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Synthesis of 2'-Hydroxydihydrochalcone from Flavone  

Kim, Mi-Hyang (Metalloenzyme Research Group and Department of Biotechnology, Chung-Ang University)
Shin, Bok-Kyu (Metalloenzyme Research Group and Department of Biotechnology, Chung-Ang University)
Won, Dong-Ho (Metalloenzyme Research Group and Department of Biotechnology, Chung-Ang University)
Han, Jae-Hong (Metalloenzyme Research Group and Department of Biotechnology, Chung-Ang University)
Publication Information
Journal of Applied Biological Chemistry / v.50, no.2, 2007 , pp. 85-87 More about this Journal
Abstract
To establish the synthetic method for dihydrochalcones as an important bioactive compounds, 2'-hydroxydihydrochalcone has been synthesized from the reduction of flavone in 20% yield. Flavone with five equivalents of ammonium formate in the presence of Pd/C in methanol under $N_2$ atmosphere produced the C-ring opened product. It was characterized by UV-VIS, ESI-MS and $^1H-NMR$ spectroscopy, and identified as 2'-hydroxydihydrochalcone.
Keywords
flavone; flavonoids; 2'-hydroxydihydrochalcone; Pd/C; reduction;
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