• Transactions of the Korean Society of Mechanical Engineers B
• /
• v.33 no.1
• /
• pp.1-8
• /
• 2009

Recently microscale biofluid flows have been receiving large attention in various research areas. However, most conventional imaging techniques are unsatisfactory due to difficulties encountered in the visualization of microscale biological flows. Recent advances in optics and digital image processing techniques have made it possible to develop several advanced micro-PIV/PTV techniques. They can be used to get quantitative velocity field information of various biofluid flows from visualized images of tracer particles. In this paper, as new advanced micro-PIV techniques suitable for biofluid flow analysis, the basic principle and typical applications of the time-resolved micro-PIV and X-ray micro-PIV methods are explained. As a 3D velocity field measurement technique for measuring microscale flows, holographic micro-PTV method is introduced. These advanced PIV/PTV techniques can be used to reveal the basic physics of various microscale biological flows and will play an important role in visualizing veiled biofluid flow phenomena, for which conventional methods have many difficulties to analyze.

• Animal Systematics, Evolution and Diversity
• /
• v.18 no.1
• /
• pp.99-120
• /
• 2002

Three species of the family Gynodiastylidae, Gynodiastylis anguicephala Harada, 1962, G. tubicola Harada, 1962 and G. rotundicaudata Gamo, 1961 are recorded newly to Korean fauna. New information on the mouthparts of these species is given, and the male of G. rotundicaudatus is described for the first time.

• Journal of Biomedical Engineering Research
• /
• v.15 no.1
• /
• pp.57-62
• /
• 1994

The demand of image compression is increasing now for the integration of medical images into the hospital information system. Even though the quantitative distortion can be measured from the difference between original and reconstructed images, it doesn't include the nonlinear characteristics of human visual system. In this study, we have evaluated the nonlinear characteristics of human visual system and applied them to the compression of medical images. The distortion measures which reflect the characteristics of human visual system has been considered. This image compression procedure consists of coding scheme using JND (Just Noticeable Difference) curve, polynomial approximation and BTC (Block Truncation Coding). Results show that this method can be applied to CT images, scanned film images and other kinds of medical images with the compression ratio of 5-10:1 without any noticeable distortion.

• Genomics & Informatics
• /
• v.2 no.1
• /
• pp.7-18
• /
• 2004

Integrated genomics refers to the use of large-scale, systematically collected data from various sources to address biological and biomedical problems. A critical ingredient to a successful research program in integrated genomics is the establishment of an effective computational infrastructure. In this review, we suggest that the computational infrastructure challenges include developing tools for heterogeneous data organization and access, innovating techniques for combining the results of different analyses, and establishing a theoretical framework for integrating biological and quantitative models. For each of the three areas - data integration, analyses integration, and model integration - we review some of the current progress and suggest new topics of research. We argue that the primary computational challenges lie in developing sound theoretical foundations for understanding the genome rather than simply the development of algorithms and programs.

• 한국생물공학회:학술대회논문집
• /
• 2000.11a
• /
• pp.119-122
• /
• 2000

Biological science is being revolutionized by the availability of much sequence information from many genome project With the advanced technology at hand, main trend in biological research is rapidly changing from a structural DNA analysis to understanding cellular function of the DNA sequences. Combined with mechanics, computer, bioinformatics and other advanced technologies, DNA chip technology provides numerous applications because of its robustness, accuracy, and automation. DNA chip is expected to become an indispensable tool in fields of biology, biotechnology, drug discovery, and other application areas. DNA chip can be used for mutation and polymorphism detection, gene expression monitoring and phenotypic analysis as well. If DNA chip is used for the development of pharmaceutical products, it can considerably reduce the cost and time for the entire process of drug discovery and development, and can also contribute in developing personal drugs.

• Environmental Analysis Health and Toxicology
• /
• v.23 no.4
• /
• pp.231-245
• /
• 2008

Various methods for detecting changes in response behaviors of indicator specimens are presented for monitoring effects of toxic treatments. The movement patterns of individuals are quantitatively characterized by statistical (i.e., ANOVA, multivariate analysis) and computational (i.e., fractal dimension, Fourier transform) methods. Extraction of information in complex behavioral data is further illustrated by techniques in ecological informatics. Multi-Layer Perceptron and Self-Organizing Map are applied for detection and patterning of response behaviors of indicator specimens. The recent techniques of Wavelet analysis and line detection by Recurrent Self-Organizing Map are additionally discussed as an efficient tool for checking time-series movement data. Behavioral monitoring could be established as new methodology in integrative ecological assessment, tilling the gap between large-scale (e.g., community structure) and small-scale (e.g., molecular response) measurements.

• Analytical Science and Technology
• /
• v.18 no.6
• /
• pp.520-528
• /
• 2005

Two biological Certified Reference Materials (CRMs), KRISS 108-04-001 (oyster tissue) and 108-05-001 (water dropwort stem), were prepared by Korea Research Institute of Standards and Science (KRISS)during FY '01. The certified values of these materials had been determined by Isotope Dilution Mass Spectrometry (IDMS) for six elements (Cd, Cr, Cu, Fe, Pb and Zn). Additional analytical works are now progressing to certify the concentrations of a number of the environmental and nutrimental elements in these CRMs. The certified values in a CRM are usually determined by using a single primary method with confirmation by other method(s) or using two independent critically-evaluated methods. Instrumental Neutron Activation Analysis (INAA) plays an important role in the determination of certified values as it can eliminate the possibility of common error sources resulting from sample dissolution. In this study INAA procedure was used in determination of 23 elements in these two biological CRMs to acquire the concentration information and the results were compared with KRISS certified values.

• Proceedings of the KOSOMBE Conference
• /
• v.1996 no.11
• /
• pp.33-36
• /
• 1996

In this paper, we present the Computerized Polysomnographic System, which we developed for aiding manual polysomnographic diagnonis. This system is composed of four sub parts: patient information management tool, polysomno-graphic signal acquisition tool, signal analysis tool, and result-reporting tool. We calculated the parameters of sleep diagnosis, both on the sleep stage hypnogram and event lists. We developed this system on the Windows NT 4.0 and Pentium Pro 200Mhz. We are testing this system on the clinical site.

• Molecules and Cells
• /
• v.40 no.2
• /
• pp.83-89
• /
• 2017

Error-free replication and repair of DNA are pivotal to organisms for faithful transmission of their genetic information. Cells orchestrate complex signaling networks that sense and resolve DNA damage. Post-translational protein modifications by ubiquitin and ubiquitin-like proteins, including SUMO and NEDD8, are critically involved in DNA damage response (DDR) and DNA damage tolerance (DDT). The expression of interferon-stimulated gene 15 (ISG15), the first identified ubiquitin-like protein, has recently been shown to be induced under various DNA damage conditions, such as exposure to UV, camptothecin, and doxorubicin. Here we overview the recent findings on the role of ISG15 and its conjugation to target proteins (e.g., p53,$ {\Delta}Np63{\alpha}$, and PCNA) in the control of cellular responses to genotoxic stress, such as the inhibition of cell growth and tumorigenesis.

• ALGAE
• /
• v.29 no.2
• /
• pp.127-136
• /
• 2014

Endophytic green algae growing in fronds of Grateloupia spp. were examined for infection frequency from their field populations of Jeju, Wando, and Uljin, Korea in August and September 2013. Three endophytes were isolated in laboratory culture from a G. lanceolata thallus collected in Jeju. Unialgal cultures were made from the endophytes, and their morphological characteristics were observed with light microscopy. In addition, a phylogenetic analysis based on chloroplast-encoded elongation factor tufA gene sequences was performed to identify the G. lanceolata endophytes. Three filamentous green endophytic species, Ulvella leptochaete, Blastophysa rhizopus, and Bolbocoleon piliferum were reported for the first time in Korea. General biological information for the three endophytes was also described.