• Korean Journal of Acupuncture
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• 제23권2호
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• pp.113-123
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• 2006

Objectives: Pharmacopuncture which is a combination of acupuncture and herbal medicine helps to prevent and treat the diseases and symptoms including various pains. However, little was known about the therapeutic effects and its mechanisms on acute pain, although pharmacopuncture has been used frequently in acupuncture clinics. Acupuncture is known for producing analgesia for persistent ankle sprain pain in human. Furthermore, it also produces analgesia in a rat model of ankle sprain pain. Methods: To illuminate the underlying mechanisms of capsaicin pharmacopuncture-induced analgesia, weight bearing force (WBF) was observed on the acute ankle sprained rat model. Ankle sprain was induced in the rat by manually hyper-extending ligaments of the right ankle. Capsaicin pharmacopuncture was applied to SI6 (Yanglo) on the left forelimb (contralateral to the sprained ankle). Results: In behavioral test, capsaicin pharmacopuncture produced marked analgesic effects on acute ankle sprained animals as measured by WBF of the affected limb similar to manual acupuncture. Capsaicin pharmacopuncture was also suppressed by serotonin (5-HT) receptor antagonist methysergide (2 mg/kg, Lp.), but not by opioids receptor antagonist naltrexone (10 mg/kg, Lp.) and alpha adrenoceptor antagonist phentolamine (5 mg/kg, Lp.). Conclusion: The data suggest that capsaicin pharmacopuncture-induced analgesia is accomplished by activating the descending serotonergic inhibitory systems.

• Korean Journal of Acupuncture
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• 제34권1호
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• pp.1-7
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• 2017

Objectives : The purpose of this study was to evaluate effects of taping therapy on recovery of behavioral symptoms and neural excitability of the lumbar spinal cord in rat model for ankle sprain. Methods : Adult Sprague-Dawley rats was used and divided into 3 experimental groups: normal group(n=6), ankle sprain(n=6), and ankle sprain with taping treatment(n=6). In order to induce ankle sprain the right ankle joint was injured with 4~5 repetitive over-flexions and over-extensions manually. The severity of joint pain was evaluated by measuring foot weight bearing force ratio(FWBRF) of the hind limb and the injury-induced edema formation by diameter of the joint following ankle sprain. The changes of neural excitability in the lumbar spinal cord was tested by observation of cFos protein expression, a metabolic marker for neural excitation. Results : Severity of ankle injury induced in this experiment coincided with Grade 1 ankle sprain. Compared with ankle sprain group, ankle sprain＋taping showed a significant reductions of joint pain as well as of edema formation at the ankle joint following ankle sprain. There was significant upregulation of cFos-immunoreactive neurons in the lumbar spinal cord 24 hours after ankle sprain. In contrast, taping therapy resulted in significant inhibition of cFos-immunoreactive neurons in the lumbar spinal cord. Conclusions : Collectively, these results suggest that taping therapy may be an alternative therapeutic intervention for symptom recovery of the mild ankle sprain.

• The Korean Journal of Pain
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• 제27권3호
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• pp.219-228
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• 2014

Background: A lipo-prostaglandin E1 agonist is effective for the treatment of neurological symptoms of spinal stenosis when administered by an oral or intravenous route. we would like to reveal the therapeutic effect of an epidural injection of lipo-prostaglandin E1 on hyperalgesia in foraminal stenosis. Methods: A total of 40 male Sprague-Dawley rats were included. A small stainless steel rod was inserted into the L5/L6 intervertebral foramen to produce intervertebral foraminal stenosis and chronic compression of the dorsal root ganglia (DRG). The rats were divided into three groups: epidural PGE1 (EP) (n = 15), saline (n = 15), and control (n = 10). In the EP group, $0.15{\mu}g{\cdot}kg-1$ of a lipo-PGE1 agonist was injected daily via an epidural catheter for 10 days from postoperative day 3. In the saline group, saline was injected. Behavioral tests for mechanical hyperalgesia were performed for 3 weeks. Then, the target DRG was analyzed for the degree of chromatolysis, chronic inflammation, and fibrosis in light microscopic images. Results: From the fifth day after lipo-PGE1 agonist injection, the EP group showed significant recovery from mechanical hyperalgesia, which was maintained for 3 weeks (P < 0.05). Microscopic analysis showed much less chromatolysis in the EP group than in the saline or control groups. Conclusions: An epidurally administered lipo-PGE1 agonist relieved neuropathic pain, such as mechanical hyperalgesia, in a rat foraminal stenosis model, with decreasing chromatolysis in target DRG. We suggest that epidurally administered lipo-PGE1 may be a useful therapeutic candidate for patients with spinal stenosis.

• Journal of Microbiology and Biotechnology
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• 제23권2호
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• pp.161-166
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• 2013

At present, acetylcholinesterase (AChE) inhibitors are the first group of drugs to treat mild to moderate Alzheimer's disease (AD). Although beneficial in improving cognitive and behavioral symptoms, the effectiveness of AChE inhibitors has been questioned since they do not delay or prevent neurodegeneration in AD patients. Therefore, in the present study, in order to develop new and effective anti-AD agents from lichen products, both the AChE inhibitory and the neuroprotective effects were evaluated. The AChE inhibitory assay was performed based on Ellman's reaction, and the neuroprotective effect was evaluated by using the MTT method on injured PC12 cells. One AChE inhibitor ($IC_{50}$ = 27.1 ${\mu}g/ml$) was isolated by means of bioactivity-guided isolation from the extract of lichen-forming fungus Cladonia macilenta, which showed the most potent AChE inhibitory activity in previous screening experiment. It was then identified as biruloquinone by MS, and $^1H$- and $^{13}C$-NMR analyses. The inhibitory kinetic assay suggested that biruloquinone is a mixed-II inhibitor on AChE. Meanwhile, biruloquinone improved the viability of the $H_2O_2$- and ${\beta}$-amyloid-injured PC12 cells at 1 to 25 ${\mu}g/ml$. The protective effects are proposed to be related to the potent antioxidant activities of biruloquinone. These results imply that biruloquinone has the potential to be developed as a multifunctional anti- AD agent.

• 동서간호학연구지
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• 제8권1호
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• pp.126-134
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• 2003

Purpose: The purpose of this study is to supply the basic materials for the development of objective tools to measure 'Hwa-byung' and for the development of the theories and statements associated with 'Hwa-byung' by making clear the meaning and characteristics of 'Hwa-byung' and by analyzing the concept of 'Hwa-byung'. Method: The concept analysis of Hwa-byung was proceeded according to the concept analysis process of Walker and Avant(1995). Result: The conceptual characteristics of Hwa-byung resulted from the research are like these : (1) Injustice (2) Anger (3) Rumination (4) Anxiety. Therefore, we can describe Hwa-byung as the feeling repeatedly accumulated through the heavy mental pain, injustice, and anger and it is appeared with the physical and behavioral symptoms. Conclusion: Through this concept analysis, we propose as followings ; First, there's need of the objective tools which make it possible to assess Hwa-byung through the theory development and the statement associated with Hwa-byung. Second, there's need of interdisciplinary approach in the development of nursing intervention to coordinate the characteristics of Hwa-byung by understanding the total nature of Hwa-byung and finding the variables associated with Hwa-byung.

• Molecules and Cells
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• 제41권5호
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• pp.486-494
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• 2018

Recently, we have reported that animals with telomerase reverse transcriptase (TERT) overexpression exhibit reduced social interaction, decreased preference for novel social interaction and poor nest-building behaviors-symptoms that mirror those observed in human autism spectrum disorders (ASD). Overexpression of TERT also alters the excitatory/inhibitory (E/I) ratio in the medial prefrontal cortex. However, the effects of TERT overexpression on hippocampal-dependent learning and synaptic efficacy have not been investigated. In the present study, we employed electrophysiological approaches in combination with behavioral analysis to examine hippocampal function of TERT transgenic (TERT-tg) mice and FVB controls. We found that TERT overexpression results in enhanced hippocampal excitation with no changes in inhibition and significantly impairs long-term synaptic plasticity. Interestingly, the expression levels of phosphorylated CREB and phosphorylated $CaMKII{\alpha}$ were significantly decreased while the expression level of $CaMKII{\alpha}$ was slightly increased in the hippocampus of TERT-overexpressing mice. Our observations highlight the importance of TERT in normal synaptic function and behavior and provide additional information on a novel animal model of ASD associated with TERT overexpression.

• 초등상담연구
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• 제4권1호
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• pp.191-214
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• 2005

This study aimed to examine the effect of Cyber Group Counseling on the depression of internet addiction children in elementary school. In this study, the following questions were posed: How effective is the Cyber Group Counseling on the depression of internet addiction children? In this study, subjects were 24 students who got 14 points over in KAIS and got 11 points over in CDI among 245 of 5th, 6th grade students in Daegu and Chongdo Kyungbuk who did Internet addiction scale for Korean Adolescent(KAIS) and Children's Depression Inventory(CDI). They were divided into experimental group and comparative group. Subjects in experimental group practiced Cyber Group Counseling for 12 sessions(60 minutes per session) for 6 weeks. But the control group had no treatment during the period. During the experiment, 2 of each groups were left out. The counseling schedule and hor· to join the Cyber Group Counseling clinic were notified by e-mail. The Cyber Group Counseling was on every Monday and Thursday. The Cyber Group Counseling progressed by internet chatting, bulletin board, e-mail and a slip paper counsel. The collected data were analyzed with SPSS/PC+ (statistical package for the social science/personal computer) program and t -test. The findings of this study were as follows: First, the depression of internet addiction children who joined in Cyber Group Counseling was significantly reduced than the others. So, Cyber Group Counseling was proved one of the useful psychotherapy approach. Second, the subordinate of depression including behavioral disturbance and anhedonia was significantly reduced. Third, the subordinate of depression including the dysphoric mood, the self-deprecation and physiological symptoms was reduced. But it was not statistically significant.

• 대한한방부인과학회지
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• 제21권3호
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• pp.111-120
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• 2008

Purpose: Although premsnstrual syndromes(PMS) have long been recognized, there has been difficulty to evaluate the symtoms. Usually the questionnaire has been used to dignose the PMS. Objective is to investigate the relationship of body temperature between women with PMS and without PMS. Methods: We studied 23 patients visiting ㅇㅇ hospital from 26th December 2005 to 26th April 2006. The Questionnaire for PMS was used to evaluate physical, emotional, and behavioral symptoms accompanying the menstrual cycle of the subjects. The subjects were categorized in two groups, non-PMS(11) and PMS group(12). Body temperature was assessed by Dorex spectrum 9000MB (DOREX Inc.. USA). We measured CV4, CV3, CV12 and CV17 to evaluate the distribution of body temperature, compared the difference of temperature(${\Delta}T$) between CV17-CV4, CV17-CV3, CV17-CV12 and CV12-CV3. We investigated the of temperature and ${\Delta}T$ between two groups by Mann-Whitney U-test. Results: The temperature of CV3 and CV 4 of PMS located in low abdomen were lower than those of non-PMS located in chest. But there was no statistical significance of temperature between two groups. There was lower temperature of low abdomen in PMS group than non-PMS group without statistical significance. Conclusion: The results suggest that DITI could be useful to assess the PMS objectively. But more research should be needed.

• Asian Journal for Public Opinion Research
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• 제10권4호
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• pp.316-339
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• 2022

The effects of the COVID-19 pandemic across various sectors are far-reaching, and the education sector is not an exemption. Approved and recognized vaccines are clinically proven to provide protection and have been considered one of the primary mitigations against the virus. Knowledge, attitude, and related practices (henceforth KAP) toward the virus is widely considered to be an essential cognitive key in public health for health intervention, prevention, and promotion. Previous studies revealed a positive correlation between knowledge and attitude. This study investigated the KAP and their relationship among the 857 college students in one state college in the Philippines using an online survey. Using descriptive statistics, the findings showed that the majority of the respondents have been fully vaccinated against COVID-19. Respondents were shown to be knowledgeable about COVID-19, specifically about its transmission, clinical symptoms, treatment, risk groups, isolation, prevention, and control. Positive attitudes toward individual and governmental mitigation and control of the virus were shown. Their scores on practices revealed that they always exhibit protective and preventive behavioral practices. Pearson correlation revealed a weak significant relationship between knowledge and practice, and a fair significant relationship between attitude and practice. No significant relationship is found between knowledge and attitude. This study hopes to find its place in the literature worthy of consideration as empirical support toward understanding a specific group's perceptive risk and preventive behavior toward the virus, policy making, and health intervention and promotion.

• 지역사회간호학회지
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• 제30권3호
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• pp.295-306
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• 2019

Purpose: There has been a growing recognition that person-centered care enhances the quality of life of nursing home residents with dementia. This study was conducted to develop a person-centered dementia care online education program for direct care staff in long-term care facilities. Methods: Delphi method with expert group was used to validate contents. We developed 61 draft items based on literature review. Twenty experts participated in consecutive three round surveys including 5-point Likert scale questions and open-ended questions. Based on experts' opinions, the content validity ratio for content validity and the coefficient of variation for stability were calculated. Results: Three-round Delphi surveys and additional feedback from the expert panel established a consensus of core contents: 1) dementia (7 categories), 2) person-centered care (6 categories), 3) communication (8 categories), and 4) behavioral and psychological symptoms of dementia (6 categories). Specific sub-categories in each category were differentiated according to the job qualifications (65 sub-categories for registered nurses, 64 sub-categories for nursing aids, and 41 sub-categories for personal care workers). Conclusion: This delphi study identified person-centered dementia education curricula, in which the person-centered approach should be a key policy priority in Korean long-term care system. Now it is urgently needed to develop education programs utilizing online platforms that enable efficient and continuous learning for long-term care staff, which can contribute to behavior changes in the person-centered dementia care approach and improvement of care quality in long-term care facilities.