• Title/Summary/Keyword: Bio-dynamic Response

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Quantitative Label-free Biodetection of Acute Disease Related Proteins Based on Nanomechanical Dynamic Microcantilevers

  • Hwang, Kyo-Seon;Cha, Byung-Hak;Kim, Sang-Kyung;Park, Jung-Ho;Kim, Tae-Song
    • JSTS:Journal of Semiconductor Technology and Science
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    • v.7 no.3
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    • pp.151-160
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    • 2007
  • We report the label-free biomolecules detection based on nanomechanical micro cantilevers operated in dynamic mode for detection of two marker proteins (myoglobin and creatin kinase-MB (CK-MB)) of acute myocardical infarctions. When the specific binding between the antigen and its antibody occurred on the fuctionalized microcantilever surface, mechanical response (i.e. resonant frequency) of microcantilevers was changed in lower frequency range. We performed the label-free biomolecules detection of myoglobin and CK-MB antigen in the low concentration (clinical threshold concentration range) as much as 1 ng/ml from measuring the dynamic response change of micro cantilevers caused by the intermolecular force. Moreover, we estimate the surface stress on the dynamic microcantilevers generated by specific antibody-antigen binding. It is suggested that our dynamic microcantilevers may enable one to use the sensitive label-free biomolecules detection for application to the disease diagnosis system based on mechanical immuno-sensor.

Dynamic response of free-end rod with consideration of wave frequency

  • Kim, Sang Yeob;Lee, Jong-Sub;Tutumluer, Erol;Byun, Yong-Hoon
    • Geomechanics and Engineering
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    • v.28 no.1
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    • pp.25-33
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    • 2022
  • The energy transferred on drill rods by dynamic impact mainly determines the penetration depth for in-situ tests. In this study, the dynamic response and transferred energy of drill rods are determined from the frequency of the stress waves. AW-type drill rods of lengths 1 to 3 m are prepared, and strain gauges and an accelerometer are installed at the head and tip of the connected rods. The drill rods are hung on strings, allowing free vibration, and then impacted by a pendulum hammer with fixed potential energy. Increasing the rod length L increases the wave roundtrip time (2L/c, where c is the wave velocity), and hence the transferred energy at the rod head. At the rod tip, the first velocity peak is higher than the first force peak because a large and tensile stress wave is reflected, and the transferred energy converges to zero. The resonant frequency increases with rod length in the waveforms measured by the strain gauges, and fluctuates in the waveforms measured by the accelerometer. In addition, the dynamic response and transferred energy are perturbed when the cutoff frequency is lower than 2 kHz. This study implies that the resonant frequency should be considered for the interpretation of transferred energy on drill rods.

The rheological properties of poly(vinylidene fluoride-co-hexafluoropropylene) solutions in dimethyl acetamide

  • Lee, Ki-Hyun;Song, In-Kyu;Kim, Byoung-Chul
    • Korea-Australia Rheology Journal
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    • v.20 no.4
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    • pp.213-220
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    • 2008
  • The effects of temperature on the rheological properties of the solutions of poly(vinylidene fluoride-co-hexafluopropylene) (PVDF-HFP) in dimethyl acetamide (DMAc) were investigated in terms of frequency and concentration. The effects of temperature on the intrinsic viscosity of the solutions were discussed. In dynamic rheological measurement, the concentrated solutions showed a little unexpected rheological response; as temperature was increased dynamic viscosity was increased and the solutions exhibited more noticeable Bingham body character over the temperature range, 30 to $70^{\circ}C$. In addition, the solution gave longer relaxation time, lower value of loss tangent and higher value of yield stress at higher temperature and at higher concentration. On the other hand, the dilute solutions revealed that intrinsic viscosity was decreased and its Huggins constant was increased with increasing temperature. These physical parameters suggested that the increase of viscosity with increasing temperature resulted from the localized gelation of PVDF-HFP due to reduced solubility to the solvent.

Optimization of Input Parameters by Using DOE for Dynamic Analysis of Bio-inspired Robotic Fish 'Ichthus' (생체모방형 물고기 로봇 '익투스'의 동적 해석을 위한 DOE를 이용한 입력파라미터 최적화)

  • Chung, Chang-Hyun;Lee, Sang-Hyo;Kim, Kyoung-Sik;Cha, You-Sung;Ryuh, Young-Sun
    • Journal of Institute of Control, Robotics and Systems
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    • v.16 no.8
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    • pp.799-803
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    • 2010
  • Recently, there is a rising interest on studying bio-inspired robotic fish because of real fish's great maneuverability and high energy efficiency. However, the researches about the robotic fish have not been done so much and there are still lots of problems to use them in the real environment such as in the river. This paper describes a bio-inspired robotic fish 'Ichthus' which is developed in KITECH and has 3 DOF propulsive mechanism. We develop the dynamic motion equation of 'Ichthus' in the underwater environment and analyze response characteristics of 'Ichthus' according to the input parameters of tail fin's amplitude and oscillation frequency. Then we propose control parameters at the various velocities. These parameters are useful to increase energy efficiency and it can be used when the fish robot moves in the real environment, for example, we can propose proper amplitude and oscillation frequency when the fish robot passes through the narrow space between obstacles.

Development and Performance Evaluation of In-situ Dynamic Stiffness Analyzer (원위치 동적강성 분석기의 개발 및 성능평가)

  • Kim, Dong-Ju;Byun, Yong-Hoon
    • Journal of The Korean Society of Agricultural Engineers
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    • v.61 no.2
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    • pp.41-50
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    • 2019
  • Stiffness characteristic of subgrade is one of the most important aspects for the design and evaluation of pavement and railway. However, adequate field testing methods for evaluating the stiffness characteristics of the subgrade have not been developed yet. In this study, an in-situ dynamic stiffness analyzer (IDSA) is developed to evaluate the characteristics of subgrade stiffness along the depth, and its performance is evaluated in elastic materials and a compacted soil. The IDSA consists of a falling hammer system, a connecting rod, and a tip module. Four strain gauges and an accelerometer are installed at the tip of the rod to analyze the dynamic response of the tip generated by the drop of hammer. Based on the Boussinesq's method, the stiffness and Young's modulus of the specimens can be calculated. The performance of IDSA was tested on three elastic materials with different hardness and a compacted soil. For the repeatability of test performance, the dynamic signals for force and displacement of the tip are averaged from the hammer impact tests performed five times at the same drop height. The experimental results show that the peak force, peak displacement, and the duration depend on the hardness of the elastic materials. After calculating the stiffness and elastic modulus, it is revealed that as the drop height of hammer increases, the stiffness and elastic moduli of MC nylon and the compacted soil rapidly increase, while those of urethanes less increase.

Flight Dynamic Identification of a Model Helicopter using CIFER®(II) - Frequency Response Analysis - (CIFER®를 이용한 무인 헬리콥터의 동특성 분석 (II) - 주파수 응답 해석 -)

  • Bae, Yeoung-Hwan;Koo, Young-Mo
    • Journal of Biosystems Engineering
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    • v.36 no.6
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    • pp.476-483
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    • 2011
  • The aerial application using an unmanned helicopter has been already utilized and an attitude controller would be developed to enhance the operational convenience and safety of the operator. For a preliminary study of designing flight controller, a state space model for an RC helicopter would be identified. Frequency sweep flight tests were performed and time history data were acquired in the previous study. In this study, frequency response of the flight test data of a small unmanned helicopter was analyzed by using the CIFER software. The time history flight data consisted of three replications each for collective pitch, aileron, elevator and rudder sweep inputs. A total of 36 frequency responses were obtained for the four control stick inputs and nine outputs including linear velocities and accelerations and angular velocities in 3-axis. The results showed coherence values higher than 0.6 for every primary control inputs and corresponding on-axis outputs for the frequency range from 0.07 to 4 Hz. Also the analysis of conditioned frequency response showed its effectiveness in evaluating cross coupling effects. Based on the results, the dynamic characteristics of the model helicopter can further be analyzed in terms of transfer functions and the undamped natural frequency and damping ratio of each critical mode.

Coherent Diffraction Imaging at PAL-XFEL

  • Kim, Sangsoo;Nam, Kihyun;Park, Jaehyun;Kim, Kwangoo;Kim, Bongsoo;Ko, Insoo
    • Proceedings of the Korean Vacuum Society Conference
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    • 2016.02a
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    • pp.85.2-85.2
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    • 2016
  • With the advent of ultra-short high-intense XFEL (X-ray Free Electron Laser), time-resolved dynamics has become of great importance in exploring femtosecond real-world phenomena of nanoscience and biology. These include studying the response of materials to femtosecond laser excitation and investigating the interaction of XFEL itself with condensed matter. A variety of dynamic phenomena have been investigated such as radiation damage, ultrafast melting process, non-equilibrium phase transitions caused by orbital-lattice-spin couplings. As far as bulk materials are concerned, the sample size has no effect on the following dynamic process. As a result, imaging information is not required by and large. If the sample size is of tens of nanometers, however, sample starts to experience quantum confinement effect which, in turn, affects the following dynamic process. Therefore, to understand the fundamental dynamic phenomena in nano-science, time-resolved imaging information is essential. In this talk, we will briefly introduce scientific highlights achieved in XFEL-based dynamics. In case of bio-imaging, recent scientific topics will be mentioned as well. Finally, we will aim to present feasible topics in ultrafast time-resolved imaging and to discuss the future plan of CXI beamline at PAL-XFEL.

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Experimental Investigation of the Response Characteristics of Korean -seated Subjects under Vertical Vibration: (II) Mechanical Impedances (한국인 앉은 자세에 대한 수직 진동 -응답특성의 실험적 연구 : (II) Mechanical Impedances)

  • 정완섭;김영태;권휴상;홍동표
    • Transactions of the Korean Society for Noise and Vibration Engineering
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    • v.13 no.9
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    • pp.713-719
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    • 2003
  • This paper introduces attempts to obtain the ‘representative’ characteristics of the mechanical impedance of seated Korean subjects under vertical vibration. Individual responses of driving-point mechanical impedance obtained from forty one Korean subjects are illustrated. Four kinds of vibration levels and three different sitting postures are selected to collect the responses of each subject. Those individual responses are used to estimate the ‘mean’ mechanical impedance, which may be expected to be a representative model to Korean subjects. Several interesting features of the estimated mechanical impedance are suggested and compared to those of ISO/DIS 5982.

Study on the Thermal and Dynamic Behaviors of Air Spring for vibration isolation of LCD panel inspecting machine connected with an External Chamber through a flexible tube: PART I, Theoretical Modeling (외부챔버와 유연한 튜브로 연결된 LCD 패널 검사기 방진용 공기 스프링의 열 및 동적 연성거동에 대한 연구: PART I, 이론적 모델링)

  • Seok, Jong-Won;Lee, Ju-Hong;Kim, Pil-Kee
    • Journal of the Semiconductor & Display Technology
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    • v.10 no.1
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    • pp.33-41
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    • 2011
  • Due to the recent quantum leaps forward in bio-, nano-, and information-technologies (BT, NT and IT), the precisionization and miniaturization of mechanical and electrical components are in high demand. In particular, the ITrelated equipments that take a great part in our domestic industry are in the area requiring high precision technologies. As a consequence, the researches on the development vibration isolation systems that diminish external disturbance or internal vibration are highly required. Among the components comprising the vibration isolation system, air spring has become on a focal point for the researchers due to its merits. This air spring is able to support heavy loads, keep a low natural frequency despite of having a lower value of stiffness, and control the performance of vibration isolation. However, sometimes the sole use of air spring is in demand due to some economic reasons. Under this circumstance, the damping effect of sole air spring may not enough to reduce sufficient amount of vibration. In this study, the air spring mount system connecting with an external chamber is proposed to increase or control the damping effect. To investigate its damping mechanism, the thermal and dynamic behaviors of the system is examined through a theoretical modeling approach in this part of research. In this approach, thermomechanical and Helmholtz resonator type models are to be employed for the air spring/external chambers and connecting tube system, respectively. The frequency response functions (FRFs) derived from the modeling effort are evaluated with physical parametric values and the effects of connecting tube length on these FRFs are identified through computer simulations.

A Heuristic Approach for Simulation of time-course Visual Adaptation for High Dynamic Image Streams

  • Kelvin, Bwalya;Yang, Seung-Ji;Choi, Jong-Soo;Park, Soo-Jun;Ro, Yong-Man
    • Annual Conference of KIPS
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    • 2007.05a
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    • pp.285-288
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    • 2007
  • There is substantial evidence from earlier researches that older adults have difficult seeing under low illumination and at night, even in the absence of ocular diseases. During human aging, there is a rampant decrease in rod/cone-meditated adaptation which is caused by delayed rhodopsin regeneration and pigment depletion. This calls for a need to develop appropriate visual gadgets to effectively aid the aging generation. Our research culminates its approach from Pattanaik's model by making extensions to temporal visual filtering, thereby simulating a reduction of visual response which comes with age. Our filtering model paves way and lays a foundation for future research to develop a more effective adaptation model that may be further used in developing visual content adaptation aids and guidelines in MPEG 21 environment. We demonstrate our visual model using a High Dynamic Range image and the experiment results are in conversant with the psychophysical data from previous vision researches.