• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• 제10권1호
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• pp.34-42
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• 1999

본 연구는 정서 행동적 문제를 자주 동반하는 것으로 알려진 아토피피부염 소아 청소년에 대해, 정신과적 문제의 정도와 병변 심각도에 영향을 미칠 수 있는 심리 사회적요인을 알아보고자 하였다. 서울대학교병원 아토피 크리닉을 방문한 아토피피부염 환자 70명(평균 나이 9.9세, 범위：$4{\sim}15$세)과 그 어머니를 대상으로 병력조사설문지, CBCL, MBRI, CDI, STAI을 주어 완성하도록 한 후, 정신과적 면담을 시행하였다, 환자의 피부 병변에 대해 SCORAD index를 이용하여 침범부위, 병변의 경중도, 주관적 증상으로 나누어 평가하였다. 16명(22.9%)이 임상적으로 유의한 정서 행동적 문제가 있을 것으로 예측되었으며 이들은 우울, 특성 불안, 어머니의 통제적 태도, 부정적평가 척도에서 다른 아토피 군보다 점수가 높았다. 병변의 경중도는 특성불안이나 우울정도와, 주관적 증상은 우울, 특성불안, 가족영향, 사회능력, 내재화 및 외현화 문제, 성문제, 아이에 대한 부정적 평가와 관련이 있었다. 아토피피부염을 가진 소아 청소년은 정신과적 문제의 고위험군이며 이러한 정신과적 문제는 양육태도와 함께 피부증상의 주관적 지각에 영향을 미칠 가능성이 높다고 할 수 있다. 향후 이에 대한 정신과적 개입이 필요할 것으로 생각된다.

• 생물정신의학
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• 제7권2호
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• pp.186-190
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• 2000

Objective : The authors experienced that cognitive behavioral therapy(CBT) could replace medication for controlling panic attacks and anticipatory anxiety symptoms. The objective of this study was finding out predicting factors of discontinuation of medication after CBT for patients with panic disorder. Method : A hundred forty-eight patients who met DSM-IV criteria for panic disorder with or without agoraphobia for at least 3 months had completed 12 weekly sessions of Panic Control Therapy(PCT ; Barlow et al). Eighty-one patients who could discontinue medication and sixty-seven patients who could not discontinue medication were measured with several scales as the pre- and post-treatment aassessment. The scales were Beck Depression Inventory(BDI), Clinical Global Impression(CGI), Spielberger State Anxiety Inventory(STAI-state), Anxiety Sensitivity Index(ASI), Body Sensation Questionnaire (BSQ), Panic Belief Questionnaire(PBQ), Agoraphobic Cognition Questionnaire(ACQ), Fear Questionnaire(FQ), Toronto Alexithymia Scale(TAS). Results : At the pre-treatment assessment, the scores of BDI, CGI, STAI-state, ACQ, BSQ were higher in the patients who could discontinue medication than in the patients who could not discontinue medication(t=-2.68, t=-4.88, t=-3.07, t=-3.68, t=-3.35, p<0.01). Conclusion : Patients with panic disorder who were less depressed, less anxious, less agoraphobic and who had less negative cognitions for the bodily sensation and who had higher scores in the therapist's assessment could discontinue their medications.

• Biomolecules & Therapeutics
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• 제20권1호
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• pp.1-18
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• 2012

Schizophrenia is a devastating psychiatric illness that afflicts 1% of the population worldwide, resulting in substantial impact to patients, their families, and health care delivery systems. For many years, schizophrenia has been felt to be associated with dysregulated dopaminergic neurotransmission as a key feature of the pathophysiology of the illness. Although numerous studies point to dopaminergic abnormalities in schizophrenia, dopamine dysfunction cannot completely account for all of the symptoms seen in schizophrenia, and dopamine-based treatments are often inadequate and can be associated with serious side effects. More recently, converging lines of evidence have suggested that there are abnormalities of glutamate transmission in schizophrenia. Glutamatergic neurotransmission involves numerous molecules that facilitate glutamate release, receptor activation, glutamate reuptake, and other synaptic activities. Evidence for glutamatergic abnormalities in schizophrenia primarily has implicated the NMDA and AMPA subtypes of the glutamate receptor. The expression of these receptors and other molecules associated with glutamate neurotransmission has been systematically studied in the brain in schizophrenia. These studies have generally revealed region- and molecule-specifi c changes in glutamate receptor transcript and protein expression in this illness. Given that glutamatergic neurotransmission has been implicated in the pathophysiology of schizophrenia, recent drug development efforts have targeted the glutamate system. Much effort to date has focused on modulation of the NMDA receptor, although more recently other glutamate receptors and transporters have been the targets of drug development. These efforts have been promising thus far, and ongoing efforts to develop additional drugs that modulate glutamatergic neurotransmission are underway that may hold the potential for novel classes of more effective treatments for this serious psychiatric illness.

• Journal of Microbiology and Biotechnology
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• 제22권5호
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• pp.708-720
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• 2012

In this study, we assessed the effects of ginsenoside Re (GRe) administration on repeated immobilization stress-induced behavioral alterations using the forced swimming test (FST), the elevated plus maze (EPM), and the active avoidance conditioning test (AAT). Additionally, we examined the effect of GRe on the central adrenergic system by observing changes in neuronal tyrosine hydroxylase (TH) immunoreactivity and brain-derived neurotrophic factor (BDNF) mRNA expression in the rat brain. Male rats received 10, 20, or 50 mg/kg GRe (i.p.) 30 min before daily exposures to repeated immobilization stress (2 h/day) for 10 days. Activation of the hypothalamic-pituitary-adrenal (HPA) axis in response to repeated immobilization was confirmed by measuring serum levels of corticosterone (CORT) and the expression of corticotrophin-releasing factor (CRF) in the hypothalamus. Repeated immobilization stress increased immobility in the FST and reduced open-arm exploration in the EPM test. It also increased the probability of escape failures in the AAT test, indicating a reduced avoidance response. Daily administration of GRe during the repeated immobilization stress period significantly inhibited the stress-induced behavioral deficits in these behavioral tests. Administration of GRe also significantly blocked the increase in TH expression in the locus coeruleus (LC) and the decrease in BDNF mRNA expression in the hippocampus. Taken together, these findings indicate that administration of GRe prior to immobilization stress significantly improved helpless behaviors and cognitive impairment, possibly through modulating the central noradrenergic system in rats. These findings suggest that GRe may be a useful agent for treating complex symptoms of depression, anxiety, and cognitive impairment.

• 디지털콘텐츠학회 논문지
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• 제18권3호
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• pp.443-455
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• 2017

본 연구는 청소년 우울증 측정 및 관리를 위한 스마트폰 어플리케이션 콘텐츠 개발(박정선 외, 2016) 연구의 후속 연구로, 인지행동치료이론에 기반하여 스마트폰 어플리케이션을 설계하고 구현했다. 이 앱은 우울증에 대한 분석과 간편하고 연속적인 자기점검을 가능하게 하며, 이를 통해 우울의 단발적 분석 및 진단이 위주였던 이전 앱과 달리 심리 상태의 지속적 관리가 가능하도록 하였다. 더불어 실질적인 상담 서비스가 연계되도록 하였다. 이러한 목표를 달성하기 위해 청소년 우울증에 대한 선행연구 뿐만 아니라, 우울증 관련 모바일 어플리케이션을 조사하였다.

• 한국정보전자통신기술학회논문지
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• 제8권2호
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• pp.133-139
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• 2015

연구의 목적은 지적장애인 생활시설 입소자의 스트레스, 행동지수 요인이 삶의 만족도에 미치는 영향을 분석하고자 한다. 연구대상은 대전광역시 지적장애인 생활시설 지적장애인 200명을 대상으로 2014년 3월 5일부터 9월 22일 까지 설문조사를 실시하였다. 분석방법은 SPSS WIN 18.0, Amos 21.0 프로그램을 사용하여 t-test와 일원변량분석, 확인적 요인분석, 구조방정식을 실시하여 유의수준 5%에서 검증하였다. 연구결과는 첫째는 스트레스가 삶의 만족도에 영향을 미치지 않음을 알 수 있다. 둘째, 행동지수요인이 이용만족도에 영향을 미치지 않음을 알 수 있다. 셋째, 신체증상의 경우에 이용자 만족도에 의하여 삶의 만족도에 영향을 미치는 것을 알 수 있다. 향후 생활시설 지적장애인의 이용만족도와 일상생활 스트레스의 개선에 대한 정책적 기초자료에 활용이 요구된다.

• Animal Bioscience
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• 제37권5호
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• pp.944-951
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• 2024

Objective: Parturition is crucial for dams, their calves, and cow managers. The prediction of calving time, which assists cow managers to decide on the relocation of cows to maternity pens and necessity of human supervision, is a pivotal aspect of livestock farming. However, existing methods of predicting calving time in dairy cows based on hormonal changes and clinical symptoms are time-consuming and yield unreliable predictions. Accordingly, we investigated whether heart rate variability (HRV) which is a non-invasive assessment of autonomic nervous system (ANS) activity and behavior during the prepartum period would be useful for predicting calving time in dairy cows. Methods: Eight pregnant cows were surveilled under electrocardiogram and video recordings for HRV and behavioral analyses, respectively. HRV parameters in time and frequency domains were evaluated. A 24-h time budget was calculated for each of six types of behavior (standing and lying with or without rumination, sleeping, and eating). Results: Heart rate on calving day is considerably higher than those recorded on the days preceding calving. Low frequency power declined, whereas high frequency power escalated on the calving day compared to the period between 24 and 48 h before calving. The time budget for ruminating while lying decreased and that while standing increased markedly on the calving day compared to those allocated on the preceding days; nonetheless, the total time budget for ruminating did not differ during the prepartum period. Conclusion: We elucidated the ANS activity and behavioral profiles during prepartum period. Our results confirm that HRV parameters and behavior are useful for predicting calving time, and interestingly indicate that the time budget for ruminating while standing (or lying) may serve as a valuable predictor of calving. Collectively, our findings lay the foundation for future investigations to determine other potential predictors and formulate an algorithm for predicting calving time.

• 한국사회복지학
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• 제63권1호
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• pp.187-215
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• 2011

본 연구는 긴장감소가설과 독성가설을 토대로 우울수준이 음주행위에 미치는 영향과 음주행위가 우울수준에 미치는 영향의 경로를 동시에 고려하여 우울수준과 음주행위의 종단적상호관계를 파악하고, 심리사회행동적 요인들(흡연량,자아존중감,가족관계만족,사회적친분관계만족)이 우울수준과 음주행위에 미치는 영향은 어떠한지를 살펴보았다. 본 연구는 한국복지패널 1,2,3차년도 자료를 활용하여, 변수들간의 종단적인 변화 관계를 추정하는데 적합한 잠재성장모형을 이용하여 분석하였다. 분석결과 음주행위 초기값이 우울수준 변화율에 미치는 영향과 우울수준 초기값이 음주행위 변화율에 미치는 영향 모두 정적으로 유의한 것으로 나타났으나, 음주행위 초기값이 우울수준 변화율에 미치는 경로의 영향력이 더 크게 나타났다. 심리사회행동적 요인들 중에서 자아존중감과 가족관계만족수준은 우울수준의 초기값과 변화율에 가장 큰 영향을 미치는 변수로 나타난 반면, 흡연량과 사회적친분관계만족은 음주행위 초기값과 변화율에 가장 큰 영향을 미치는 변수로 나타났다. 본 연구는 음주행위와 우울수준 간의 복합적 관계 기제를 밝히었다는데 그 의의가 있으며, 분석결과를 통해 연구의 정책 및 실천적 함의를 제시하였다.

• 대한영양사협회학술지
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• 제18권2호
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• pp.97-114
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• 2012

This study was performed to assess the nutritional status and hair mineral content of children with behavioral problems and compare the values with a gender, age-matched control group. The subjects were recruited from S elementary school children in Seoul, Korea. Students scored higher than 60 points were diagnosed with behavioral problems according to the Korean-Child Behavior Checklist. Nutritional assessment of the two groups (behavior problem group: male n=15, female n=24; $9.6{\pm}1.6$ years, control group: male n=16, female n=18; $9.5{\pm}1.9$ years) was performed using a nutritional survey and by measuring hair mineral contents. In the results, food frequency questionnaire analysis showed that the intakes of anchovy (P<0.05), soybean curb (P<0.01), radish (P<0.05), bean sprouts (P<0.05), spinach (P<0.05), carrot (P<0.05), pumpkin (P<0.05), lettuce (P<0.05), cabbage (P<0.01), apple (P<0.05), and milk (P<0.01) were higher in the control group than the behavior problem group, whereas intakes of ramyeon (P<0.05), cookies (P<0.05), and coke (P<0.01) were higher in the behavior problem group than the control group. Intakes of most nutrients such as plant-derived protein (P<0.05), fiber (P<0.05), plant-derived calcium (P<0.05), phosphorus (P<0.05), plant-derived iron (P<0.05), vitamin B2 (P<0.05), vitamin B6 (P<0.05), vitamin C (P<0.01), vitamin E (P<0.05), and folate (P<0.05) were significantly higher in the control group than the behavior problem group. Hair analysis showed that the levels of arsenic (P<0.05), mercury (P<0.001), uranium (P<0.05), iron (P<0.001), boron (P<0.01), and germanium (P<0.001) were lower, but the levels of phosphate (P<0.05), chromium (P<0.001), sodium (P<0.05), and sulfur (P<0.001) were higher in the behavior problem group than the control group. Conclusively, behavioral problems constitute a complicated condition in which nutritional factors may play major roles. However, it is still under investigation as to whether or not modification of dietary habits or nutritional supplementation can improve children's behavior, since symptoms require a broad understanding of the environmental and genetic interactions.

• 정신신체의학
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• 제22권1호
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• pp.23-30
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• 2014

연구목적 호모시스테인은 인지기능의 손상과 다양한 정신과 증상들과 연관되어 있다. 본 연구는 혈중 호모시스테인 농도와 치매의 행동심리증상 사이에 연관성을 검증하기 위해서 시행되었다. 방법 DSM-IV에 의해 알쯔하이머형 치매로 진단된 환자 41명의 혈중 호모시스테인, 엽산, 비타민 $B_{12}$ 농도를 측정하였다. 그리고 병력청취, 신체검사와 간이정신상태기능검사(MMSE), 전반적 퇴화척도(GDS), 임상치매 평가척도(CDR), 한국형 신경정신행동검사(K-NPI)를 수행하였다. 결과 호모시스테인 농도와 NPI 총 점수 사이에 통계적으로 유의한 양의 상관관계가 관찰되었고 망상, 초조/공격성, 우울/불쾌, 들뜸/흥분과 같은 여러 하위항목과도 양의 상관관계가 관찰되었다. 호모시스테인 농도와 MMSE, GDS, CDR 점수 사이에는 유의한 상관관계가 관찰되지 않았다. 결론 본 연구는 혈중 호모시스테인 농도가 치매의 행동심리증상과 연관되어 있음을 보여준다. 추가적인 연구를 통하여 이와 연관된 병태생리학적 기전을 밝히는 것이 필요하다.