Conessine Treatment Reduces Dexamethasone-Induced Muscle Atrophy by Regulating MuRF1 and Atrogin-1 Expression |
Kim, Hyunju
(Division of Biological Science and Technology, Yonsei University)
Jang, Minsu (Division of Biological Science and Technology, Yonsei University) Park, Rackhyun (Division of Biological Science and Technology, Yonsei University) Jo, Daum (Division of Biological Science and Technology, Yonsei University) Choi, Inho (Division of Biological Science and Technology, Yonsei University) Choe, Joonho (Department of Biological Sciences, Korea Advanced Institute of Science and Technology) Oh, Won Keun (Korea Bioactive Natural Material Bank, College of Pharmacy, Seoul National University) Park, Junsoo (Division of Biological Science and Technology, Yonsei University) |
1 | Atherton PJ, Greenhaff PL, Phillips SM, Bodine SC, Adams CM, Lang CH. 2016. Control of skeletal muscle atrophy in response to disuse: clinical/preclinical contentions and fallacies of evidence. Am. J. Physiol. Endocrinol. Metab. 311: E594-E604. DOI |
2 | Dua VK, Verma G, Singh B, Rajan A, Bagai U, Agarwal DD, et al. 2013. Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica. Malar. J. 12: 194. DOI |
3 | Zirihi GN, Grellier P, Guede-Guina F, Bodo B, Mambu L. 2005. Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf. Bioorg. Med. Chem. Lett. 15: 2637-2640. DOI |
4 | Paris R. 1951. [On a new acquisition in phytotherapy: Holarrhena floribunda and its principal alkaloid: conessine]. Gaz. Med. Fr. Spec. No.: 79-83. |
5 | Zhao C, Sun M, Bennani YL, Gopalakrishnan SM, Witte DG, Miller TR, et al. 2008. The alkaloid conessine and analogues as potent histamine H3 receptor antagonists. J. Med. Chem. 51: 5423-5430. DOI |
6 | Bodine SC, Baehr LM. 2014. Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1. Am. J. Physiol. Endocrinol. Metab. 307: E469-E484. DOI |
7 | Attaix D, Baracos VE. 2010. MAFbx/Atrogin-1 expression is a poor index of muscle proteolysis. Curr. Opin. Clin. Nutr. Metab. Care 13: 223-224. DOI |
8 | Fitts RH, Riley DR, Widrick JJ. 2001. Functional and structural adaptations of skeletal muscle to microgravity. J. Exp. Biol. 204: 3201-3208. |
9 | Bodine SC, Latres E, Baumhueter S, Lai VK, Nunez L, Clarke BA, et al. 2001. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 294: 1704-1708. DOI |
10 | Clarke BA, Drujan D, Willis MS, Murphy LO, Corpina RA, Burova E, et al. 2007. The E3 ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle. Cell Metab. 6: 376-385. DOI |
11 | Sacheck JM, Ohtsuka A, McLary SC, Goldberg AL. 2004. IGF-I stimulates muscle growth by suppressing protein breakdown and expression of atrophy-related ubiquitin ligases, atrogin-1 and MuRF1. Am. J. Physiol. Endocrinol. Metab. 287: E591-E601. DOI |
12 | Senf SM, Dodd SL, McClung JM, Judge AR. 2008. Hsp70 overexpression inhibits NF-kappaB and Foxo3a transcriptional activities and prevents skeletal muscle atrophy. FASEB J. 22: 3836-3845. DOI |
13 | Park J, Kim K, Lee EJ, Seo YJ, Lim SN, Park K, et al. 2007. Elevated level of SUMOylated IRF-1 in tumor cells interferes with IRF-1-mediated apoptosis. Proc. Natl. Acad. Sci. USA 104: 17028-17033. DOI |
14 | Kim H, Lee KI, Jang M, Namkoong S, Park R, Ju H, et al. 2016. Conessine interferes with oxidative stress-induced C2C12 myoblast cell death through inhibition of autophagic flux. PLoS One 11: e0157096. DOI |
15 | Zhou C, Liu J. 2003. Inhibition of human telomerase reverse transcriptase gene expression by BRCA1 in human ovarian cancer cells. Biochem. Biophys. Res. Commun. 303: 130-136. DOI |
16 | Paumelle R, Tulasne D, Kherrouche Z, Plaza S, Leroy C, Reveneau S, et al. 2002. Hepatocyte growth factor/scatter factor activates the ETS1 transcription factor by a RAS-RAF-MEK-ERK signaling pathway. Oncogene 21: 2309-2319. DOI |
17 | Datto MB, Li Y, Panus JF, Howe DJ, Xiong Y, Wang XF. 1995. Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism. Proc. Natl. Acad. Sci. USA 92: 5545-5549. DOI |
18 | Wu CL, Cornwell EW, Jackman RW, Kandarian SC. 2014. NF-kappaB but not FoxO sites in the MuRF1 promoter are required for transcriptional activation in disuse muscle atrophy. Am. J. Physiol. Cell Physiol. 306: C762-C767. DOI |
19 | Adams V, Mangner N, Gasch A, Krohne C, Gielen S, Hirner S, et al. 2008. Induction of MuRF1 is essential for TNF-alpha-induced loss of muscle function in mice. J. Mol. Biol. 384: 48-59. DOI |
20 | Kimbrel EA, Kung AL. 2009. The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity. J. Biol. Chem. 284: 13033-13044. DOI |
21 | Namkoong S, Kim TJ, Jang IS, Kang KW, Oh WK, Park J. 2011. Alpinumisoflavone induces apoptosis and suppresses extracellular signal-regulated kinases/mitogen activated protein kinase and nuclear factor-kappaB pathways in lung tumor cells. Biol. Pharm. Bull. 34: 203-208. DOI |
22 | Murray-Zmijewski F, Slee EA, Lu X. 2008. A complex barcode underlies the heterogeneous response of p53 to stress. Nat. Rev. Mol. Cell Biol. 9: 702-712. DOI |
23 | Brunet A, Park J, Tran H, Hu LS, Hemmings BA, Greenberg ME. 2001. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol. Cell. Biol. 21: 952-965. DOI |
24 | Sanchez AM, Csibi A, Raibon A, Cornille K, Gay S, Bernardi H, et al. 2012. AMPK promotes skeletal muscle autophagy through activation of forkhead FoxO3a and interaction with Ulk1. J. Cell. Biochem. 113: 695-710. DOI |
25 | Ni HM, Du K, You M, Ding WX. 2013. Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity. Am. J. Pathol. 183: 1815-1825. DOI |
26 | Datta K, Babbar P, Srivastava T, Sinha S, Chattopadhyay P. 2002. p53 dependent apoptosis in glioma cell lines in response to hydrogen peroxide induced oxidative stress. Int. J. Biochem. Cell Biol. 34: 148-157. DOI |
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