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Development of Scaffold Fabrication System using Multi-axis RP Software Technique

다축 RP 소프트웨어 기술을 이용한 스캐폴드 제조 장비 개발

  • Park, Jung-Whan (School of Mechanical Engineering, Yeungnam Univ.) ;
  • Lee, Jun-Hee (Department of Nature-Inspired Nano Convergence System, KIMM) ;
  • Cho, Hyeon-Uk (School of Mechanical Engineering, Yeungnam Univ.) ;
  • Lee, Su-Hee (Department of Nature-Inspired Nano Convergence System, KIMM) ;
  • Park, Su-A (Department of Nature-Inspired Nano Convergence System, KIMM) ;
  • Kim, Wan-Doo (Department of Nature-Inspired Nano Convergence System, KIMM)
  • 박정환 (영남대학교 기계공학부) ;
  • 이준희 (한국기계연구원 자연모사연구실) ;
  • 조현욱 (영남대학교 기계공학부) ;
  • 이수희 (한국기계연구원 자연모사연구실) ;
  • 박수아 (한국기계연구원 자연모사연구실) ;
  • 김완두 (한국기계연구원 자연모사연구실)
  • Received : 2011.11.14
  • Accepted : 2011.11.24
  • Published : 2012.01.01

Abstract

The scaffold serves as 3D substrate for the cells adhesion and mechanical support for the newly grown tissue by maintaining the 3D structure for the regeneration of tissue and organ. In this paper, we proposed integrated scaffold fabrication system using multi-axis rapid prototyping (RP) technology. It can fabricate various types of scaffolds: arbitrary sculptured shape, primitive shape, and tube shape scaffolds by layered dispensing biocompatible/ biodegradable polymer strands in designated patterns. In order to fabricate the 3D scaffold, we need to generate the plotting path way for the scaffold fabrication system. We design a data processing program - scaffold plotting software, which can convert the 3D STL file, primitive and tube model images into the NC code for the system. Finally, we fabricated the customized 3D scaffolds with high accuracy using the plotting software and the fabrication system.

Keywords

References

  1. Langer, R. and Vacanti, J. P., "Tissue engineering," Science, Vol. 260, No. 5110, pp. 920-926, 1993. https://doi.org/10.1126/science.8493529
  2. Yang, S., Leong, K. F., Du, Z. and Chua, C. K., "The design of scaffolds for use in tissue engineering. Part I. Traditional factors," Tissue Eng., Vol. 7, No. 6, pp. 679-689, 2001. https://doi.org/10.1089/107632701753337645
  3. Sachlos, E. and Czernuszka, J. T., "Making tissue engineering scaffolds work. Review on the application of solid freeform fabrication technology to the production of tissue engineering scaffolds," Euro. Cells Mater., Vol. 5, No. 29, pp. 29-40, 2003.
  4. Hollister, S. J., "Porous scaffold design for tissue engineering," Nat. Mater., Vol. 4, No. 7, pp. 518-524, 2005. https://doi.org/10.1038/nmat1421
  5. Wang, X., Yan, Y. and Zhang, R., "Rapid prototyping as a tool for manufacturing bioartificial livers," Trends Biotechnol., Vol. 25, No. 11, pp. 505-513, 2007. https://doi.org/10.1016/j.tibtech.2007.08.010
  6. Lee, K., "Principles of CAD/CAM/CAE systems," Addison Wesley, 1999.
  7. Materialise, http://www.materialise.com/mimics
  8. Choi, B. K., "Surface modeling for CAD/CAM," Elsevier, 1991.
  9. Liao, Y. S. and Chiu, Y. Y., "A new slicing procedure for rapid prototyping system," Int. J. of Adv. Manufact. Tech., Vol. 18, No. 8, pp. 578-585, 2001.
  10. Luo, R. C., Yu, P. T., Lin, Y. F. and Leong, H. T., "Efficient 3D CAD model slicing for rapid prototyping manufacturing systems," Proc. of The 25th Annual Conference of the IEEE, Vol. 3, pp. 1504-1509, 1999.
  11. Jamieson, R. and Hacker, H., "Direct slicing of CAD models for rapid rototyping," Rapid Prototyping J., Vol. 1, No. 2, pp. 4-12, 1995. https://doi.org/10.1108/13552549510086826