• International Journal of Vascular Biomedical Engineering
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• 제3권1호
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• pp.6-13
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• 2005

Individual clinical significance of each layer of CCA (common carotid artery) has not been well studied. We intended to measure the intima thickness (IT), media thickness (MT), and intima-media thickness (IMT) of CCA separately and tried to analyze the clinical significance. One hundred fifty one consecutive patients (mean age: $57{\pm}15$ years; 77 males, 74 females) underwent CCA scanning using high-resolution ultrasound. The images were off-line analyzed using B-mode ultrasound image processing, devised for individual measurement of IT and MT as well as IMT. The mean coefficients of variation of new method measuring IT, MT, and IMT separately were 0.16% for IMT and 0.21% for both IT and MT. The IT (p < 0.01), MT (p < 0.01) as well as IMT (p < 0.001) of patients with atherosclerotic disease were significantly thicker than that of the patients without atherosclerotic disease. Patients with hypertension showed significantly thicker IT (p < 0.01), MT (p < 0.001), and IMT (p < 0.001) than that of the patients without hypertension. However, only IT was thicker in patients with smoking (p<0.01) than that of the patients without smoking.

• International Journal of Vascular Biomedical Engineering
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• 제3권1호
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• pp.14-22
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• 2005

In the present study, our aim is to investigate whether responses to the head-up tilt (HUT) on nonlinear properties of heart rate variability (HRV) in young and elderly subjects are different or not. Thirteen young-healthy subjects ($24.5{\pm}3.7$ years) and 18 old-aged healthy subjects ($74.5{\pm}7.4$ years) participated in this study. An electrocardiogram (ECG) in the supine posture, at $0^{\circ}$, and in the standing posture, at $70^{\circ}$ of head-up tilt, was recorded. Detrended fluctuation analysis (DFA) and approximate entropy (ApEn), measures of short-/long-term correlation properties and overall complexity of heart rate (HR) respectively, along with spectral components of HR variability (HRV) were analyzed for both the supine and HUT postures. We observed that the short-term fractal exponent ${\alpha}_1$ increased during HUT posture (F(1, 29) = 39.79, P = 0.000), especially, the young subjects showed a significantly higher values compared to the elderly subjects. ApEn significantly decreased (F(1, 29) = 8.61, P = 0.006) during HUT posture. HUT posture decreased the complexity in HR dynamics and increased short-term fractal exponent values in young subjects but not in elderly subjects. These results imply that there are differences of response to HUT on nonlinear properties between young and elderly subjects.

• Journal of Microbiology
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• 제45권6호
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• pp.541-546
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• 2007

Red algae are distributed globally, and the group contains several commercially important species. Griffithsia okiensis is one of the most extensively studied red algal species. In this study, we conducted expressed sequence tag (ESTs) analysis and synonymous codon usage analysis using cultured G. okiensis samples. A total of 1,104 cDNA clones were sequenced using a cDNA library made from samples collected from Dolsan Island, on the southern coast of Korea. The clustering analysis of these sequences allowed for the identification of 1,048 unigene clusters consisting of 36 consensus and 1,012 singleton sequences. BLASTX searches generated 532 significant hits (E-value <$10^{-4}$) and via further Gene Ontology analysis, we constructed a functional classification of 434 unigenes. Our codon usage analysis showed that unigene clusters with more than three ESTs had higher GC contents (76.5%) at the third position of the codons than the singletons. Also, the majority of the optimal codons of G. okiensis and Chondrus crispus belonging to Bangiophycidae were G-ending, whereas those of Porphyra yezoensis belonging to Florideophycidae were G-ending. An orthologous gene search for the P. yezoensis EST database resulted in the identification of 39 unigenes commonly expressed in two rhodophytes, which have putative functions for structural proteins, protein degradation, signal transduction, stress response, and physiological processes. Although experiments have been conducted on a limited scale, this study provides a material basis for the development of microarrays useful for gene expression studies, as well as useful information for the comparative genomic analysis of red algae.

• 한국소음진동공학회논문집
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• 제23권3호
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• pp.258-266
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• 2013

This paper presents the correlation between psychological and physiological acoustics for the automotive acceleration sound. The research purpose of this paper is to evaluate the sound quality of acceleration sound of a passenger car based EEG signal. The previous method for the objective evaluation of sound quality is to use sound metrics based on psychological acoustics. This method uses not only psychological acoustics but also physiological acoustics. For this work, the sounds of 7 premium passenger cars are recorded and evaluated subjectively by 33 people. The correlation between the subjective rating and sound metrics is calculated based on physiological acoustics. Finally the correlation between the subjective rating and the EEG signal measured on the brain is also calculated. Throughout these results the new evaluation system for the sound quality on the automotive acceleration sound of a passenger car has been developed based on bio-signal.

• 패션비즈니스
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• 제22권1호
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• pp.41-55
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• 2018

The purpose of this study was to investigate the trends of product design for textile convergence wearable smart textile fashion products according to college students' fashion life style. In this study, we used information obtained from a questionnaire issued to 201 female college students who were 20 years old for the final analysis. The questionnaires were to classify female college students groups according to the fashion life style, to examine characteristics, needs and wants of each group. The survey on the tendency of wearable smart textiles consisted of 22 items about concept and type of smart clothing product, functional material and intelligent material, recognition, preference, purchase intention, purchase factor and brand preference tendency. A total of 201 samples were analyzed by factor analysis, cluster analysis, ANOVA, crosstabs and $x^2-test$ using SPSS package program. 'brand preference oriented type was found to be interested in 'wearable' smart clothing product with monitoring function of bio-signal' and 'high functional fiber and textile product', but the credibility of 'smart clothes that can be worn and smart textile products to be useful in modern life' was low. 'fashionable individuality oriented' type showed interest in 'smart clothing and smart product', 'intelligent fiber' and 'wearable smart clothing product with monitoring function of bio-signal', but the preferences of 'light emitting fiber products' was low. 'practically purchasing-oriented' type was very interested in 'high-functional fiber and its textile products', but had inadequate knowledge on 'smart clothing and smart textile product' and showed low interest. Despite the fact that 'wearable smart clothing and smart textile products' are expensive, they were willing to purchase considering practicality and sophisticated style.

• 전자공학회논문지
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• 제54권7호
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• pp.103-109
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• 2017

병원 현장에서 환자 모니터링 시스템을 적용하기 위해서는 환자감시장치에서 기본적으로 다루고 있는 주요 생체신호의 측정과 데이터의 분석이 가능해야 한다. 본 논문에서는 이러한 요구사항을 수용하고자 심전도와 산소포화도 측정이 가능한 웨어러블 디바이스와 환자 모니터링 시스템을 구현하였다. 구현된 시스템은 측정된 생체신호를 블루투스를 통해 간호스테이션 상의 서버로 전송되고 환자 모니터링 시스템에서 의료진이 확인할 수 있는 그래프 파형과 수치로 표현된다. 설계한 시스템을 통해 수집된 데이터와 기존 장비에서 얻어진 데이터를 비교하여 본 시스템의 유효성을 검증하였다.

• 대한교통학회지
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• 제24권7호
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• pp.7-14
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• 2006

최근 개통되고 있는 고속도로는 설계속도 및 제한속도가 상향되고 있어 주행환경의 양호성 확보와 함께 이에 따른 다양한 안전시설물들이 설치되고 있다. 특히 양호한 선형으로 인한 졸음운전이나 야간 및 이상기후로 차로를 제대로 볼 수 없을 때 차량의 차로 이탈사고를 미리 방지할 수 있도록 하는 노면요철포장(rumble strip)의 설치가 꾸준히 증가하고 있다. 그러나 이러한 시설물이 운전자에게 미치는 효과의 크기가 얼마나 되는지에 대한 실질적인 연구가 미흡하여 명확한 효과를 제시하지 못하고 있는 실정이다. 본 연구에서는 운전 중인 운전자 뇌파를 측정하여 도로구간에서 적정한 데이터를 수집하고 수집된 자료로부터 노면요철포장(rumble strip)의 효과를 분석할 수 있는 방법 및 생체 신호 파라메터를 제시하였다. 분석결과 뇌의 중심엽 부위에서 추출된 세타파 값은 본선 2차로 주행구간에서 0.619, 노면요철포장(Rumble strip)구간에서 0.157으로 0.462가감소하여 본선 2차로 구간대비 약 74% 수치 감소를 보였으며 신뢰수준 95%에서 통계적으로 유의한 결과를 나타내었다. 이러한 수치의 감소는 운전자의 각성이 그 만큼 증가하였음을 의미하는 것으로 노면요철포장의 효과에 대한 운전자 측면의 수치적 해석이 가능함을 나타낸다

• 한국인터넷방송통신학회논문지
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• 제13권6호
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• pp.109-114
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• 2013

낮은 저항이나 좋은 전기투과도 지점으로 알려진 생물학적 활성점(biological active points, BAP)인 BAP검출을 위한 새로운 방법으로 적응주파수추적필터와 과도이벤트검출을 기반으로 하는 생체임피던스측정시스템을 사용하는 방식에 대해 제안하였다. 이 생체임피던스장치에 다중주파수 전류주입과 전압측정 모두 표면전극을 사용하였다. 또한 마이크로컨트롤러를 통하여 적응주파수추적필터를 사용한 다중주파수요소에 의해 변조된 신호의 연속적인 복조를 처리하였다. 또한 위상공간방식의 과도이벤트검출방식이 제안된 BAP등가모델에 각주파수에 대해 적용되었다.

• Mycobiology
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• 제41권1호
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• pp.37-41
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• 2013

Laccases (EC 1.10.3.2) are copper-containing polyphenol oxidases found in white-rot fungi. Here, we report the cloning and analysis of the nucleotide sequence of a new laccase gene, fvlac7, based on the genomic sequence of Flammulina velutipes. A primer set was designed from the putative mRNA that was aligned to the genomic DNA of F. velutipes. A cDNA fragment approximately 1.6-kb long was then amplified by reverse transcriptase-PCR using total RNA, which was subsequently cloned and sequenced. The cDNA sequence of fvlac7 was then compared to that of the genomic DNA, and 16 introns were found in the genomic DNA sequence. The fvlac7 protein, which consists of 538 amino acids, showed only 42~51% identity with 12 different mushroom species containing two laccases of F. velutipes, suggesting the fvlac7 is a novel laccase gene. The first 25 amino acids of Fvlac7 correspond to a predicted signal sequence, four copper-binding sites, and four N-glycosylation sites. Fvlac7 cDNA was heterologously overexpressed in an Escherichia coli system with an approximate expected molecular weight of 60 kDa.

• 한국엔터테인먼트산업학회논문지
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• 제14권2호
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• pp.165-176
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• 2020

최근 개인의 생체 데이터를 수집·활용하여 적시에 효과적인 예방과 치료를 제공하는 맞춤형 의료 및 서비스가 가능하며, 사용자의 헬스케어에 활용되고 있다. 실시간 건강관리 서비스로 개발하여 스마트폰, PC 태블릿 등을 활용하여 각 개인에게 정보를 제공·수집된 데이터를 통해 경보하고 관리자에게 분석 데이터 및 결과를 알려서 양방향 커뮤니케이션을 지원하며, 이에 따른 건강관리를 구성할 수 있는 시점에 직면하고 있다. 본 연구에서는 생체신호를 통한 헬스케어 디바이스와 실시간 건강관리 시스템을 포함하는 스마트 웨어러블 헬스케어 기술 동향을 분석하여 현재 시점에서의 기술개발 특허 출원에 대비하고자 한다. 스마트 웨어러블 헬스케어 기술 관련 특허는 연구개발 집중도가 비교적 높은 것으로 조사되었다. 분석 구간 전반에 걸쳐 한국은 실시간 헬스케어 시스템에 대한 특허 활동에 집중하고 있으며, 미국 및 유럽은 생체기술을 통한 헬스케어 디바이스에 대한 특허 활동을, 일본은 생체기술을 통한 헬스케어 디바이스 및 시스템 전반에 걸쳐 특허 활동을 활발하게 하는 것으로 나타났다. 생체기술을 통한 헬스케어 디바이스와 실시간 건강관리 시스템에 대한 특허는 최근 한국에서 시장을 주도하고 있으며, 해당 기술에 대한 특허 및 시장을 확보하고 있는 것으로 나타남에 따라 스마트 웨어러블 헬스케어 기술은 시장진입 장벽이 높은 분야로 판단된다. 향후 기술을 상업화시킬 계획이 있다면 제품의 형상, 제조방법 및 기타 관련 기술 시스템에 대한 특허권을 획득하여 특허 포트폴리오를 구축하는 것이 중요하다.