• Journal of the Institute of Electronics and Information Engineers
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• v.52 no.3
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• pp.3-12
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• 2015

Recently, various studies have been attempted to provide a biological information monitoring service through integrating with the web service. The medical information transmission standard ISO/IEEE 11073 PHD defines the optimized exchange protocol ISO/IEEE 11073-20601 based on the No-IP to exchange the biometric information between the ISO/IEEE 11073 agent and the manager. It's system structure based on the No-IP using ISO/IEEE 11073-20601 is not suitable for providing a remote biological information monitoring services. That is because it is difficult to provide to control and manage the biological information measurement devices, which have installed IP protocol stack at the remote. Furthermore, ACSE and CMDISE in ISO/IEEE 11073-20601 are not suitable to provide U-healthcare services based on IoT because they are complicated and difficult to implement it caused by the structural complexity. In order to solve the problems, in this paper, we propose the biological information monitoring architecture based on ISO/IEEE 11073 DIM/REST of IoT environment to provide the biological information monitoring service based on IoT. To do this, we designed biological information monitoring system architecture based on IoT and the message exchange protocol of ISO/IEEE 11073 DIM/REST between the ISO/IEEE 11073 agent and the ISO/IEEE 11073 manager. In order to verify the realistic possibility of the proposed system architecture, we developed the service prototype.

• Journal of Ecology and Environment
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• v.31 no.1
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• pp.45-67
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• 2008

Ocean climate variables ($1900{\sim}2005$), time series of catches ($1910{\sim}2005$) and body size data were used to assess the year-to-year and decadal scale fluctuations in abundance of the fish populations (Japanese sardine, anchovy, jack mackerel, chub mackerel, Pacific saury and common squid) that have spawning grounds in the East China Sea and its adjacent regions. A negative correlation between the abundance of pelagic fishes (e.g. jack mackerel) in the Tsushima Warm Current (TWC) region and the Kuroshio-Oyashio Current (KOC) region was attributed to the climatic modulation of larval transport and recruitment, which depends on the winter monsoon-induced drift, current systems, and spawning season and site. The changes in abundance and alternation of dominant fish populations in the two regions in the 1930s, 1970s, and late 1980s mirrored changes in the climate indices (ALPI, AOI and MOI). Oscillations in the decadal climate shifts between the two regions led to zonal differences in larval transport and recruitment, and hence differences in the abundance of the pelagic fish populations. During deep Aleutian Lows, as in the 1980s, larval transport from the East China Sea to the KOC region increases in association with the strong winter Asian monsoon, cool regime and increased volume transport of the Kuroshio Current systems, whereas during a weak Aleutian Low (as in the 1990s), larval transport to the TWC region increased in association with a weak winter Asian monsoon, a warm regime, and increased volume transport of the Tsushima current system. We postulate that the increased chub mackerel abundance in the TWC region and the decreased abundance in the KOC region in the 1990s are partly attributed to changes in recruitment and availability to the fishing fleets under the warm regime in the spawning and nursery grounds in the East China Sea in association with the quasi-steady state of mild winter monsoon in the 1990s. The fluctuations in chub mackerel and jack mackerel abundance are under the environment-dependant growth form, although the tropicalization was identified in the TWC region. The density-dependant growth form was found in Japanese sardine populations, but no tropicalization by fishing was identified in the long ($10{\sim}15$ year) periods of abundance despite their short ($3{\sim}4$ year) generation time, suggesting that the environment-dependant growth form drove the changes in abundance. Year-to-year and decadal scale variations in abundance and population structure of the Pacific saury responded to climate regime shifts (1976/1977, 1988/1989), suggesting that the fish is a key bio-indicators for changes in the ecosystem.

• Journal of the Korean Society of Food Science and Nutrition
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• v.41 no.7
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• pp.907-913
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• 2012

Piceatannol (trans-3,4,3',5'-tetrahydroxystilbene) is a polyphenol detected in grapes, rhubarb, and sugarcane. Although recent experimental data revealed that this compound is known to exhibit immunosuppressive and antitumorigenic activities in several cell lines, the molecular mechanisms underlying anticancer activity are poorly understood. In the present study, we investigated possible further mechanisms by which piceatannol exerts its anti-proliferative action in cultured human gastric cancer AGS cells. Piceatannol treatment resulted in the inhibition of growth and G1 arrest of the cell cycle in a concentration-dependent manner, as determined by MTT assay and flow cytometry analysis. The induction of G1 arrest by piceatannol was associated with the modulation of cyclin-dependent kinases (Cdks) and cyclins, up-regulation of the expression of Cdk inhibitor p21 (WAF1/CIP1) in both transcriptional and translational levels, and the inhibition of phosphorylation of retinoblastoma proteins and E2F1 expression. In addition, piceatannol treatment caused a progressive decrease in the expression levels of cyclooxygenase (COX)-2 without significant changes in the levels of COX-1, which was correlated with a decrease in prostaglandin $E_2$ synthesis.

• Journal of Oral Medicine and Pain
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• v.24 no.2
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• pp.207-217
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• 1999

This study was performed to investigate the effects of clutch adaptation on the mandibular rotational torque movement in normal people. 69 dental students were selected for the study. Their mean age were 23.6 years and they did not present any signs and symptoms of temporomandibular disorders. $BioEGN^{(R)}$ with $Rotate^{(R)}$ program was used to observe and record the amount of mandibular rotational torque on protrusion, on right excursion, on left excursion, and on comfortable wide opening movement. The natural tooth contact movement and the movement with clutch were performed in the above four each mandibular movement. Clutch was made by the method used in $Pantronic^{(R)}$ clutch fabrication. Distance of slant frontal which was translatory trajectory in frontal plane and degree of rotational torque in horizontal and in frontal plane were recorded. The data obtained were processed with SPSSWIN program and the results were as follows : 1. Distance of slant frontal in each mandibular movement generally increased with clutch. 2. Degree of rotational torque in horizontal and in frontal plane on protrusion and on lateral excursions did not increase with clutch, but the degree on wide opening increased with clutch. 3. Degree of rotational torque in horizontal plane on protrusion and on lateral excursions did not show any difference between right and left side, but the degree in frontal plane on protrusion and on lateral excursions showed significant difference between right and left side. 4. Total amount of rotational torque from right and left sides on protrusion and lateral excursions were not increased with clutch, but the degree on wide opening movement was increased with clutch. And in this case, degree in horizontal plane was larger than that in frontal plane. 5. Correlation between total amount of rotational torque in horizontal plane and that in frontal plane were highly significant on protrusion and on lateral excursions with or without clutch, but the significant correlation on wide opening without clutch became not significant with clutch.

• Interdisciplinary Bio Central
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• v.3 no.3
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• pp.10.1-10.8
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• 2011

Introduction: Hash functions are computer algorithms that protect information and secure transactions. In response to the NIST's "International Call for Hash Function", we developed a biological hash function using the computing capabilities of bacteria. We designed a DNA-based XOR logic gate that allows bacterial colonies arranged in a series on an agar plate to perform hash function calculations. Results and Discussion: In order to provide each colony with adequate time to process inputs and perform XOR logic, we designed and successfully demonstrated a system for time-delayed bacterial growth. Our system is based on the diffusion of ${\ss}$-lactamase, resulting in destruction of ampicillin. Our DNA-based XOR logic gate design is based on the op-position of two promoters. Our results showed that $P_{lux}$ and $P_{OmpC}$ functioned as expected individually, but $P_{lux}$ did not behave as expected in the XOR construct. Our data showed that, contrary to literature reports, the $P_{lux}$ promoter is bidirectional. In the absence of the 3OC6 inducer, the LuxR activator can bind to the $P_{lux}$ promoter and induce backwards transcription. Conclusion and Prospects: Our system of time delayed bacterial growth allows for the successive processing of a bacterial hash function, and is expected to have utility in other synthetic biology applications. While testing our DNA-based XOR logic gate, we uncovered a novel function of $P_{lux}$. In the absence of autoinducer 3OC6, LuxR binds to $P_{lux}$ and activates backwards transcription. This result advances basic research and has important implications for the widespread use of the $P_{lux}$ promoter.

• The Journal of Korean Orthopaedic Ultrasound Society
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• v.4 no.2
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• pp.101-110
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• 2011

To describe the background, mechanism, clinical results and complications of prolotheapy based on the literature review. Prolotherapy is a minimally invasive injection-based treatment of chronic musculoskeletal pain, including ligament and joint laxity. The mechanism of this injection-based technique is to initiate a local inflammatory response with resultant tissue healing. The used proliferants are classified by bio-mechanism to act in three different ways as osmotic, irritants, and chemotatics. The most commonly used proliferant is hyperosmolar (10~25%) dextrose to act by osmotic rupture of cells. High resolution ultrasound imaging of musculoskeletal structure provide a more accurate diagnosis. Also ultrasound-guided intervention provides a more high efficacy and low rate of complications. The most common complication is local pain at the injected site, that is self-limited and good responsive to anti-inflammatory agents. Other complications are rare. It is reported that prolotherapy appears safe when performed by an experienced clinician. Prolotherapy has grown in popularity and has received significant recent attention. However there are limited evidence-based data supporting the indication and efficacy of prolotherapy in the treatment of chronic musculoskeletal pain or soft tissue injuries. Future studies are necessary to determine whether prolotherapy can play an independent and definitive role in a treatment for chronic musculoskeletal pain.

• Journal of Life Science
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• v.29 no.12
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• pp.1358-1363
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• 2019

In this study, the effect on the free amino acid content and anti-oxidative activity of Arctium lappa samples by heat treatment were compared to obtain data on the conditions required for properly processing the root as a raw material for tea. The results of DPPH and ABTS radical scavenging activity assays showed that 180℃-4 min and 200℃-3 min treatments retained relatively high activity. All heat treatment conditions showed increased polyphenol content compared to the initial sample value of 42.72 mg/l, and the 180℃-4 min and 200-3 min treatments were higher than the others at 60.09 mg/l and 62.74 mg/l, respectively. In the free amino acid analysis of the A. lappa root tea, the tendency of the initial content was confirmed to decrease as temperature and time increased. Changes in phenylalanine, histidine, leucine, and isoleucine were found to be high, while aspartic acid and proline changes were relatively low. Overall, amino acid content decreased significantly under heating conditions above 180℃-3 min and 200℃-2 min. From these results, heat treatment of A. lappa root at 180℃-4 min was deemed optimal based on anti-oxidative activity and free amino acid content.

• Korean Journal of Remote Sensing
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• v.31 no.5
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• pp.473-490
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• 2015

There are diverse sea areas within the coverage of GOCI which is observed around the Korea at one-hour intervals. It includes not only very clear ocean of East Sea, but also extremely turbid waters of the Yangtze River estuary. In this study, we analyzed the different optical characteristics of various sea areas using absorption coefficients of phytoplankton, Suspended Particulate Matter(SPM), Dissolved Organic Matter(DOM). Totally 959 sets of bio-optical and marine environmental data were obtained from 2009 to 2014 around the sea area of Korea. The East Sea, South Sea, East China Sea and offshore part of Yellow Sea showed similar pattern having high levels of contribution of phytoplankton and DOM. On the other hands, the coastal part of Mokpo and Gyeonggi Bay showed opposite pattern having high levels of contribution of SPM and DOM. As a result of the algorithm performance for chlorophyll-a(Chl-a) and SPM, Chl-a is mostly overestimated and SPM is mainly tended to be underestimated. Large amount of errors are induced by the SPM rather than the chl-a and DOM. These errors are primarily founded in the coastal waters having relatively high levels of $a_{SPM}$ contribution of more than 60%.

• Weed & Turfgrass Science
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• v.4 no.1
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• pp.44-48
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• 2015

This study was conducted to evaluate the efficacy of weed control and phytotoxicity of oxyfluorfen using a transgenic rice line (CPPO06 event) resistant to protoporphyrinogen oxidase (Protox) inhibiting herbicides in the direct-seeding flooded rice. Five annual weeds including Echinochloa oryzoides and two perennial weeds were occurred in the test field. Oxyfluorfen at 120 g a.i. $ha^{-1}$ in the application timing of two days before sowing and 0 and five days after sowing showed more than 90% weed control value except for Juglans mandshurica. Total weed control value was more than 95% in any application timing indicating a highly effective herbicide in the direct-seeding flooded rice. When compared with untreated control, no visual injuries were detected at single and double dosage of oxyfluorfen. The agronomic characteristics and yield components of CPPO06 event was reasonable in any time of application in this study. Based on these data, oxyfluorfen application before and after sowing can be applied to provide effective weed management in the direct-seeding flooded field.

• Nuclear Medicine and Molecular Imaging
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• v.43 no.5
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• pp.451-458
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• 2009

Purpose: Optical molecular luminescence imaging is widely used for detection and imaging of bio-photons emitted by luminescent luciferase activation. The measured photons in this method provide the degree of molecular alteration or cell numbers with the advantage of high signal-to-noise ratio. To extract useful information from the measured results, the analysis based on a proper quantification method is necessary. In this research, we propose a quantification method presenting linear response of measured light signal to measurement time. Materials and Methods: We detected the luminescence signal by using lab-made optical imaging equipment of animal light imaging system (ALIS) and different two kinds of light sources. One is three bacterial light-emitting sources containing different number of bacteria. The other is three different non-bacterial light sources emitting very weak light. By using the concept of the candela and the flux, we could derive simplified linear quantification formula. After experimentally measuring light intensity, the data was processed with the proposed quantification function. Results: We could obtain linear response of photon counts to measurement time by applying the pre-determined quantification function. The ratio of the re-calculated photon counts and measurement time present a constant value although different light source was applied. Conclusion: The quantification function for linear response could be applicable to the standard quantification process. The proposed method could be used for the exact quantitative analysis in various light imaging equipments with presenting linear response behavior of constant light emitting sources to measurement time.