• Title/Summary/Keyword: Biological evaluation

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A study on the evaluation of artificial cartilage using synthetic biodegradable polymers

  • Oh, Ho-Jung;Lee, Nam-Kyung;Kim, Soon-Nam;Hong, Choong-Man;Lee, Ki-Hong;Yoo, Si-Hyung;Shin, In-Soo;Lim, Jae-Hyun;Choi, Seung-Eun
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.100.1-100.1
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    • 2003
  • Tissue engineering has arisen to address the extreme shortage of tissues and organs for transplantation and repair. One of the most successful techniques has been the seeding and culturing cells on three-dimensional biodegradable scaffolds in vitro followed by implantaion in vivo. We used PLA and PLGA as biodegradable polymers and rabbit chondrocytes were isolated and applied to PLA and PLGA to make artificial cartilage. To evaluate the biocompatibility and biological safety of polymers, in vitro cytotoxicity and in vivo animal tests were investigated. (omitted)

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Xylaroisopimaranin A, a New Isopimarane Derivative from an Endophytic Fungus Xylaralyce sp.

  • Bao, Shang-Song;Liu, Hui-Hui;Zhang, Xue-Qing;Liu, Cheng-Xiong;Li, Xiao-Cong;Guo, Zhi-Yong
    • Natural Product Sciences
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    • v.25 no.3
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    • pp.228-232
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    • 2019
  • Five secondary metabolites, including a new isopimarane derivative xylaroisopimaranin A (1), were isolated from the endophytic fungus Xylaralyce sp. (HM-1), and their structures were elucidated by 1D, 2D NMR, MS and CD spectra. Their bioactivities were performed to antibacterial, Hep G2 cells cytotoxicity and brine shrimp inhibition. The biological evaluation results showed that the xylaroisopimaranin A (1), xylabisboein B (2), griseofulvin (3), 5-methylmellein (4) and mellein-5-carboxlic acid (5) displayed no significant Hep G2 cells cytotoxicity and antibacterial acitivity, but they inhibited the brine shrimp with $IC_{50}$ from 0.5 to $25{\mu}mol/mL$.

Biological Evaluation of Water Quality and Community Structure of Benthic Macroinvertebrates in the Pyungchang River Water System, Gangwon-do, Korea (강원도 평창강 일대 저서성 대형무척추동물의 군집구조 및 수질의 생물학적 평가)

  • 박준우;황명기;어성준;최신석;정평림
    • Korean Journal of Environmental Biology
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    • v.19 no.2
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    • pp.119-128
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    • 2001
  • A biological assessment of water quality was carried out in the Pyungchang River water system, Gangwon-do, Korea from September 1999 through August 2000. The benthic macroinvertebrates collected seasonally from 15 field sites were identified mostly up to species level. Benthic macroinvertebrates composed of 109 species, 77 genera, 31 families, 10 orders, 4 classes in 4 phyla. Dominant species occurring in all the field sites were mostly ephemeropterans and trichopterans. On the basis of the values of species diversity and biological indices such as Trent Biotic Index (TBI) Modified Biological Monitoring Working Party Score System (BMWP) and Biotic Index (BI), the Pyungchang River Water system was generally regarded as showing oligosaprobic water quality.

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Role of Diazotrophic Bacteria in Biological Nitrogen Fixation and Plant Growth Improvement

  • Shin, Wansik;Islam, Rashedul;Benson, Abitha;Joe, Manoharan Melvin;Kim, Kiyoon;Gopal, Selvakumar;Samaddar, Sandipan;Banerjee, Somak;Sa, Tongmin
    • Korean Journal of Soil Science and Fertilizer
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    • v.49 no.1
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    • pp.17-29
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    • 2016
  • Though there is an abundant supply of nitrogen in the atmosphere, it cannot be used directly by the biological systems since it has to be combined with the element hydrogen before their incorporation. This process of nitrogen fixation ($N_2$-fixation) may be accomplished either chemically or biologically. Between the two elements, biological nitrogen fixation (BNF) is a microbiological process that converts atmospheric di-nitrogen ($N_2$) into plant-usable form. In this review, the genetics and mechanism of nitrogen fixation including genes responsible for it, their types and role in BNF are discussed in detail. Nitrogen fixation in the different agricultural systems using different methods is discussed to understand the actual rather than the potential $N_2$-fixation procedure. The mechanism by which the diazotrophic bacteria improve plant growth apart from nitrogen fixation such as inhibition of plant ethylene synthesis, improvement of nutrient uptake, stress tolerance enhancement, solubilization of inorganic phosphate and mineralization of organic phosphate is also discussed. Role of diazotrophic bacteria in the enhancement of nitrogen fixation is also dealt with suitable examples. This mini review attempts to address the importance of diazotrophic bacteria in nitrogen fixation and plant growth improvement.

Evaluation of antidiarrhoeal activity of Cardamom (Elettaria cardamomum) on mice models

  • Rahman, Tasmina;Rahman, Khandaker Ashfaqur;Rajia, Sultana;Alamgir, Mahiuddin;Khan, Mahmud Tareq Hassan;Choudhuri, M Shahabuddin Kabir
    • Advances in Traditional Medicine
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    • v.8 no.2
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    • pp.130-134
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    • 2008
  • Diarrhoea is a major health care problem in developing countries. Elettaria cardamomum Maton fruits, commonly known as cardamom are widely used for flavoring purposes in food. In this study we evaluated the antidiarrhoeal activity of hot water extract of cardamom against experimental diarrhoeal models on mice. Cardamom extract showed significant antidiarrhoeal activity against castor oil and magnesium sulphate induced models. Whereas, the gastrointestinal motility was slightly increased.

A Study on Optical Properties in Biological Tissue Using A Photon Path Diffusion Model (광 항적경로 모델을 이용한 피하조직에서의 광 특성에 관한 연구)

  • 임현수
    • Journal of Biomedical Engineering Research
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    • v.15 no.3
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    • pp.265-274
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    • 1994
  • This paper proposes a method of noninvasive reflectance light to measure the blood fractional volume (Vb) and oxygen saturation ($SO_2$) of biological tissue. We chose the red light of 660nm and infrared light of 880nm. In Vivo reflectance data were obtained by the physiological changes front the surface of the skin over the calf in human subject. The reflected light intensity from different layers within a biological tissue was measured by specially designed reflectometer to apply photon path diffusion model. The collected data represent the changes of blood (ractional volume and oxygen saturation at each reflected light wavelengths. The data evaluation was assessed by examining the slopes of the plotted indices for the changes in oxygen saturation and blood (ractional volume. The results presented in this paper claim that light reflectance can separately discriminate the change of blood volume and that of oxygenation in muscle and also in skin.

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