• Journal of Acupuncture Research
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• 제22권5호
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• pp.67-77
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• 2005

Objectives : The purpose of this study is to examine if Bee Venom Acupuncture may be effective to the neuropathic pain(mechanical allodynia, cold allodynia) in a rat model of neuropathic pain. Methods : To produce the model of neuropathic pain, under isoflurane 2.5% anesthesia, tibial nerve and sural nerve was resected. After the neuropathic surgery, the author examined if the animals exhibited the behavioral signs of alloynia. The allodynia was assessed by stimulating the medial malleolus with von Frey filament and acetone. Three weeks after the neuropathic surgery, Bee Venom Acupuncture was injected at Hwando(GB30) one time a day for one week. After that, the author examined the withdrawl response of neuropathic rats' legs by yon Frey filament and acetone stimulation. And also the author examined c-Fos in the midbrain central gray of neuropathic rats and the change of WBC count in the blood of neuropathic rats. Results : The Bee Venom Acupuncture injected Hwando(GB30) decreased the withdrawl response of mechanical allodynia in BV-2, BV-3 group as compared with control group. The Bee Venom Acupuncture injected Hwando(GB30) decreased the withdrawl response of chemical allodynia(cold allodynia) in BV-2, BV-3 group as compared with control group. The Bee Venom Acupuncture injected Hwando(GB30) showed the significant difference between control group and BV-2 group, control group and BV-3 group in the c-Fos expression and U count. Conclusion : We have noticed that Bee Venom Acupuncture at Hwando(GB30) decreased mechanical allodynia and cold allodynia in the model of neuropathic pain compared with the control group. C-Fos expression in the central gray of that group was also decreased compared with the control group. Psin control using Bee Venom Acupuncture was accumulated as time goes by. This study can be used as a basic resource on a study and a treatment of pain.

• 대한한방부인과학회지
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• 제30권4호
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• pp.100-113
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• 2017

Objectives: Bee Venom has been used to relieve pain and to treat various diseases, such as arthritis, cancer and skin disease. Although Bee Venom has used extensively in gynecological fields, we don't have enough evidence with it. This study is to investigate efficacy and safety of Bee Venom on women by investigating papers, then we are going to suggest the direction of research. Methods: We searched for papers which had Bee Venom from Pubmed, OASIS, Journal of Korean Obstetrics & Gynecology, Journal of Korean Medicine up to August 2017, then classified according to the type of studies. Results: Eleven papers have been finally selected. One paper was a case report about atypical squamous cells of undetermined significance. Four papers were in vivo studies about 1 endometriosis and 1 polycystic ovarian syndrome and 2 human cervical cancer. Among eight papers that were in vitro studies, four papers were reported about ovarian cancer and four papers reported about human cervical cancer. Among ten papers that were experimental studies, two papers have been studied both in vivo and in vitro. Most of studies have shown that Bee Venom is useful for gynecological disorders. Conclusions: It has been identified that Bee Venom could be a good treatment for female disorder. However, more clinical reports and well-designed studies will be needed.

• 생명과학회지
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• 제17권11호
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• pp.1596-1600
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• 2007

본 연구에서 봉독의 apoptosis 유도에 의한 항암기전 효능을 A549 인체폐암세포를 대상으로 조사하였으며, apoptosis 유발에 관여할 것으로 예상되는 중요한 유전자들의 발현 및 활성에 미치는 봉독의 영향을 조사하였다. A549 세포의 생존율은 봉독의 처리 농도 증가에 따라 강력하게 억제되었으며, 이는 염색질 응축 현상을 동반한 apoptosis 유발에 의한 것임을 알 수 있었다. 봉독 처리에 의한 apoptosis 유발은 Bax 및 Bcl-xL의 발현 변화 없이 Bcl-2의 발현 감소에 따른 상대적인 Bax의 발현 증가와 IAP family에 속하는 인자들의 발현 감소 및 caspase의 활성화와 연관성이 있었다.

• 대한약침학회지
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• 제3권1호
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• pp.157-175
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• 2000

In order to study Bee venom and Pain, We searched Journals and Internet. The results were as follows: 1. The domestic papers were total 13. 4 papers were published at The journal of korean acupuncture & moxibustion society, 3 papers were published at The journal of korean oriental medical society, Each The journal of KyoungHee University Oriental Medicine and The journal of korean sports oriental medical society published 1 papers and Unpublished desertations were 3. The clinical studies were 4 and the experimental studies were 9. 2. The domestic clinical studies reported that Bee venom Herbal Acupuncture therapy was effective on HIVD, Subacute arthritis of Knee Joint and Sequale of sprain. In the domestic experimental studies, 5 were related to analgesic effect of Bee vnom and 4 were related to mechanism of analgesia. 3. The journals searched by PubMed were total 18. 5 papers were published at Pain, Each 2 papers were published at Neurosci Lett. and Br J Pharmacol, and Each Eur J Pain, J Rheumatol, Brain Res, Neuroscience, Nature and Toxicon et al published 1 paper. 4. In the journals searched by PubMed, Only the experimental studies were existed. 8 papers used Bee Venom as pain induction substance and 1 paper was related to analgesic effects of Bee venom. 5. 15 webpage were searched by internet related to Bee Venom and pain. 11 were the introduction related to arthritis, 1 was the advertisement, 1 was the patient's experience, 1 was the case report on RA, 1 was review article.

• Journal of Acupuncture Research
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• 제17권1호
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• pp.169-174
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• 2000

The immune response of Bee Venom Therapy is commonly appear in clinics. It is whole body delayed allergy type and generally like fatigue. Therefore, in order to analysis the clinical form, we have observed immune response of 100 patients who visited Sangji University Oriental Medical Hospital and treated Bee Venom Therapy over 10 times from November 1998 to October 1999. The results were summarized as follows. 1. The distribution of Sex was 60 females, 40 males, and the average of patients age was $50.6{\pm}1.5years$. 2. The distribution of disease was degenerative arthritis, HIVD of L-spine, RA, etc. 3. The total treated time is 2765 and is observed 361 immume responses. 4. The average of keeping time in immume response is $11.8{\pm}0.6(hr)$, and the cases of over 24hrs is occupied 24.0%. 5. In the correlation between treated times and immume response is generally in inverse proportion. 6. The general aspect of immume response is chilling, heating, powerless, headache, dizziness, etc. 7. $M{\ddot{u}}ller$ Grade II-III was observed only 1%.

• Journal of Acupuncture Research
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• 제25권3호
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• pp.29-39
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• 2008

Methods : We investigated 28 cases of patients with thoracolumbar compression fracture. We divided patients into two groups : We treated one group with complex oriental medical treatment focusing on Bee Venom Acupuncture therapy, and did the other group with complex oriental medical treatment focusing on acupuncture therapy. To investigate the effectiveness of treatment applied for two groups, we used Visual Analog Scale(VAS) and Oswestry Low-back Pain Disability Index(ODI). We compared the VAS score and ODI score of two groups statistically. Results : 1. Female is prominent in distribution of sex, the average age bracket is 70's, and the largest group was Faccidental fall in the distribution of cause. 2. In regard to level of injury, T12 was found to be most prominent, followed in turn by L1, L2. In regard to grade of clinical symptoms, Grade III was most prominent, followed by Grade IV, Grade II. 3. As a result of evaluation by using VAS score and ODI score, treatment score at final was significantly different from that at the baseline in each group. 4. After treatment, Bee Venom acupuncture therapy group showed significant difference on VAS score and ODI score compared with acupuncture therapy group. Conclusions : Bee Venom acupuncture therapy can be available for relieving symptoms related with thoracolumbar compression fracture.

• 대한약침학회지
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• 제4권3호
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• pp.119-126
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• 2001

Objective : In order to report the process of treatment of Aplastic anemia by herbal acupuncture Methods: This case was diagnosed as deficiency of Yang of spleen and kidneys, deficiency of Ki and blood, and fevescence from the deficiency of Urn. Hominis Placenta herbal acupuncture and Bee-venom acupuncture were choosen as the method to treat the case. Results: 1. The nocturnal fevescence and indigestion was decreased during the times when Hominis Placenta herbal acupuncture was used once a day. 2. The mobility of the joints was improved and the inflamation on the joints was decreased during the times when Bee-venom acupuncture was used every other day. 3. The interval between the transfusion was extended during the times when Hominis Placenta herbal acupuncture and Bee-venom acupuncture were used by turns. Conclution : Hominis Placenta herbal acupuncture and Bee-venom acupuncture sucessfully imporved the symtoms of patient with Aplastic anemia

• Journal of Acupuncture Research
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• 제21권4호
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• pp.251-262
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• 2004

Objective: Ths research was to investigate the efficacy of bee venom theraphy on peripheral facial paralysis. Methods: Thirty patients were deyided into two groups with fifteen patients each. Group A and B were both treated with basic oriental medicine treatment, and also group A was treated with bee venom aqua-acupunture additionaly. The groups were evaluated by Yanagihara's unweighted grading system before treatment, and at every one week till four weeks after treatment. Results: The Yanagihara's scores of group B were higher than those of group A before treatment, after one week and two weeks, but not statistically significant. After three and four weeks, the Yanagihara's scores of group A were higher than those of group B, but not statistically significant. The improvement indexes of group A were higher than those of group B from the first week and statistically significant after three and four weeks. Conclusion: Combinding bee venom aqua-acupunture theraphy on peripheral facial paralysis was more efficacious than the only use of basic oriental medicine treatment.

• 대한약침학회지
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• 제8권3호
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• pp.99-105
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• 2005

Objectives : The purpose of this study is to analyze the functional and clinical improvement effect on temporomandibular disorder by additional Hominis Placenta and bee venom herbal acupuncture treatment. Methods : A patient was treated with Hominis Placenta, bee venom herbal acupuncture, simple acupuncture, chiropractic therapy, and herbal medicine. We evaluated the improvement by visual analogue scale(VAS) score, mouth opening range, and X-ray image. Results : The VAS score was significantly decreased and mouth opening range was increased after treatment. X-ray image showed improved change after treatments. Conclusions : We think Hominis Placenta and bee venom herbal acupuncture treatment mainly contributed to the improvement of temporomandibular disorders. Further study is needed for the confirmation of this effect of on temporomandibular disorders.

• 대한약침학회지
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• 제5권2호
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• pp.109-115
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• 2002

Objective : This study was performed to evaluate the treatment of Acupuncture therapy including Herbal Acupuncture theraphy and Korean Bee Venom Theraphy in Klippel-Trenaunay-Weber Syndrome. Methods : We treated 1 case of Klippel-Trenaunay-Weber Syndrome patient with mainly Korean Bee Venom Theraphy, and herbal Acupuncture, acupuncture theraphy from 27th August, 2001 to February, 2003. Results : After 3 weeks of Korean Bee Venom Theraphy, and herbal Acupuncture, acupuncture theraphy, a remarkable improvement was made for Klippel-Trenaunay-Weber Syndrome. Conclusions : Korean Bee Venom Theraphy and other acupuncture therapies were effective in reducing the symptoms. We think that it need the further study and clinical trial for Klippel-Trenaunay-Weber Syndrome.