• 보건교육건강증진학회지
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• 제34권1호
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• pp.1-12
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• 2017

Objectives: The aim of this study was to verify relationships between light- and heavy alcohol drinking and health-risk behaviors such as smoking, inappropriate weight control, physical inactivity, and sexual activity among adolescents. Methods: The data of 68,043 adolescents in middle- and high school collected from the Korea Youth Risk Behavior Web-based Survey in 2015 were analyzed. For statistical analysis, logistic regression model was used. Results: The rate of heavy alcohol drinking increased with increasing age up to 21.5% among boys and 13.9% among girls. Among boys, heavy alcohol drinkers were at a higher risk of smoking (adjusted odds ratios [OR]=3.3, 95% confidence interval [CI]=2.8-3.8), inappropriate weight control (OR=1.7; 95% CI=1.4-2.1), having sexual intercourse (OR=3.6; 95% CI=3.0-4.2) than light drinkers. Multiple health-risk behaviors of smoking, inappropriate weight control and sexual intercourse also increased in accordance with the severity of drinking alcohol beverage compared to non-drinker. Physical inactivity was decreased among heavy drinkers compared to light drinkers (OR=0.8; 95% CI=0.7-0.9 for inactivity of moderate exercise). Similar results were observed among girls. Conclusions: Alcohol drinking especially heavy alcohol drinking among adolescents is related to other risky behaviors including smoking, inappropriate weight control, and sexual activity. To prevent health problems in adolescents, it is necessary to adopt a combined approach regarding heavy drinking and health-risk behaviors.

• 지역사회간호학회지
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• 제29권3호
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• pp.349-358
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• 2018

Purpose: This study was conducted to investigate the combined effects of abdominal obesity and alcohol drinking on the risk of hypertension in Korean adults (aged ${\geq}30yrs$). Methods: Data of 13,885 subjects from the sixth Korea National Health and Nutrition Examination Survey were analyzed. The multiple logistic regression tests were used for the analysis, including potential covariates of the model. Results: Frequency of drinking, typical drinking quantity, and frequency of binge drinking had a positive relation to hypertension. The odds ratio of hypertension for risk drinkers with abdominal obesity was 4.81 compared to non-risk drinkers with normal waist circumstance, whereas the odds ratios of hypertension for risk drinkers with normal waist circumstance and non-risk drinkers with abdominal obesity were 1.58 and 2.37 respectively. Conclusion: Both abdominal obesity and alcohol drinking patterns were strong risk factors of hypertension in the Korean adults. Risk drinkers with abdominal obesity showed a marked high risk in hypertension compared to those with a single condition alone.

• Natural Product Sciences
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• 제27권3호
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• pp.201-207
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• 2021

We have previously reported that Acer tegmentosum extract, which is traditionally used in Korea to reduce alcohol-related liver injury, suppresses liver inflammation caused by excessive alcohol consumption and might improve metabolism. The active ingredient, 6-O-galloylsalidroside (GAL), was isolated from A. tegmentosum, and we hypothesized that GAL could provide desirable pharmacological benefits by ameliorating physiological conditions caused by alcohol abuse. Therefore, this study focused on whether GAL could ameliorate alcoholic fat accumulation and repair liver injury in mice. During chronic alcohol consumption plus binge feeding in mice, GAL was administered orally once per day for 11 days. Intrahepatic lipid accumulation was measured in vivo using a noninvasive method, ¹H magnetic resonance imaging, and confirmed by staining with hematoxylin and eosin and Oil Red O. The serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured using a Konelab system, and the triglyceride content was measured in liver homogenates using an enzymatic peroxide assay. The results suggested that GAL alleviated alcohol-induced steatosis,e as indicated by decreased hepatic and serum triglyceride levels in ethanol-fed mice. GAL treatment also correlated with a decrease in the Cd36 mRNA expression, thus potentially inhibiting the development of alcoholic steatosis via the hepatic de novo lipogenesis pathway. Furthermore, treatment with GAL inhibited the expression of cytochrome P450 2E1 and attenuated hepatocellular damage, as reflected by a reduction in ALT and AST levels. These findings suggest that GAL extracted from A. tegmentosum has the potential to serve as a bioactive agent for the treatment of alcoholic fatty liver and liver damage.

• 한국전문물리치료학회지
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• 제12권3호
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• pp.56-66
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• 2005

The purposes of this study were to test that complex motor training enhance motor function significantly, to test change in cerebellum, and to test the synaptic plasticity into the immunohistochemistry response of synaptophysin. Using an animal model of fetal alcohol syndrome - which equates peak blood alcohol concentrations across developmental period - the effects of alcohol on body weight during periods were examined. The effect of complex motor training on motor function and synaptic plasticity of rat exposed alcohol on postnatal days 4 through 10 were studied. Newborn rats were assigned to one of two groups: (1) normal group (NG), via artificial rearing to milk formula and (2) alcohol groups (AG), via 4.5 g/kg/day of ethanol in a milk solution. After completion of the treatments, the pups were fostered back to lactating dams, where they were raised in standard cages (two-and three animals per cage) until they were postnatal 48 days. Rats from alcohol group of postnatal treatment then spent 10 days in one of two groups: Alcohol-experimental group was had got complex motor training (learning traverse a set of 6 elevated obstacles) for 4 weeks. The alcohol-control group was not trained. Before consider replacing with "the experiment/study", (avoid using "got" in writing) the rats were examined during four behavioral tests and their body weights were measured, then their coronal sections were processed in rabbit polyclonal antibody synaptophysin. The synaptophysin expression in the cerebellar cortex was investigated using a light microscope. The results of this study were as follows: 1. The alcohol groups contained significantly higher alcohol concentrations than the normal group. 2. The alcohol groups had significantly lower body weights than the normal group. 3. In alcohol groups performed significantly lower than the normal group on the motor behavioral test. 4. In alcohol-control group showed significantly decreased immunohistochemistric response of the synaptophysin in the cerebellar cortex compared to the nomal group. These results suggest that improved motor function induced by complex motor training after postnatal exposure is associated with dynamically altered expression of synaptophysin in cerebellar cortex and that is related with synaptic plasticity. Also, these data can potentially serve as a model for therapeutic intervention.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2021년도 춘계학술대회
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• pp.5-5
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• 2021

Alcoholic and nonalcoholic steaohepatitis is a leading form of chronic liver disease with few biomakers ad treatment options currently available. a progressive disease of NAFLD may lead to fibrosis, cirrhosis, and hepatocellular carcinoma. Recently, we extracted HIMH0021, which is an active flavonoid component in the Acer tegmentosum extract, has been shown to protect against liver damage caused by hepatic dysfunction. Therefore, in this study, we aimed to investigate whether HIMH0021 could regulate steatohepatitis and liver fibrosis during alcoholic or nonalcoholic metabolic process. HIMH0021, which was isolated from the active methanol extract of A. tegmentosum, inhibited alcohol-induced steatosis and attenuated the serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) during hepatocellular alcohol metabolism, both of which promote lipogenesis as well as liver inflammation. Treatment with HIMH0021 conferred protection against lipogenesis and liver injury, inhibited the expression of cytochrome P4502E1, and increased serum adiponectin levels in the mice subjected to chronic-plus-binge feeding. Furthermore, in hepatocytes, HIMH0021 activated fatty acid oxidation by activating pAMPK, which comprises pACC and CPT1a. These findings suggested that HIMH0021 could be used to target a TNFα-related pathway for treating patients with alcoholic hepatitis.

• 한국응급구조학회지
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• 제20권2호
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• pp.127-144
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• 2016

Purpose: The purpose of this study was to investigate the drinking behavior of university students in Jeju for the safe campus life. Methods: A self-reported questionnaire was completed by 549 students in 4 universities in Jeju. The data were analyzed by t-test, one way ANOVA, and multiple regression using SPSS Win 19.0 program. The questionnaire instruments consisted of Alcohol Use Disorders of Identification Test-Korea (AUDIT-K) and Life Stress Scale for College Students adapted by Chon. Results: The alcohol consumption rate of participants accounted for 96.2%. The binge drinking rate in female students were 33.9% and that in male students was 29.5%. The result by scoring AUDIT showed that 30.7% of participants were normal drinking group, 36.0% were hazardous drinking group, and 33.3% were estimated alcohol abuse group. The average score of stress was 1.45 by Likert 4 point scale. The female students tended to have more stresses than male. The most important influencing factors on drinking behavior were the first alcohol drinking(${\beta}=-.250$, p< .001), gender(${\beta}=.202$, p< .001), and relationship problem(${\beta}=.116$, p < .05). Conclusion: The drinking rate of university students revealed higher than that in other age groups. So the early systematic education is strongly recommended to prevent the physical and mental side effects.

• 한국학교ㆍ지역보건교육학회지
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• 제24권3호
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• pp.23-35
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• 2023

Objectives: The purpose of this study is to examine the marital status, drinking behavior, and mental health characteristics of alcohol consumers, and to explore the relationship between marital status and mental health among alcohol consumers. Methods: The research data utilized raw data from the 8th Korea National Health and Nutrition Examination Survey (2020), Second Round. A total of 3,713 participants were included in the final analysis. Data analysis was performed using the statistical software SPSS version 26.0. Results: The relationship between the study participants and mental health revealed that compared to those with a spouse, individuals who were divorced or separated had an odds ratio (OR) of 2.598 for 'depression' and an OR of 2.142 for 'suicidal thoughts'. In the case of 'stress perception', individuals who were divorced or separated had an OR of 3.434. In terms of gender, females had an OR of 4.867 for 'depression', an OR of 2.510 for 'suicidal thoughts', and an OR of 1.847 for 'stress perception', compared to males. Regarding age, the odds of 'depression' were 1.801 times higher in the 60 to 79 age group compared to the 18 to 39 age group. For smoking status, smokers had an OR of 2.812 for 'depression' compared to non-smokers. The OR for 'suicidal thoughts' was 3.047, and the OR for 'stress perception' was 1.463. However, the relationship between mental health and binge drinking frequency and quantity of alcohol consumed in a single session was not significant. Conclusion: The divorced, separated, or bereaved groups may be vulnerable to 'depression,' 'suicidal ideation,' and 'stress.' Therefore, there is an expectation to explore strategies for the development and enhancement of community-based mental counseling and health education support programs, aiming to improve the mental well-being and quality of life of individuals and the local community.

• 한국융합학회논문지
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• 제12권1호
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• pp.361-368
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• 2021

본 연구는 우리나라 성인의 흡연 및 음주상태가 삶의 질에 미치는 영향을 융합적으로 분석하기 위해 수행되었으며 제7기 2차 년도(2017년) 국민건강영양조사 자료를 활용하여 만 30세 이상의 성인을 대상으로 분석하였다. 연구에 사용된 대상자수는 총5,465이며 사회 인구학적 특성과 건강관련 변수, 삶의 질 수치인 EQ-5D index scores를 분석에 이용하였다. 통계분석은 IBM SPSS ver.23 프로그램을 이용하였으며 분석결과 흡연상태, 폭음정도, 주관적 건강상태, 스트레스 인지율이 삶의 질과 통계적으로 유의한 차이를 보였다. 통제변수를 투입하여 흡연 및 음주형태가 삶의 질에 미치는 영향을 분석한 회귀분석 결과 '한번에 마시는 음주량(β=.106)'은 통계적으로 유의하였으며 삶의 질의 차이를 9.1% 설명하는 것으로 나타났다. 그러나 흡연상태와 폭음은 통계적으로 유의하지 않았다. 따라서 성인의 삶의 질을 향상시키기 위해서는 흡연보다는 음주와의 관련성을 주요한 보건학적 이슈로 접근하여 생활양식을 개선할 수 있도록 있는 융합적 금주 중재프로그램의 개발과 적용이 필요하다.

• 한국콘텐츠학회논문지
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• 제21권5호
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• pp.627-637
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• 2021

우리나라는 신체적 위해 뿐만 아니라, 사회경제적으로도 규모와 심각도를 더해가고 있는 음주폐해의 감소를 위해 다양한 방안들을 모색하고 있다. 그 중에서도 개인들의 음주행태 개선은 음주폐해를 줄이는 가장 직접적인 방법이다. 외국에서는 '보호행동전략'의 사용이 음주폐해를 줄이는 효과적인 방안으로 알려져 있는데, 우리나라에서는 성인을 대상으로 이를 조사하여 검증한 연구들이 매우 부족하다. 따라서 본 연구는 보호행동전략의 사용이 음주폐해 감소에 유의한 영향을 끼치는지를 확인하고자 하였다. 전국 성인 남녀 2,000명을 대상으로 한 연구 결과, 보호행동전략의 사용은 음주폐해를 줄이는 것으로 나타났으며, 음주폐해에 가장 큰 영향을 끼친 것은 심각한 폐해감소 전략 영역이었고, 다음으로 음주방법 제한 영역이었다. 음주량 감소 영역의 영향은 유의하지 못한 것으로 나타났다. 이 외에도 음주빈도, 폭음, 음주 동기는 음주폐해에 정적인 영향을 끼쳤으며, 사교 동기의 경우만 부적인 영향을 끼쳤다. 본 연구에서는 향후 종단연구를 통한 면밀한 요인들 간의 관계 파악, 대상층을 세분화한 보호행동전략 사용 강화 방안에 관한 후속 연구들을 제안하였다.

• 한국융합학회논문지
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• 제9권8호
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• pp.95-100
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• 2018

본 연구의 목적은 우리나라 30세 이상 성인에서 알코올 소비와 치주질환 간의 관련성을 파악하고자 하였다. 본 연구의 자료는 2014년 국민건강영양조사 자료를 이용하였으며, 4,328명을 최종분석대상자로 선정하였다. 치주질환은 지역사회치지수를 이용하였다. 참조군은 비음주이며, 성별, 연령, 교육, 당뇨를 공변량으로 하여 음주경험, 음주빈도, 음주량, 음주 시작연령, 음주기간에 대한 이분형 로지스틱회귀분석을 실시하였다. 본 연구결과 30세이상 성인의 음주상태에 따른 치주질환 위험은 비음주군에 비해 한 번에 마시는 음주량이 7잔 이상인 경우에서 1.39배(95% CI=1.01-1.90) 위험이 높음을 확인하였다. 폭음빈도, 음주량, 음주기간이 증가할수록 치주질환 위험에 대한 용량-반응관계가 나타났다. 음주는 치주질환의 잠재적인 위험요인으로 나타났다. 치과 의료인은 음주를 하는 경우 더 높은 치주질환 위험이 있을 수 있으므로 금주와 정기적인 치과방문을 하도록 권고해야 할 것이다.