• 제목/요약/키워드: Bioactive treatment

검색결과 392건 처리시간 0.022초

The Trend of Organic Based Nanoparticles in the Treatment of Diabetes and Its Perspectives

  • Vijayakumar Natesan;Sung-Jin Kim
    • Biomolecules & Therapeutics
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    • 제31권1호
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    • pp.16-26
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    • 2023
  • Diabetes is an untreatable metabolic disorder characterized by alteration in blood sugar homeostasis, with submucosal insulin therapy being the primary treatment option. This route of drug administration is attributed to low patient comfort due to the risk of pain, distress, and local inflammation/infections. Nanoparticles have indeed been suggested as insulin carriers to allow the drug to be administered via less invasive routes other than injection, such as orally or nasally. The organic-based nanoparticles can be derived from various organic materials (for instance, polysaccharides, lipids, and so on) and thus are prevalently used to enhance the physical and chemical consistency of loaded bioactive compounds (drug) and thus their bioavailability. This review presents various forms of organic nanoparticles (for example, chitosan, dextron, gums, nanoemulsion, alginate, and so on) for enhanced hypoglycemic drug delivery relative to traditional therapies.

Milk-Derived Growth factors as Neutraceuticals

  • Kang, Shin-Ho
    • Journal of Dairy Science and Biotechnology
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    • 제25권1호
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    • pp.27-31
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    • 2007
  • Colostrum has lots of bioactive components and many growth factors including insulin-like growth factors, transforming growth factors and epidermal growth factor. Colostrum and milk derived growth factors widely mediate the growth of overall development and could be used as treatment of gastrointestinal disorder, wound repair process, bioacrivity in the neonatal GI tract and induction of oral tolerance. It is possible that milk derived growth factors as potential neutraceuticals for the specific consumers may have a great role in future food industry.

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Conessine Treatment Reduces Dexamethasone-Induced Muscle Atrophy by Regulating MuRF1 and Atrogin-1 Expression

  • Kim, Hyunju;Jang, Minsu;Park, Rackhyun;Jo, Daum;Choi, Inho;Choe, Joonho;Oh, Won Keun;Park, Junsoo
    • Journal of Microbiology and Biotechnology
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    • 제28권4호
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    • pp.520-526
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    • 2018
  • Conessine, a steroidal alkaloid, is a potent histamine H3 antagonist with antimalarial activity. We recently reported that conessine treatment interferes with $H_2O_2$-induced cell death by regulating autophagy. However, the cellular signaling pathways involved in conessine treatment are not fully understood. Here, we report that conessine reduces muscle atrophy by interfering with the expression of atrophy-related ubiquitin ligases MuRF-1 and atrogin-1. Promoter reporter assay revealed that conessine treatment inhibits FoxO3a-dependent transcription, $NF-{\kappa}B$-dependent transcription, and p53-dependent transcription. We also showed by quantitative RT-PCR and western blot assays that conessine treatment reduced dexamethasone-induced expression of MuRF1 and atrogin-1. Finally, we demonstrated that conessine treatment reduced dexamethasone-induced muscle atrophy using differentiated C2C12 cells. These results collectively suggest that conessine is potentially useful in the treatment of muscle atrophy.

칡의 대량 생산이용 및 생리활성물질에 관한 연구 I. 진한황산 처리가 칡 종자의 발아 및 생육에 미치는 영향 (Studies on Mass Production , Utilization and Bioactive Substance of Kudzu I. The effect of concentrated sulfate on germination rate and growth chracte in kudzu)

  • 정대수;김대진
    • 한국초지조사료학회지
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    • 제13권3호
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    • pp.190-194
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    • 1993
  • This experiment was conducted to investigate the effects of concentrated sulfate on the germination rate, growth rate and the productivity of weight of kudzu (Pueraria thwnbergiana Bentham). The germination rate of kudzu seed by one or two treatment retreatment with the concentrated sulfate for minutes of 5. 10, 15 and 20 were determined respectively. The results obtained were summarized as follows; 1. In the time of concentrated sulfate treatment, the germination rate was the highest in the once treatment for 20 minute. and the retreatment was higher than the once treatment in the germination rate. 2. The changes of plant length by growth stage was grown gradually until for 60 day and rapidly after for 60 day. The growth rate was the highest in treatment for 15 minute than in other treatments. 3. The stem diameter. stem weight. fresh weight and root weight by the treatment with sulfate 15 minute as the treatment with once were high degree of productivity. 4. The number of branch. number of nodes and root weight by the growth stage were higher growth rate before for 90 day than after for 90 day, however stem weight and fresh weight were high degree of productivity after for 60 day.

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Health Effects of Small Volatile Compounds from East Asian Medicinal Mushrooms

  • Pennerman, Kayla K.;Yin, Guohua;Bennett, Joan Wennstrom
    • Mycobiology
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    • 제43권1호
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    • pp.9-13
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    • 2015
  • Medicinal fungi, taken whole or as various forms of extracts, have been used to alleviate, cure or prevent human ailments since pre-historic times. In particular, Asian cultures have incorporated a variety of mushrooms into their medical practices. Chemically pure, bioactive metabolites from fungi have been a mainstay of modern pharmacological research and in addition to antibiotics, include anticancer agents, immunosuppressants, enzyme inhibitors, antagonist and agonists of hormones, and a variety of psychotropic substances. However, to date not many studies have focused on the possible health benefits of odorant volatile organic compounds (i.e., gas phase compounds). An analysis of these compounds for their health related effects will expand the range of compounds available for the treatment of chronic and acute diseases. This review highlights phenolic acids and monoterpenes from Asian medicinal mushrooms (AMMs), which not only produce pleasant odors but also have antioxidant and antibacterial effects. Odorant bioactive volatile phase compounds from medicinal mushrooms remain an essentially untapped source for future medicines, and AMMs remain a promising resource for future pharmacological research.

Synthesis of Highly Dispersed and Conductive Graphene Sheets by Exfoliation of Preheated Graphite in a Sealed Bath and its Applications to Polyimide Nanocomposites

  • Hossain, Muhammad Mohsin;Hahn, Jae Ryang;Ku, Bon-Cheol
    • Bulletin of the Korean Chemical Society
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    • 제35권7호
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    • pp.2049-2056
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    • 2014
  • A simple method for exfoliating pristine graphite to yield mono-, bi-, and multi-layers of graphene sheets as a highly concentrated (5.25 mg/mL) and yielded solution in an organic solvent was developed. Pre-thermal treatment of pristine graphite at $900^{\circ}C$ in a sealed stainless steel bath under high pressures, followed by sonication in 1-methyl-2-pyrrolidinone solvent at elevated temperatures, produced a homogeneous, well-dispersed, and non-oxidized graphene solution with a low defect density. The electrical conductivities of the graphene sheets were very high, up to 848 S/cm. These graphene sheets were used to fabricate graphene-polyimide nanocomposites, which displayed a higher electrical conductivity (1.37 S/m) with an improved tensile strength (95 MPa). The synthesized graphene sheets and nanocomposites were characterized by transmission electron microscopy, scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy, and Raman spectroscopy.

Screening of Bioconversion Components from Gumiganghwal-tang on Fermentation by Lactobacillus Strains

  • Liang, Chun;Lee, Kwang Jin;Cho, Chang-Won;Ma, Jin Yeul
    • Natural Product Sciences
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    • 제20권2호
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    • pp.102-106
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    • 2014
  • Gumiganghwal-tang (GMT) is a traditional herbal prescription used for treatment of the common cold, pain, and inflammatory diseases. Variations in the amounts of bioactive components of GMT and GMT fermented with 10 Lactobacillus strains were investigated by high-performance liquid chromatography coupled with diode array detection (HPLC-DAD). Simultaneous qualitative and quantitative analyses of eleven bioactive compounds (prim-O-glucosylcimifugin, liquiritin, cimifugin, baicalin, liquiritigenin, wogonoside, baicalein, wogonin, butylphthalide, imperatorin, and isoimperatorin) were performed, with comparison of their retention times (tR) and UV spectra with those of standard compounds. The amounts of baicalin (8.71 mg/g), liquiritigenin (5.28 mg/g) and butylphthalide (5.10 mg/g) were the major compounds in GMT. We found that L. fermentum KFRI 145 fermented wogonoside and baicalin to their aglycones, wogonin and baicalein, respectively. These results indicated that L. fermentum KFRI 145 has potential as a functional starter culture for manufacturing fermented GMT.

Changes in Bioactive Compounds Contents of 'Maehyang' and 'Seolhyang' Strawberry Fruits by UV Light Illumination

  • Kim, Sung-Kyeom;Bae, Ro-Na;Chun, Chang-Hoo
    • 원예과학기술지
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    • 제29권3호
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    • pp.172-180
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    • 2011
  • The net photosynthetic rate of 'Seolhyang' strawberry plants was measured daily for 7 days after treatment at three UV illumination dosages (0, 9.8, and 29.5 $kJ{\cdot}m^{-2}$). The net photosynthetic rates of the strawberry plants with 9.8 and 29.5 $kJ{\cdot}m^{-2}$ UV light illumination decreased by 20.2 and 61.4%, respectively, at 7 days after UV light treatments. UV treatments with two illumination dosages (7.9 and 15.7 $kJ{\cdot}m^{-2}$) altered the phenolic compounds contents during the cultivation period when compared to those in the control fruits. The anthocyanin content with 7.9 $kJ{\cdot}m^{-2}$ UV light illumination of 'Seolhyang' increased by 18.7% compared with those in control fruits at the 11 DAT. However, the anthocyanin content of 'Maehyang' was not significantly different among treatments during experiment period. The highest level of ellagic acid was found with 7.9 $kJ{\cdot}m^{-2}$ UV light illumination in both cultivars at the 11 DAT. Our results showed that strawberries illuminated with UV light during cultivation period had higher bioactive compounds contents than control fruits. These results suggest that UV light treatments may be a useful non-chemical way of promoting strawberry fruits quality.

수정된 유사체액 내에서 티타늄에 생성된 아파타이트의 고분해능 전자현미경에 의한 분석 (HRTEM Analysis of Apatite Formed on Bioactive Titanium in Modified-SBF)

  • 김현욱;김우정;이갑호;홍순익
    • 한국재료학회지
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    • 제17권8호
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    • pp.408-413
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    • 2007
  • Process of the hydroxyapapite(HA) precipitation on bioactive titanium metal prepared by NaOH in a modified-simulated body fluid(mSBF) was investigated by high resolution transmission electron microscope (HRTEM) attached with energy dispersive X-ray spectrometer(EDX). The amorphous titanate phase on titanium surface is form by NaOH treatment and an amorphous titanate incorporated calcium and phosphate ions in the liquid to form an amorphous calcium phosphate. With increasing of soaking time in the liquid, the HA particles are observed in amorphous calcium phosphate phase with a Ca/P atomic ratio of I.30. The octacalcium phosphate (OCP) structure is not detected in HRTEM image and electron diffraction pattern. After a long soaking time, the HA particles grow as needle-like shape on titanium surface and a large particle-like aggregates of needle-like substance were observed to form on titanium surface within needle-like shape. A long axis of needle parallels to c-direction of the hexagonal HA structure.

야채 및 과일추출물의 항산화작용 (Antioxidant Activity of Vegetables or Fruits Extract in Mice)

  • 허찬;김남이;김현표;허문영
    • 약학회지
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    • 제49권3호
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    • pp.249-254
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    • 2005
  • The ethanol extracts of the mixed vegetables (Bioactive Vegetables, BV) and the mixed fruits (Bioactive Fruits, BF) were evaluated for their in vivo antioxidant activities. Four weeks treatment of oral administration was performed to mice. A $KBrO_3$ as a potent oxidant was used to induce the oxidative stress for in vivo experiment. BV and BF were shown to possess the significant inhibitory effect of lipid peroxidation as measured by the level of malondialdehyde (MDA) formation although the potencies were not higher than those of well-known antioxidants such as vitamin C, trolox and quercetin. Furthermore, BV and BF inhibited DNA damage assessed by single cell gel electrophoresis (comet assay) and reduced the micronucleated reticulocyte (MNRET) formation of peripheral blood. Antioxidants tested also revealed potent inhibitory activities higher than BV and BF. These antigenotoxic activity profiles were similar to that of abovementioned inhibition of lipid peroxidation. Therefore, BV and BF having mild antioxidant activity as functional food candidates may be useful natural antioxidants by the inhibiting of lipid peroxidation and the protecting oxidative DNA and chromosomal damage.