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http://dx.doi.org/10.15204/jkobgy.2017.30.4.100

A Review of the Utility of Bee Venom on Gynecological Disorders  

Lee, Jin-Wook (Dept. of Clinical Korean Medicine, Graduate School, Kyung-Hee University)
Kang, Na-Hoon (Dept. of Clinical Korean Medicine, Graduate School, Kyung-Hee University)
Yoo, Eun-Sil (Dept. of Clinical Korean Medicine, Graduate School, Kyung-Hee University)
Park, Nam-Chun (Dept. of Clinical Korean Medicine, Graduate School, Kyung-Hee University)
Yang, He-Rynn (Dept. of Clinical Korean Medicine, Graduate School, Kyung-Hee University)
Kim, Nam-Hoon (Women's Healthcare Center, Kyung-Hee University Korean Medicine Hospital)
Park, Kyoung-Sun (Dept. of Gynecology, College of Korean Medicine, Kyung-Hee University)
Lee, Jin-Moo (Dept. of Gynecology, College of Korean Medicine, Kyung-Hee University)
Lee, Chang-Hoon (Dept. of Gynecology, College of Korean Medicine, Kyung-Hee University)
Jang, Jun-Bok (Dept. of Gynecology, College of Korean Medicine, Kyung-Hee University)
Hwang, Deok-Sang (Dept. of Gynecology, College of Korean Medicine, Kyung-Hee University)
Publication Information
The Journal of Korean Obstetrics and Gynecology / v.30, no.4, 2017 , pp. 100-113 More about this Journal
Abstract
Objectives: Bee Venom has been used to relieve pain and to treat various diseases, such as arthritis, cancer and skin disease. Although Bee Venom has used extensively in gynecological fields, we don't have enough evidence with it. This study is to investigate efficacy and safety of Bee Venom on women by investigating papers, then we are going to suggest the direction of research. Methods: We searched for papers which had Bee Venom from Pubmed, OASIS, Journal of Korean Obstetrics & Gynecology, Journal of Korean Medicine up to August 2017, then classified according to the type of studies. Results: Eleven papers have been finally selected. One paper was a case report about atypical squamous cells of undetermined significance. Four papers were in vivo studies about 1 endometriosis and 1 polycystic ovarian syndrome and 2 human cervical cancer. Among eight papers that were in vitro studies, four papers were reported about ovarian cancer and four papers reported about human cervical cancer. Among ten papers that were experimental studies, two papers have been studied both in vivo and in vitro. Most of studies have shown that Bee Venom is useful for gynecological disorders. Conclusions: It has been identified that Bee Venom could be a good treatment for female disorder. However, more clinical reports and well-designed studies will be needed.
Keywords
Bee Venom; Pharmacopuncture; Gynecological Disorder; Immunology;
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Times Cited By KSCI : 2  (Citation Analysis)
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1 Jo MR, et al. Anti-cancer Effect of Bee Venom Toxin and Melittin in Ovarian Cancer Cells through Induction of Death Receptors and Inhibition of JAK2/STAT3 Pathway. Toxicology and Applied Pharmacology. 2011;258(1) :72-81.   DOI
2 Alizadehnohi M, et al. The Synergistic Cytotoxic Effect of Cisplatin and Honey Bee Venom on Human Ovarian Cancer Cell Line A2780cp. J Venom Res. 2012;3:22-7.
3 Alonezi S, et al. Metabolomic Profiling of the Effects of Melittin on Cisplatin Resistant and Cisplatin Sensitive Ovarian Cancer Cells Using Mass Spectrometry and Biolog Microarray Technology. Metabolites. 2016;6(4):1-18. Available from:URL:http://dx.doi.org/10.3390/metabo6040035.   DOI
4 Alonezi S, et al. Metabolomic Profiling of the Synergistic Effects of Melittin in Combination with Cisplatin on Ovarian Cancer Cells. Metabolites. 2017;7(2):1-18. Available from:URL: http://dx.doi.org/10.3390/metabo7020014.   DOI
5 Ip SW, et al. Bee Venom Induced Cell Cycle Arrest and Apoptosis in Human Cervical Epidermoid Carcinoma Ca Ski Cells. Anitocancer Research. 2008; 28(2A);833-75.
6 Shin JM, et al. Melittin Suppresses HIF-$1{\alpha}$/VEGF Expression through Inhibition of ERK and mTOR/p70S6K Pathway in Human Cervical Carcinoma Cells. Plos One. 2013;8(7):77-84.
7 Park JW, et al. An Analysis of the Study Tendency on Bee Venom - Focusing on Study of Bee Venom in Domestic Theses. J Oriental Rehab Med. 2006;16(2):31-52.
8 Kim MH. Bee Venom Therapy & Bee Acupuncture Therapy. Seoul:Korean Education Company. 1992:144.
9 Han CH, et al. The Review on the Study of Bee Venom in the Journals of Korean Medicine. Korean Journal of Acupuncture. 2013;30(1):27-36.   DOI
10 Chen J, Lariviere WR. The Nociceptive and Anti-nociceptive Effects of Bee Venom Injection and Therapy: a Double-edged Sword. Progress in Neurobiology. 2010;92(2):151-83.   DOI
11 Lee JA, et al. Bee Venom Acupuncture for rheumatoid Arthritis: a Systematic Revuew of Randomised Clinical Trials. Complementary Medicine. 2014:4(11):1-9. Available from:URL:http://dx.doi.org/10.1136/bmjopen-2014-006140.   DOI
12 Teles A, Ana Claudia Zenclussen, Anne Schumacher. Regulatory T Cells are Baby's Best Friends. American Journal of Reproductive Immunolgy. 2013;69(4) :331-9.   DOI
13 Winger EE, Reed JL. Low Circulating CD4+ CD25+ Foxp3+ T Regulatory Cell Levels Predict Miscarriage Risk in Newly Pregnant Women with a History of Failure. American Journal of Reproductive Immunology. 2011; 66(4):320-8.   DOI
14 Prins JR, et al. Preeclampsia is Associated with Lower Percentages of Regulatory T Cells in Maternal Blood. Hypertension in Pregnancy. 2009;28(3):300-11.   DOI
15 Santner-Nanan B, et al. Systemic Increase in the Ratio between Foxp3+ and IL-17-producing CD4+ T Cells in Healthy Pregnancy but not in Preeclampsia. J Immunol. 2009;183(11):7023-30.   DOI
16 Kang NH. Bee Venom Phospholipase A2 Protects Against Lipopolysaccharide Induced Abortion in Mice. Department of Clinical Korean Medicine, Graduate School, Kyung Hee University. 2017.
17 Son DJ, et al. Therapeutic Application of Anti-arthritis, Pain-releasing, and Anti-cancer Effects of Bee Venom and its Constituent Compounds. Pharmacal. Ther. 2007;115(2):246-70.   DOI
18 Lee JD, et al. An Overview of Bee Venom Acupuncture in the Treatment of Arthritis. Evid. Based Complement. Altern. Med. 2005;2(1):79-84.   DOI
19 Hwang DS, et al. Therapeutic Effects of Bee Venom on Immunological and Neurological Diseases. Toxins. 2015; 7(7):2413-21.   DOI
20 Choi MS, et al. Bee Venom Ameliorates Ovalbumin Induced Allergic Zsthma via Modulating CD4+CD25+ Regulatory T Cells in Mice. Cytokine. 2013;61(1) :256-65.   DOI
21 Cho SY, et al. Effectiveness of Acupuncture and Bee Venom Acupuncture in Idiopathic Parkinson's Disease. Park. Relat. Disord. 2012;18(8):948-52.   DOI
22 Kang SY, et al. Repetitive Treatment with Diluted Bee Venom Reduces Neuropathic Pain via Potentiation of Locus Coeruleus Noradrenergic Neuronal Activity and Modulation of Spinal NR1 Phosphotylation in Rats. J Pain. 2012; 13(2):155-66.   DOI
23 Lee HJ, et al. Bee Venom-associated Th1/Th2 Immunoglobulin Class Switching Results in Immune Tolerance of NZB/W F1 Murine Lupus Nephritis. Am J Nephrol. 2011;34(2):163-235.   DOI
24 Lee YH, et al. Effects of Bee Venom Acupuncture on Surgically Induced Endometriosis Rats. Journal of Pharmacopuncture. 2006;9(1):21-32.   DOI
25 Yang EJ, et al. Bee venom attenuates neuroinflammatory events and extends survival in amyotrophic lateral sclerosis models. Neuroinflamm. 2010;7(1):1-12. Available from:URL:http://doi.org/10.1186/1742-2094-7-69.   DOI
26 Ernerudh J, Berg G, Mjosberg J. Regulatory T Helper Cells in Pregnancy and their Roles in Systemic versus Local Immune Tolerance. American Journal of Reproductive Immunology. 2011;66(1):31-43.   DOI
27 Lee SK, et al. Th17 and Regulatory T cells in Women with Recurrent Pregnancy Loss. American Journal of Rproductive Immunology. 2012; 67(4):311-8.   DOI
28 Dorota DK, et al. The Predominance of Th17 Lymphocytes and Decreased Number and Function of Treg Cells in Preeclampsia. Journal of Reproductive Immunology. 2012;93(2):75-81.   DOI
29 Kim SW, et al. A Report of Atypical Squamous Cells of Undetermined Significance(ASCUS) Treated by Bee Venom Therapy. J Korean Obstet Gynecol. 2005;18(2):169-75.
30 Karimzadeh L, et al. Effect of Bee Venom on IL-6, COX-2 and VEGF Levels in Polycystic Ovarian Syndrome Induced in Wistar Rats by Estradiol Valerate. Journal of Venomous Animals and Toxins Including Tropical Diseases. 2013;19(1):1-8. Available from:URL: http://doi.org/10.1186/1678-9199-19-32.   DOI
31 Kim YW, et al. Honeybee Venom Possesses Anticancer and Antiviral Effects by Differential Inhibition of HPV E6 and E7 Expression on Cervical Cancer Cell Line. Oncology Reports. 2015;33(4):1675-82.   DOI
32 Lee HL, et al. Bee Venom Inhibits Growth of Hyman Cervical Tumors in Mice. Oncotarget. 2015;6(9):7280-92.