• Title/Summary/Keyword: Basic Research Program

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1H NMR-based metabolite profiling of diet-induced obesity in a mouse mode

  • Jung, Jee-Youn;Kim, Il-Yong;Kim, Yo-Na;Kim, Jin-Sup;Shin, Jae-Hoon;Jang, Zi-Hey;Lee, Ho-Sub;Hwang, Geum-Sook;Seong, Je-Kyung
    • BMB Reports
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    • v.45 no.7
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    • pp.419-424
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    • 2012
  • High-fat diets (HFD) and high-carbohydrate diets (HCD)-induced obesity through different pathways, but the metabolic differences between these diets are not fully understood. Therefore, we applied proton nuclear magnetic resonance ($^1H$ NMR)-based metabolomics to compare the metabolic patterns between C57BL/6 mice fed HCD and those fed HFD. Principal component analysis derived from $^1H$ NMR spectra of urine showed a clear separation between the HCD and HFD groups. Based on the changes in urinary metabolites, the slow rate of weight gain in mice fed the HCD related to activation of the tricarboxylic acid cycle (resulting in increased levels of citrate and succinate in HCD mice), while the HFD affected nicotinamide metabolism (increased levels of 1-methylnicotineamide, nicotinamide-N-oxide in HFD mice), which leads to systemic oxidative stress. In addition, perturbation of gut microflora metabolism was also related to different metabolic patterns of those two diets. These findings demonstrate that $^1H$ NMR-based metabolomics can identify diet-dependent perturbations in biological pathways.

Effects of Physical Activity Program on Body Composition and Basic Motor Skills in Obese Children (신체활동 프로그램이 비만유아의 체성분과 기본운동능력에 미치는 영향)

  • Kim, Won-Jun;Na, Seung-Hee
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.11 no.11
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    • pp.4266-4272
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    • 2010
  • The purpose of this study was to find the effects of physical activity program on obese young children's body composition and basic motor skills. The physical activity program was conducted with 16 participants whose Kaup Index were higher than 20 were divided into 2 groups(experimental group and control group) for 12 weeks three times a week. Results of the study are as following. First, the physical activity program was found to improve sub-factors of body composition(weight, body fat mass, % body fat, lean body mass and total body water) in the experimental group compared to the control group. There was statistically significant difference between two groups. Second, the physical activity program was found to improve locomotor and manipulation skills of basic motor skills in the experimental group compared to the control group. There was a statistically significant difference between two groups. Based on these results, the physical activity program have positive effects on the changes in obese young children's body composition and basic motor skills.

Development of a Computation Program for Automatic Processing of Calibration Data of Radiation Instrument (방사선 측정기 교정 데이터의 자동처리를 위한 전산프로그램 개발)

  • Jang, Ji-Woon;Shin, Hee-Sung;Youn, Cheung;Lee, Yun-Hee;Kim, Ho-Dong;Jung, Ki-Jung
    • Journal of the Korean Society for Nondestructive Testing
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    • v.26 no.4
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    • pp.246-254
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    • 2006
  • A computation program has been developed for automatic data processing in the calibration process of gamma survey meter. The automatic processing program has been developed based on Visual Basic. The program has been coded according to steps of calibration procedure. The OLE(object linking an embedding) Excel automation method fur automatic data processing is used in this program, which is a kind of programming technique for the Excel control. The performance test on the basis of reference data has been carried out by using the developed program. In the results of performance test, the values of calibration factors and uncertainties by the developed program were equal to those obtained from the reference data. In addition, It was revealed that the efficiency and precision of working are significantly increased by using the developed program.

The Development of Basic Skill Program and e-Learning Contents ; self-development capability for Vocational High School Students (직업기초능력 프로그램 및 e-Learning 콘텐츠 개발 연구 -전문계고생의 자기개발능력을 중심으로-)

  • Byun, Sook-Young;Lee, Soo-Kyoung
    • Journal of Digital Contents Society
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    • v.11 no.3
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    • pp.349-356
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    • 2010
  • This study was to develop improving vocational basic skill program and content which are basic of instruction-learning ability for the vocational education substantiality. To pursue this goal, 'self-development capability' among vocational basic skills was developed through the research methodology and procedure. The interpersonal relation capability was selected as one of vocational basic skill areas when it was more effective by e-learning contents through literature review, expert conference etc. The self-development capability can be self-control and development under performing business tasks. In this study, self-development capability was programmed a interpersonal scheme, a cooperative capability, a leadership capability, a conflict management, negotiation capability, and a customer service capability. Especially this program was developed as a form of e-Learning contents focusing on improving problem solving under real case using multimedia strategies such as movies, simulation, game.

Development of Microcomputerized Master Standard Data (마이크로 컴퓨터를 이용한 기본표준자료(基本標準資料) 개발)

  • Park, Gyeong-Su
    • Journal of the Ergonomics Society of Korea
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    • v.4 no.1
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    • pp.3-6
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    • 1985
  • This research developes a microcomputer program for MSD which is one of the most widely llsed predetermined time standards. The program is written in BASIC and designed mainly for desk-top or portable microcomputer to facilitate the development of standard times for time study analysis. A simple case is illustrated to show the program running procedure.

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Development target of intelligent DAS with the function of distribution transformer monitoring (배전변압기 감시제어 기능이 통합된 지능형 배전자동화 시스템 개발 방향)

  • Ha, Bok-Nam;Seol, Lee-Ho;Park, Shin-Yeol;Jeong, Yeong-Beom
    • Proceedings of the KIEE Conference
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    • 2005.07a
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    • pp.554-556
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    • 2005
  • Distribution Automation System (DAS) will provide supervision and remote control of switches and reclosers such as pole pounted switches and pad-mounted switchgears on high voltage distribution line. Kepco had developed basic function such as remote monitoring, remote control, remote measuring and remote setting at first. As a next step, Kepco has been developed diverse application programs such as single line diagram drawing program, relay coordination program, feeder reconfiguration program, over load elimination program, bad data detection program, section load management program, fault processing program and so on. Kepco is examining to develop more powerful functions for special specification of foreign distribution automation system. This paper explains what is the target for overseas DAS market.

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A Study on the Effect of MBTI (Myers and Briggs Type Indicator) Basic Program on the Interpersonal Relationship Between Nursing Science Major Students and Their Cohesion (MBTI 기본 프로그램이 간호대학생의 대인관계와 집단응집력에 미치는 영향)

  • Hwang Seung Sook
    • Journal of Korean Public Health Nursing
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    • v.18 no.1
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    • pp.61-73
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    • 2004
  • This study is intended to suggest fundamental data necessary for developing MBTI program that can help improve interpersonal relation skills of nursing science major students and their cohesion. This study is pre-experimental research by one group pretest-post test design to examine the effect of MBTI(Myers and Briggs Type Indicator) basic program on the interpersonal relationship between nursing science major students and their group cohesion and the relationship between interpersonal relationship and their group cohesion. I selected 39 of sophomore students in the department nursing science of K university in I metropolitan city as test group. 35 of them joined post-test. Pretest and MBTI basic program were done before conducting MBTI program. Collected data were analyzed by SPSS window 7.5. The difference in test group before and after conducting program was examined by paired t-test. The correlation between interpersonal relationship and group cohesion was measured by using Pearson Correlation Coefficient. The findings are as follows. $\cdot$ The difference before and after conducting MBTI program by sub-factors of interpersonal relation: There was no significant difference, as the average figure of interpersonal relation in test group was 87.22 before conducting MBTI and 85.08 after conducting MBTI respectively. The average figure of sensitivity among the sub-factors of interpersonal relation was 7.71 before conducting MBTI and reduced to 7.08 after conducting MBTI and there was significant difference between before and after conducting MBTI(t=-2.484, p=.018) $\cdot$ The difference in group cohesion before and after conducting MBTI program: The average figure of group cohesion in test group was 56.68 before conducting MBTI and increased a bit to 56.80 after conducting MBTI\, but there was no significant difference between them. $\cdot$ The relationship between interpersonal relationship and group cohesion before and after conducting MBTI: As the relationship between interpersonal relationship and group cohesion before and after conducting MBTI is examined, there was positive correlation of the significance level. p<.05 before conducting MBTI(r=.320, p=.047), and of the significance level, p<.01 after conducting MBTI(r=.780, p=.000). The investigation on the relation between sub-factors of group cohesion and of interpersonal relation before conducting MBTI basic program revealed that there was positive correlation between openness, reliability, friendliness and satisfaction, and group intervention, between receptivity among group members and reliability, and between group atmosphere and satisfaction. The investigation on the relation between sub-factors of group cohesion and of interpersonal relation after conducting MBTI basic program revealed that there was positive correlation between openness, communication, understanding, friendliness and satisfaction. and group intervention. There was positive correlation between receptivity among group members and openness, communication, understanding, friendliness and satisfaction. There was positive correlation between openness, communication, friendliness and satisfaction, and group atmosphere. Based on the above findings, I realize that MBTI basic program is essential to the improvement of group cohesion. In addition, it is shown that the sub-factors of interpersonal relation such as openness, communication, friendliness, satisfaction, and understanding, and the sub-factors such as group intervention and receptivity among group members are major factors to improve interpersonal relationship and group cohesion. So, the future MBTI program should include sub-programs that deal with the above factors to improve interpersonal relationship and group cohesion.

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Development of Water Environmental Education Program Using Streams - Focused on ENVISION - (소하천 물 환경교육 프로그램 개발 - ENVISION을 중심으로 -)

  • Kim, Jeong-Hwa;Lee, Du-Gon
    • Hwankyungkyoyuk
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    • v.20 no.4
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    • pp.12-26
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    • 2007
  • The purpose of this research is to develop a water environmental education (EE) program using streams, based on the core ideas of ENVISION and materializing elements that were extracted in this research. This research realized the elements and presented a model of the water EE program using a local stream. First, this research developed a basic model of a water EE program using streams by extracting 10 materializing elements and realizing the elements in 4 stage-procedural model. The 10 materializing elements were 1. experiencing the process of inquiry, 2. inquiring local environments, 3. self-directing learning and mutual interaction with colleagues, 4. collecting real data and interpreting, 5. utilizing the ICT(information and communication technology), 6. inquiring with the view point of the 'Environmental Studies for EE', 7. inquiring with the watershed concept, 8. inquiring with the integrating and the holistic view point, 9. pursuing the macroscopic understanding about environment, and 10. connecting the real world phenomena with the environmental concepts and theories. This research materialized these 10 elements in 4 stage model, following the previous ENVISION research, which are 1. preparing stage and visual assessment, 2. writing the report of the inquiry plan, 3. collecting the real data in the environment and performing the investigation, and 4. presenting the inquiry results. Second, with using this basic model, this research developed and presented a model of the specific water EE program using a case stream called 'Baig Cheon' stream, which is a local stream. This research is considered to have a considerable meaning in developing a EE program with ENVISION ideas for the watershed concept and inquiry with environmental science using local streams. The developed model can help the professional development of teachers and teacher education of water EE.

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Primary hepatic hemangiosarcoma (HSA) in a Schnauzer dog

  • Kang, Min-Hee;Heo, Ra-Young;Park, Hee-Myung
    • Korean Journal of Veterinary Research
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    • v.49 no.3
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    • pp.249-252
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    • 2009
  • A 6-year-old, neutered male, Schnauzer was presented with a one year history of weight loss and exercise intolerance. Physical examination revealed abdominal distention and ecchymosis on the abdominal skin. CBC and serum chemistry profiles revealed anemia and increased serum liver enzymes. Ultrasonography revealed a large liver mass which was characterized by multiple hypoechoic lesions. Postmortem examination revealed primary hepatic hemangiosarcoma. The tumor had extended to the mesentery and diaphragm, but distant metastasis was not found. This case report describes primary hepatic hemangiosarcoma which is very rare in a dog.

A Development of Internet Based Educational Program for Nursing Informatics (인터넷을 활용한 간호정보학 교육 프로그램 개발)

  • Jung, Myun-Sook
    • Journal of Korean Academy of Nursing Administration
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    • v.6 no.2
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    • pp.177-194
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    • 2000
  • This study was conducted to develop the internet based Nursing Informatics educational program. This program is consisted of 14 weeks (2 credit, 1 semester) course. Classes include, 'Understanding of Nursing Informatics'. 'Basic computing technologies', 'Basic web page building', 'Navigating Healthcare related Information', 'Nursing Informatics-Practice, Education, Research', 'Issues in Nursing Informatics'. After finishing the course, students' satisfaction about this program was very high and positive. The results suggest that this program is useful to the education of Nursing Informatics and can be used as an alternative teaching method which does restrict time and place in Nursing Education in a newly changing era.

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