• 한국건축시공학회지
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• 제3권2호
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• pp.103-110
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• 2003

In the early 1990's the clean room system was a new trend of the operating room. This is the concept using in seminconductor plants. That is what the space around the operating table so clean as it remove contaminations with circulation of interior air. These articles describe the standard of interior construction and drawing details.

• 설비공학논문집
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• 제25권1호
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• pp.7-13
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• 2013

Bio Clean Room(BCR) and pharmaceutical product manufacturing facilities require careful assessment of many factors, including HVAC, controls, room finishes, process equipment, room operations, and utilities. Flow of equipment, personnel, and product must also be considered along with system flexibility, redundancy, and maintenance shutdown strategies. It is important to involve designers, operators, commissioning staff, quality control, maintenance, constructors, validation personnel, and the production representative during the conceptual stage of design. Critical variables for room environment and types of controls vary greatly with the clean space's intended purpose. It is particularly important to determine critical parameters with quality assurance to set limits and safety factors for temperature, humidity, room pressure, and other control requirements. In this paper, oxygen cluster ion equipment was utilized in order to enhance the indoor air quality and to prevent the airborne infection of ward in hospital. Moreover, the performance test of the equipment was also performed in order to develop the optimal sterilization system of BCR using the equipment.

• 산업경영시스템학회지
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• 제36권2호
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• pp.1-7
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• 2013

Cleanroom could be largely classified into industrial cleanroom that can be contaminated by particles and bio-cleanroom that can be contaminated by biological particles. Electrical manufacturing companies producing precision machines and electrical parts essentially have industrial cloom facilities and clean technologies to produce defects free products due to particles. Industrial cleanroom should be controlled in respect of 4M1E to prevent from foreign materials of sub-micro unit and to keep out contamination sources from outside. In this paper, a concept for a quantitative methodology to measure the particles from running components was suggested by combining both newly making clean booth such as wear tester and laser particle counter.

• 분석과학
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• 제25권3호
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• pp.190-196
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• 2012

납에 의한 노출에 대한 평가에는 주로 전혈 중 납을 사용하고 있으나 전혈 중 납은 납의 단기 노출에 대한 정보만을 제공한다는 단점이 있다. 납 노출의 만성적 노출지표인 혈장 중 납을 분석하기 위해서는 수 ng/L의 극미량 분석이 요구되어 납의 만성지표로서의 효용성 검증에 어려움이 있다. 본 연구에서는 납 노출 근로자의 만성 노출 지표로서 혈장 중 납을 분석하기 위하여 유도결합플라즈마 질량분석법을 정립하였다. 외부환경으로부터의 오염을 최소화시키기 위해 class 1,000 수준의 청정실을 설치한 후 가동 전과 후의 부유 분진량을 확인한 후 극미량 시료 분석을 수행하였다. 표준 우태아 혈청을 이용하여 표준물 첨가법에 의한 표준편차를 이용하여 계산한 최소검출한계는 4.3 ng/L, 최소정량한계는 12.2 ng/L이었으며, 신호-대-잡음 비로 계산한 최소검출한계는 7.0 ng/L, 최소정량한계는 22.1 ng/L이었다. 20 ng/L부터 2,000 ng/L 농도 범위에서 정밀도는 4% 이내였으며, 우태아 혈청에 20-2,000 ng/L의 농도로 첨가하여 계산한 회수율은 92.3-101.3%로 양호한 결과를 얻었다. 본 연구에서 제시한 방법을 사용하여 납 노출근로자의 혈장 및 혈청 중 납 분석이 가능하였으며 이를 통해 납의 만성노출에 대한 조사가 가능할 것으로 판단된다.

• Smart Structures and Systems
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• 제12권1호
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• pp.1-22
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• 2013

Magnetic nanoparticle based bioseparation in microfluidics is a multiphysics phenomenon that involves interplay of various parameters. The ability to understand the dynamics of these parameters is a prerequisite for designing and developing more efficient magnetic cell/bio-particle separation systems. Therefore, in this work proof-of-concept experiments are combined with advanced numerical simulation to design and optimize the capturing process of magnetic nanoparticles responsible for efficient microfluidic bioseparation. A low cost generic microfluidic platform was developed using a novel micromolding method that can be done without a clean room techniques and at much lower cost and time. Parametric analysis using both experiments and theoretical predictions were performed. It was found that flow rate and magnetic field strength greatly influence the transport of magnetic nanoparticles in the microchannel and control the capturing efficiency. The results from mathematical model agree very well with experiments. The model further demonstrated that a 12% increase in capturing efficiency can be achieved by introducing of iron-grooved bar in the microfluidic setup that resulted in increase in magnetic field gradient. The numerical simulations were helpful in testing and optimizing key design parameters. Overall, this work demonstrated that a simple low cost experimental proof-of-concept setup can be synchronized with advanced numerical simulation not only to enhance the functional performance of magneto-fluidic capturing systems but also to efficiently design and develop microfluidic bioseparation systems for biomedical applications.

• 설비공학논문집
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• 제24권7호
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• pp.578-584
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• 2012

In this study, the analysis on the distribution of indoor airflow velocity and temperature by using numerical simulation has carried out to make fundamental data for establishing the optimum design of laboratory animal facilities. From the results, it was found that replacement of cage lacks, air supply and exhaust system, supply air temperature, supply air velocity affect to the optimum design of laboratory animal facilities as a important element.