• The Korea Genome Conference
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• 2005.09a
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• pp.70-70
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• 2005

• Maxillofacial Plastic and Reconstructive Surgery
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• v.32 no.2
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• pp.149-153
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• 2010

The purpose of this retrospective study was to evaluate relapse, comparing large and small maxillary advancements with four-plate rigid fixation and without bone grafting. All patients had skeletal class III malocclusion, and underwent bimaxillary surgery. Standardized cephalometric analysis by one examiner was performed on serial radiographs of 14 patients immediately before surgery, and within 1 week and at least 6 months postoperatively (mean 10 months). The group was divided into two subsets to determine whether the magnitude of relapse. In group 1 ($\leq$ 5 mm, n = 8), the average advancement was $4.0{\pm}0.9\;mm$, with a mean relapse of $0.1{\pm}0.5\;mm$. In group 2 (6-8 mm, n = 4), the average advancement was $6.8{\pm}0.9\;mm$, with a mean relapse of $0.7{\pm}0.4\;mm$. There was no statistical difference in the measured relapse among the groups. Maxillary advancement with a 1-piece Le Fort I osteotomy is a relatively stable procedure.

• The Plant Pathology Journal
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• v.25 no.1
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• pp.77-85
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• 2009

Pseudomonas fluorescens strain Gpf01, isolated from ginseng rhizosphere showed antiviral activity against Cucumber mosaic virus, when tested in a local host of CMV, Chenopodium amaranticolor. Transposon mutant library of Gpf01 was prepared using pGS9::Tn5 and the mutant Gpf01-RS19 was found to loose antiviral production. We developed primers from the flanking region of Tn5 and found a cosmid clone pAV1123, harboring 1.2 kb antiviral compound producing (avcf01) locus. When a sub-clone pPH9, which carried 9.3 kb region of pAV1123, was introduced into antivirus deficient P. fluorescens wild type strain B16, it exhibited antiviral activity. Using Tn3-gus mutagenesis and complementation analysis, it was found that the genes related to antiviral activity production resided in a 9.3 kb HindIII-HindIII fragment of pAV1123, indicating that the plasmid carries an essential genes promoting antiviral activity.

• Proceedings of the Korean Society for Bioinformatics Conference
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• 2003.10a
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• pp.251-257
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• 2003

Metabolic engineering has become a new paradigm for the more efficient production of desired bioproducts. Metabolic engineering can be defined as directed modification of cellular metabolism and properties through the introduction, deletion, and modification of metabolic pathways by using recombinant DNA and other molecular biological tools. During the last decade, metabolic flux analysis(MFA) has become an essential tool fur metabolic engineering. By MFA, the intracellular metabolic fluxes can be quantified by the measurement of extracellular metabolite concentrations in combination with the stoichiometry of intracellular reactions and mass balances. The usefulness and functionality of MFA are demonstrated by applying to metabolic pathways in E. coli. First, a large-scale in silico E. coli model is constructed, and then the effects of carbon sources on intracellular flux distributions and succinic acid production were investigated on the basis of the uptake and secretion rates of the relevant metabolites. The results indicated that succinic acid yields increased in order of gluconate, glucose and sorbitol. Acetic acid and lactic acid were produced as major products rather than when gluconate and glucose were used carbon sources. The results indicated that among three carbon sources available, the most reduced substrate is sorbitol which yields efficient succinic acid production.

• Journal of the Korean Society of Industry Convergence
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• v.20 no.1
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• pp.8-18
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• 2017

This research analyzed the ventilation effect of the multi-span greenhouse based on the types of greenhouse structure, weather conditions, and locations inside the greenhouse. To compare and analyze the ventilation effects with different types of greenhouse, the uniform environmental conditions should be selected in advance. But these factors are not controlled and require tense many precision facilities and labor forces. Thus, the CFD simulation was used for the air stream to be analyzed qualitatively and quantitatively. In addition, for the ventilation effect analysis, the TGD (Tracer Gas Decay) was used to overcome the shortcomings of the current ventilation measurement method. The calculation error of ventilation rate using TGD was low (10.5%). Thus, the TGD is very effective in calculating the ventilation efficiency. The wind direction of 90 degrees showed the best ventilation effect. The ventilation rate also decreased along the air circulation path, and the rate was the lowest around the outlet. The computed fluid method (CFD) turned out to be a power tool for simulating flow behavior in greenhouse.

• The Journal of the Korea Contents Association
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• v.8 no.6
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• pp.74-81
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• 2008

Protein interaction network contains a small number of highly connected protein, denoted hub and many destitutely connected proteins. Recently, several studies described that a hub protein is more likely to be essential than a non-hub protein. This phenomenon called as a centrality-lethality rule. This nile is widely credited to exhibit the importance of hub proteins in the complex network and the significance of network architecture as well. To confirm whether the rule is accurate, we Investigated all protein interaction DBs of yeast in the public sites such as Uetz, Ito, MIPS, DIP, SGB, and BioGRID. Interestingly, the protein network shows that the rule is correct in lower scale DBs (e.g., Uetz, Ito, and DIP) but is not correct in higher scale DBs (e.g., SGD and BioGRID). We are now analyzing the features of networks obtained from the SGD and BioGRD and comparing those of network from the DIP.

• Journal of Biomedical Engineering Research
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• v.32 no.1
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• pp.37-44
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• 2011

This paper describes the development and assessment of conductive fabric sensor for evaluating knee movement using bio-impedance measurement method. The proposed strip-typed conductive fabric sensor is compared with a dot-typed Ag/AgCl electrode for evaluating validity under knee movement condition. Subjects are composed of ten males($26.6{\pm}2.591$) who have not had problems on their knee. The strip-typed conductive fabric sensor is analyzed by correlation and reliability between a dot-typed Ag/AgCl electrode and the strip-typed conductive fabric sensor. The difference of bio-impedance between a dot-typed Ag/AgCl electrode and the strip-typed conductive fabric sensor averages $7.067{\pm}13.987\;{\Omega}$ As the p-value is under 0.0001 in 99% of t-distribution, the strip-typed conductive fabric sensor is correlated with a dot-typed Ag/AgCl electrode by SPSS software. The strip-typed conductive fabric sensor has reliability when it is compared with a dot-typed Ag/AgCl electrode because most of bio-impedance values are in ${\pm}1.96$ standard deviation by Bland-Altman Analysis. As a result, the strip-typed conductive fabric sensor can be used for assessing knee movement through bio-impedance measurement method as a dot-typed Ag/AgCl electrode. Futhermore, the strip-typed conductive fabric sensor is available for wearable circumstances, applications and industries in the near future.

• Environmental Analysis Health and Toxicology
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• v.21 no.2 s.53
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• pp.147-151
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• 2006

난생 생물의 알 생성유도 단백질인 비텔로제닌(viteILogenin, VTG)을 성숙한 암컷 황소개구리 (Rana catesbeiana)혈청으로부터 음이온 교환 크로마토그래피를 이용하여 정제 하였으며 정제한 비텔로제닌을 BALB/c mice에 주사하여 폴리크로날 항체를 생산하였고 이것은 protein A column으로 정제 하였다. 이렇게 정제된 폴리크로날 항체를 이용하여 황소개구리 비탈로제닌 측정용 효소면역측정법을 개발하였으며 그 측정 범위는 $12{\sim}1,560ng/mL$였다. 또한 이 효소면역측정법을 평가하기 위해 성숙한 수컷 황소개구리를 청정지역과 폐수처리장 하류 하천에서 서식하는 황소개구리 혈액 속의 비텔로제닌을 측정하였다. 그 결과 폐수처리장 하류 하천에 서식하는 수컷 황소개구리 비텔로제닌이 청정지역보다 현저하게 높게 유도됨을 알 수 있었다.

• Korean Journal of Medicinal Crop Science
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• v.28 no.3
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• pp.200-208
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• 2020

Background: Salvia miltiorrhiza Bunge has been used in traditional medicine. The type of light source has an effect on the growth properties and composition of functional compounds in plants. In this study, we analyzed the effects of different artificial light sources on the growth characteristics as well as antioxidant and antimicrobial activities of S. miltiorrhiza. Methods and Results: Seedlings of S. miltiorrhiza were grown under various artificial light sources, including fluorescent light (FL), light emitting diode (LED), and microwave electrodeless light (MEL), for 8 weeks. Growth characteristics were the best in plants treated with MEL. DPPH scavenging activity of the shoot was more pronounced with the FL treatments, while the roots were more active in plants grown under single wavelength lights (i.e., blue and red LEDs). Among the different light source treatments, the blue LED resulted in a higher total phenolic content in the plants. Furthermore, growing plants growth under the red LED enhanced their total flavonoid content. Notably, the antimicrobial properties of plants varied significantly between light source treatments in this study. Except for E. coli, all the tested microorganisms were susceptible to the plant extracts. Conclusions: The type of light source may be an important parameter for the enhancement of plant growth and functional compounds in S. miltiorrhiza.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.36 no.1
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• pp.39-42
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• 2010

Maxillary sinus lift and bone graft are used to reconstruct atrophic maxilla molar area for endosseous dental implants. Many different grafting materials and techniques can be used for maxillary sinus bone graft. Bio-$Oss^{(R)}$ has been proposed as bone substitute and successfully utilized as osteoconductive filler. Platelet rich plasma (PRP) is an autologous material with many growth factors, such as PDGF, TGF-$\beta$, IGF, VEGF, facilitating bone healing process. And Platelet poor plasma (PPP) is the by-product in procedure of producing PRP. Six rabbits were used as experimental animal. Both maxillary sinus were grafted with Bio-$Oss^{(R)}$ and PRP, and Bio-$Oss^{(R)}$ and PPP. Rabbits were sacrificed at 4, 8 and 12 weeks. The grafting sites were evaluated by histomorphometric analysis. As a result, using PRP showed excellent bone formation in the early stage, but no further significant effect after that. In late stage, the ability of bone formation of using PRP was even worse than using PPP. The further studies need to be considered in this case.