• 제목/요약/키워드: Biological evaluation

검색결과 1,933건 처리시간 0.044초

A study on the evaluation of artificial cartilage using synthetic biodegradable polymers

  • Oh, Ho-Jung;Lee, Nam-Kyung;Kim, Soon-Nam;Hong, Choong-Man;Lee, Ki-Hong;Yoo, Si-Hyung;Shin, In-Soo;Lim, Jae-Hyun;Choi, Seung-Eun
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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    • pp.100.1-100.1
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    • 2003
  • Tissue engineering has arisen to address the extreme shortage of tissues and organs for transplantation and repair. One of the most successful techniques has been the seeding and culturing cells on three-dimensional biodegradable scaffolds in vitro followed by implantaion in vivo. We used PLA and PLGA as biodegradable polymers and rabbit chondrocytes were isolated and applied to PLA and PLGA to make artificial cartilage. To evaluate the biocompatibility and biological safety of polymers, in vitro cytotoxicity and in vivo animal tests were investigated. (omitted)

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Xylaroisopimaranin A, a New Isopimarane Derivative from an Endophytic Fungus Xylaralyce sp.

  • Bao, Shang-Song;Liu, Hui-Hui;Zhang, Xue-Qing;Liu, Cheng-Xiong;Li, Xiao-Cong;Guo, Zhi-Yong
    • Natural Product Sciences
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    • 제25권3호
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    • pp.228-232
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    • 2019
  • Five secondary metabolites, including a new isopimarane derivative xylaroisopimaranin A (1), were isolated from the endophytic fungus Xylaralyce sp. (HM-1), and their structures were elucidated by 1D, 2D NMR, MS and CD spectra. Their bioactivities were performed to antibacterial, Hep G2 cells cytotoxicity and brine shrimp inhibition. The biological evaluation results showed that the xylaroisopimaranin A (1), xylabisboein B (2), griseofulvin (3), 5-methylmellein (4) and mellein-5-carboxlic acid (5) displayed no significant Hep G2 cells cytotoxicity and antibacterial acitivity, but they inhibited the brine shrimp with $IC_{50}$ from 0.5 to $25{\mu}mol/mL$.

강원도 평창강 일대 저서성 대형무척추동물의 군집구조 및 수질의 생물학적 평가 (Biological Evaluation of Water Quality and Community Structure of Benthic Macroinvertebrates in the Pyungchang River Water System, Gangwon-do, Korea)

  • 박준우;황명기;어성준;최신석;정평림
    • 환경생물
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    • 제19권2호
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    • pp.119-128
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    • 2001
  • 본 연구는 1999년 9월부터 2000련 8월까지 1년간 강원도 평창군 소재 평창강 일대의 15개 조사지점을 대상으로 계절별로 저서성 대형무척추동물을 채집, 분류, 동정하고 현지 수질을 생태학적으로 평가한 것이다. 총 4문 4강 10목 31과 77속 109종이 채집되었으며, 조사지점 중 진부면 간평리에서 53종(48.0%)이 채집되어 가장 많은 종들이 출현하였고 마하리와 창동리에서도 각각 51종(46.7%), 50종(45.8%)이 채집되었다. 그러나 수하리 스키장 하부에서는 13종(11.9%)이 채집되어 전 조사지점 중 가장 적은 종들이 출현되었다. 한편 조사지점 전역에 걸쳐 하루살이류가 가장 풍부하게 서식하고 있었으며, 우점종에 있어서는 하루살이류(ephemeropterans)와 날도래류(trichopterans)가 대부분을 차지하고 있었다. 종다양도 지수치(H')는 개수리 지역이 3.67로 가장 높고, 방림리가 1.38으로 가장 낮았다. TBI 지수치는 대다수 지점이 9 이상으로서 청정 지역으로 간주되나 수하리에서는 4-5로 낮은 수치를 나타내었다. BMWP 지수치에서는 대부분 지점이 7.0 이상이나 수하리 지역은 3.5-5.2로 역시 가장 낮은 수치를 나타내었다. BI 지수에서도 수하리 지역을 제외하고 모두 1.5 이하의 낮은 수치로 청정한 수역으로 판정되었다.

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Role of Diazotrophic Bacteria in Biological Nitrogen Fixation and Plant Growth Improvement

  • Shin, Wansik;Islam, Rashedul;Benson, Abitha;Joe, Manoharan Melvin;Kim, Kiyoon;Gopal, Selvakumar;Samaddar, Sandipan;Banerjee, Somak;Sa, Tongmin
    • 한국토양비료학회지
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    • 제49권1호
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    • pp.17-29
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    • 2016
  • Though there is an abundant supply of nitrogen in the atmosphere, it cannot be used directly by the biological systems since it has to be combined with the element hydrogen before their incorporation. This process of nitrogen fixation ($N_2$-fixation) may be accomplished either chemically or biologically. Between the two elements, biological nitrogen fixation (BNF) is a microbiological process that converts atmospheric di-nitrogen ($N_2$) into plant-usable form. In this review, the genetics and mechanism of nitrogen fixation including genes responsible for it, their types and role in BNF are discussed in detail. Nitrogen fixation in the different agricultural systems using different methods is discussed to understand the actual rather than the potential $N_2$-fixation procedure. The mechanism by which the diazotrophic bacteria improve plant growth apart from nitrogen fixation such as inhibition of plant ethylene synthesis, improvement of nutrient uptake, stress tolerance enhancement, solubilization of inorganic phosphate and mineralization of organic phosphate is also discussed. Role of diazotrophic bacteria in the enhancement of nitrogen fixation is also dealt with suitable examples. This mini review attempts to address the importance of diazotrophic bacteria in nitrogen fixation and plant growth improvement.

Evaluation of antidiarrhoeal activity of Cardamom (Elettaria cardamomum) on mice models

  • Rahman, Tasmina;Rahman, Khandaker Ashfaqur;Rajia, Sultana;Alamgir, Mahiuddin;Khan, Mahmud Tareq Hassan;Choudhuri, M Shahabuddin Kabir
    • Advances in Traditional Medicine
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    • 제8권2호
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    • pp.130-134
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    • 2008
  • Diarrhoea is a major health care problem in developing countries. Elettaria cardamomum Maton fruits, commonly known as cardamom are widely used for flavoring purposes in food. In this study we evaluated the antidiarrhoeal activity of hot water extract of cardamom against experimental diarrhoeal models on mice. Cardamom extract showed significant antidiarrhoeal activity against castor oil and magnesium sulphate induced models. Whereas, the gastrointestinal motility was slightly increased.