• Radiation Oncology Journal
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• 제37권3호
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• pp.185-192
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• 2019

Purpose: The effectiveness of thoracic radiation therapy (TRT) in extensive-stage small cell lung cancer (ES-SCLC) patients is increasingly reported, but there is no definite consensus on its application. The aim of this study was to identify factors associated with better outcomes of TRT among patients with ES-SCLC, focusing on whether a higher TRT dose could improve treatment outcome. Materials and Methods: The medical records of 85 patients with ES-SCLC who received TRT between January 2008 and June 2017 were retrospectively reviewed. Eligibility criteria were a biological effective dose with α/β = 10 (BED) higher than 30 Gy₁₀ and completion of planned radiotherapy. Results: During a median follow-up of 5.3 months, 68 patients (80.0%) experienced disease progression. In univariate analysis, a BED >50 Gy₁₀ was a significant prognostic factor for overall survival (OS; 40.8% vs. 12.5%, p = 0.006), progression-free survival (PFS; 15.9% vs. 9.6%, p = 0.004), and intrathoracic PFS (IT-PFS; 39.3% vs. 20.5%, p = 0.004) at 1 year. In multivariate analysis, a BED >50 Gy₁₀ remained a significant prognostic factor for OS (hazard ratio [HR] = 0.502; 95% confidence interval [CI], 0.287-0.876; p = 0.015), PFS (HR = 0.453; 95% CI, 0.265-0.773; p = 0.004), and IT-PFS (HR = 0.331; 95% CI, 0.171-0.641; p = 0.001). Response to the last chemotherapy was also associated with better OS in both univariate and multivariate analysis. Conclusion: A TRT dose of BED >50 Gy₁₀ may be beneficial for patients with ES-SCLC. Further studies are needed to select patients who will most benefit from high-dose TRT.

• Toxicological Research
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• 제22권4호
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• pp.339-348
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• 2006

Misaengtang (MST), a formula of Korean herbal medicines, has been used as a weight-controlling recipe. We have investigated two experiment of body weight regulation by MST In rats. i) The anti-obesity effect of MTS on a high fat diet-induced obesity, male Sprague-Dawley rats were fed with a high-fat diet containing 30% in the absence or presence of MST (0.3, 1 or 3%) or a reference orlistat (0.05%) for 6 weeks. ii) weight-decrease effect of MST on normal diet, same animal were fed with a normal diet in the absence or presence of MST (3%) for 6 weeks. And the body weights, daily feed and water consumptions, organ weights, fat weights serum biochemistry were measured. In both experiments, MST and orlistat did not affect the body weight gain. But orlistat significantly increased the feed and water consumptions, leading to low-feed efficiency, and orlistat markedly reduced abdominal, paratesticular and perirenal fat weights, although increased the kidney weights. In MST, low dose (0.3%) of MST decreased the perirenal fat and increased the kidney weights in rats fed HFD, and MST 3% decreased the abdominal fat weights in rats fed normal diet. In addition, Orlistat caused changes in parameters of hepatotoxicity (AST and glucose), nephrotoxicity (BUN and B/C ratio) and lipid metabolism (HDL and triglycerides). In comparison, MST decreased AST, ALP and ALT, the hepatotoxicity markers, and somewhat improved the hepatic fatty degeneration. Taken together, it is suggested that MST does not exert anti-obesity activity as well as remarkably direct effects, but MST may be potentially benefit for dietary cure and exercise-cure of obesity.

• 패션비즈니스
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• 제19권4호
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• pp.183-199
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• 2015

This study aimed to systematize the apparel vendor work processes and provide useful information to future employees of clothing export units by analyzing the processes of vendors' manufacturing tasks. A survey of 20 apparel vendors servicing mainly U.S. buyers was conducted on employees of overseas business departments working for more than five years. buyers. Based on the results, vendors mainly manufactured cut-and-sew knit products. Regarding the production method, OEM was used more frequently than ODM. Fourteen (70%) companies used the ODM method. This suggests that vendors are expanding their production method from OEM to ODM. In order to summarize the work of each business based on the clothing production process research results, buyers were in charge of planning products and the vendors were in charge of sampling. Production of materials and the approval of material tests were out sourced. Overseas factories of vendors were in charge of bulk (mass) production and garment finishing, as well as packaging and shipping the completed products. Even though the vendors' head offices do not directly produce clothes, they play a pivotal role in ensuring planning and management progress in clothing production. As buyers prefer direct contracts for cost reduction, the vendor additionally performs the role of an agent. Also, with the increase in ODM production ratio, the work area of the vendor is expanding. If Korean clothing exporters improve their global competitiveness by investing in the R&D of materials and design to enhance the ODM method, the development of Korea's clothing and export industry will benefit significantly.

• 대한교통학회지
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• 제32권5호
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• pp.421-430
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• 2014

수송 분야의 온실가스 감축에서 차량운행 중 공회전에 따른 온실가스 발생 문제는 중요한 요소이므로 최근 버스, 트럭, 택시에서의 공회전제한장치(ISG) 장착이 법제화되고 있으며, 일반 승용차에도 ISG 장착을 확대하려는 추세이다. 이에 본 연구에서는 수도권 지역을 대상으로 승용차의 차종별 ISG 장착 전략에 따른 경제적 효과분석 결과를 기반으로 그에 따른 정책 방향성을 제시하고자 한다. 분석 결과, 서울시 사업용 승용차에 ISG를 장착하는 전략이 가장 효과적(B/C: 8.55)으로 나타났고, 그에 따른 연료절감량은 660(${\ell}$/년/대)이며, $CO_2$ 저감량은 1,606(kg/년/대)인 것으로 분석되었다. 이러한 결과는 향후 일반 승용차의 ISG 장착에 대한 적정 보조금 산정 등의 정책 판단 지표로 활용 가능할 것으로 판단된다.

• 기술혁신연구
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• 제20권3호
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• pp.181-198
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• 2012

경기도는 도(道)의 지원으로 성공한 기업의 초과 이윤을 지역으로 환원시킬 수 있는 제도의 틀을 마련하기 위하여 2011년도에 성공기술료 제도를 도입하였다. 향후 성공기술료 징수를 통해 가용 재원 감소기에 지자체의 과학기술 정책 추진을 위한 추가적인 재원을 확보하고, 기술개발사업의 성과를 설명할 수 있는 근거를 확보할 수 있을 것으로 기대한다. 그러나 부담능력이 없는 기업에 추가적인 기술료를 징수함으로써 기업의 혁신에 대한 인센티브를 저하할 가능성에 대한 우려가 있다. 본 연구는 사례분석을 통해서 성공기술료 발생 시의 기업의 부담능력을 분석하는 것으로 목적으로 한다. 분석결과로부터 성공기술료는 실질적으로 부담능력이 있는 기업에만 징수하게 됨으로써 제도의 도입이후에도 기업의 혁신 성공 인센티브를 유지하여 공공기술개발 사업의 정책적 목표를 달성할 수 있는 것으로 나타났다. 그러나 징수의 객관성 확립, 기술사업화의 체계적 지원확대, 고정기술료율 인하로 적정한 기대기술료 수준 유지 등의 제도적 개선이 필요한 것으로 나타났다.

• Ocean Science Journal
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• 제40권3호
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• pp.127-143
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• 2005

The taxonomic sufficiency approach has been proposed as a surrogate for the typical analysis of species-abundance data, especially in conditions involving prominent pollution gradients. Here, we evaluate the use of taxonomic sufficiency with infralittoral macrobenthic data derived from samples taken in a moderate polluted subtropical environment in southeastern Brazil, analysing five taxonomic levels and including two functional levels throughout polychaete feeding guilds and trophic groups. The data were collected seasonally at nine stations and studied for two abundance data series (0.5 and 1.0 mm sieve mesh-size). The results showed a similar ordination pattern between the two sieve mesh-size, but with the 0.5 mm sieve data a different pattern was observed during austral summer. A slight loss of information was detected using genus, family, polychaete species and their feeding guilds as taxonomic/functional units. These results together with those of the cost! benefit ratio, suggested that the family level seemed to be sufficient to detect the impact caused by moderate pollution in this shallow-water, subtropical environment. In additional, through the use of feeding guilds, similar patterns are obtained. Correlation analysis showed that chlorophyll a, total organic matter, zinc, and chromium sediment content were the variables that best explained the biological pattern observed and not always the best correlation coefficient occurring at the species level. The feeding guild approach seems to be useful and generates interpretable results similar to those obtained with the species level of the whole macroinfauna. The results showed an important cost reduction in the sample processing, suggesting that it is possible to adopt a coarser taxonomic level monitoring program even in species-rich communities.

• 한국국방경영분석학회지
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• 제33권2호
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• pp.75-86
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• 2007

본 논문은 육군이 10년여의 연구개발을 통하여 2005년에 개발 완료한 지상전술 C4I체계(Army Tactical Command Information System, ATCIS)의 가치평가를 위한 분석의 틀과 그 실증분석 결과를 제시하고 있다. ATCIS의 가치평가를 위해 육군본부, 국방관련기관, 그리고 업체 등 관련기관들이 지원한 자료를 활용하고 해당분야 전문가들이 참여하였으며, 가능한 가치평가 방법론을 적용하여 합당한 가치평가의 들을 제시하고 이를 실증분석 하였다. 가치평가의 결과는 경제적, 기술적, 그리고 전략증장적 효과 측면에서 ATCIS에 대한 정성적, 정량적 가치로 제시하였으며 의국의 유사 시스템과 비교시 비용대효과 측면에서 최소 6.55배 이상이며, 약 1조 7,291억원 이상의 가치를 창출한 것으로 평가되었다. 본 연구의 의의는 무기체계 개발에 따라 요구되는 가치평가의 틀과 그 실종분석을 통해 향후 타 무기체계개발 가치평가 및 선행연구, 절충교역 기술가치평가 및 성과분석 등에 효과적으로 적용할 수 있는 구체적 방안을 제시하였다는데 있다.

• 환경영향평가
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• 제21권2호
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• pp.297-314
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• 2012

This study investigates the stigma effect of unwelcomed facilities on apartment prices through multiple regressions based on hedonic price method. The areas studied are Sang-gye Jugong 7, 9, 10 apartment complexes. The facilities analyzed are the Chang-dong Electric Subway Depot and the Do-bong Driver's License Agency. The factors studied include the environmental variable (the elapsed time since the announcement of the re-location of these facilities), the view commanding, the distance from Chang-dong Depot, the distance from Do-bong Driver's License Test Course, the distance from neighboring facilities (subway stations, schools, parks and so on), the floor and each dwelling's exclusive space. The data used are 2,822 sales which have been collected since January 1, 2006. The facts found are as follows; first, the view commanding and the distance from the unwelcomed facilities are statistically significant. second, the environmental variable, 'days' turns out to have a positive (+) and a negative (-) significant relationship with the dependent variable, 'price', in period II and period IV respectively. This implies that the stigma effect is real. third, there are significant differences in the influence on the apartment prices among the independent variables according to time. fourth, the stigma effect is estimated as 33,686,920 Korean won in the case of the apartments which have the view commanding and 30,311,844 won in the other case before the global economic crisis. This effect seems to decrease to 22,085,078 won after the crisis. These facts suggest that stigma effects could be considered as one of the benefits in the cost-benefit analysis of Chang-dong Depot re-location project to produce somewhat higher NPV or B/C ratio.

• Preventive Nutrition and Food Science
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• 제21권3호
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• pp.165-170
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• 2016

Recent trial results suggest that the consumption of a low glycemic index (GI) diet is beneficial in the prevention of high blood glucose levels. Identifying active hypoglycemic substances in ordinary foods could be a significant benefit to the management of blood glucose. It has been hypothesized that noodles with Bombyx mori powder are a low GI food. We evaluated GI and changes in postprandial glucose levels following consumption of those noodles and compared them with those following consumption of plain wheat flour noodles (control) and glucose (reference) in healthy subjects. Thirteen males (age: $34.2{\pm}4.5years$, body mass index: $23.2{\pm}1.1kg/m^2$) consumed 75 g carbohydrate portions of glucose and the 2 kinds of noodle after an overnight fast. Capillary blood was measured at time 0 (fasting), 15, 30, 45, 60, 90, 120, and 180 min from the start of each food intake. The GI values were calculated by taking the ratio of the incremental area under the blood glucose response curve (IAUC) for the noodles and glucose. There was a significant difference in postprandial glucose concentrations at 30 and 45 min between the control noodles and the noodles with Bombyx mori powder: the IAUC and GI for the noodles with Bombyx mori powder were significantly lower than those for glucose and plain wheat flour noodles. The wheat flour noodles with Bombyx mori powder could help prevent an increase in postprandial glucose response and possibly provide an alternative to other carbohydrate staple foods for glycemic management.

• Tuberculosis and Respiratory Diseases
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• 제81권2호
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• pp.148-155
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• 2018

Background: Although targeted therapy and immuno-oncology have shifted the treatment paradigm for lung cancer, platinum-based combination is still the standard of care for advanced non-small cell lung cancer (NSCLC). Pemetrexed continuation maintenance therapy has been approved and increasingly used for patients with nonsquamous NSCLC. However, the efficacy of this strategy has not been proven in patients without driving mutations. The objective of this study was to compare the clinical benefit of pemetrexed continuation maintenance to conventional platinum-based doublet in epidermal growth factor receptor (EGFR)-negative lung adenocarcinoma. Methods: A total of 114 patients with EGFR-negative lung adenocarcinoma who were treated with platinum doublet were retrospectively enrolled. We compared the survival rates between patients received pemetrexed maintenance after four-cycled pemetrexed/cisplatin and those received at least four-cycled platinum doublet without maintenance chemotherapy as a first-line treatment. Results: Forty-one patients received pemetrexed maintenance and 73 received conventional platinum doublet. Median progression-free survival (PFS), which was defined as the time from the day of response evaluation after four cycles of chemotherapy to disease progression or death, was significantly higher in the pemetrexed maintenance group compared to conventional group (5.8 months vs. 2.2 months, p<0.001). Median overall survival showed an increasing trend in the pemetrexed maintenance group (22.3 months vs. 16.1 months, p=0.098). Multivariate analyses showed that pemetrexed maintenance chemotherapy was associated with better PFS (hazard ratio, 0.73; 95% confidence interval, 0.15-0.87). Conclusion: Compared to conventional platinum-based chemotherapy, premetrexed continuation maintenance treatment is associated with better clinical outcome for the patients with EGFR wild-type lung adenocarcinoma.