• Journal of Gastric Cancer
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• 제21권2호
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• pp.122-131
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• 2021

Purpose: To date, there are no promising treatments for gastric carcinoma with peritoneal metastasis. Some researchers have suggested a survival benefit of gastrectomy in select patients. This study investigated the survival of gastric carcinoma patients with stand-alone peritoneal metastasis according to the type of treatment modality. Materials and Methods: We reviewed the data of 132 patients with gastric carcinoma and stand-alone peritoneal metastasis. We performed gastrectomy when the primary tumor was deemed resectable and systemic chemotherapy was administered. We analyzed patient survival according to the type of treatment, and the prognostic value of gastrectomy was evaluated in univariate and multivariate models. Results: Among all patients, 70 underwent gastrectomy plus chemotherapy, 20 underwent gastrectomy alone, 36 underwent chemotherapy alone, and 6 received supportive care. The median patient survival was 13 months. Patients who underwent gastrectomy had significantly longer survival than those who did not undergo gastrectomy (14 vs. 8 months, P<0.001). Patients who received chemotherapy showed significantly longer survival than those who did not (13 vs. 7 months, P=0.032). Patients who underwent gastrectomy plus chemotherapy showed better survival than those who underwent other treatments. In multivariate analysis, gastrectomy was found to be an independent prognostic factor (hazard ratio, 0.52; 95% confidence interval, 0.33-0.82) in addition to chemotherapy. Conclusions: Our study showed that patients who underwent gastrectomy plus chemotherapy had the best survival. Although the survival benefit of gastrectomy remains uncertain, it is a favorable prognostic indicator in patients with stand-alone peritoneal metastasis.

• 수산경영론집
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• 제52권2호
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• pp.1-31
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• 2021

This study is to evaluate the prior economic feasibility of the off-shore fisheries stock enhancement project. The main findings of this study can be summarized as follows: first, offshore fisheries stock enhancement project shall be implemented by dividing them into 1st·2nd·3rd projects for efficient promotion. The 1st·2nd·3rd projects will be conducted in a total of 50 locations (the eastern sea, the western sea, the southern sea, and the jeju sea areas), and the project period per unit will be five years, which will cost 1 trillion won. Second, according to the results of the survey on public awareness, the most consumed marine species in Korea over the past year were analyzed in the order of mackerel, hairtail, squid, yellow corvina, blue crab, and cod. The dominant response to the reason for consuming marine products in Korea was healthy well-being food and safe food. In addition, 67.9% of them have hesitated to purchase offshore fish species over the past year due to high prices, indicating that they are burdened by high prices. On the other hand, 79% of the respondents said that the government's policy was insufficient, according to a survey on whether the government's coastal marine resource creation policy was sufficient. Third, as a result of preliminary economic analysis of offshore fisheries stock enhancement project, the benefit-cost ratio is 4.01, net present price is 1,283.7 billion won, and internal rate of return is 91.7% per year, which means that the economic analysis ensures the feasibility of the projects. The results of this study provide useful information on securing or organizing budgets for offshore fisheries stock enhancement project by securing economic feasibility as a national infrastructure project that increases fishery income and public benefits such as consumption of marine products.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2022년도 학술발표회
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• pp.386-386
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• 2022

우리나라에서는 '물의 재이용 촉진 및 지원에 관한 법률 시행규칙' 등 다양한 법률에 따라 특정 규모 이상의 시설에 빗물이용시설을 설치하도록 규정하고 있으며, 지자체에서는 빗물이용시설의 이용을 장려하고자 설치비 및 시설 운영비를 지원하고 있다. 현업에서 빗물이용시설의 설계는 간편식을 이용하여 목표 우수이용률 또는 공급보장률을 만족하는 용량으로 결정하고 있다. 또한, 산정된 빗물이용시설의 용량에 대해서만 경제성 분석을 하고 있으며, 경제성 분석에 포함된 수식에 대한 근거가 부족한 실정이다. 본 연구에서는 기 개발된 빗물이용시설 설계 프로그램인 CARAH(capacity design aid for rainwater harvesting)의 추가 기능으로 경제성 분석을 통한 빗물이용시설의 적정 용량 결정 도구 및 사용자 편의 환경 개발 결과를 제시하고자 한다. 본 연구를 통해 개발된 CARAH의 경제성 분석 도구는 빗물이용시설의 용량, 설치비, 유지보수비용, 지자체의 설치비 지원 및 빗물 이용에 따른 요금 감면액 등을 고려하여 빗물이용시설의 비용편익 비율(benefit cost ratio; BCR) 산정 결과를 제시하는 기능이다. 본 연구에서는 개발된 CARAH의 경제성 분석 도구를 이용하여 기 설치된 광교 신도시의 빗물저류조 5호를 대상으로 경제성 분석을 수행하였으며, 경제성을 고려한 적정 저류 용량을 제시하였다. 경제성 분석 기간은 빗물이용시설의 내용 연수인 30년으로 하였으며, 여러 목표 공급보장률에 따른 최소 저류 용량별 BCR 결과를 비교하여 광교 신도시의 빗물저류조 5호의 적정 저류 용량을 결정하였다. 그 결과, 공급보장률이 60%에 해당하는 저류 용량 341 m3의 BCR이 7.28로 가장 경제적인 빗물이용시설의 저류 용량으로 산정되었다.

• 한국간담췌외과학회지
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• 제28권2호
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• pp.229-237
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• 2024

Backgrounds/Aims: While patients with borderline resectable pancreatic cancer (BRPC) are a target population for neoadjuvant chemotherapy (NAC), formal guidelines for neoadjuvant therapy are lacking. We assessed the perioperative and oncological outcomes in patients with BRPC undergoing NAC with FOLFIRINOX for patients undergoing upfront surgery (US). Methods: The AHPBA criteria for borderline resectability and/or a CA19-9 level > 100 µ/mL defined borderline resectable tumors retrieved from a prospectively populated institutional registry from 2007 to 2020. The primary outcome was overall survival (OS) at 1 and 3 years. A Cox Proportional Hazard model based on intention to treat was used. A receiver-operator characteristics (ROC) curve was constructed to assess the discriminatory capability of the use of CA19-9 > 100 µ/mL to predict resectability and mortality. Results: Forty BRPC patients underwent NAC, while 46 underwent US. The median OS with NAC was 19.8 months (interquartile range [IQR], 10.3-44.24) vs. 10.6 months (IQR, 6.37-17.6) with US. At 1 year, 70% of the NAC group and 41.3% of the US group survived (p = 0.008). At 3 years, 42.5 % of the NAC group and 10.9% of the US group survived (p = 0.001). NAC significantly reduced the hazard of death (adjusted hazard ratio, 0.20; 95% confidence interval, 0.07-0.54; p = 0.001). CA19-9 > 100 µ/mL showed poor discrimination in predicting mortality, but was a moderate predictor of resectability. Conclusions: We found a survival benefit of NAC with FOLFIRINOX for BRPC. Greater pre-treatment of CA19-9 and multivessel involvement on initial imaging were associated with progression of the disease following NAC.

• 기술혁신학회지
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• 제14권spc호
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• pp.1096-1127
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• 2011

본 연구는 TOD 시스템이 가져오는 경제적 파급효과에 대해 신규시장창출, 연구기획비용절감, 사업화 성공률 증대효과라는 세 가지 측면에서 정량적으로 추정하고자 하였으며 시스템 개발이 가져오는 효율성 제고라는 측면을 강조하여 패러미터들을 도출하고 시뮬레이션과 시나리오 분석을 실시하였다. 시나리오별로 (1) TOD 시스템 적용비율이 해당부문 R&D 기획과제의 1.4%라고 가정한 경우 R&D 기여율을 적용한 경제적 파급효과 편익의 총합은 2011년 가격기준으로 921.3억원으로 도출되며 연구개발 투입비용(2012-2017년까지 6년간 30억원이 투자되며 2011년 현재가치로는 149.9억원이 투입)을 감안하면 B/C ratio는 6.15으로 도출된다. 시나리오 (2) TOD 시스템 적용비율이 1.9%라고 가정한 경우 경제적 편익의 총합은 1,250.3억원, B/C ratio는 8.34, 시나리오 (3) TOD 시스템 적용비율이 0.9%라고 가정한 경우 경제적 편익은 592.2억원, B/C ratio는 3.95가 도출된다. 본 연구는 기술기회 탐색에 대한 새로운 시스템 개발이 가지는 경제적 효과에 대해서 사전적 타당성을 점검하였고, 시스템 관점에서 연구개발투자의 경제성 평가방법론에 대한 새로운 사례를 제공하였다는데 연구의 의의가 있다.

• 생물정신의학
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• 제19권4호
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• pp.153-158
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• 2012

Understanding of a clinical trial is essential in developing clinical guideline and adopting evidence based practice. In designing and executing clinical trials, following ethical requirements should be considered : social value, scientific validity, fair subject selection, informed consent, favorable risk-benefit ratio, institutional review board, and respect for human subjects. According to the stage of drug development, purpose of trials, accumulated scientific data, clinical trials for drug development are classified as phase 1, 2, 3, and 4. Phases of clinical trials can be overlapped and the judgment of entering into the next phase should be considered highly strategically. In reading, evaluating and interpreting clinical trial reports, various skills and challenges exist. Patient sample composition, trial duration, selection of endpoints, responders and non-responders, placebo effect, patient recruitment, and extrapolation to the real world are the examples of those challenges. Treatment success will come from the well balanced approach of evidence based decision making and consideration of specific single case.

• 제어로봇시스템학회:학술대회논문집
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• 제어로봇시스템학회 2004년도 ICCAS
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• pp.1694-1700
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• 2004

In this paper, we propose the AWLS/MFT (Adaptive Weighed Least Squares/ Modulation Function Technique) devised by A. E. Pearson et al. for the transfer function estimation of a modal system and investigate the performance of several algorithms, the Gram matrix method, a Luenberger Observer (LO), Least Squares (LS), and Recursive Least Squares (RLS), for the estimation of initial conditions. With the benefit of the Modulation Function Technique (MFT), we can separate the estimation problem into two phases: the transfer function parameters are estimated in the first phase, and the initial conditions are estimated in the second phase. The LO method produces excellent IC estimates in the noise free case, but the other three methods show better performance in the noisy case. Finally, we compared our result with the Prony based method. In the noisy case, the AWLS and one of the three methods - Gram matrix, LS, and RLS- show better performance in the output Signal to Error Ratio (SER) aspect than the Prony based method under the same simulation conditions.

• International Journal of Fluid Machinery and Systems
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• 제9권2호
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• pp.129-136
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• 2016

An experimental investigation was carried out to improve the performance of a counter-rotating type horizontal-axis tidal stream power unit. Front and rear blades were designed separately based on modified blade element momentum (BEM) theory, and their performances at different conditions of blade tip speed ratio were measured in a wind tunnel. Three different groups of blades were designed successively, and the results showed that Group3 possessed the highest power coefficient of 0.44 and was the most satisfactory model. This experiment shows that properly increasing diameter and reducing chord length will benefit the performance of the blade.

• 대한치과의사협회지
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• 제56권10호
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• pp.572-580
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• 2018

Adequate access cavity is the key to achieving endodontic success. The aims of the access cavity can be considered as follows: 1) Creation of a smooth unimpeded pathway for instruments to canal orifices 2) Removal of the entire roof of the pulp chamber in order to inspect the pulp floor, 3) Preservation of natural tooth substance consistent with the above. Recently, contracted endodontic cavities based on minimally invasive endodontics has introduced. This has the benefit of preserving the pericervical dentin more than traditional access cavity with achieving long-term success. However, some studies reported controversial results regarding root canal detection, instrumentation efficacy (noninstrumented canal area, hard tissue debris accumulation, canal transportation, and centering ratio) as well as fracture resistance. Therefore, further studies are required for accepting contracted access cavity, and modified form of traditional and contracted access cavity could be considered.

• 생물정신의학
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• 제1권1호
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• pp.7-16
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• 1994

I will try to serve as the basis for the development of a clinical therapeutic guideline of antipsychotic drugs. Knowing that many patients fail standard treatment recommendations, either because of insufficient efficacy or intolerance to adverse effects, led us to emphasize the importance of the guideline. The clinicians continually assimilate new information about recent advances, including : novel agents targeted to impact specific components of various neurotransmitter systems ; combination strategies ; alternative uses of existing agents ; and specialized requirements of a growing number of identified diagnostic subtypes. The cost to benefit ratio must always be considered when developing a therapeutic guideline.