Journal of the Korean Association of Oral and Maxillofacial Surgeons

  • 제36권1호
  • /
  • Pages.39-42
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  • 2010
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  • 2234-7550(pISSN)
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  • 2234-5930(eISSN)
대한구강악안면외과학회 (The Korean Association of Oral and Maxillofacial Surgeons)
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가토 상악동 거상술 후 Bovine Bone (Bio-$Oss^{(R)}$)과 함께 이식된 혈소판풍부혈장과 혈소판결핍혈장의 골치유능 비교

Effect of bovine bone (Bio-$Oss^{(R)}$) and platelet rich plasma, platelet poor plasma on sinus bone graft in rabbit

  • 이태형 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 정유민 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 최용근 (EB 치과) ;
  • 이의석 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 장현석 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 임재석 (고려대학교 의과대학 구강악안면외과학교실)
  • Lee, Tai-Hyung (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University) ;
  • Jeong, You-Min (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University) ;
  • Choi, Yong-Kun (EB Dental Clinic) ;
  • Lee, Eui-Seok (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University) ;
  • Jang, Hyon-Seok (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University) ;
  • Rim, Jae-Suk (Department of Oral and Maxillofacial Surgery, College of Medicine, Korea University)
  • 발행 : 2010.02.26
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초록

Maxillary sinus lift and bone graft are used to reconstruct atrophic maxilla molar area for endosseous dental implants. Many different grafting materials and techniques can be used for maxillary sinus bone graft. Bio-$Oss^{(R)}$ has been proposed as bone substitute and successfully utilized as osteoconductive filler. Platelet rich plasma (PRP) is an autologous material with many growth factors, such as PDGF, TGF-$\beta$, IGF, VEGF, facilitating bone healing process. And Platelet poor plasma (PPP) is the by-product in procedure of producing PRP. Six rabbits were used as experimental animal. Both maxillary sinus were grafted with Bio-$Oss^{(R)}$ and PRP, and Bio-$Oss^{(R)}$ and PPP. Rabbits were sacrificed at 4, 8 and 12 weeks. The grafting sites were evaluated by histomorphometric analysis. As a result, using PRP showed excellent bone formation in the early stage, but no further significant effect after that. In late stage, the ability of bone formation of using PRP was even worse than using PPP. The further studies need to be considered in this case.

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참고문헌

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