• Genomics & Informatics
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• v.2 no.2
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• pp.99-106
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• 2004

In this paper we introduce PubMiner, an intelligent machine learning based text mining system for mining biological information from the literature. PubMiner employs natural language processing techniques and machine learning based data mining techniques for mining useful biological information such as protein­protein interaction from the massive literature. The system recognizes biological terms such as gene, protein, and enzymes and extracts their interactions described in the document through natural language processing. The extracted interactions are further analyzed with a set of features of each entity that were collected from the related public databases to infer more interactions from the original interactions. An inferred interaction from the interaction analysis and native interaction are provided to the user with the link of literature sources. The performance of entity and interaction extraction was tested with selected MEDLINE abstracts. The evaluation of inference proceeded using the protein interaction data of S. cerevisiae (bakers yeast) from MIPS and SGD.

• Journal of Biomedical Engineering Research
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• v.18 no.3
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• pp.261-266
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• 1997

Nonevasive multifrequency microwave radiometry using coaxial waveguide antenna has been investigated for a homogeneous and four layer human body model. The coupling between coaxial waveguide antenna and a biological object was analyzed by use of the finite-difference time-domain(FDTD) method to obtain the absorbed power patterns in the media. The object studied in this paper was a homogeneous and four-layered lossy medium. The specific absorption rates(SAR) distribution which was corresponding to the temperature distribution was calculated in each region by use of the steady-state response in FDTD method. The SAR pattern of 1.2GHz was compared with that of 1.8GHz.

• Journal of Korean Society of Water Science and Technology
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• v.26 no.6
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• pp.81-87
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• 2018

This research was done to investigate the bioreduction characteristics of perchlorate in raw sewage because sewage contains biodegradable organics and various microorganisms for biological perchlorate reduction. Two different types of sewage were tested for biological perchlorate reduction in the flasks. Sewage A was collected from the screening equipment and sewage B was collected from the primary settlement in the municipal wastewater treatment facilities. Perchlorate was completely reduced within 72hours from 8.2 and 10.4 mg/L in the sewage A and sewage B flask tests. When perchlorate and nitrate were added in sewage A, both perchlorate and nitrate were reduced. However, perchlorate and nitrate removal rates were 9.3% and 64.0% at 72hours in sewage B. Perchlorate reduction was significantly inhibited by high salinity(0.5% NaCl) in the sewage A and B. These results showed the sewage has potential for the biological perchlorate reduction in the sewage pipe.

• Journal of Biomedical Engineering Research
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• v.37 no.3
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• pp.112-118
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• 2016

The neck pain is fairly common occurance. Forward head posture and text neck are poor postures which may be related with neck pain but the evidence is not enough. We developed the wearable sensor which can assess the head & neck posture in daily life. Microprocessor, Bluetooth low energy, and 3-axis accelerometer, rechargeable battery and vibratior for reminding are used to implement the wearable sensor. Real-time algorithm to parameterize the posture for one epoch is implemented which classifies the posture in the epoch into three classed; dynamic, static_good posture, and static_poor posture. Also the algorithm makes reminding to its wearer to give them the prolonged poor posture is detected. The mean error of measurement was 1.2 degree. The correlation coefficient between neck angle and craniovertebral angle was 0.9 or higher in all cases. With the pilot study on text neck syndrome was also quatified. Average of neck angle were 74.3 degree during the listening in the classroom and 57.8 degree during the smartphoning. Using the wearable sensor suggested, the poor postures of forward head posture and neck neck can be detected in real-time which can remind the wearer according to his/her setting.

• Plant Biotechnology Reports
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• v.5 no.2
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• pp.107-120
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• 2011

The ability to feed an expanding world population poses one of the greatest challenges to mankind in the future. Accompanying the increased demand for food by the expected nine billion inhabitants of Earth in 2050 will be a continual decrease in arable land area, together with a decline in crop yield due to a variety of stresses. For these formidable challenges to be met, future crops should not only by high-yielding, but also stress-tolerant and disease-resistant. In this review, we highlight the importance of genetic engineering as an indispensable tool to generate just such future crops. We briefly discuss strategies and available tools for biotechnological crop improvement and identify selected examples of candidate genes that may be manipulated so that current biological maxima in yield may be surpassed by comfortable margins. Future prospects and the necessity for basic research aimed at identifying novel target genes are also discussed.

• Korean Journal of Plant Tissue Culture
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• v.27 no.4
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• pp.269-282
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• 2000

Benzylisoquinoline alkaloids are a diverse group of natural products that include many pharmacologically active compounds produced in a limited number of plant families. Despite their complexity, intensive biochemical research has extended our knowledge of the chemistry and enzymology of many important benzylisoquinoline alkaloid pathways, such as those leading to the analgesic drugs morphine and codeine, and the antibiotics sanguinarine and berberine. The use of cultured plant cells as an experimental system has facilitated the identification and characterization of more than 30 benzylisoquinoline alkaloid biosynthetic enzymes, and the molecular cloning of the genes that encode at least 8 of these enzymes. The recent expansion of biochemical and molecular technologies has creat-ed unique opportunities to dissect the mechanisms involved in the regulation of benzylisoquinoline alkaloid biosynthesis in plants. Research has suggested that product accumulation is controlled by the developmental and inducible regulation of several benzylisoquinoline alkaloid biosynthetic genes, and by the subcellular compartmentation of biosynthetic enzymes and the intracellular localization and trafficking of pathway intermediates. In this paper, we review our current understanding of the biochemistry, cell biology, and molecular regulation of benzylisoquinoline alkaloid biosynthesis in plants. We also summarize our own research activities, especially those related to the establishment of protocols for the genetic transformation of benzylisoquinoline alkaloid-producing species, and the development of metabolic engineering strategies in these plants.

• Journal of Microbiology
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• v.44 no.1
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• pp.23-28
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• 2006

We investigated the effects of halogenated aromatic compounds (HACs) including naturally occurring ones (L-thyroxine, 3-chloro-L-tyrosine, 5-chloroindole, 2-chlorophenol, 4-chlorophenol and chlorobenzene) on polychlorinated biphenyl (PCB) dechlorination in sediment cultures. A PCB-dechlorinating enrichment culture of sediment microorganisms from the St. Lawrence River was used as an initial inoculum. When the culture was inoculated into Aroclor 1248 sediments amended with each of the six HACs, the extent of dechlorination was not enhanced by amendment with HACs. The dechlorination patterns in the HAC-amended sediments were nearly identical to that of the HAC-free sediments except the 3-chloro-L-tyrosine-amended ones where no dechlorination activity was observed. When these sediment cultures were transferred into fresh sediments with the same HACs, the dechlorination specificities remained the same as those of the initial inoculations. Thus, in the present study, the substrate range of the highly selected enrichment culture could not be broadened by the HACs. It appears that HACs affect PCB dechlorination mainly through population selection rather than enzyme induction of single population.

• Korean Journal of Food Science and Technology
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• v.47 no.5
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• pp.545-555
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• 2015

Oxyresveratrol (trans-2,3',4,5'-tetrahydroxystilbene) has been receiving increasing attention because of its astonishing biological activities, including antihyperlipidemic, neuroprotection, antidiabetic, anticancer, antiinflammation, immunomodulation, antiaging, and antioxidant activities. Oxyresveratrol is a stilbenoid, a type of natural phenol and a phytoalexin produced in the roots, stems, leaves, and fruits of several plants. It was first isolated from the heartwood of Artocarpus lakoocha, and has also been found in various plants, including Smilax china, Morus alba, Varatrum nigrum, Scirpus maritinus, and Maclura pomifera. Oxyresveratrol, an aglycone of mulberroside A, has been produced by microbial biotransformation or enzymatic hydrolysis of a glycosylated stilbene mulberroside A, which is one of the major compounds of the roots of M. alba. Oxyresveratrol shows less cytotoxicity, better antioxidant activity and polarity, and higher cell permeability and bioavailability than resveratrol (trans-3,5,4'-trihydroxystilbene), a well-known antioxidant, suggesting that oxyresveratrol might be a potential candidate for use in health functional food and medicine. This review focuses on the plant sources, chemical characteristics, analysis, biosynthesis, and biological activities of oxyresveratrol as well as describes the perspectives on further exploration of oxyresveratrol.

• Fisheries and Aquatic Sciences
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• v.20 no.11
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• pp.28.1-28.17
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• 2017

Members of the phylum Echinodermata, commonly known as echinoderms, are exclusively marine invertebrates. Among the Echinodermata, sea cucumber belongs to the family Holothuroidea. The sea cucumber Stichopus (Apostichous) japonicus (Selenka) is an invertebrate animal inhabiting the coastal sea around Korean, Japan, China, and Russia. Sea cucumber has a significant commercial value, because it contains valuable nutrients such as vitamins and minerals. They possess a number of distinctive biologically and pharmacologically important compounds. In particular, the body wall of sea cucumber is a major edible part. It consists of peptide, collagen, gelatin, polysaccharide, and saponin, which possess several biological activities such as anti-cancer, anti-coagulation, anti-oxidation, and anti-osteoclastogenesis. Furthermore, the regenerative capacity of sea cucumber makes it a medically important organism. This review presents the various biological activities and biomedical potential of sea cucumber S. japonicus.

• 한국생물공학회:학술대회논문집
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• 2005.10a
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• pp.456-462
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• 2005

The objective of this study was to develop a removal process by which $H_2S$ could be biologically removed from the odoriferous gases generated in the waste food recycling process. In order to develop this process we were first required to select a proper biofilter support protocol. When the selected biofilter equipment was then tested suing a synthetic odoriferous gas containing 600 ppm of $H_2S$, we noted a maximal removal rate of 658 $g-H_2S/m^3{\cdot}hr$, using polypropylene fibrils as supporting materials. Under identical experimental conditions, we obtained a value of 411.2 $g-H_2S/m^3{\cdot}hr$, using polyurethane as a support material. We also conducted a trial in which volcanic stone was utilized as a support material, and in this trial, we logged a maximal 105.1 $g-H_2S/m^3{\cdot}hr$ removal rate. As the result of our experiments, we concluded that polypropylene fibrils constituted the ideal material for the removal of $H_2S$ gas via biological treatment.