• Journal of Integrative Natural Science
• /
• v.8 no.4
• /
• pp.273-284
• /
• 2015

Chemoattractant Receptor Homologous molecule expressed on Th2 cells (CRTh2) is a chemoattractant receptor with seven transmembrane helices targeted for inflammatory diseases such as asthma and allergic rhinitis. In this study, pharmacophore based Comparative Molecular Similarity Indices Analysis (CoMSIA) were performed on the series of 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl) acetic acids derivatives. Initially, GASP module was used for generation of pharmacophore models using five highly active compounds from the dataset. Among the generated pharmacophores, the best pharmacophore model was selected based on fitness score and was used as template for the alignment of compounds which was used for CoMSIA analysis. The best predictions were obtained utilizing steric, hydrophobic and H-bond acceptor parameters showing a $q^2$=0.559 and $r^2$=0.730. 15 test set compounds was used to investigate the predictive ability of the CoMSIA model. Contour maps suggested that presence of bulky substituents and H-bond acceptor atoms at $5^{th}$ position of benzene ring will increase the activity of the compounds. The results obtained from this study will be useful to design more potent CRTh2 antagonists.

• Journal of Korean Academy of Nursing Administration
• /
• v.21 no.1
• /
• pp.32-42
• /
• 2015

Purpose: This study was done to elicit basic data for effective human resource management by identifying the relationships among job embeddedness, emotional intelligence, social support, and the turnover intention of Nurses. Methods: Research design was to build a hypothetical causal model between variables and to verify its fitness. The sample for this study was 283 nurses with careers of more than 6 months in one hospital of more than 800 beds located in Seoul. They agreed in writing and this study was approved by the Institutional Review Board. Data were analyzed using SPSS 18.0 and AMOS 18.0 program. Results: Differences in general characteristics for the variables were significant for age, marital status, education, work experience, job title, income, and department. Job embeddedness, emotional intelligence and social support were significantly correlated to turnover intention. Job embeddedness to emotional intelligence and social support showed positive effects and a negative effect to turnover intention. Emotional intelligence to turnover intention showed a positive effect, but social support was not significant. Conclusion: Organizations should provide ways to minimize voluntary turnover of a competent workforce and demonstrate their competency. Also it should develop training and management programs to effectively utilize emotional intelligence.

• Journal of Dental Rehabilitation and Applied Science
• /
• v.19 no.1
• /
• pp.43-48
• /
• 2003

During the past several years, significant advances have occurred in the utilization of osseointegrated implants for the treatment of partially edentulous patients. One of the biggest purposes for treating of these patients is the high demand for improved esthetics, especially in the anterior region. For this esthetics, the new trend in dental implants is the immediate placement and immediate superstructure fabrication. The refined surgical technique, the skillful soft tissue management, and the proper prosthetic coordination are the main factors to achieve natural looking of implant supported prosthesis. The customized provisional restoration and the customized impression coping are recommended for the optimal peri-implant soft tissue contour. The basic concept of Frialit 2 system was the immediate replacement of a tooth with root-analog fixture after extraction. This system guarantees an ideal result in function and esthetics. The ceramic abutment system offers improved quality in the respect of esthetics, fitness, translucency, and biocompatibility. In this clinical report, the final restoration made with IPS Empress 2 crown on the CeraBase abutmen of Frialit 2 system allowed the reproduction of the natural vitality of tooth and adjacent gingiva.

• Transactions of the Korean Society of Mechanical Engineers A
• /
• v.24 no.8 s.179
• /
• pp.1940-1948
• /
• 2000

A design method for maximizing fatigue life of the deep groove ball bearing without enlarging mounting space is proposed by using a genetic algorithm. The use of gradient-based optimization methods for the design of the bearing is restricted because this design problem is characterized by the presence of discrete design variables such as the number of balls and standard ball diameter. Therefore, the design problem of rolling element bearings is a constrained discrete optimization problem. A genetic algorithm using real coding is used to efficiently find the optimum discrete design values. To effectively deal with the design constraints, a ranking method is suggested for constructing a fitness function in the genetic algorithm. Constrains for manufacturing are applied in optimization scheme. Results obtained for several 63 series deep groove ball bearings demonstrated the effectiveness of the proposed design methodology by showing that the average basic dynamic capacities of optimally designed bearings increased about 9-34% compared with the standard ones.

• Journal of the Korean Society of Clothing and Textiles
• /
• v.25 no.1
• /
• pp.91-102
• /
• 2001

The purpose of this study is to suggest a individually fitted slacks pattern in order to help ourselves prepared for the days of the order-based production like the EC in the apparel industry. A pattern was designed to make the personal fit improved based on the present study and the analysis of the measurements and the body shapes. The main characteristics of this newly designed slacks pattern are as follows. To improve fitting, the pattern requires more detailed data such as front and back waist arc, front and back hip arc, hip depth, the gradient of hip. And for personal fitted pattern, knee girth was established in the proportion to the hip girth and the crotch curve was adjusted to the measurements after drawing and the side seam curve was changed according to the front hip type and the ease in waist and hip was established by the percentage. Slacks pattern was developed into an automatic drafting program. Through the sensory evaluation for the appearance and moving fitness, newly designed slacks pattern was turned out to be improved in personal fit espacially for the body type out of the average.

• Journal of the Korean Society of Clothing and Textiles
• /
• v.28 no.3_4
• /
• pp.509-520
• /
• 2004

The aim of this study was to provide the basic 2-dimensional statistics requisite in the siting system and design of gloves. The 64 static measurements were selected to provide information about hands. Participants in the study were 824 adults, aged between 18 and 64. Subjects were divided into four age groups: 18 to 29, 30 to 39, 40 to 49, and 50 to 64, and separated according to sex. Statistical tests such as Descriptive Analysis, and Anova were conducted to analyze the data and ascertain the differences among the ages. The disparities between sex groups were compared by T-test. In addition, correlation among the 57 measurements was analyzed and the results were compared to the data from Japanese and other studies. The results indicated that all the measurements were significantly larger in the male group. There were significant differences among age groups for most hand circumferences, breadths and thickness items. As the age increased, the hand circumferences, breadths and thickness items became wider and thicker. In addition, as the age increased, the mean measurement value of the length items decreased, so that it became shorter. Hand length was highly correlated with finger length, palm length and height. Maximum hand circumference II was highly correlated with hand circumferences, hand breadth and weight.

• Journal of the Korean Society of Clothing and Textiles
• /
• v.34 no.5
• /
• pp.715-725
• /
• 2010

This study suggests through an examination of maternity wear sold in domestic markets a design for maternity wear trousers that integrate functionality, aesthetics, and marketability. This study targeted women who had maternity wear experience to obtain basic information for the design of maternity wear trousers. This study conducted questionnaire research on maternity wear and surveyed the growing on-line maternity market. The results are as follows. First, in the questionnaire research on wearers of maternity wear, women 26-35 years old were the main consumers and emphasized comfortableness as the significant reason for buying and using maternity wear. Second, the centering on pants were evaluated to be the most uncomfortable item among maternity wear and confirms the necessity for a maternity wear design whose bodily fitness is high according to the trouser panel. Third, a standard for the specific design was established to solve maternity wear problems based on the analyzed information. This was established by having a concept as a minimal motive in 'new naturalism' that is the aesthetics of slackness for the $21^{st}$ century. A specific design was developed with 6 kinds for skirts and 9 kinds for pants.

• Journal of the Korea Fashion and Costume Design Association
• /
• v.12 no.4
• /
• pp.137-147
• /
• 2010

This study set out to make experimental clothes by giving variations to the connecting part of a seamless sweater, propose designs and composition approaches to improve the wearing sensation and satisfaction with appearance through wearing trials, and provide basic data that would be of practical help to follow-up study on seamless knit and the growth of seamless knit in the Korean knit industry. The connecting part is the biggest characteristic and the most important part in seamless knitwear and affect the functionality and fitness of the clothes and the appearance of the armhole. The investigator thus made five different pieces of experimental clothes according to the composition methods for connecting part and put them to the test by a group of experts for appearance assessment. The assessment results were analyzed through Analysis of variance(ANOVA), and the items with similar results were put to the Duncan test for intergroup comparison. According to the analysis results, experimental clothes C and E received the highest evaluation in almost every assessment item, whereas experimental clothes A did the lowest appearance evaluation.

• The Journal of Korean Physical Therapy
• /
• v.14 no.4
• /
• pp.423-440
• /
• 2002

The purpose of this study is to investigate the conception and developmental process of stretching in sports physical therapy. This study is to find conception of stretching, feature and effect, principles and fundamental rule, consideration of enforcement and developmental process in order to use the basic material which is very helpful in the every field and the scene of sports needing stretching. Flexibility is the ability to move muscles and joints through their full ranges of motion. Flexibility is developed by stretching. About player who insufficiency of flexibility, patient and disabled person who restrict of range of motion, older adult who reduce of flexibility, promote of flexibility for upgrading stability and efficiency of body on the based of scientific principles is completed by stretching. The method of stretching has been developed with passive stretching, CR, PNF stretching, PIC stretching, MET stretching in the order. The effects that we can get through stretching are as follows : 1. Enhance physical fitness. 2. Optimize learning, practice and performance of many types of skilled movement. 3. Increase mental and physical relaxation. 4. Promote development of body awareness. 5. Reduce risk of joint sprain or muscle strain. 6. Reduce risk of back problem. 7 Reduce muscular soreness. 8. Reduce the severity of painful menstruation for female athletes. 9. Reduce muscular tension. 10. Advance recognition of body.

• Journal of Fashion Business
• /
• v.7 no.4
• /
• pp.129-141
• /
• 2003

The aim of this study was to improve the fitness of Korean made apparel products being exported to China by developed the standard bodice block for the standard body of chinese women. For study, 139 adult Chinese women(aged between 19 and 24) in Beijing and Shanghai were sampled to be measured for there body sizes. In order to develope the standard bodice block, 3 women was selected closely the standard body measurement and the fitting was tested. The results of this study were as follows. As compared with the means measurement of chinese women in Beijing and Shanghai, there were difference between the two. Especially, width, thickness, girth and hight items. The standard bodice block drafted and tested. It showed unfit problems. and were adjusted. The application measurements of standard body was selected. As based on item, it has finally developed the standard bodice block of tight-fitting shape.