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Chondrogenic Properties of Human Periosteum-derived Progenitor Cells (PDPCs) Embedded in a Thermoreversible Gelation Polymer (TGP)  

Choi, Yang-Soo (Department of Biological Engineering, Inha University)
Lim, Sang-Min (Department of Biological Engineering, Inha University)
Shin, Hyun-Chong (Department of Biological Engineering, Inha University)
Lee, Chang-Woo (Good Shepherd Hospital)
Kim, Dong-Il (Department of Biological Engineering, Inha University)
Publication Information
Biotechnology and Bioprocess Engineering:BBE / v.11, no.6, 2006 , pp. 550-552 More about this Journal
Abstract
Periosteum-derived progenitor cells (PDPCs) were isolated using a fluorescence-activated cell sorter and their chondrogenic potential in biomaterials was investigated for the treatment of defective articular cartilage as a cell therapy. The chondrogenesis of PDPCs was conducted in a thermoreversible gelation polymer (TGP), which is a block copolymer composed of temperature-responsive polymer blocks such as poly(N-isopropylacrylamide) and of hydrophilic polymer blocks such as polyethylene oxide, and a defined medium that contained transforming growth $factor-{\beta}3\;(TGF-{\beta}3)$. The PDPCs exhibited chondrogenic potential when cultured in TGP. As the PDPCs-TGP is an acceptable biocompatible complex appropriate for injection into humans, this product might be readily applied to minimize invasion in a defected knee.
Keywords
chondrogenesis; periosteum-derived cells; thermoreversible gelation polymer;
Citations & Related Records

Times Cited By Web Of Science : 7  (Related Records In Web of Science)
Times Cited By SCOPUS : 5
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