• Applied Biological Chemistry
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• 제37권6호
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• pp.522-525
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• 1994

2-Butanoyl-5,5-dimethyl-3-hydroxy-2-cyclohexen-1-one과 여러 가지의 치환 아닐린의 축합반응으로 14가지의 2-(1-anilinobutylidene)-5,5-dimethyl-3-hydroxy-2-cyclohexen-1-ones들을 좋은 수율로 합성하였다. 이들 화합물들을 여섯 가지의 다른 담수조건 잡초들에 대하여 제초활성을 검색하였다. 대부분의 화합물들은 벼의 생육에 지장을 주지 않는 우수한 선택성을 가지면서 피(Echinochloa crus-galli)와 올미(Sagittaria pygmaea)에 대하여 우수한 제초활성을 보였다.

• Applied Biological Chemistry
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• 제41권3호
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• pp.258-263
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• 1998

본 연구는 polyyne계 항생물질의 분자 구조와 활성관계를 체계적으로 살펴본 최초의 보고로서 친수성기와 tetrayne 부분을 갖고 있는 화합물이 강한 항균활성을 가질 것이라는 결과를 얻었다. 이와 같은 선행 연구결과를 바탕으로 보다 개선된 활성을 갖는 화합물을 합성하기 위하여 tetrayneol 부분 구조를 가지는 novel한 polyhydroxy 화합물인 당류 유도체를 합성하고 항균성과 구조와의 관계를 검토하였다.

• Journal of Applied Biological Chemistry
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• 제50권2호
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• pp.85-87
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• 2007

To establish the synthetic method for dihydrochalcones as an important bioactive compounds, 2'-hydroxydihydrochalcone has been synthesized from the reduction of flavone in 20% yield. Flavone with five equivalents of ammonium formate in the presence of Pd/C in methanol under $N_2$ atmosphere produced the C-ring opened product. It was characterized by UV-VIS, ESI-MS and $^1H-NMR$ spectroscopy, and identified as 2'-hydroxydihydrochalcone.

• 한국생물공학회:학술대회논문집
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• 한국생물공학회 2005년도 생물공학의 동향(XVII)
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• pp.661-661
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• 2005

• 생물정신의학
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• 제20권1호
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• pp.1-5
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• 2013

Glutamate receptors are important components of synaptic transmission in the nervous system. Especially, ${\alpha}$-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors mediate most abundant excitatory synaptic transmission in the brain. There is elaborate mechanism of regulation of AMPA receptors including protein synthesis/degradation, intracellular trafficking, exocytosis/endocytosis and protein modification. In recent studies, it is revealed that functional dysregulation of AMPA receptors are related to major psychiatric disorders. In this review, we describe the structure and function of AMPA receptors in the synapse. We will introduce three steps of mechanism involving trafficking of AMPA receptors to neuronal membrane, lateral diffusion into synapses and synaptic retention by membrane proteins and postsynaptic scaffold proteins. Lastly, we will describe recent studies showing that regulation of AMPA receptors is important pathophysiological mechanism in psychiatric disorders.

• BMB Reports
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• 제43권9호
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• pp.584-592
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• 2010

Tetrahydrobiopterin (BH4) is a multifunctional cofactor of aromatic amino acid hydroxylases and nitric oxide synthase (NOS) as well as an intracellular antioxidant in animals. Through regulation of NOS activity BH4 plays a pivotal role not only in a variety of normal cellular functions but also in the pathogenesis of cardiovascular and neurodegenerative diseases, which develop under oxidative stress conditions. It appears that a balanced interplay between BH4 and NOS is crucial for cellular fate. If cellular BH4 homeostasis maintained by BH4 synthesis and regeneration fails to cope with increased oxidative stress, NOS is uncoupled to generate superoxide rather than NO and, in turn, exacerbates impaired BH4 homeostasis, thereby leading to cell death. The fundamental biochemical events involved in the BH4-NOS interplay are essentially the same, as revealed in mammalian endothelial, cardiac, and neuronal cells. This review summarizes information on the cellular BH4 homeostasis in mammals, focusing on its regulation under normal and oxidative stress conditions.

• Journal of Applied Biological Chemistry
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• 제50권3호
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• pp.120-126
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• 2007

Volatile components in red bean (Vigna angularis) were investigated. Extracts prepared by simultaneous steam distillation and solvent extraction were analyzed by gas chromatography/mass spectrometry. One hundred and forty-two components including alkanes/alkenes (17), aromatics (5), furans (15), miscellaneous compounds (2), other nitrogen-containing compounds (11), aldehydes (11), naphthalenes (11), alcohols (34), ketones (23), sulfur-containing compounds (5) and esters (8) were identified. Some of these components, e.g. hexanal, were known to contribute to the "beany" odor in other beans. Due to the presence of such odor, red beans may not be acceptable to some consumers.

• Applied Biological Chemistry
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• 제37권3호
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• pp.216-220
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• 1994

염소 및 이소프로필알콜이 리간드로 작용하는 여러 형태의 anisyltitanium 화합물을 합성 분리하였다. 즉 anisyltitanium 화합물을 합성한 뒤 해당 염화티탄 화합물과 치환시킴으로써 용이하게 유기티탄화합물을 합성, 순수분리 하였다. 이 화합물들은 아르곤하에서 또 낮은 온도 $0^{\circ}C$ 이하에서 대체로 안정하였으며, 카르보닐 화합물과 용이하게 첨가반응을 일으켜 알콜을 형성하였다. 화학선택성 조사에서 이 화합물들은 낮은 온도에서 알데히드-케톤 혼합물과 반응시킬 때 완벽한 알데히드 선택성을 나타내어 알데히드-케론의 두 가지 카르보닐 화합물 중 반응성이 큰 알데히드에 anisyl기가 선택적으로 첨가됨을 알았다.

• 한국환경농학회지
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• 제16권3호
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• pp.269-273
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• 1997

천연의 (S)-(+)-ABA 보다 우수한 생육저해 활성을 갖는 ABA 유도체를 개발하기 위한 연구의 일환으로 p-hydroxy methyl cinnamate와 umbelliferone을 (S)-(+)-2-cis, 4-trans-ABA에 ester 결합시켜서 ABA-methyl cinnamate ester(AC)와 ABA-umbelliferone ester(AU) 화합물을 각각 83%와 78%의 높은 수율로 얻었다. 이들의 벼 유묘 생육저해 활성은 (+)-ABA에 비해서 AC가 $3{\sim}10$배, AU가 $10{\sim}30$배 정도로 훨씬 더 강한 활성을 보였다.

• Bulletin of the Korean Chemical Society
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• 제35권2호
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• pp.518-520
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• 2014

Hybrids of some natural compounds are promising to obtain new leads with good biological activities for drug discovery. Three quercetin aspirinates were synthesized by esterification of the 3-and 7-hydroxyl groups of quercetin with aspirin. Biological activities of these quercetin aspirinates were initially screened and showed better cytotoxic activities against tumor cell lines HL-60 and HepG2 and less scavenging activity against DPPH than the quercetin respectively.