• Communications for Statistical Applications and Methods
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• 제22권2호
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• pp.181-199
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• 2015

In a short history, RNA-seq data have established a revolutionary tool to directly decode various scenarios occurring on whole genome-wide expression profiles in regards with differential expression at gene, transcript, isoform, and exon specific quantification, genetic and genomic mutations, and etc. RNA-seq technique has been rapidly replacing arrays with seq-based platform experimental settings by revealing a couple of advantages such as identification of alternative splicing and allelic specific expression. The remarkable characteristics of high-throughput large-scale expression profile in RNA-seq are lied on expression levels of read counts, structure of correlated samples and genes, larger number of genes compared to sample size, different sampling rates, inevitable systematic RNA-seq biases, and etc. In this study, we will comprehensively review how robust Bayesian and non-parametric methods have a better performance than classical statistical approaches by explicitly incorporating such intrinsic RNA-seq specific features with flexible and more appropriate assumptions and distributions in practice.

• Nuclear Engineering and Technology
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• 제40권5호
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• pp.375-386
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• 2008

Conventional static reliability analysis methods are inadequate for modeling dynamic interactions between components of a system. Various techniques such as dynamic fault tree, dynamic Bayesian networks, and dynamic reliability block diagrams have been proposed for modeling dynamic systems based on improvement of the conventional modeling methods. In this paper, we review these methods briefly and introduce dynamic nodes to the existing reliability graph with general gates (RGGG) as an intuitive modeling method to model dynamic systems. For a quantitative analysis, we use a discrete-time method to convert an RGGG to an equivalent Bayesian network and develop a software tool for generation of probability tables.

• Communications for Statistical Applications and Methods
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• 제29권5호
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• pp.513-532
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• 2022

In this paper, the use of Bayes factors and the deviance information criterion for model selection are compared in a Bayesian accelerated life testing setup. In Bayesian accelerated life testing, the most used tool for model comparison is the deviance information criterion. An alternative and more formal approach is to use Bayes factors to compare models. However, Bayesian accelerated life testing models with more than one stressor often have mathematically intractable posterior distributions and Markov chain Monte Carlo methods are employed to obtain posterior samples to base inference on. The computation of the marginal likelihood is challenging when working with such complex models. In this paper, methods for approximating the marginal likelihood and the application thereof in the accelerated life testing paradigm are explored for dual-stress models. A simulation study is also included, where Bayes factors using the different approximation methods and the deviance information are compared.

• 한국환경과학회지
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• 제20권12호
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• pp.1541-1551
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• 2011

This study applied the Bayesian method for the quantification of the parameter uncertainty of spatial linear mixed model in the estimation of the spatial distribution of probability rainfall. In the application of Bayesian method, the prior sensitivity analysis was implemented by using the priors normally selected in the existing studies which applied the Bayesian method for the puppose of assessing the influence which the selection of the priors of model parameters had on posteriors. As a result, the posteriors of parameters were differently estimated which priors were selected, and then in the case of the prior combination, F-S-E, the sizes of uncertainty intervals were minimum and the modes, means and medians of the posteriors were similar to the estimates using the existing classical methods. From the comparitive analysis between Bayesian and plug-in spatial predictions, we could find that the uncertainty of plug-in prediction could be slightly underestimated than that of Bayesian prediction.

• 공학논문집
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• 제2권1호
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• pp.49-56
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• 1997

Emission computed tomography에 있어서 Bayesian방법에 근거한 통계학적 영상 재구성법이 수년간에 걸쳐 중요한 관심사로 대두되어 왔다. 이는 Bayesian 접근 방법을 사용할 경우 영상 재구성 알고리즘에 재구성하고자 하는 영상에 대한 사전정보를 포함시킬 수 있기 때문이었다. 이러한 방법은 경우에 따라 향상된 성능을 보이고 있으나, 막대한 계산시간으로 인해 실제 임상에 적용되기가 매우 어려운 상황이다. 한편, filtered backprojection(FBP)은 알고리즘 자체가 간단하고 계산시간도 매우 단축되므로 대부분의 임상에 널리 적용되고 있다. 본 연구에서는 Bayesian 영상 재구성에서 매우 유용하게 사용되는 spline 모델을 FBP의 고주파 감쇠를 위한 정칙자로 사용함으로써 FBP 영상 재구성에 Bayesian 방법과 유사한 효과를 얻을 수 있음을 보인다.

• 대한의용생체공학회:의공학회지
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• 제22권4호
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• pp.311-319
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• 2001

Statistical reconstruction methods in the context of a Bayesian framework have played an important role in emission tomography since they allow to incorporate a priori information into the reconstruction algorithm. Given the ill-posed nature of tomographic inversion and the poor quality of projection data, the Bayesian approach uses regularizers to stabilize solutions by incorporating suitable prior models. In this work we show that, while the quantitative performance of the standard filtered backprojection (FBP) algorithm is not as good as that of Bayesian methods, the application of spline-regularized smoothing to the sinogram space can make the FBP algorithm improve its performance by inheriting the advantages of using the spline priors in Bayesian methods. We first show how to implement the spline-regularized smoothing filter by deriving mathematical relationship between the regularization and the lowpass filtering. We then compare quantitative performance of our new FBP algorithms using the quantitation of bias/variance and the total squared error (TSE) measured over noise trials. Our numerical results show that the second-order spline filter applied to FBP yields the best results in terms of TSE among the three different spline orders considered in our experiments.

• 한국통계학회:학술대회논문집
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• 한국통계학회 2003년도 춘계 학술발표회 논문집
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• pp.167-170
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• 2003

We develop semiparametric methods for matched case-control studies using regression splines. Three methods are developed: an approximate crossvalidation scheme to estimate the smoothing parameter inherent in regression splines, as well as Monte Carlo Expectation Maximization (MCEM) and Bayesian methods to fit the regression spline model. We compare the approximate cross-validation approach, MCEM and Bayesian approaches using simulation, showing that they appear approximately equally efficient, with the approximate cross-validation method being computationally the most convenient. An example from equine epidemiology that motivated the work is used to demonstrate our approaches.

• Journal of Information Processing Systems
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• 제16권2호
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• pp.318-328
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• 2020

Letter of Credit (L/C) is currently a very popular international settlement method frequently used in international trade processes amongst countries around the globe. Compared with other international settlement methods, however, L/C has some obvious shortcomings. Firstly, it is not easy to use due to the sophisticated processes its usage involves. Secondly, it is sometimes accompanied by a few risks and some uncertainty. Thus, highly efficient methods need to be used to assess and control these risks. To begin with, FAHP and KMV methods are used to resolve the problem of incomplete information associated with L/C and then, on this basis, Bayesian game theory is used in order to make more scientific and reasonable decisions with respect to international trade.

• 응용통계연구
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• 제22권3호
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• pp.607-616
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• 2009

In many epidemiological studies, the occurrence times of the event of interest are right-censored or interval censored. In certain situations such as the AIDS data, however, the incubation period which is the time between HIV infection and the diagnosis of AIDS is usually doubly censored. In this paper, we impute the interval censored HIV infection time using three imputation methods. Mid imputation, conditional mean imputation and approximate Bayesian bootstrap are implemented to obtain right censored data, and then Gibbs sampler is used to estimate the coefficient factor of the incubation period. By using Bayesian approach, flexible modeling and the use of prior information is available. We applied both parametric and semi-parametric methods for estimating the effect of the covariate and compared the imputation results incorporating prior information for the covariate effects.

• Communications for Statistical Applications and Methods
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• 제29권5호
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• pp.561-589
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• 2022

When multiple classifications and regression trees are combined, tree-based ensemble models, such as random forest (RF) and Bayesian additive regression trees (BART), are produced. We compare the model structures and performances of various ensemble models for regression settings in this study. RF learns bootstrapped samples and selects a splitting variable from predictors gathered at each node. The BART model is specified as the sum of trees and is calculated using the Bayesian backfitting algorithm. Throughout the extensive simulation studies, the strengths and drawbacks of the two methods in the presence of missing data, high-dimensional data, or highly correlated data are investigated. In the presence of missing data, BART performs well in general, whereas RF provides adequate coverage. The BART outperforms in high dimensional, highly correlated data. However, in all of the scenarios considered, the RF has a shorter computation time. The performance of the two methods is also compared using two real data sets that represent the aforementioned situations, and the same conclusion is reached.