• 한국전문물리치료학회지
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• 제15권4호
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• pp.27-33
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• 2008

The purpose of this study was to investigate the changes of the center of pressure (COP) trajectory in healthy elderly subjects while crossing an obstacle before and after participation in Tai Chi training. Forty healthy elderly subjects participated either in a 12-week intervention of Tai Chi training or in a health education program. The participants were divided into two groups (the experimental group and the control group). Subsequently, the participants were pre- and post-tested on crossing over an obstacle from a quiet stance. Participants in the experimental group received Tai Chi training that emphasized the smooth integration of trunk rotation, a shift in weight bearing from bilateral to unilateral support and coordination and a gradual narrowing of the lower-extremity stance three times weekly. The participants in the control group attended a health education program one hour weekly and heard lectures about general information to promote health. Performance was assessed by recording the changes in the displacement of the COP in the anteroposterior (A-P) and mediolateral (M-L) directions using a force platform. Participants in the Tai Chi group significantly increased the A-P and M-L displacement of the COP after Tai Chi training (p<.05). No significant differences in the A-P and the M-L displacement of the COP between pre-testing and post-testing in the control group were found. This study has shown that participation in Tai Chi exercise increased the magnitude of the A-P and M-L displacement of the COP, thereby improving the ability of healthy elderly participation to generate momentum to initiate gait. These findings support the use of Tai Chi training as an effective fall-prevention program for the elderly.

• Journal of Preventive Medicine and Public Health
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• 제46권3호
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• pp.118-126
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• 2013

We investigated the major trends in health aid financing in the Democratic People's Republic of Korea (DPRK) by identifying the primary donor organizations and examining several data sources to track overall health aid trends. We collected gross disbursements from bilateral donor countries and international organizations toward the DPRK according to specific health sectors by using the Organization for Economic Cooperation and Development creditor reporting system database and the United Nations Office for the Coordination of Humanitarian Affairs financial tracking service database. We analyzed sources of health aid to the DPRK from the Republic of Korea (ROK) using the official records from the ROK's Ministry of Unification. We identified the ROK, United Nations Children's Fund (UNICEF), World Health Organization (WHO), United Nations Population Fund (UNFPA), and The Global Fund to Fight AIDS, Tuberculosis and Malaria (GFATM) as the major donor entities not only according to their level of health aid expenditures but also their growing roles within the health sector of the DPRK. We found that health aid from the ROK is comprised of funding from the Inter-Korean Cooperation Fund, private organizations, local governments, and South Korean branches of international organizations such as WHO and UNICEF. We also distinguished medical equipment aid from developmental aid to show that the majority of health aid from the ROK was developmental aid. This study highlights the valuable role of the ROK in the flow of health aid to the DPRK, especially in light of the DPRK's precarious international status. Although global health aid from many international organizations has decreased, organizations such as GFATM and UNFPA continue to maintain their focus on reproductive health and infectious diseases.

• 대한치과교정학회지
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• 제42권2호
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• pp.56-63
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• 2012

Objective: To identify the right and left difference of the facial soft tissue landmarks three-dimensionally from the subjects of normal occlusion individuals. Materials and Methods: Cone-beam computed tomography (CT) scans were obtained in 48 normal occlusion adults (24 men, 24 women), and reconstructed into 3-dimensional (3D) models by using a 3D image soft ware. 3D position of 27 soft tissue landmarks, 9 midline and 9 pairs of bilateral landmarks, were identified in 3D coordination system, and their right and left differences were calculated and analyzed. Results: The right and left difference values derived from the study ranged from 0.6 to 4.6 mm indicating a high variability according to the landmarks. In general, the values showed a tendency to increase according to the lower and lateral positioning of the landmarks in the face. Overall differences were determined not only by transverse differences but also by sagittal and vertical differences, indicating that 3D evaluation would be essential in the facial soft tissue analysis. Conclusions: Means and standard deviations of the right and left difference of facial soft tissue landmarks derived from this study can be used as the diagnostic standard values for the evaluation of facial asymmetry.

• 한국전문물리치료학회지
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• 제15권3호
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• pp.44-52
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• 2008

The purpose of this study was to investigate the effects of different objects and target location of dominant hand on the non-dominant hand movement kinematics in a bimanual reaching task. Fifteen right-handed volunteers were asked to reach from same starting point to the different target point of right and left hand with grasping the objects of different size. Independent variables were 1) three different object types (small mug cup, name pen, and PET bottle), and 2) three different target locations (shorter distance, same distance, and longer distance than the non-dominant hand) of the dominant hand. Dependent variables were movement time (MT), movement distance (MD), movement mean velocity ($MV_{mean}$), and movement peak velocity ($MV_{peak}$) of the non-dominant hand. Repeated measures two-way analysis of variance (ANOVA) was used to test for differences in the non-dominant hand movement kinematics during bimanual reaching. The results of this study were as follows: 1) MT of the non-dominant hand was increased significantly when traveling with grasping the mug cup and reaching the far target location, and was decreased significantly when traveling with grasping the PET bottle and reaching the near target location of the dominant hand. 2) MD of the non-dominant hand was significantly increased during reaching the far target location, and significantly decreased during reaching the near target location with dominant hand. 3) $MV_{mean}$ of the non-dominant hand was increased significantly when traveling with grasping the PET bottle, and was decreased significantly when traveling with grasping the mug cup of the dominant hand. Therefore, it can be concluded that the changes of the ipsilateral hand movement have influence on coupling of the contralateral hand movement in bimanual reaching.

• 경영정보학연구
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• 제8권2호
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• pp.103-117
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• 2006

기업간 전자상거래에서 조합경매(combinational auction)에 대한 관심이 증가함에 따라 다양한 조합경매 유형이 제시되고 있다. 조합경매의 실용성에 대한 잠재적 중요성을 고려할 때, 다양한 조합경매모델을 지원할 수 있는 통합적이고 체계적인 설계방법이 필요하다. 조합경매 설계에 대한 기존 연구들은 조합경매에 관한 일부 설계요소들에 대해서만 제시하였으며, 부분적인 측면에서 연구가 진행되어 전체적인 관점에서의 설계체계가 제시되지 않았다. 이에 본 연구에서는 조합경매모형에 대한 설계의 토대가 될 수 있는 체계적인 틀을 제시하고자 한다. 설계단계는 크게 아키텍처, 프로토콜, 거래전략 설계 과정으로 이루어진다. 설계과정에서 아키텍처 유형과 프로세스 유형을 분류하고 이들의 조합으로 나타나는 메커니즘 유형을 분류하여 조합경매 모형에 대한 분류체계를 제시하였다. 또한, 거래전략 설계 단계에서는, 거래 당사자들의 다양한 전략을 반영하여 최적의 거래대상을 선정하는 최적화 모형에 기반한 효과적인 조합경매모형 설계방법을 제안하였다. 마지막으로, 본 방법론에 기반하여 새로운 조합경매 모형인 다자간 일반 조합경매 시장에 대한 설계과정을 예시함으로써, 본 방법론의 적용 가능성을 제시하였다.

• 국제물리치료학회지
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• 제10권2호
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• pp.1803-1809
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• 2019

Background: Cervical mobilization has been applied mainly for the improvement of arm and neck movements and pain reduction, and little research has been done to improve the executive function. Since this kind of so-called mechanical neck pain is one of most common symptoms, there are controversial issues about this with spine alignment. Posteroanterior (PA) mobilization from the Maitland concept is a process of examination, assessment, and treatment of neuromusculoskeletal disorder by manipulative physical therapy. Objective: To examine the short-term benefits of mobilization for patients with non-specific neck pain. Design: Dual-group Pretest-Posttest Design from the Quasi-Experimental research Methods: Fourteen participants (male 8, female 6; 20's of their age) with non-specific neck pains which are distributed all the unilateral or bilateral body side were recruited. Participants were categorized to Neck Pain with Movement Coordination Impairments (NPMCI) and Neck Pain with Mobility Deficits (NPMD) groups according to the results of physical examination. Professional physical therapist who has over 15-years-of clinical experience applicated manipulative therapy for the neck pain, an occupational therapist only conducted evaluations; K-NDI (Korean version of the Neck Disability Index), VAS (Visual Analog Scale), BDS-K (Korean version of Behavioral Dyscontrol Scale) for decreasing possible adverse effects; there were no person who reported other symptoms followed 4 weeks from the trial. Results: In the NPMCI group, data analysis indicated statistical differences between the PA mobilization interventions in NDI and BDS-K; even though, pain was reduced in VAS, this is not a significantly differ. In the NPMD group, data analysis represented statistical differences between the PA mobilization interventions in NDI, VAS and BDS-K; the scores were represented to be increased or the pain got relief. Conclusions: PA mobilization techniques according to Maitland concept have beneficial effects in patients with neck pain and other clinical positive effects which included neck disability, pain itself and motor function of upper extremity.

• The Korean Journal of Physiology and Pharmacology
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• 제24권1호
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• pp.11-18
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• 2020

The present study was aimed to explore the neuroprotective role of imatinib in global ischemia-reperfusion-induced cerebral injury along with possible mechanisms. Global ischemia was induced in mice by bilateral carotid artery occlusion for 20 min, which was followed by reperfusion for 24 h by restoring the blood flow to the brain. The extent of cerebral injury was assessed after 24 h of global ischemia by measuring the locomotor activity (actophotometer test), motor coordination (inclined beam walking test), neurological severity score, learning and memory (object recognition test) and cerebral infarction (triphenyl tetrazolium chloride stain). Ischemia-reperfusion injury produced significant cerebral infarction, impaired the behavioral parameters and decreased the expression of connexin 43 and phosphorylated signal transducer and activator of transcription 3 (p-STAT3) in the brain. A single dose administration of imatinib (20 and 40 mg/kg) attenuated ischemia-reperfusion-induced behavioral deficits and the extent of cerebral infarction along with the restoration of connexin 43 and p-STAT3 levels. However, administration of AG490, a selective Janus-activated kinase 2 (JAK2)/STAT3 inhibitor, abolished the neuroprotective actions of imatinib and decreased the expression of connexin 43 and p-STAT3. It is concluded that imatinib has the potential of attenuating global ischemia-reperfusion-induced cerebral injury, which may be possibly attributed to activation of JAK2/STAT3 signaling pathway along with the increase in the expression of connexin 43.

• 대한감각통합치료학회지
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• 제8권1호
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• pp.41-49
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• 2010

목적 : 다감각 통합은 인지과제나 운동실행을 위해 다양한 감각정보를 사용하는 데 있어서 필수적인 처리과정이다. 특히 시각 및 체감각의 통합은 운동 행동의 주요한 요소이다. 본 연구는 감각통합 과정의 시간적 경로와 뇌의 담당 위치를 파악하기 위해 신경생리학적 연구방법을 사용하여 시각과 체감각의 통합과정과 관련된 뇌의 시간적 및 공간적 특성을 조사하였다. 연구 방법 : 실험실 상황에서 시각과 촉각 자극을 독립적으로 또는 동시에 제시하고 유발전위검사(ERP: Event-Related Potentials)를 통해 통합작용 시 뇌에서 일어나는 신경세포들의 전기생리적활동을 측정하였다. 이때 시각 과 촉각을 각각 제시하여 얻은 유발전위신호들의 선형합과 두 개의 자극을 동시에 제공하였을 시 발생되는 유발전 위신호를 측정하여 비교하였다. 결과 : 시각과 촉각을 독립적으로 각각 제시하여 얻은 유발전위신호(SUM)의 합과 두 개의 자극을 동시에 제공하여 얻은 유발전위신호(SIM)는 같지 않았다. 특히나 자극의 반대측인 오른쪽 일차체감각영역(C4)에서 SIM은 SUM 보다 특정시간대에 통계적으로 유의미한 차이를 보였으며, Bilateral parietal areas(P3, Pz, P4) 뿐만 아니라 일차 시각영역(O1,O2)에서도 두 조건간 추가적인 통합관련 신경활동전기신호에 의한 통계적으로 유의미한 차이를 나타내고 있다. 결론 : 뇌 속에서 2개 이상의 감각이 통합될 경우 이와 관련된 추가적인 신경세포활동이 일어나고 있으며, 이는 다 감각을 동시에 제공할 경우 뇌의 활동을 더욱 활발하게 촉진시키고 있음을 시사한다.

• 한국신경인지재활치료학회지
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• 제10권2호
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• pp.1-7
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• 2018

목적: 본 연구는 정상 발달아동과 자폐스펙트럼으로 진단받은 아동에게 목표관리 훈련을 실시하여 그 효과를 비교하였다. 방법: 연구대상자는 정상 발달아동 4명과 자폐스펙트럼으로 진단 받은 아동 4명을 대상으로 실시하였으며, 모든 대상자에게 동일한 목표관리 훈련을 제공하였다. 아동 및 보호자가 원하는 목표활동을 선정하여 3가지 활동에 모두 목표 관리훈련을 실시하였다. 중재기간은 총 10회로 주 2회씩 5주 동안 진행되었으며, 두 그룹의 총 8명의 대상자에게 연구자가 1:1로 각 대상자에게 40분씩 목표 관리 훈련을 실시하였다. 통계방법으로는 기술통계와 빈도분석을 사용하였으며, 두 그룹의 차이를 비교하기 위해 비모수 통계분석인 Mann-Whitney 검정을 실시하였다. 통계학적 유의수준은 0.05로 설정하였다. 결과: 목표관리 훈련은 두 그룹에서 COPM의 수행도에서는 통계학적으로 유의하게 차이가 없었다(p>.05). 목표 관리훈련은 운동기능을 평가하는 BOT-2의 총점에서 자페스펙트럼 장애 그룹과 정상아동 그룹 간에 통계적으로 유의한 차이가 있었다(p<.05). 또한 시지각 기능을 평가하는 DTVP에서도 양측 활동을 하는 눈손협응 하위검사에서 자폐스펙트럼 아동과 정상아동 그룹간에 통계적으로 유의한 차이가 있었다(p<.05). 결론: 본 연구는 정상아동과 비교하여 자페스펙트럼 아동에게 목표관리 훈련을 적용가능성을 확인하였으며, 그 효과성도 확인하였다.

• Journal of Ginseng Research
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• 제46권4호
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• pp.515-525
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• 2022

Background: The incidence of ischemic cerebrovascular disease is increasing in recent years and has been one of the leading causes of neurological dysfunction and death. Ginsenoside Rg1 has been found to protect against neuronal damage in many neurodegenerative diseases. However, the effect and mechanism by which Rg1 protects against cerebral ischemia-reperfusion injury (CIRI) are not fully understood. Here, we report the neuroprotective effects of Rg1 treatment on CIRI and its possible mechanisms in mice. Methods: A bilateral common carotid artery ligation was used to establish a chronic CIRI model in mice. HT22 cells were treated with Rg1 after OGD/R to study its effect on [Ca²⁺]_i. The open-field test and poleclimbing experiment were used to detect behavioral injury. The laser speckle blood flowmeter was used to measure brain blood flow. The Nissl and H&E staining were used to examine the neuronal damage. The Western blotting was used to examine MAP2, PSD95, Tau, p-Tau, NOX2, PLC, p-PLC, CN, NFAT1, and NLRP1 expression. Calcium imaging was used to test the level of [Ca²⁺]_i. Results: Rg1 treatment significantly improved cerebral blood flow, locomotion, and limb coordination, reduced ROS production, increased MAP2 and PSD95 expression, and decreased p-Tau, NOX2, p-PLC, CN, NFAT1, and NLRP1 expression. Calcium imaging results showed that Rg1 could inhibit calcium overload and resist the imbalance of calcium homeostasis after OGD/R in HT22 cells. Conclusion: Rg1 plays a neuroprotective role in attenuating CIRI by inhibiting oxidative stress, calcium overload, and neuroinflammation.