• Communications for Statistical Applications and Methods
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• v.22 no.6
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• pp.531-542
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• 2015

In this survey, we use the normal linear model to demonstrate the use of the linear Bayes method. The superiorities of linear Bayes estimator (LBE) over the classical UMVUE and MLE are established in terms of the mean squared error matrix (MSEM) criterion. Compared with the usual Bayes estimator (obtained by the MCMC method) the proposed LBE is simple and easy to use with numerical results presented to illustrate its performance. We also examine the applications of linear Bayes method to some other distributions including two-parameter exponential family, uniform distribution and inverse Gaussian distribution, and finally make some remarks.

• Journal of Korean Library and Information Science Society
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• v.36 no.3
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• pp.213-231
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• 2005

Yeonhaengrok is a document recorded by one member of the envoy sent to the China from 17 to 19 century. Ik-mo Lee, a member of the envoy, wrote a full explanation of the visit from Nov. 24 1796 to Mar. 7 1797 in his writing $\ulcorner$Byongjin Yeonhaengrok${\lrcorner}$. $\ulcorner$Byongjin Yeonhaengrok${\lrcorner}$, which is omitted in the complete collection of $\ulcorner$Yeonhaengrok${\lrcorner}$, has been newly found at the Family of Suwon Baek's house locating at the Sanggum Vil., Yongsan Town, Jangheung County of Chonnam Province. $\ulcorner$Byongjin Yeonhaengrok${\lrcorner}$ contains an historical meaning that it is an official record of the official envoy that was sent first after the Injong's enthronement in China. This study observed the bibliographical features of $\ulcorner$Byongjin Yeonhaengrok${\lrcorner}$, the time of the transcription, the progress of receiving by the Suwon Baek family. And certified the details of the Byongjin envoy, going and returning between Hanyang and Beijing, staying schedules of the envoy in Beijing.

• BMB Reports
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• v.44 no.12
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• pp.811-815
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• 2011

Inhalational anthrax is caused by B. anthracis, a virulent sporeforming bacterium which secretes anthrax toxins consisting of protective antigen (PA), lethal factor (LF) and edema factor (EF). LF is a Zn-dependent metalloprotease and is the main determinant in the pathogenesis of anthrax. Here we report the identification of a lead small-molecule inhibitor of anthrax lethal factor by screening an available synthetic small-molecule inhibitor library using fluorescence-based high-throughput screening (HTS) approach. Seven small molecules were found to have inhibitory effect against LF activity, among which SM157 had the highest inhibitory activity. All theses small molecule inhibitors inhibited LF in a noncompetitive inhibition mode. SM157 and SM167 are from the same family, both having an identical group complex, which is predicted to insert into S1' pocket of LF. More potent small-molecule inhibitors could be developed by modifying SM157 based on this identical group complex.

• Journal of the Korean housing association
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• v.26 no.3
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• pp.33-43
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• 2015

According to aging society and social network society, the necessary of suitable alternative housing in the era has been increasing. The purpose of this research is to understand housing preference depended on the social relation of the elderly who lives in Beijing, China. The social relation was comprised of contact degree with child, contact degree with friend, contact degree with relative, degree of community participation, satisfaction with spouse and satisfaction with child. The housing preference was comprised of housing ownership, housing location, housing size and housing type. The survey was conducted on the elderly of 150 above fifties who lived in Beijing, China. For the result, the social relation was associated with the housing preference. Particularly, the relationship between the children was related to the housing ownership, housing location and housing size. The relationship between friends was related to the housing type. The level of community participation was related to the housing location. Social independence of the elderly, family cohesion, community attachment and adaption tendency were correlated with the housing preference. In conclusion, it was empirically identified that the social relation of the elderly had a relation with predicting housing preference. This result is expected to be useful in development of housing for the elderly in the future.

• Environmental Engineering Research
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• v.15 no.1
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• pp.49-56
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• 2010

Based on a survey of citizens and data analysis on the environmental status of the Miyun Reservoir watershed, China, the environmental awareness of citizens residing in the watershed and the impacting factors are discussed. The contingent valuation method was used to evaluate the willingness of villagers to pay (WTP) for abatement of the rural domestic pollution and to assess the intensity level of the villagers' desire for improving environmental conditions in the Miyun Reservoir watershed. It was found that rural watershed residents had a fundamental cognitive understanding of the pollution status and protection measures of the Miyun Reservoir. However, based on the survey, local residents had only a small interest in their participation to improve the environmental status of the reservoir, despite their general attitude to protect the reservoir being very positive. Gender and family income were closely associated with the overall attitudes of the population. Public media are the most preferable means for conveying knowledge of environmental protection to people living in the watershed. Increasing the educational level, along with income, are the best ways to enhance the desire of the villagers to improve the environmental quality and management.

• Korea journal of population studies
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• v.17 no.2
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• pp.116-135
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• 1994

China's population and family planning program has heen successful. Women's fertility as measured by total fertility rate (TFR) has declined from 5.8 in 1970 to 2.3 in 1990, accordingly the annual crude birth rate(CBR) has declined from 34 per thousand in 1970 to 21 per thousand in 1989, and the annual natural growth rate from 2.6 percent in 1970 to 1.4 percent in 1989 (Coale and Chen, 1987; SSB, 1991; Gu, 1994). While this is indeed an astonishing achievement for a developing country to have its fertility down to replacement within a short period, some new issues emerging along with the rapid fertility decline require careful considerations. One of them is the uprising of the sex ratio at birth in China. The 1990 population census reported the sex ratio at birth in China of 113.8 in 1989, which is ohviously much higher than the acceptable level of normal ratio around 106. It has received since then a lot of tention in China and abroad, among demographic professionals and governmental agencies alike (Hull, 1990; Johansson and Nygren, 1991; Xuand Guo, 1991; Tu, 1993; Gu and Xu, 1994; among others). Based on the available demographic data and research results this paper will first have a review of the patterns and trends of sex ratio at birth in China, then turn to the immediate causes of abnormal sex ratio at birth and the determinants of the son preference, followed with a conceptual framework for understanding of the phenomenon, and finally the policy implications and recommendations will be discussed.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.4
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• pp.462-469
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• 2017

Objective: The aim of this study is to identify genomic regions or genes controlling growth traits in pigs. Methods: Using a panel of 54,148 single nucleotide polymorphisms (SNPs), we performed a genome-wide Association (GWA) study in 562 pure Yorshire pigs with four growth traits: average daily gain from 30 kg to 100 kg or 115 kg, and days to 100 kg or 115 kg. Fixed and random model Circulating Probability Unification method was used to identify the associations between 54,148 SNPs and these four traits. SNP annotations were performed through the Sus scrofa data set from Ensembl. Bioinformatics analysis, including gene ontology analysis, pathway analysis and network analysis, was used to identify the candidate genes. Results: We detected 6 significant and 12 suggestive SNPs, and identified 9 candidate genes in close proximity to them (suppressor of glucose by autophagy [SOGA1], R-Spondin 2 [RSPO2], mitogen activated protein kinase kinase 6 [MAP2K6], phospholipase C beta 1 [PLCB1], rho GTPASE activating protein 24 [ARHGAP24], cytoplasmic polyadenylation element binding protein 4 [CPEB4], GLI family zinc finger 2 [GLI2], neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 [NYAP2], and zinc finger protein multitype 2 [ZFPM2]). Gene ontology analysis and literature mining indicated that the candidate genes are involved in bone, muscle, fat, and lung development. Pathway analysis revealed that PLCB1 and MAP2K6 participate in the gonadotropin signaling pathway and suggests that these two genes contribute to growth at the onset of puberty. Conclusion: Our results provide new clues for understanding the genetic mechanisms underlying growth traits, and may help improve these traits in future breeding programs.

• Journal of Microbiology and Biotechnology
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• v.27 no.9
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• pp.1628-1638
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• 2017

Viola tianshanica Maxim, belonging to the Violaceae plant family, is traditionally used in Uighur medicine for treating pneumonia, headache, and fever. There is, however, a lack of basic understanding of its pharmacological activities. This study was designed to observe the effects of the ethanol extract (TSM) from Viola tianshanica Maxim on the inflammation response in acute lung injury (ALI) induced by LPS and the possible underlying mechanisms. We found that TSM (200 and 500 mg/kg) significantly decreased inflammatory cytokine production and the number of inflammatory cells, including macrophages and neutrophils, in bronchoalveolar lavage fluid. TSM also markedly inhibited the lung wet-to-dry ratio and alleviated pathological changes in lung tissues. In vitro, after TSM ($12.5-100{\mu}g/ml$) treatment to RAW 264.7 cells for 1 h, LPS ($1{\mu}g/ml$) was added and the cells were further incubated for 24 h. TSM dose-dependently inhibited the levels of proinflammatory cytokines, such as NO, $PGE_2$, $TNF-{\alpha}$, IL-6, and $IL-1{\beta}$, and remarkably decreased the protein and mRNA expression of $TNF-{\alpha}$ and IL-6 in LPS-stimulated RAW 264.7 cells. TSM also suppressed protein expression of $p-I{\kappa}Ba$ and p-ERK1/2 and blocked nuclear translocation of $NF-{\kappa}B$ p65. The results indicate that TSM exerts anti-inflammatory effects related with inhibition on $NF-{\kappa}B$ and MAPK (p-ERK1/2) signaling pathways. In conclusion, our data demonstrate that TSM might be a potential agent for the treatment of ALI.

• Human Ecology Research
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• v.59 no.1
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• pp.45-58
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• 2021

The present study examined whether enjoyable couple activity and common dyadic coping as daily positive couple interactions have direct or indirect effects on marital satisfaction through the mediation of sexual intimacy among urban Chinese women in the early years of marriage. The subjects were 182 urban women born under the one-child policy, who live in Heilongjiang, Anhui and Beijing provinces of China, and have been married up to six years. Data were collected using a self-administered questionnaire. We conducted a hierarchical multiple regression analysis in SPSS software and tested the significance of the mediation effects using bootstrapping method in Mplus software. The results of the study are as follows. First, both enjoyable couple activity and common dyadic coping had positive direct impacts on urban Chinese women's marital satisfaction and positive indirect impacts on marital satisfaction via sexual intimacy. Second, enjoyable couple activity was the strongest predictor of marital satisfaction, followed by common dyadic coping and sexual intimacy. The path model explained 48% of the variance in marital satisfaction. The results suggest that enjoyable couple activity, common dyadic coping, and sexual intimacy should be considered in the design of interventions to enhance urban Chinese women's marital satisfaction in the early years of marriage.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.18
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• pp.7947-7950
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• 2014

Background: Pancreatic cancer is the sixth leading cause of cancer death with an increasing trend in China. Dietary intake is believed to play an important role in pancreatic cancer carcinogenesis. The aim of this paper was to evaluate associations between some dietary factors and risk of pancreatic cancer in a multi-centre case-control study conducted in China. Materials and Methods: Cases (n=323) were ascertained from four provincial cancer hospitals. Controls (n=323) were randomly selected from the family members of patients without pancreatic cancer in the same hospitals, 1:1 matched to cases by gender, age and study center. Data were collected with a questionnaire by personal interview. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated using conditional logistic regression. Results: Tea intake (OR =0.49; 95%CI: 0.30-0.80) was associated with a half reduction in risk of pancreatic cancer. Reduced vegetable consumption (P trend: 0.04) was significant related to pancreatic cancer. Although no significant association was found for meat and fruit, ORs were all above or below the reference group. A protective effect was found for fruit (OR=1.73 for consumption of 1-2 times/week vs more than 3 times/week; 95%CI: 1.05-2.86). A high intake of meat was associated to a higher risk of pancreatic cancer (OR=0.59 for consumption of 1-2 times/week vs. more than 3 times/week; 95%CI: 0.35-0.97). Conclusions: The present study supports fruit consumption to reduce pancreatic cancer risk and indicates that high consumption of meat is related to an elevated risk. Direct inverse relations with tea and vegetable intake were also confirmed.