• Title/Summary/Keyword: Biocompatible Polymer

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Fabrication and Performance Evaluation of Diaphragm-type Actuators using Biocompatible polymer (생체적합형 고분자를 이용한 박막형 이동기의 제작 및 특성평가)

  • Jung, Young-Dae;Jeong, Hae-Do
    • Proceedings of the KSME Conference
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    • 2007.05a
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    • pp.1254-1258
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    • 2007
  • Electro-active polymer (EAP), one of the smart materials, is a new alternative offering ultra-precise movements and bio-compatibility. We present the results of the design, fabrication, and performance evaluation of a fabricated diaphragm-type polymer actuator using segmented polyurethane(SPU). This paper illustrates the relationship between the elastic modulus and maximum deflection as a key property of the Maxwell stress effect and also presents the relationship between the dielectric constant and maximum deflection as a key property of the electrostriction effect, especially in polymer actuators using SPU. A diaphragm-type actuator was used to induce an equation of the vertically distributed load by using a fully clamped circular plate as the boundary condition. To verify the equation, the results were compared to the data measured from load cell. In the near future, a low-cost check valves and bio-robot can be applied by its actuators.

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Preparation and Characterization of Multilayer Microcapsules using Biocompatible Polymers (생체적합성 고분자를 사용한 다층 조립 구조 캡슐의 제조와 특성)

  • Jeon, Woohong;Kim, Gwang Yeon;Kim, Gue-Hyun;Ha, Chang-Sik
    • Korean Chemical Engineering Research
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    • v.48 no.2
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    • pp.178-184
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    • 2010
  • The aim of this work is the fabrication of polyelectrolyte microcapsules composed of biocompatible polymers such as chitosan, heparin and alginate, to encapsulate the fluorescein isothiocyanate(FITC)-albumin, and to investigate the protein release behavior therefrom. Polyelectrolyte capsules with 4-layer structures could be prepared with biocompatible materials by oppositely charged adsorption using melamin-foramide as a template. Transmission electron microscope(TEM), scanning electron microscope(SEM) and optical microscope confirmed hollow capsule structures. Protein release before and after encapsulation was monitored with a UV-Vis spectrometer. Microcapsules have different behaviors depending on the kind of polyelectrolyte polymers, chitosan-heparin capsules or chitosan-alginate capsules. In conclusion, the polyelectrolyte multilayer shells can be switched between an open and closed state by means of tuning the pH value.

Effects of Mixing Ratio on the Mechanical and Thermal Properties of Polyelectrolyte Complex Film

  • Son Tae-Won;Kim Byung-Giu;Park Young-Mi;Lim Hak-Sang;Kwon Oh-Kyung
    • Macromolecular Research
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    • v.14 no.3
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    • pp.267-271
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    • 2006
  • Polyelectrolyte complex films were prepared with two compounds, chitosan and poly(ethylene glycol)-monosuccinate, using a casting in order to synthesize a polyelectrolyte complex film with various mole ratios of chitosan and poly(ethylene glycol)-monosuccinate. The solution properties of isolated PEC were investigated for the effects of FTIR, pH value, Brookfield viscosity and cell viability assay using MTT staining. The PEC films were evaluated for mechanical properties by typical stress-strain curve, far thermal properties by DSC and TGA and for surface morphology Properties by SEM. Furthermore, the surface resistance, moisture regain and water content of the films were characterized. The solution properties were affected by several factors including the chitosan content in the PEC, the mixing ratio of PEG and chitosan, and pH. Several PEC in acidic conditions exhibited film formation under appropriate conditions of mixing ratio and chitosan concentration in the mixing process. These PEC films were found to have sufficiently flexible and stable properties due to their hydrophilic structure, which was farmed by the oppositely charged interaction between PEG-MS and chitosan matrix. The results showed the potential applicability of chitosan and poly(ethylene glycol)-monosuccinate films as a biocompatible polymer.

Chondrogenic Properties of Human Periosteum-derived Progenitor Cells (PDPCs) Embedded in a Thermoreversible Gelation Polymer (TGP)

  • Choi, Yang-Soo;Lim, Sang-Min;Shin, Hyun-Chong;Lee, Chang-Woo;Kim, Dong-Il
    • Biotechnology and Bioprocess Engineering:BBE
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    • v.11 no.6
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    • pp.550-552
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    • 2006
  • Periosteum-derived progenitor cells (PDPCs) were isolated using a fluorescence-activated cell sorter and their chondrogenic potential in biomaterials was investigated for the treatment of defective articular cartilage as a cell therapy. The chondrogenesis of PDPCs was conducted in a thermoreversible gelation polymer (TGP), which is a block copolymer composed of temperature-responsive polymer blocks such as poly(N-isopropylacrylamide) and of hydrophilic polymer blocks such as polyethylene oxide, and a defined medium that contained transforming growth $factor-{\beta}3\;(TGF-{\beta}3)$. The PDPCs exhibited chondrogenic potential when cultured in TGP. As the PDPCs-TGP is an acceptable biocompatible complex appropriate for injection into humans, this product might be readily applied to minimize invasion in a defected knee.

Development of Scaffold Fabrication System using Multi-axis RP Software Technique (다축 RP 소프트웨어 기술을 이용한 스캐폴드 제조 장비 개발)

  • Park, Jung-Whan;Lee, Jun-Hee;Cho, Hyeon-Uk;Lee, Su-Hee;Park, Su-A;Kim, Wan-Doo
    • Journal of the Korean Society for Precision Engineering
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    • v.29 no.1
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    • pp.33-40
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    • 2012
  • The scaffold serves as 3D substrate for the cells adhesion and mechanical support for the newly grown tissue by maintaining the 3D structure for the regeneration of tissue and organ. In this paper, we proposed integrated scaffold fabrication system using multi-axis rapid prototyping (RP) technology. It can fabricate various types of scaffolds: arbitrary sculptured shape, primitive shape, and tube shape scaffolds by layered dispensing biocompatible/ biodegradable polymer strands in designated patterns. In order to fabricate the 3D scaffold, we need to generate the plotting path way for the scaffold fabrication system. We design a data processing program - scaffold plotting software, which can convert the 3D STL file, primitive and tube model images into the NC code for the system. Finally, we fabricated the customized 3D scaffolds with high accuracy using the plotting software and the fabrication system.