• The Korean Journal of Pain
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• 제34권2호
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• pp.185-192
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• 2021

Background: It is known that some analgesics as well as pain can affect the immune system. The aim of this study was to investigate the analgesic effect and immunomodulation of pregabalin (PGB) in a mouse incisional pain model. Methods: A postoperative pain model was induced by hind paw plantar incision in male BALB/c mice. Mice were randomly divided into four groups (n = 8): a saline-treated incision (incision), PGB-treated incision (PGB-incision), sham controls without incision or drug treatment (control), and a PGB-treated control (PGB-control). In the PGB treated groups, PGB was administered intraperitoneally (IP) 30 minutes before and 1 hour after the plantar incision. Changes of the mechanical nociceptive thresholds following incision were investigated. Mice were euthanized for spleen harvesting 12 hours after the plantar incision, and natural killer (NK) cytotoxicity to YAC 1 cells and lymphocyte proliferation responses to phytohemagglutinin were compared among these four groups. Results: Mechanical nociceptive thresholds were decreased after plantar incision and IP PGB administration recovered these decreased mechanical nociceptive thresholds (P < 0.001). NK activity was increased by foot incision, but NK activity in the PGB-incision group was significantly lower than that in the Incision group (P < 0.001). Incisional pain increased splenic lymphocyte proliferation, but PGB did not alter this response. Conclusions: Incisional pain alters cell immunity of the spleen in BALB/c mice. PGB showed antinocieptive effect on mouse incisional pain and attenuates the activation of NK cells in this painful condition. These results suggest that PGB treatment prevents increases in pain induced NK cell activity.

• 한국기계가공학회지
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• 제13권2호
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• pp.1-7
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• 2014

Recent experimental observations support the hypothesis that mechanical stimuli play a role in regulating the specialized molecular expression of articular cartilage in vitro and in vivo. Other studies have demonstrated that the continuous passive motion(CPM)bioreactor for whole joints can provide a platform for possible future in vitro studies and applications, including possible interactions of bio-mechanical and biochemical signals. In this study, we have developed acustom-made bioreactor capable of bending and stretching with circular type motion, and a biomimetic knee joint model, using a 3D printer. This system could be used to investigate the effects of rehabilitative joint motion of dynamic culture.

• 한국산업융합학회 논문집
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• 제20권1호
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• pp.27-33
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• 2017

An agriculture machines are subjected to different loads conditions. Due to this loads variations there will be certain deformations and stress which affect the performance of the electric vehicle in adverse manner. The purpose of this paper is to analyze the total deformation and stress of the electric farm vehicle middle frame based on the finite element method. The proposed electric farm vehicle has lifting and dumping capability. Therefore, in this research four operational condition such as normal condition, dumping condition, lifting condition, and lifting-dumping condition was analyzed. In this research, the design for whole frame structure is elaborated. According to the mechanical characteristics of the frame, materials are selected and manufacturability requirements are limited. Based on ANSYS 15 software, the finite element model of electric farm vehicle is established to carry out static analysis on full-loaded conditions. The simulation results shows that the proposed design meet the strength requirements and displacement requirements. The maximum deformation 0.53611 mm and maximum stress 30.163 MPa occurred at lifting-dumping condition.

• Biomolecules & Therapeutics
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• 제25권3호
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• pp.259-265
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• 2017

This study aimed to investigate the analgesic effect of substance P (SP) in an animal model of neuropathic pain. An experimental model of neuropathic pain, the chronic constriction injury (CCI) model, was established using ICR mice. An intravenous (i.v.) injection of SP (1 nmole/kg) was administered to the mice to examine the analgesic effects of systemic SP on neuropathic pain. Behavioral testing and immunostaining was performed following treatment of the CCI model with SP. SP attenuated mechanical allodynia in a time-dependent manner, beginning at 1 h following administration, peaking at 1 day post-injection, and decaying by 3 days post-injection. The second injection of SP also increased the threshold of mechanical allodynia, with the effects peaking on day 1 and decaying by day 3. A reduction in phospho-ERK and glial fibrillary acidic protein (GFAP) accompanied the attenuation of mechanical allodynia. We have shown for the first time that i.v. administration of substance P attenuated mechanical allodynia in the maintenance phase of neuropathic pain using von Frey's test, and simultaneously reduced levels of phospho-ERK and GFAP, which are representative biochemical markers of neuropathic pain. Importantly, glial cells in the dorsal horn of the spinal cord (L4-L5) of SP-treated CCI mice, expressed the anti-inflammatory cytokine, IL-10, which was not seen in vehicle saline-treated mice. Thus, i.v. administration of substance P may be beneficial for improving the treatment of patients with neuropathic pain, since it decreases the activity of nociceptive factors and increases the expression of anti-nociceptive factors.

• Composites Research
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• 제20권3호
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• pp.50-54
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• 2007

본 연구에서는 IPMC의 기본적인 기계적 특성을 알아보았다. 기전폴리머의 한 종류인 IPMC는 굽힘형 작동, 가벼움, 저전력 소모, 유연성 등의 많은 장점을 가진 재료이다. 따라서 IPMC는 생체모방형 작동기와 센서로서 많은 가능성을 가지고 있다. 이런 가능성을 바탕으로 IPMC를 실제로 응용하기 위하여 IPMC의 변형, 구동력, 주파수 응답 등 기본적인 기계적 특성을 연구하였다. 우선 이온교환폴리머의 한 종류인 네피온 용액을 사용하여 여러 가지 두께의 네피온 막을 만들고, 무전해 도금을 통해 IPMC를 제작하였다. 이렇게 제작된 IPMC의 규격, 인가 전압에 따른 변형, 구동력, 주파수 응답 특성에 관한 실험을 수행하고, 실험 결과를 통해 IPMC 성능의 실험식과 등가 강성 모델을 수립하였다.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2008년도 춘계학술대회논문집
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• pp.21-24
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• 2008

The present study numerically investigates the glottal airflow characteristics as well as acoustic features of phonation fully coupled with dynamic behavior of vocal folds. The vocal folds are described by a low-dimensional body-covered model characterized by bio-mechanical parameters such as glottal width, vocal folds stiffness, and subglottal pressure. The flow in the vocal tract is modeled as an incompressible, axisymmetric form of the Navier-Stokes equations (INS), while the acoustic field is predicted by the linearized perturbed compressible equations (LPCE). The computed result shows that a two-mass model of vocal folds is sufficient to reproduce temporal variations in oral airflow and glottis motion produced by female speakers. It is also found that i) the glottal width has a significant effect on the amplitude of glottal flow, and thus on the amplitude of acoustic wave in the vocal tract, ii) the vocal fold tension is the main control parameter for the fundamental frequency of phonation, iii) the subglottal pressure plays an appreciable role on reproduction of the self-sustained oscillation of vocal folds, and iv) the strength of pulsating airflow and vortical structures are primarily affected by glottal width and subglottal pressure, and are closely related to pitch, loudness, and voice quality. Finally, more comprehensive explanation about the difference between one- and two-mass models is presented with discussion of effectiveness of vocal folds oscillation and voice quality.

• 대한기계학회논문집B
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• 제39권11호
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• pp.853-859
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• 2015

본 연구에서는 모의 생체조직에 광을 조사하고 그에 따른 조직 내의 열전달 현상을 분석하였으며 이를 이용하여 수치해석 시 필요한 표면 경계조건에 대한 관계식을 도출하였다. 세 가지 서로 다른 파장의 광을 높이를 바꾸면서 조사하여 표면에서부터 깊이방향으로 조직 내의 온도를 측정하였다. 그 결과 파장과 조사 시간이 길수록 한천조직의 온도는 높아졌으나 붉은 색 파장과 근적외선은 큰 차이를 나타내지 않았다. 도출된 경계조건을 사용한 수치해석 결과는 측정된 온도와 잘 일치하였다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2008년도 추계학술대회A
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• pp.1651-1654
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• 2008

Previous reports have introduced the technique of spinous process osteotomy to decompress spinal stenosis, a procedure which aims to afford excellent visualization while minimizing destruction of tissures not directly involved in the pathologic process. However, bio-mechanically it has not been investigated whether the sacrifice of posterior spinous process might have potential risk of spinal instability or not, even though supra-spinous and inter-spinous ligament are preserved. Therefore the aim of this study is to evaluate the bio-mechanical properties after spinous process osteotomiy, using finite element analysis. In the model of spinous process osteotomy the increase of stress in the disc and segmental rangesof motions were not changed significantly. It is due to the fact that the instability of lumbar spine has been maintained by the two-types of ligaments compared with the prior surgical technique. Therefore, according to the finite element result on this study, these osotetomy was considered to be a clinicallysafe surgical procedure and could not cause the instability of patient.

• 대한의용생체공학회:의공학회지
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• 제32권3호
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• pp.207-217
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• 2011

Electrode impedances are measured to quantitatively characterize the electrode-electrolyte or cell-electrode interfaces. In the case of high-density microelectrode arrays(MEAs) that have been developed for brainmachine interface applications, the characterization process becomes a repeating and time-consuming task; a system that can perform the measurement and analysis in an automated fashion with accuracy and speed is required. However, due to the large number of channels, parasitic capacitance and off-capacitance components of the switching system become the major factors that decreased the accuracy for the measurement of high impedance microelectrodes. Here we investigated the implementation of automatic impedance measurement system with analyzing the causes of possible measurement-related problems in multichannel switching configuration. Based on our multi-channel measurement circuit model, we suggest solutions to the problems and introduce a novel impedance measurement scheme using electro-mechanical relays. The implemented measurement system could measure |Z| < 700 $k{\Omega}$ of impedance in - 10% errors, which can be widely applicable to high density neural recording MEAs.

• 설비공학논문집
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• 제29권8호
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• pp.391-400
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• 2017

Understanding of seawater fouling characteristics is critical in designing a heat exchanger adapted in an effluent utilization system for a power plant. We reviewed three types of fouling mechanisms of general, biological, and crystallizing for a plate-frame heat exchanger, to be used for heat exchanging with heated effluent from a power plant. Also, mathematical models for each type of seawater fouling were suggested. Actual thermal resistance calculated from seawater fouling models were compared and implemented in designing a plate-frame heat exchanger. The bio-fouling model revealed the largest thermal resistance and the highest number of plates for a plate-frame heat exchanger under the same heat load. Overall heat transfer coefficient and pressure drop of a plate-frame heat exchanger under fouling conditions was lower by 58 percent and higher by 2.85 times than those under clean conditions, respectively.