘이 밝혀지지 않고 있다. 새로운 알츠하이머병의 생물학적 모델을 제시하기 위해, KEGG의 알츠하이머병의 신호전달패스웨이와 문헌정보를 기반으로 구축된 신호전달 네트워크를 병합함으로써 새로운 질병의 모델을 생성하였다. 분석결과 로바스타틴하부경로를 포함하는 새로운 알츠하이머 생물학적 경로 모델을 제시하고자 한다. 향후 메디컬 페스웨이의 병합기술을 통해 보다 다양한 질병의 원인 기작을 연구하는데 활용하고자 한다.

• Proceedings of the Korean Information Science Society Conference
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• 2005.11b
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• pp.271-273
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• 2005

유전자, 단백질 등의 생물정보를 이용하는 여러 툴은 효율성의 극대화를 위하여 각각의 시스템에 맞는 데이터 에이스 스키마 구성 및 필요한 정보의 선택적 저장이 필요하다. 하지만 구조 복잡성, 동일한 객체 데이터의 분산 등, 생물 정보 XML의 일반적인 특성 때문에 기존의 XML정보 저장 기법으로는 유연한 데이터베이스 스키마구성에 한계를 지닌다. 이 때문에 생물정보 XML로부터 로컬 데이터베이스를 구성하는 과정은 1:1파서를 구현하여 진행하고 있어 많은 시간과 비용이 소모된다. 본 논문에서는 생물정보 XML 의 특성과 그에 따른 유연한 RDB 스키마 구성의 제약에 대해 논하고, 이를 극복한 자유로운 RDB 스키마 구성을 위한 규칙을 소개한다. 본 규칙은 사용자가 원하는 RDB 스키마를 구성하여 생물정보 XML의 데이터를 저장하게 해주며, SQL 형태를 따르고 있어 사용자에게 익숙하다. 또한 분산된 생물정보 XML의 통합에도 유리하다.

• Genomics & Informatics
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• v.9 no.2
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• pp.85-88
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• 2011

The National Agricultural Biotechnology Information Center (NABIC) constructed an agricultural biology-based infrastructure and developed a biological information-based database. The major functions of the NABIC are focused on biotechnological developments for agricultural bioinformatics and providing a web-based service to construct bioinformatics workflows easily, such as protein function prediction and genome systems biology programs. The NABIC has concentrated on the functional genomics of major crops, building an integrated biotechnology database for agro-biotech information that focuses on the proteomics of major agricultural resources, such as rice, Chinese cabbage, rice Ds-tagging lines, and microorganisms.

• Proceedings of the Korea Information Processing Society Conference
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• 2014.11a
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• pp.849-852
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• 2014

Reverse engineering of gene regulatory network is a challenging task in computational biology. To detect a regulatory relationship among genes from time series data is called reverse engineering. Reverse engineering helps to discover the architecture of the underlying gene regulatory network. Besides, it insights into the disease process, biological process and drug discovery. There are many statistical approaches available for reverse engineering of gene regulatory network. In our paper, we propose pairwise mutual information for the reverse engineering of a gene regulatory network from time series data. Firstly, we create random boolean networks by the well-known $Erd{\ddot{o}}s-R{\acute{e}}nyi$ model. Secondly, we generate artificial time series data from that network. Then, we calculate pairwise mutual information for predicting the network. We implement of our system on java platform. To visualize the random boolean network graphically we use cytoscape plugins 2.8.0.

• Journal of Life Science
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• v.19 no.4
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• pp.549-552
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• 2009

Genetic mutations by gene fusion result from chromosomal rearrangement, trans-splicing, and intergenic splicing. Trans-splicing is a phenomenon in which two pre-mRNAs grow together into one. We analyzed the trans-splicing products in embryonic stem cells. By using bioinformatic tools, 70 trans-splicing transcripts were identified. They are classified into 6 types according to fusion pattern: 5'UTR-5'UTR, 5'UTR-3'UTR, 3'UTR-3'UTR, 5'UTR-CDS, 3'UTR-CDS, CDS-CDS. The fusion products are more abundant in CDS regions than in UTR regions, which contain multiple intron numbers. Chromosome analysis showing gene fusion via trans-splicing indicated that chromosomes 17 and 19 were activated. These data are of great use for further studies in relation to fusion genes and human diseases.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.4
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• pp.1621-1626
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• 2014

Background: Breast cancer is the most common malignant tumor in females worldwide. Many differences exist in clinico-pathological characteristics of breast cancer patients between China and Western countries. This study aimed to analyze clinico-pathological characteristics of breast cancer from central China. Methods: Clinico-pathological information on breast cancer from three hospitals in central China was collected and analyzed. Results: From 1994 to 2012, 2,525 patients with a median age 50 years were included in this study. The 45-49-year age group and invasive ductal carcinoma not otherwise specified accounted for the highest proportions (19.1%, 480/2,525 and 81.0%, 1,982/2,446). Stages 0-I, II and III accounted for 28.0% (682/2,441), 48.4% (1,180/2,441), and 23.7% (578/2,441), respectively. Distribution of N stage showed that N0 accounted for 53.2% (1,344/2,525), and proportion of N0 rose from 51.1% (157/307) in 30-39-year age group to 64.3% (110/171) in ${\geq}$ 70-year age group, with an average increase of 2.1% in each age group. Modified radical mastectomy, radical mastectomy, breast-conserving surgery and simple mastectomy were performed for 71.8% (1,812/2,525), 18.0% (454/2,525), 5.2% (131/2,525) and 2.6% (66/2,525), respectively. Proportions of breast-conserving surgery in age ${\leq}$ 44-year group (68/132, 51.5%) and simple mastectomy in age ${\geq}$ 60-year group (57/89, 64.0%) were higher than in the other age groups. Breast cancers positive for estrogen receptor accounted for 53.0% (1,107/ 2,112). The comparisons among this study and other reports showed higher proportion of younger patients, lower proportion of breast-conserving surgery and positive estrogen receptor patients in China than western countries. Conclusions: Clinico-pathological characteristics in this study demonstrated clear differences between the center of China than Western countries. Additional classification systems should be developed to guide grading of early breast cancer more accurately, especially for N0 patients. Invasive ductal carcinoma is a focus for intensive research.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.16 no.1
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• pp.199-207
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• 2016

In this paper, we propose efficient smart indoor emotional lighting control system based on android platform using the biological signal. The proposed smart indoor smart emotional lighting control system were configured as the biological signal measurement device and removable smart wall pad, lighting driver, luminaire. The control system was extracts the emotional language by measured the biological signal, and it was transmitted a control signal to each lighting driver using a bluetooth in the wall pad. The lighting driver were designed to control the lighting device through an expansion board by collected control signal and the illuminance information the surrounding. In this case, the wall pad can be selecting of manual control and the bio signal mode by that indoor emotional lighting control algorithms, and it was implemented the control program that possible to partial control by selecting the wanted light. Experiment results of the proposed smart indoor emotional lighting control system, it were possible to the optional control about the luminaire of required area, and the manual control by to adjustable of color temperature with that the efficiently adjustable of lighting by to biological signal and emotional language. Therefore, were possible to effective control for improvement of concentration and business capability of indoor space business conduct by controlling the color and brightness that is appropriate for your situation. And, was reduced power consumption and dimmer voltage, lighting-current than the existing-emotional lighting control system.

• Korean Journal of Ecology and Environment
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• v.46 no.1
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• pp.103-115
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• 2013

The purpose of this study was to analyze fish fauna and species compositions along with trophic guilds, tolerance indicators, and fish community conditions before weir construction (BWC) and after weir construction (AWC) in the Yeongsan River watershed. Total 45 and 44 fish species were sampled in BWC and AWC, respectively without any distinct differences through weir constructions. Fish fauna analysis revealed that the dominant species was the same, Zacco platypus with 24.3% and 20.8% in BWC and AWC, respectively. However, the subdominant species were Carassius auratus with 8.9% in BWC but Opsarichthys uncirostris amurensis with 20.3%, almost identical that of the dominant species AWC. This phenomenon showed the distinct modification of species composition in the watershed. We sampled the $1^{st}$ class endangered species, Liobagrus obesus in tributary stream as previously reported. Also Culter brevicauda was sampled in the mainstream of Yeongsan River watershed and this was the first sampled record in this watershed. One of the most important features were an increase of exotic species, such as Micropterus salmoides and Lepomis macrochirus, with 3.2% BWC vs. 10.2% AWC as well as the increase in tolerant species with 49.2% BWC vs. 73.7% AWC, indicating ecological degradation through weir construction. Overall, our results indicated that fish fauna and composition analyses showed distinct ecological degradations related to increases of exotic and tolerant species AWC. Further long-term studies of fish monitoring should be conducted in the future to configure existent status of river conditions and to provide key information in order to conserve the healthy ecosystem.

• Journal of Soil and Groundwater Environment
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• v.22 no.6
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• pp.74-84
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• 2017

Soil erosion is often extreme in Korea due to high rainfall intensities and steep slopes, and climate change has also increased the risk of erosion. Despite its significane, erosion-induced soil organic carbon (SOC) emission and water resource loss are not well understood, along with the lack of an integrated surface soil erosion protection policy. Therefore, to design adequate protection policies, land users, scientists, engineers and decision makers need proper information about surface soil and watershed properties related to greenhouse gas emission potential and water conservation capability, respectively. Assuming the total soil erosion of $346Tg\;yr^{-1}$, soil organic matter (SOM) content of 2% (58% of SOM is SOC), and mineralization rate of 20% of the displaced carbon, erosion-induced carbon emission could reach $800Gg\;C\;yr^{-1}$. Also the available water capacity of the soil was estimated to be 15.8 billion tons, which was 14 times higher than the yearly water supply demand in Seoul, Korea. Therefore, in order to prevent of soil erosion, this study proposes a three-stage plan for surface soil erosion prevention: 1) classification of soil erosion risk and scoring of surface soil quality, 2) selection of priority areas for conservation and best management practices (BMP), and 3) application of BMP and post management.

• Korean Journal of Ecology and Environment
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• v.48 no.3
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• pp.195-202
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• 2015

We identified research trends for freshwater exotic species in South Korea using text mining methods in conjunction with bibliometric analysis. We searched scientific and common names of freshwater exotic species as searching keywords including 1 mammal species, 3 amphibian-reptile species, 11 fish species, 2 aquatic plant species. A total of 245 articles including research articles and abstracts of conference proceedings published by 56 academic societies and institutes were collected from scientific article databases. The search keywords used were the common names for the exotic species. The $20^{th}$ century (1900's) saw the number of articles increase; however, during the early $21^{st}$ century (2000's) the number of published articles decreased slowly. The number of articles focusing on physiological and embryological research was significantly greater than taxonomic and ecological studies. Rainbow trout and Nile tilapia were the main research topic, specifically physiological and embryological research associated with the aquaculture of these species. Ecological studies were only conducted on the distribution and effect of large-mouth bass and nutria. The ecological risk associated with freshwater exotic species has been expressed yet the scientific information might be insufficient to remove doubt about ecological issues as expressed by interested by individuals and policy makers due to bias in research topics with respect to freshwater exotic species. The research topics of freshwater exotic species would have to diversify to effectively manage freshwater exotic species.