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Screening of Bioconversion Components from Gumiganghwal-tang on Fermentation by Lactobacillus Strains  

Liang, Chun (KM-based Herbal Drug Research Group, Korea Institute of Oriental Medicine (KIOM))
Lee, Kwang Jin (KM-based Herbal Drug Research Group, Korea Institute of Oriental Medicine (KIOM))
Cho, Chang-Won (Processing Technology Research Group, Korea Food Reaserch Institute)
Ma, Jin Yeul (KM-based Herbal Drug Research Group, Korea Institute of Oriental Medicine (KIOM))
Publication Information
Natural Product Sciences / v.20, no.2, 2014 , pp. 102-106 More about this Journal
Abstract
Gumiganghwal-tang (GMT) is a traditional herbal prescription used for treatment of the common cold, pain, and inflammatory diseases. Variations in the amounts of bioactive components of GMT and GMT fermented with 10 Lactobacillus strains were investigated by high-performance liquid chromatography coupled with diode array detection (HPLC-DAD). Simultaneous qualitative and quantitative analyses of eleven bioactive compounds (prim-O-glucosylcimifugin, liquiritin, cimifugin, baicalin, liquiritigenin, wogonoside, baicalein, wogonin, butylphthalide, imperatorin, and isoimperatorin) were performed, with comparison of their retention times (tR) and UV spectra with those of standard compounds. The amounts of baicalin (8.71 mg/g), liquiritigenin (5.28 mg/g) and butylphthalide (5.10 mg/g) were the major compounds in GMT. We found that L. fermentum KFRI 145 fermented wogonoside and baicalin to their aglycones, wogonin and baicalein, respectively. These results indicated that L. fermentum KFRI 145 has potential as a functional starter culture for manufacturing fermented GMT.
Keywords
Gumiganghwal-tang; Bioconversion; Identification; HPLC;
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